Published in Immunol Rev on January 01, 1983
The antigen-specific, major histocompatibility complex-restricted receptor on T cells. VI. An antibody to a receptor allotype. J Exp Med (1984) 4.29
The T cell antigen receptor complex expressed on normal peripheral blood CD4-, CD8- T lymphocytes. A CD3-associated disulfide-linked gamma chain heterodimer. J Exp Med (1987) 2.52
Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets. Proc Natl Acad Sci U S A (1985) 1.78
Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation. Proc Natl Acad Sci U S A (1998) 1.26
Murine T cell receptor beta chain is encoded on chromosome 6. J Exp Med (1984) 1.16
Heterogeneity of T cell receptor idiotypes in rheumatoid arthritis. Clin Exp Immunol (1988) 0.97
Augmentation of cell-mediated responses in vitro by a monoclonal anti-helper factor antibody. Immunology (1985) 0.80
Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24
Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69
T-lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu Rev Immunol (1985) 6.98
LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell (1998) 6.15
In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice. J Exp Med (1975) 5.53
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med (1987) 5.48
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (1989) 5.20
LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity (1998) 4.56
Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20
Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science (1989) 4.19
Medicinal applications of delta-9-tetrahydrocannabinol and marijuana. Ann Intern Med (1997) 4.08
A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family. Nature (1987) 3.96
T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell (1991) 3.95
Essential role of LAT in T cell development. Immunity (1999) 3.94
Monoclonal antibody against an Ir gene product? J Exp Med (1980) 3.88
A subset of CD4+ thymocytes selected by MHC class I molecules. Science (1994) 3.87
Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc Natl Acad Sci U S A (1990) 3.69
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67
Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc Natl Acad Sci U S A (1983) 3.66
Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol (1990) 3.51
Activation events during thymic selection. J Exp Med (1992) 3.43
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (1995) 3.40
The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell (1982) 3.38
LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36
Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30
Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29
Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem (2000) 3.03
Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00
Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol (1987) 2.85
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature (1988) 2.84
Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med (1984) 2.71
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64
Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58
Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med (1982) 2.58
Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc Natl Acad Sci U S A (1987) 2.57
Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A (1983) 2.57
Diagnosis and management of group A streptococcal pharyngitis: a practice guideline. Infectious Diseases Society of America. Clin Infect Dis (1997) 2.54
T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50
Allogeneic non-T spleen cells restore the responsiveness of normal T cell clones stimulated with antigen and chemically modified antigen-presenting cells. J Immunol (1988) 2.48
LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity (2000) 2.48
Complex complexes: signaling at the TCR. Immunity (1996) 2.42
Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes. Science (1986) 2.40
Reversal of in vitro T cell clonal anergy by IL-2 stimulation. Int Immunol (1992) 2.39
Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol (1990) 2.37
Prevention of Bacterial Endocarditis. A statement for health professionals by the Committee on Rheumatic Fever and Infective Endocarditis of the Council on Cardiovascular Disease in the Young. Circulation (1984) 2.33
Validity of adolescent self-report of alcohol and other drug involvement. Int J Addict (1992) 2.32
Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med (1977) 2.30
T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation. J Exp Med (1976) 2.27
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J Immunol (1999) 2.26
Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science (1992) 2.25
The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells. J Biol Chem (1992) 2.25
Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J Biol Chem (1993) 2.19
Direct cloning and extended culture of antigen-specific MHC-restricted, proliferating T lymphocytes. Nature (1980) 2.15
T lymphocyte-enriched murine peritoneal exudate cells. I. A reliable assay for antigen-induced T lymphocyte proliferation. J Immunol (1975) 2.11
Separation of murine lymphoid cells using nylon wool columns. Recovery of the B cell-enriched population. Transplantation (1974) 2.10
Effects of cyclosporine A on T cell development and clonal deletion. Science (1988) 2.08
T-cell unresponsiveness in vivo and in vitro: fine specificity of induction and molecular characterization of the unresponsive state. Immunol Rev (1987) 2.07
The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem (1988) 2.04
Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol (1999) 2.00
Differential expression of two distinct T-cell receptors during thymocyte development. Nature (1987) 1.95
Characterization of an anti-peptide antibody that recognizes the murine analogue of the human T cell antigen receptor-T3 delta-chain. J Immunol (1986) 1.91
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science (1990) 1.89
p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. Mol Cell Biol (1992) 1.87
The Ia molecule of the antigen-presenting cell plays a critical role in immune response gene regulation of T cell activation. J Mol Cell Immunol (1983) 1.84
Demonstration that monocytes rather than lymphocytes are the insulin-binding cells in preparations of humah peripheral blood mononuclear leukocytes: implications for studies of insulin-resistant states in man. Proc Natl Acad Sci U S A (1975) 1.83
The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11). J Exp Med (1976) 1.81
Immune response (Ir) genes of the murine major histocompatibility complex. Adv Immunol (1986) 1.81
Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide. Proc Natl Acad Sci U S A (1990) 1.80
Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors. J Biol Chem (1988) 1.79
Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J Biol Chem (1994) 1.77
Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J Exp Med (1984) 1.76
IA mutant functional antigen-presenting cell lines. J Immunol (1983) 1.76
The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem (1994) 1.72
T cell antigen-receptor signal transduction. Curr Opin Immunol (1999) 1.68
The effect of allogeneic presensitization on H-Y graft survival and in vitro cell-mediated responses to H-y antigen. J Exp Med (1976) 1.67
Studies of Ia antigens on murine peritoneal macrophages. Scand J Immunol (1976) 1.66
Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules. J Exp Med (1981) 1.65
Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome C. J Immunol (1983) 1.63
Multiple kinases and signal transduction. Phosphorylation of the T cell antigen receptor complex. J Biol Chem (1987) 1.63
Intrathymic signalling in immature CD4+CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain. Nature (1989) 1.62
Alloreactivity of an antigen-specific T-cell clone. Nature (1980) 1.62
A 20-kDa protein associated with the murine T-cell antigen receptor is phosphorylated in response to activation by antigen or concanavalin A. Proc Natl Acad Sci U S A (1985) 1.62
The product of the proto-oncogene c-cbl: a negative regulator of the Syk tyrosine kinase. Science (1997) 1.60
Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70. J Biol Chem (1995) 1.60
Antigen-specific clones of proliferating T lymphocytes. I. Methodology, specificity, and MHC restriction. J Immunol (1981) 1.60
T cell CD3-zeta eta heterodimer expression and coupling to phosphoinositide hydrolysis. Science (1988) 1.57
Expression of genes of the T-cell antigen receptor complex in precursor thymocytes. Nature (1985) 1.57
A clonal deletion model for Ir gene control of the immune response. Scand J Immunol (1978) 1.56
Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion. Proc Natl Acad Sci U S A (1978) 1.55
T cell antigen receptor engagement stimulates c-raf phosphorylation and induces c-raf-associated kinase activity via a protein kinase C-dependent pathway. J Biol Chem (1990) 1.53