Published in Nature on October 28, 1983
Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: relation to hypercortisolism and corticotropin-releasing hormone. Proc Natl Acad Sci U S A (2000) 2.19
Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc Natl Acad Sci U S A (1994) 2.14
Stress, depression and cardiovascular dysregulation: a review of neurobiological mechanisms and the integration of research from preclinical disease models. Stress (2009) 1.61
The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry (2009) 1.43
Sexual dimorphism of stress response and immune/ inflammatory reaction: the corticotropin releasing hormone perspective. Mediators Inflamm (1995) 0.95
The CRF system and social behavior: a review. Front Neurosci (2013) 0.88
Evidence for a role of endogenous corticotropin-releasing factor in cold, ether, immobilization, and traumatic stress. Proc Natl Acad Sci U S A (1985) 0.86
Distribution of corticotropin-releasing factor receptors in primate brain. Proc Natl Acad Sci U S A (1986) 0.85
Effects of intra-PAG infusion of ovine CRF on defensive behaviors in Swiss-Webster mice. Behav Brain Res (2006) 0.84
Corticotropin-releasing factor. Mechanisms to inhibit gastric acid secretion in conscious dogs. J Clin Invest (1985) 0.83
Regulation of duodenal bicarbonate secretion during stress by corticotropin-releasing factor and beta-endorphin. Proc Natl Acad Sci U S A (1989) 0.82
The effects of beta-endorphin: state change modification. Fluids Barriers CNS (2015) 0.80
Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption. Elife (2015) 0.80
Time- and dose-dependent effects of corticotropin releasing factor on cerebral glucose metabolism in rats. J Neural Transm (Vienna) (2005) 0.77
Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin. Science (1981) 9.64
Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science (1973) 7.47
A receptor in pituitary and hypothalamus that functions in growth hormone release. Science (1996) 5.45
Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature (1983) 5.20
Organization of ovine corticotropin-releasing factor immunoreactive cells and fibers in the rat brain: an immunohistochemical study. Neuroendocrinology (1983) 4.67
Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse. J Comp Neurol (2000) 4.17
The melanin-concentrating hormone system of the rat brain: an immuno- and hybridization histochemical characterization. J Comp Neurol (1992) 3.53
Interleukin-1 stimulates the secretion of hypothalamic corticotropin-releasing factor. Science (1987) 3.45
A radioimmunoassay for rat plasma ACTH. Endocrinology (1971) 3.35
beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell (1995) 3.33
Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor. Proc Natl Acad Sci U S A (2001) 3.23
Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res (1997) 3.21
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14
Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron (1998) 3.08
Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors. Proc Natl Acad Sci U S A (2001) 2.87
Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science (1984) 2.83
Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A. Mol Cell Biol (1993) 2.79
Diversity of Conus neuropeptides. Science (1990) 2.78
Peptide neurotoxins from fish-hunting cone snails. Science (1985) 2.77
beta-Endorphin and adrenocorticotropin are selected concomitantly by the pituitary gland. Science (1977) 2.68
Characterization of a growth hormone-releasing factor from a human pancreatic islet tumour. Nature (1982) 2.44
Characterization of a bipartite activator domain in transcription factor CREB. Cell (1990) 2.41
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid. Nature (1986) 2.29
Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures. Cell (1990) 2.22
Long-term treatment of acromegaly with bromocriptine. Br Med J (1977) 2.18
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature (2000) 2.17
Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary. Proc Natl Acad Sci U S A (1994) 2.14
Culture of enzymatically dispersed pituitary cells: functional validation of a method. Endocrinology (1972) 2.09
Rapid regression of uterine leiomyomas in response to daily administration of gonadotropin-releasing hormone antagonist. Fertil Steril (1993) 2.09
CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat. Psychopharmacology (Berl) (1991) 2.04
Differential distribution of 5HT1D- and 5HT1B-immunoreactivity within the human trigemino-cerebrovascular system: implications for the discovery of new antimigraine drugs. Cephalalgia (1997) 1.99
Increased beta-endorphin but not met-enkephalin levels in human cerebrospinal fluid after acupuncture for recurrent pain. Lancet (1980) 1.94
Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A (1984) 1.93
Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science (1996) 1.91
Age-related cognitive deficits, impaired long-term potentiation and reduction in synaptic marker density in mice lacking the beta-amyloid precursor protein. Neuroscience (1999) 1.88
Synthetic competitive antagonists of corticotropin-releasing factor: effect on ACTH secretion in the rat. Science (1984) 1.87
Identification of a second corticotropin-releasing factor receptor gene and characterization of a cDNA expressed in heart. Proc Natl Acad Sci U S A (1995) 1.86
Chemical and biological characterization of corticotropin releasing factor. Recent Prog Horm Res (1983) 1.86
Corticotropin releasing factor produces behavioural activation in rats. Nature (1982) 1.82
Suppression of pancreatic endocrine tumour secretion by long-acting somatostatin analogue. Lancet (1979) 1.81
Primary structure of corticotropin-releasing factor from ovine hypothalamus. Proc Natl Acad Sci U S A (1981) 1.78
Corticotropin releasing factor decreases postburst hyperpolarizations and excites hippocampal neurons. Science (1983) 1.77
Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study. J Neurosci (1985) 1.77
Tissue distribution of adenosine receptor mRNAs in the rat. Br J Pharmacol (1996) 1.72
Molecular and functional diversity of the expanding GABA-A receptor gene family. Ann N Y Acad Sci (1999) 1.71
Somatostatin. Recent Prog Horm Res (1975) 1.67
Preliminary observations on the effect of synthetic thyrotropin releasing factor on plasma thyrotropin levels in man. J Clin Endocrinol Metab (1970) 1.67
Regulatory peptides of the hypothalamus. Annu Rev Physiol (1977) 1.64
Modulation of stress-induced ACTH release by corticotropin-releasing factor, catecholamines and vasopressin. Nature (1983) 1.64
Diagnosis and management of ACTH-dependent Cushing's syndrome: comparison of the features in ectopic and pituitary ACTH production. Clin Endocrinol (Oxf) (1986) 1.62
Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J Neurosci (1991) 1.62
Mechanisms contributing to the deficits in hippocampal synaptic plasticity in mice lacking amyloid precursor protein. Neuropharmacology (1999) 1.60
Somatotroph hyperplasia. Successful treatment of acromegaly by removal of a pancreatic islet tumor secreting a growth hormone-releasing factor. J Clin Invest (1982) 1.60
Corticotropin-releasing factor: actions on the sympathetic nervous system and metabolism. Endocrinology (1982) 1.58
Characterization of rat hypothalamic corticotropin-releasing factor. Proc Natl Acad Sci U S A (1983) 1.58
"Medical oophorectomy" using a long-acting GNRH agonist--a possible new approach to the treatment of endometriosis. J Clin Endocrinol Metab (1982) 1.57
Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol Psychiatry (2009) 1.57
Intraventricular corticotropin-releasing factor enhances behavioral effects of novelty. Life Sci (1982) 1.57
Reversible inhibition of testicular steroidogenesis and spermatogenesis by a potent gonadotropin-releasing hormone agonist in normal men: an approach toward the development of a male contraceptive. N Engl J Med (1981) 1.57
Primary structure of the ovine hypothalamic luteinizing hormone-releasing factor (LRF) (LH-hypothalamus-LRF-gas chromatography-mass spectrometry-decapeptide-Edman degradation). Proc Natl Acad Sci U S A (1972) 1.57
Ectopic hormone production by non-endocrine tumours. Clin Endocrinol (Oxf) (1974) 1.56
Corticotropin releasing factor produces increases in brain excitability and convulsive seizures in rats. Brain Res (1983) 1.55
theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci U S A (1999) 1.54
Lung tumours and ACTH production. Clin Endocrinol (Oxf) (1977) 1.54
Assay of corticotropin releasing factor. Methods Enzymol (1983) 1.53
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem (2002) 1.53
The functional neuroanatomy of corticotropin-releasing factor. Ciba Found Symp (1993) 1.52
Regulation of transforming growth factor beta- and activin-induced transcription by mammalian Mad proteins. Proc Natl Acad Sci U S A (1996) 1.46
A reappraisal of human beta MSH. Nature (1974) 1.46
Corticotropin-releasing factor antagonist attenuates the "anxiogenic-like" effect in the defensive burying paradigm but not in the elevated plus-maze following chronic cocaine in rats. Psychopharmacology (Berl) (1999) 1.46
Effect of ethanol on the hypothalamic-pituitary-adrenal axis in the rat: role of corticotropin-releasing factor (CRF). J Pharmacol Exp Ther (1984) 1.46
Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor. Proc Natl Acad Sci U S A (1995) 1.45
Cushing's syndrome. Clin Endocrinol Metab (1985) 1.44
The effect of somatostatin analogs on secretion of growth, pancreatic, and gastrointestinal hormones in man. J Clin Endocrinol Metab (1981) 1.42
CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats. Gut (2005) 1.41