Published in J Biol Chem on July 10, 1984
AIPL1, a protein associated with childhood blindness, interacts with alpha-subunit of rod phosphodiesterase (PDE6) and is essential for its proper assembly. J Biol Chem (2009) 1.14
The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. J Biol Chem (2006) 0.98
Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents. Proc Natl Acad Sci U S A (1986) 0.95
RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments. Proc Natl Acad Sci U S A (2011) 0.94
Expression of the functional cone phototransduction cascade in retinoblastoma. J Clin Invest (1990) 0.91
Rod phosphodiesterase-6 (PDE6) catalytic subunits restore cone function in a mouse model lacking cone PDE6 catalytic subunit. J Biol Chem (2011) 0.87
Probing the catalytic sites and activation mechanism of photoreceptor phosphodiesterase using radiolabeled phosphodiesterase inhibitors. J Biol Chem (2009) 0.81
Effects of magnesium on cyclic GMP hydrolysis by the bovine retinal rod cyclic GMP phosphodiesterase. Biochem J (1995) 0.78
Domain organization and conformational plasticity of the G protein effector, PDE6. J Biol Chem (2015) 0.76
Regulatory sequences in the 3' untranslated region of the human cGMP-phosphodiesterase beta-subunit gene. Invest Ophthalmol Vis Sci (2009) 0.75
Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem (1979) 11.34
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol (1974) 2.97
Transmission of human immunodeficiency virus type 1 from a seronegative organ and tissue donor. N Engl J Med (1992) 2.63
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol (2000) 2.62
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. Mol Pharmacol (1970) 2.33
Immunocytochemical localization of two retinoid-binding proteins in vertebrate retina. J Cell Biol (1983) 2.29
Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. J Biol Chem (1970) 2.27
Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation (2001) 2.21
Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. J Biol Chem (1982) 2.12
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A (1999) 2.10
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. J Biol Chem (1975) 2.03
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A (1998) 2.00
Identification of specific transducin alpha subunits in retinal rod and cone photoreceptors. Science (1986) 1.96
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc Natl Acad Sci U S A (1997) 1.95
Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1977) 1.94
Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A. Proc Natl Acad Sci U S A (2000) 1.86
Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci U S A (1993) 1.81
Activation of protein kinase by physiological concentrations of cyclic AMP. Proc Natl Acad Sci U S A (1974) 1.75
CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science (1999) 1.75
Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species. Proc Natl Acad Sci U S A (1986) 1.73
Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography. Proc Natl Acad Sci U S A (1982) 1.68
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem (1998) 1.67
Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals. Neuron (1998) 1.63
Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography. J Biol Chem (1988) 1.62
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Mol Pharmacol (1986) 1.58
Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proc Natl Acad Sci U S A (1990) 1.55
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J Biol Chem (1993) 1.53
Müller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina. Invest Ophthalmol Vis Sci (1984) 1.53
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.47
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem (2000) 1.46
Chronic relapsing thrombotic thrombocytopenic purpura in infants with large von Willebrand factor multimers during remission. J Pediatr (1992) 1.44
Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle. Adv Cyclic Nucleotide Res (1975) 1.43
Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. J Biol Chem (1971) 1.41
Metastatic and nonmetastatic models of retinoblastoma. Am J Pathol (2000) 1.41
Identification and properties of cyclic nucleotide phosphodiesterases. Mol Cell Endocrinol (1983) 1.41
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. J Biol Chem (1991) 1.40
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest (1998) 1.40
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev Physiol Biochem Pharmacol (1999) 1.33
Oral contraceptives and gastrointestinal disorders. Ann Surg (1970) 1.31
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948. Mol Pharmacol (1989) 1.29
A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunit. J Biol Chem (1989) 1.28
Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets. J Biol Chem (1988) 1.24
Zonulae adherentes pore size in the external limiting membrane of the rabbit retina. Invest Ophthalmol Vis Sci (1985) 1.24
cGMP is tightly bound to bovine retinal rod phosphodiesterase. Proc Natl Acad Sci U S A (1989) 1.22
The formation and metabolism of cyclic GMP. Ann N Y Acad Sci (1971) 1.21
Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc Natl Acad Sci U S A (1997) 1.19
Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells. J Cell Biol (1980) 1.19
cGMP phosphodiesterase in rod and cone outer segments of the retina. J Biol Chem (1985) 1.19
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene (1998) 1.19
Alpha transducin is present in blue-, green-, and red-sensitive cone photoreceptors in the human retina. Neuron (1989) 1.17
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. Biochem Pharmacol (1992) 1.17
The mechanism of activation of bovine skeletal muscle protein kinase by adenosine 3':5'-monophosphate. J Biol Chem (1980) 1.15
Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. J Biol Chem (1992) 1.11
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A (2000) 1.11
Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest (1997) 1.10
Direct photolabeling of the cGMP-stimulated cyclic nucleotide phosphodiesterase. J Biol Chem (1989) 1.10
Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Methods (1998) 1.09
Regulation and function of cyclic nucleotides. Curr Opin Cell Biol (1992) 1.09
Distal revascularization-interval ligation for limb salvage and maintenance of dialysis access in ischemic steal syndrome. J Vasc Surg (1997) 1.09
Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase. Gene (1997) 1.08
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J Biol Chem (1995) 1.08
Stoichiometry of cAMP and 1,N6-etheno-cAMP binding to protein kinase. J Biol Chem (1980) 1.08
The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem (1996) 1.06
Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J Biol Chem (1993) 1.05
Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. J Biol Chem (1996) 1.05
T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. Proc Natl Acad Sci U S A (2001) 1.05
Distribution of membrane proteins in mechanically dissociated retinal rods. Invest Ophthalmol Vis Sci (1988) 1.04
Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry (2000) 1.04
Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit. J Biol Chem (1996) 1.03
Dominant thalassemia-like phenotypes associated with mutations in exon 3 of the beta-globin gene. Blood (1992) 1.03
Immune consequences of intraocular administration of modified adenoviral vectors. Hum Gene Ther (2001) 1.03
Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J Neurosci (1994) 1.03
Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol (1993) 1.02
Purification of cyclic nucleotide receptor proteins by cyclic nucleotide affinity chromatography. Adv Cyclic Nucleotide Res (1979) 1.02
Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc Natl Acad Sci U S A (2000) 1.01
cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. J Biol Chem (1999) 1.01
Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain. Biochemistry (1991) 1.01
Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. Genomics (1998) 1.00
Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A (1996) 0.99
Breakdown of the outer blood-retinal barrier in experimental commotio retinae. Exp Eye Res (1986) 0.98
Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4. J Immunol (2000) 0.98
Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. J Neurosci (2001) 0.97
Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants. J Biol Chem (1991) 0.97
Purification of rabbit skeletal muscle protein kinase regulatory subunit using cyclic adenosine-3':5'-monophosphate affinity chromatography. Biochem Biophys Res Commun (1975) 0.96
Structure and function studies of the cGMP-stimulated phosphodiesterase. J Biol Chem (1991) 0.95
Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv Pharmacol (1994) 0.95
Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain. J Biol Chem (1992) 0.95
Affinities of bovine photoreceptor cGMP phosphodiesterases for rod and cone inhibitory subunits. FEBS Lett (1993) 0.95
Donor corneal endothelial striae. Am J Ophthalmol (1986) 0.95
Clinical-ultrastructural study of a retinal dystrophy. Invest Ophthalmol Vis Sci (1983) 0.95
Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents. Proc Natl Acad Sci U S A (1986) 0.95
Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains. Mol Pharmacol (1995) 0.94
Localization of retinoid-binding proteins in developing rat retina. Exp Eye Res (1985) 0.92
Immunocytochemical localization of interphotoreceptor retinoid-binding protein in developing normal and RCS rat retinas. Invest Ophthalmol Vis Sci (1985) 0.91
Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. J Biol Chem (1995) 0.91
'Leopard spot' retinopathy in Warburg syndrome. Ophthalmic Paediatr Genet (1986) 0.91
The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol Cell Biochem (1993) 0.90