Published in J Exp Med on February 01, 1982
Several mechanisms can account for defective E alpha gene expression in different mouse haplotypes. Proc Natl Acad Sci U S A (1983) 2.84
Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A (1983) 2.57
Allele-specific control of Ia molecule surface expression and conformation: implications for a general model of Ia structure-function relationships. Proc Natl Acad Sci U S A (1987) 1.67
Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition. J Exp Med (1985) 1.46
The I-Ab mutant B6.C-H-2bm12 allows definition of multiple T cell epitopes on I-A molecules. J Exp Med (1983) 1.28
Multiple functional sites on a single Ia molecule defined using T cell clones and antibodies with chain-determined specificity. J Exp Med (1984) 1.18
Cotransfer of the Ed alpha and Ad beta genes into L cells results in the surface expression of a functional mixed-isotype Ia molecule. Proc Natl Acad Sci U S A (1986) 1.17
Functional and inducible expression of a transfected murine class II major histocompatibility complex gene. Proc Natl Acad Sci U S A (1984) 1.05
Presentation of antigen by mixed isotype class II molecules in normal H-2d mice. J Exp Med (1992) 1.02
Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products. J Exp Med (1983) 1.00
The effect of excess beta-chain synthesis on cell-surface expression of allele-mismatched class II heterodimers in vivo. Proc Natl Acad Sci U S A (1990) 1.00
Immune deficiency due to high copy numbers of an Ak beta transgene. Proc Natl Acad Sci U S A (1990) 0.91
Infiltration of CD4+ CD8+ T cells, and expression of ICAM-1, Ia antigens, IL-1 alpha and TNF-alpha in the skin lesion of BALB/c mice undergoing repeated infestations with nymphal Ixodes ricinus ticks. Immunology (1994) 0.89
Involvement of the K and I regions of the H-2 complex in resistance to hemopoietic allografts. J Exp Med (1984) 0.87
gamma delta+ T cells regulate major histocompatibility complex class II(IA and IE)-dependent susceptibility to coxsackievirus B3-induced autoimmune myocarditis. J Virol (1999) 0.86
Major histocompatibility complex restriction fragment length polymorphisms define three diabetogenic haplotypes in BB and BBN rats. J Exp Med (1985) 0.76
Role of the H-2 complex in induction of T helper cells in vivo. III. Contribution of the I-E subregion to restriction sites recognized by I-A/E-restricted T cells. J Exp Med (1982) 0.75
Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens. J Immunol (1980) 8.56
T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J Exp Med (1980) 6.62
A new I subregion (I-J) marked by a locus (Ia-4) controlling surface determinants on suppressor T lymphocytes. J Exp Med (1976) 6.11
Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79
Antigen-reactive T cell clones. I. Transcomplementing hybrid I-A-region gene products function effectively in antigen presentation. J Exp Med (1980) 4.47
The kinetics of antibody binding to membrane antigens in solution and at the cell surface. Biochem J (1980) 4.37
Monoclonal antibody against an Ir gene product? J Exp Med (1980) 3.88
Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates. Mol Immunol (1979) 2.86
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64
Variable synthesis and expression of E alpha and Ae (E beta) Ia polypeptide chains in mice of different H-2 haplotypes. Immunogenetics (1981) 2.13
Inhibition of immune responses in vitro by specific antiserums to Ia antigens. Science (1975) 1.65
The invariant chain of murine Ia antigens: its glycosylation, abundance and subcellular localization. Mol Immunol (1981) 1.65
Genetic control of specific immune responses and immune suppressions by I-region genes. Cold Spring Harb Symp Quant Biol (1977) 1.63
Effects of blocking helper T cell induction in vivo with anti-Ia antibodies. Possible role of I-A/E hybrid molecules as restriction elements. J Exp Med (1980) 1.59
Ir gene function in an I-A subregion mutant B6.C-H-2bm12. J Exp Med (1981) 1.51
Structural studies on the murine Ia alloantigens--III. Tryptic peptide comparisons of allelic products of the I-E/C sub-region. Mol Immunol (1979) 1.42
Serological and biochemical identification of hybrid Ia antigens. J Exp Med (1980) 1.38
Small subunit of I-A subregion antigens determines the allospecificity recognized by a monoclonal antibody. Nature (1980) 1.38
Structural polymorphism of I-E subregion antigens determined by a gene in the H-2K to I-B genetic interval. Nature (1979) 1.36
Structural studies on the murine Ia alloantigens. V. Evidence that the structural gene for the I-E/C beta polypeptide is encoded within the I-A subregion. J Exp Med (1979) 1.34
Interaction between I region loci influences the expression of a cell surface Ia antigen. Proc Natl Acad Sci U S A (1980) 1.20
Inhibition of antigen-induced proliferation of T cells from radiation-induced bone marrow chimeras by a monoclonal antibody directed against an Ia determinant on the antigen-presenting cell. Proc Natl Acad Sci U S A (1981) 1.18
Major histocompatibility complex-restricted self recognition. A monoclonal anti-I-Ak reagent blocks helper T cell recognition of self major histocompatibility complex determinants. J Exp Med (1980) 1.14
Gene complementation in the T lymphocyte proliferative response to poly (Glu56Lys35Phe9)n. Functional evidence for a restriction element coded for by both the I-A and I-E subregions. Eur J Immunol (1980) 1.05
The xid gene controls Ia.W39-associated immune response gene function. J Exp Med (1981) 1.04
Structural studies on the murine Ia alloantigens. VI. Evidence that both subunits of the I-A alloantigen are encoded by the I-A subregion. J Immunol (1979) 1.04
Biochemical characterization of Ia antigens. I. Characterization of the 31K polypeptide associated with I-A subregion Ia antigens. J Immunol (1980) 1.04
Rapid binding test for detection of alloantibodies to lymphocyte surface antigens. Curr Top Microbiol Immunol (1978) 0.93
Derivation of a monoclonal antibody that detects an Ia antigen encoded by 2 complementing I-subregions. J Immunol (1980) 0.91
Trans gene complementation of I-E subregion antigens. J Immunol (1979) 0.89
Complementation between I region genes is revealed by a hybridoma anti-Ia antibody. Transplantation (1981) 0.88
Gene complementation in the T lymphocyte proliferative response to poly (Glu57Lys38Tyr5): evidence for effects of polymer handling and gene dosage. J Immunol (1979) 0.84
H-2 expression by lymphoid cells of different mouse strains: quantitative interaction of H-2 with monoclonal antibodies and their Fab fragments. Immunology (1981) 0.83
Structural analysis of a new B-cell-differentiation antigen associated with products of the I-A subregion of the H-2 complex. Proc Natl Acad Sci U S A (1981) 0.83
Gene dose effects in Ir gene-controlled systems. J Immunol (1979) 0.82
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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature (1997) 23.92
Properties of monoclonal antibodies to mouse Ig allotypes, H-2, and Ia antigens. Curr Top Microbiol Immunol (1978) 13.40
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proc Natl Acad Sci U S A (1981) 10.72
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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell (1998) 8.73
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Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol (1989) 7.69
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Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin 1 is required for the expression of receptors for interleukin 2. J Immunol (1984) 5.51
Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo. J Exp Med (1987) 5.48
Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Ann N Y Acad Sci (1975) 5.26
HISTOLOGICAL AND SEROLOGICAL SEQUENCES IN EXPERIMENTAL HYPERSENSITIVITY. J Exp Med (1947) 5.11
Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma. J Exp Med (1993) 4.99
Microtubules: evidence for 13 protofilaments. J Cell Biol (1973) 4.91
Two-gene control of the expression of a murine Ia antigen. J Exp Med (1978) 4.79
Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science (1989) 4.19
Medicinal applications of delta-9-tetrahydrocannabinol and marijuana. Ann Intern Med (1997) 4.08
A novel population of T-cell receptor alpha beta-bearing thymocytes which predominantly expresses a single V beta gene family. Nature (1987) 3.96
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A subset of CD4+ thymocytes selected by MHC class I molecules. Science (1994) 3.87
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Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc Natl Acad Sci U S A (1983) 3.66
Nomenclature for the major histocompatibility complexes of different species: a proposal. Immunogenetics (1990) 3.53
Interferon gamma plays a critical role in induced cell death of effector T cell: a possible third mechanism of self-tolerance. J Exp Med (1990) 3.45
Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library. Nat Med (1999) 3.45
Activation events during thymic selection. J Exp Med (1992) 3.43
On the complexity of self. Nature (1991) 3.43
The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell (1982) 3.38
Experimental autoimmune encephalomyelitis induction in genetically B cell-deficient mice. J Exp Med (1996) 3.36
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Analysis of H-2 and Ia molecules by two-dimensional gel electrophoresis. J Exp Med (1977) 3.26
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Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition. Immunity (1999) 2.89
Intestinal intraepithelial lymphocytes are a distinct set of gamma delta T cells. Nature (1988) 2.89
Detection of a common polypeptide chain in I--A and I--E sub-region immunoprecipitates. Mol Immunol (1979) 2.86
Stimulation of normal inducer T cell clones with antigen presented by purified Ia molecules in planar lipid membranes: specific induction of a long-lived state of proliferative nonresponsiveness. J Immunol (1987) 2.85
Cooperative interaction of B lymphocytes with antigen-specific helper T lymphocytes is MHC restricted. Nature (1981) 2.85
Deletion of self-reactive thymocytes occurs at a CD4+8+ precursor stage. Nature (1988) 2.84
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Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation. J Exp Med (1982) 2.58
Molecular events in the induction of a nonresponsive state in interleukin 2-producing helper T-lymphocyte clones. Proc Natl Acad Sci U S A (1987) 2.57
Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A (1983) 2.57
The B cell is the initiating antigen-presenting cell in peripheral lymph nodes. J Immunol (1987) 2.55
Diagnosis and management of group A streptococcal pharyngitis: a practice guideline. Infectious Diseases Society of America. Clin Infect Dis (1997) 2.54
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A rapid sensitive assay for specific protein synthesis in cells and in cell-free translations: use of Staphylococcus aureus as an adsorbent for immune complexes. Anal Biochem (1979) 2.48
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. Cell (1993) 2.43
Heat-stable antigen is a costimulatory molecule for CD4 T cell growth. J Exp Med (1992) 2.42
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J Exp Med (1996) 2.42
Receptor-directed focusing of lymphokine release by helper T cells. Nature (1988) 2.41
Implantation of a foetal thymus, restoring immunological competence in a patient with thymic aplasia (Digeorge's syndrome). Lancet (1968) 2.40
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Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation (1999) 2.40
Expression of MHC antigens by mouse thymic dendritic cells. J Immunol (1979) 2.39
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Inhibition of antigen-specific proliferation of type 1 murine T cell clones after stimulation with immobilized anti-CD3 monoclonal antibody. J Immunol (1990) 2.37
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitis. Science (1996) 2.36
Monoclonal antibodies specific for Ia glycoproteins raised by immunization with activated T cells: possible role of T cellbound Ia antigens as targets of immunoregulatory T cells. J Immunol (1984) 2.35
A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. Eur J Immunol (1989) 2.33
Recognition of the product of a novel MHC TL region gene (27b) by a mouse gamma delta T cell receptor. Cell (1990) 2.33
Prevention of Bacterial Endocarditis. A statement for health professionals by the Committee on Rheumatic Fever and Infective Endocarditis of the Council on Cardiovascular Disease in the Young. Circulation (1984) 2.33
Induction of Ia and H-2 antigens on a macrophage cell line by immune interferon. J Immunol (1983) 2.32
Validity of adolescent self-report of alcohol and other drug involvement. Int J Addict (1992) 2.32
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Selection of amino acid sequences in the beta chain of the T cell antigen receptor. Science (1988) 2.30