Published in Proc Natl Acad Sci U S A on March 28, 2000
The Concise Guide to PHARMACOLOGY 2013/14: enzymes. Br J Pharmacol (2013) 5.57
cGMP-dependent protein kinases and cGMP phosphodiesterases in nitric oxide and cGMP action. Pharmacol Rev (2010) 3.27
Structure of the GAF domain, a ubiquitous signaling motif and a new class of cyclic GMP receptor. EMBO J (2000) 2.64
In vivo assessment of local phosphodiesterase activity using tailored cyclic nucleotide-gated channels as cAMP sensors. J Gen Physiol (2001) 1.78
Deletion of phosphodiesterase 4D in mice shortens alpha(2)-adrenoceptor-mediated anesthesia, a behavioral correlate of emesis. J Clin Invest (2002) 1.62
Trans effects of chromosome aneuploidies on DNA methylation patterns in human Down syndrome and mouse models. Genome Biol (2015) 1.46
A cAMP-specific phosphodiesterase (PDE8B) that is mutated in adrenal hyperplasia is expressed widely in human and mouse tissues: a novel PDE8B isoform in human adrenal cortex. Eur J Hum Genet (2008) 1.44
Crystal structure of the tandem GAF domains from a cyanobacterial adenylyl cyclase: modes of ligand binding and dimerization. Proc Natl Acad Sci U S A (2005) 1.40
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology (Berl) (2008) 1.36
Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J (2006) 1.31
Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response. Proc Natl Acad Sci U S A (2006) 1.23
Systematic analysis of off-target effects in an RNAi screen reveals microRNAs affecting sensitivity to TRAIL-induced apoptosis. BMC Genomics (2010) 1.20
T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. Proc Natl Acad Sci U S A (2001) 1.05
Prostaglandin E2 Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages. J Immunol (2015) 1.03
Increased activity of cGMP-specific phosphodiesterase (PDE5) contributes to resistance to atrial natriuretic peptide natriuresis in the pregnant rat. J Am Soc Nephrol (2004) 1.03
Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc Natl Acad Sci U S A (2000) 1.01
Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes. Proc Natl Acad Sci U S A (2010) 0.99
Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to ANP in the pregnant rat. Am J Physiol Renal Physiol (2006) 0.99
Phosphodiesterase 11A expression in the adrenal cortex, primary pigmented nodular adrenocortical disease, and other corticotropin-independent lesions. Horm Metab Res (2008) 0.98
Cyclic nucleotide phosphodiesterases in Drosophila melanogaster. Biochem J (2005) 0.97
Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer. J Clin Endocrinol Metab (2010) 0.97
cAMP signaling in skeletal muscle adaptation: hypertrophy, metabolism, and regeneration. Am J Physiol Endocrinol Metab (2012) 0.96
Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH). Br J Pharmacol (2011) 0.96
Effect of sildenafil on cyclic nucleotide phosphodiesterase activity, vascular tone and calcium signaling in rat pulmonary artery. Br J Pharmacol (2003) 0.92
Nitric oxide/cGMP-mediated effects in the outflow region of the lower urinary tract--is there a basis for pharmacological targeting of cGMP? World J Urol (2005) 0.91
Characterization of novel phosphodiesterases in the bovine ovarian follicle. Biol Reprod (2009) 0.91
Activation of PDE10 and PDE11 phosphodiesterases. J Biol Chem (2011) 0.90
Clinical and molecular genetics of the phosphodiesterases (PDEs). Endocr Rev (2013) 0.89
Cyclic AMP control measured in two compartments in HEK293 cells: phosphodiesterase K(M) is more important than phosphodiesterase localization. PLoS One (2011) 0.86
Computational determination of binding structures and free energies of phosphodiesterase-2 with benzo[1,4]diazepin-2-one derivatives. J Phys Chem B (2010) 0.86
Lung vasodilatory response to inhaled iloprost in experimental pulmonary hypertension: amplification by different type phosphodiesterase inhibitors. Respir Res (2005) 0.86
Potential role of phosphodiesterase 7 in human T cell function: comparative effects of two phosphodiesterase inhibitors. Clin Exp Immunol (2002) 0.86
Increased renal phosphodiesterase-5 activity mediates the blunted natriuretic response to a nitric oxide donor in the pregnant rat. Am J Physiol Renal Physiol (2010) 0.84
Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa. Mol Biol Cell (2005) 0.83
Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatr Dis Treat (2009) 0.83
Promoter methylation of candidate genes associated with familial testicular cancer. Int J Mol Epidemiol Genet (2012) 0.83
Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment. Curr Opin Pharmacol (2011) 0.82
Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample. Pharmacogenet Genomics (2009) 0.81
EMD273316 & EMD95833, type 4 phosphodiesterase inhibitors, stimulate fibroblastic-colony formation by bone marrow cells via direct inhibition of PDE4 and the induction of endogenous prostaglandin synthesis. BMC Pharmacol (2004) 0.80
Clinical update on phosphodiesterase type-5 inhibitors for erectile dysfunction. World J Urol (2005) 0.80
Unraveling the molecular basis of micronodular adrenal hyperplasia. Curr Opin Endocrinol Diabetes Obes (2008) 0.80
Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A. Eur J Med Chem (2011) 0.79
Adverse effects of common medications on male fertility. Nat Rev Urol (2015) 0.79
Lower urinary tract symptoms, benign prostatic hyperplasia, erectile dysfunction, and phosphodiesterase-5 inhibitors. Rev Urol (2004) 0.79
A yeast-based chemical screen identifies a PDE inhibitor that elevates steroidogenesis in mouse Leydig cells via PDE8 and PDE4 inhibition. PLoS One (2013) 0.78
Distribution and functional significance of phosphodiesterase isoenzymes in the human lower urinary tract. World J Urol (2005) 0.78
PDE-5 Inhibitor Therapy for Erectile Dysfunction Secondary to Nerve-Sparing Radical Retropubic Prostatectomy. Rev Urol (2005) 0.78
Phosphodiesterases and adrenal Cushing in mice and humans. Horm Metab Res (2014) 0.77
Phosphodiesterase sequence variants may predispose to prostate cancer. Endocr Relat Cancer (2015) 0.77
PDE5 Inhibitors as Potential Tools in the Treatment of Cystic Fibrosis. Front Pharmacol (2012) 0.77
Interactions between cyclic nucleotide phosphodiesterase 11 catalytic site and substrates or tadalafil and role of a critical Gln-869 hydrogen bond. J Pharmacol Exp Ther (2009) 0.76
The effect of DA-8159 on corpus cavernosal smooth muscle relaxation and penile erection in diabetic rabbits. Urol Res (2004) 0.76
In Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in Plants. Front Plant Sci (2016) 0.76
A short review on structure and role of cyclic-3',5'-adenosine monophosphate-specific phosphodiesterase 4 as a treatment tool. J Res Pharm Pract (2015) 0.76
Haemodynamic effects of the selective phosphodiesterase 5 inhibitor, UK-357,903, in conscious SHR. Br J Pharmacol (2003) 0.75
Sexual Function and alpha-Blockers. Rev Urol (2005) 0.75
Crystallization and preliminary crystallographic analysis of the second GAF domain of DevS from Mycobacterium smegmatis. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.75
Identification of lead BAY60-7550 analogues as potential inhibitors that utilize the hydrophobic groove in PDE2A: a molecular dynamics simulation study. J Mol Model (2016) 0.75
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res (1997) 665.31
Basic local alignment search tool. J Mol Biol (1990) 659.07
CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res (1994) 392.47
Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell (1986) 42.45
The PROSITE database, its status in 1997. Nucleic Acids Res (1997) 8.12
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev (1995) 5.45
Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors. Trends Pharmacol Sci (1990) 4.30
The GAF domain: an evolutionary link between diverse phototransducing proteins. Trends Biochem Sci (1997) 4.10
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res (1996) 3.85
Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa. Nat Genet (1993) 3.49
Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. J Urol (1998) 2.49
Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. J Biol Chem (1982) 2.12
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A (1999) 2.10
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A (1998) 2.00
Multiple cyclic nucleotide phosphodiesterases. Mol Pharmacol (1994) 1.80
CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science (1999) 1.75
Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species. Proc Natl Acad Sci U S A (1986) 1.73
Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase. J Biol Chem (1998) 1.72
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem (1998) 1.67
Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proc Natl Acad Sci U S A (1990) 1.55
Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Biochem Biophys Res Commun (1998) 1.52
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.47
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. J Biol Chem (1991) 1.40
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest (1998) 1.40
ANF elicits phosphorylation of the cGMP phosphodiesterase in vascular smooth muscle cells. Am J Physiol (1998) 1.37
Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun (1998) 1.36
The structure of a bovine lung cGMP-binding, cGMP-specific phosphodiesterase deduced from a cDNA clone. J Biol Chem (1993) 1.35
Identification of key amino acids in a conserved cGMP-binding site of cGMP-binding phosphodiesterases. A putative NKXnD motif for cGMP binding. J Biol Chem (1996) 1.26
cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction. Proc Natl Acad Sci U S A (1994) 1.24
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene (1998) 1.19
Substrate- and kinase-directed regulation of phosphorylation of a cGMP-binding phosphodiesterase by cGMP. J Biol Chem (1990) 1.18
Ariflo (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic. Pulm Pharmacol Ther (1999) 1.17
Binding of cGMP to both allosteric sites of cGMP-binding cGMP-specific phosphodiesterase (PDE5) is required for its phosphorylation. Biochem J (1998) 1.11
Direct photolabeling of the cGMP-stimulated cyclic nucleotide phosphodiesterase. J Biol Chem (1989) 1.10
Adaptation in cyclic AMP signalling processes: a central role for cyclic AMP phosphodiesterases. Semin Cell Dev Biol (1998) 1.02
Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation. Biochem J (1997) 1.02
Characterization of fhlA mutations resulting in ligand-independent transcriptional activation and ATP hydrolysis. J Bacteriol (1997) 0.98
Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv Pharmacol (1994) 0.95
Possible stimulation of retinal rod recovery to dark state by cGMP release from a cGMP phosphodiesterase noncatalytic site. J Biol Chem (1996) 0.95
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun (1998) 0.94
Phosphorylation-dephosphorylation of enzymes. Annu Rev Biochem (1979) 11.34
Preparation of homogeneous cyclic AMP-dependent protein kinase(s) and its subunits from rabbit skeletal muscle. Methods Enzymol (1974) 2.97
Regulation of cAMP and cGMP signaling: new phosphodiesterases and new functions. Curr Opin Cell Biol (2000) 2.62
Sexual transmission of enteric protozoa and helminths in a venereal-disease-clinic population. N Engl J Med (1981) 2.47
Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity. Mol Pharmacol (1970) 2.33
Hydrolysis of cyclic guanosine and adenosine 3',5'-monophosphates by rat and bovine tissues. J Biol Chem (1970) 2.27
Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance. Circulation (2001) 2.21
Purification and characterization of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase from bovine tissues. J Biol Chem (1982) 2.12
Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. Proc Natl Acad Sci U S A (1999) 2.10
Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle. J Biol Chem (1975) 2.03
Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A (1998) 2.00
A subset of olfactory neurons that selectively express cGMP-stimulated phosphodiesterase (PDE2) and guanylyl cyclase-D define a unique olfactory signal transduction pathway. Proc Natl Acad Sci U S A (1997) 1.95
Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. J Biol Chem (1977) 1.94
Activation of protein kinase by physiological concentrations of cyclic AMP. Proc Natl Acad Sci U S A (1974) 1.75
CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science (1999) 1.75
Identification of a conserved domain among cyclic nucleotide phosphodiesterases from diverse species. Proc Natl Acad Sci U S A (1986) 1.73
Purification of two calcium/calmodulin-dependent forms of cyclic nucleotide phosphodiesterase by using conformation-specific monoclonal antibody chromatography. Proc Natl Acad Sci U S A (1982) 1.68
Identification and characterization of a novel family of cyclic nucleotide phosphodiesterases. J Biol Chem (1998) 1.67
Identification of Neisseria gonorrhoea and Neisseria meningitidis by a carbohydrate disc technique. J Clin Pathol (1973) 1.64
Phosphorylation and inhibition of olfactory adenylyl cyclase by CaM kinase II in Neurons: a mechanism for attenuation of olfactory signals. Neuron (1998) 1.63
Characterization of a bovine cone photoreceptor phosphodiesterase purified by cyclic GMP-sepharose chromatography. J Biol Chem (1988) 1.62
Isolation and characterization of bovine cardiac muscle cGMP-inhibited phosphodiesterase: a receptor for new cardiotonic drugs. Mol Pharmacol (1986) 1.58
Identification of a noncatalytic cGMP-binding domain conserved in both the cGMP-stimulated and photoreceptor cyclic nucleotide phosphodiesterases. Proc Natl Acad Sci U S A (1990) 1.55
Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis. Hum Reprod (2004) 1.55
Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase-deficient Saccharomyces cerevisiae. J Biol Chem (1993) 1.53
Molecular cloning and characterization of a calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.47
Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J Biol Chem (2000) 1.46
Mechanisms of control for cAMP-dependent protein kinase from skeletal muscle. Adv Cyclic Nucleotide Res (1975) 1.43
Stimulation of adenosine 3',5'-monophosphate hydrolysis by guanosine 3',5'-monophosphate. J Biol Chem (1971) 1.41
Identification and properties of cyclic nucleotide phosphodiesterases. Mol Cell Endocrinol (1983) 1.41
High concentrations of a cGMP-stimulated phosphodiesterase mediate ANP-induced decreases in cAMP and steroidogenesis in adrenal glomerulosa cells. J Biol Chem (1991) 1.40
Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest (1998) 1.40
Properties of BK(Ca) channels formed by bicistronic expression of hSloalpha and beta1-4 subunits in HEK293 cells. J Membr Biol (2003) 1.34
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs). Rev Physiol Biochem Pharmacol (1999) 1.33
Inhibition and stimulation of photoreceptor phosphodiesterases by dipyridamole and M&B 22,948. Mol Pharmacol (1989) 1.29
A soluble form of bovine rod photoreceptor phosphodiesterase has a novel 15-kDa subunit. J Biol Chem (1989) 1.28
Phosphorylation results in activation of a cAMP phosphodiesterase in human platelets. J Biol Chem (1988) 1.24
cGMP is tightly bound to bovine retinal rod phosphodiesterase. Proc Natl Acad Sci U S A (1989) 1.22
The formation and metabolism of cyclic GMP. Ann N Y Acad Sci (1971) 1.21
Immunofluorescent localization of cyclic nucleotide-dependent protein kinases on the mitotic apparatus of cultured cells. J Cell Biol (1980) 1.19
cGMP phosphodiesterase in rod and cone outer segments of the retina. J Biol Chem (1985) 1.19
Attenuation of insulin secretion by insulin-like growth factor 1 is mediated through activation of phosphodiesterase 3B. Proc Natl Acad Sci U S A (1997) 1.19
Isolation and characterization of cDNAs encoding PDE5A, a human cGMP-binding, cGMP-specific 3',5'-cyclic nucleotide phosphodiesterase. Gene (1998) 1.19
Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP. Biochem Pharmacol (1992) 1.17
The mechanism of activation of bovine skeletal muscle protein kinase by adenosine 3':5'-monophosphate. J Biol Chem (1980) 1.15
Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. Proc Natl Acad Sci U S A (2000) 1.11
Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype. J Clin Invest (1997) 1.10
Direct photolabeling of the cGMP-stimulated cyclic nucleotide phosphodiesterase. J Biol Chem (1989) 1.10
Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases. Methods (1998) 1.09
Regulation and function of cyclic nucleotides. Curr Opin Cell Biol (1992) 1.09
A cross-sectional survey of kidney function in refinery employees. Am J Ind Med (1987) 1.09
An essential aspartic acid at each of two allosteric cGMP-binding sites of a cGMP-specific phosphodiesterase. J Biol Chem (1995) 1.08
Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase. Gene (1997) 1.08
A quantitative histological study of the cerebellar vermis in alcoholic patients. Brain (1987) 1.08
Stoichiometry of cAMP and 1,N6-etheno-cAMP binding to protein kinase. J Biol Chem (1980) 1.08
Evaluation of excess colorectal cancer incidence among workers involved in the manufacture of polypropylene. J Occup Med (1988) 1.07
Local control and site of failure in radically irradiated supraglottic laryngeal cancer. Radiology (1974) 1.06
The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue-specific manner. J Biol Chem (1996) 1.06
Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase. Tissue-specific expression of structurally related isoforms. J Biol Chem (1993) 1.05
Isolation and characterization of cDNAs corresponding to two human calcium, calmodulin-regulated, 3',5'-cyclic nucleotide phosphodiesterases. J Biol Chem (1996) 1.05
T cell activation up-regulates cyclic nucleotide phosphodiesterases 8A1 and 7A3. Proc Natl Acad Sci U S A (2001) 1.05
Cell cycle-regulated transcription in fission yeast: Cdc10-Res protein interactions during the cell cycle and domains required for regulated transcription. Mol Biol Cell (1999) 1.04
Binding of the delta subunit to rod phosphodiesterase catalytic subunits requires methylated, prenylated C-termini of the catalytic subunits. Biochemistry (2000) 1.04
Solubilization of membrane-bound rod phosphodiesterase by the rod phosphodiesterase recombinant delta subunit. J Biol Chem (1996) 1.03
Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain. J Neurosci (1994) 1.03
Immunochemical characterization of the distinct monocyte cyclic AMP-phosphodiesterase from patients with atopic dermatitis. J Allergy Clin Immunol (1993) 1.02
Purification of cyclic nucleotide receptor proteins by cyclic nucleotide affinity chromatography. Adv Cyclic Nucleotide Res (1979) 1.02
cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and delta subunits. J Biol Chem (1999) 1.01
Cloning and characterization of two splice variants of human phosphodiesterase 11A. Proc Natl Acad Sci U S A (2000) 1.01
Evidence for domain organization within the 61-kDa calmodulin-dependent cyclic nucleotide phosphodiesterase from bovine brain. Biochemistry (1991) 1.01
Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. Genomics (1998) 1.00
Identification and tissue-specific expression of PDE7 phosphodiesterase splice variants. Proc Natl Acad Sci U S A (1996) 0.99
Immunologic characterization of the photoreceptor outer segment cyclic GMP phosphodiesterase. J Biol Chem (1984) 0.99
Infection of CD4+ memory T cells by HIV-1 requires expression of phosphodiesterase 4. J Immunol (2000) 0.98
Studies of instrumental behavior with sexual reinforcement in male rats (Rattus norvegicus): II. Effects of preoptic area lesions, castration, and testosterone. J Comp Psychol (1987) 0.98
Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus. J Neurosci (2001) 0.97
Molecular cloning of a cyclic GMP-stimulated cyclic nucleotide phosphodiesterase cDNA. Identification and distribution of isozyme variants. J Biol Chem (1991) 0.97
Is the inferior colliculus an obligatory relay in the cat auditory system? Neurosci Lett (1984) 0.96
Purification of rabbit skeletal muscle protein kinase regulatory subunit using cyclic adenosine-3':5'-monophosphate affinity chromatography. Biochem Biophys Res Commun (1975) 0.96
Structure and function studies of the cGMP-stimulated phosphodiesterase. J Biol Chem (1991) 0.95
Cyclic GMP and regulation of cyclic nucleotide hydrolysis. Adv Pharmacol (1994) 0.95
Molecular cloning of cDNA encoding a "63"-kDa calmodulin-stimulated phosphodiesterase from bovine brain. J Biol Chem (1992) 0.95
Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology. Int J Impot Res (2005) 0.95
Affinities of bovine photoreceptor cGMP phosphodiesterases for rod and cone inhibitory subunits. FEBS Lett (1993) 0.95
Immunological identification of the major platelet low-Km cAMP phosphodiesterase: probable target for anti-thrombotic agents. Proc Natl Acad Sci U S A (1986) 0.95
Primary management of operable breast cancer by minimal surgery and radiotherapy. Cancer (1978) 0.94
Molecular cloning and expression of human cGMP-binding cGMP-specific phosphodiesterase (PDE5). Biochem Biophys Res Commun (1998) 0.94
Characterization of cyclic nucleotide phosphodiesterases with cyclic GMP analogs: topology of the catalytic domains. Mol Pharmacol (1995) 0.94
Studies of instrumental behavior with sexual reinforcement in male rats (Rattus norvegicus): I. Control by brief visual stimuli paired with a receptive female. J Comp Psychol (1987) 0.93
The outcome of treatment by tumorectomy and radiotherapy of patients with operable breast cancer. Int J Radiat Oncol Biol Phys (1981) 0.91
Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. J Biol Chem (1995) 0.91
The role of protein phosphorylation in the regulation of cyclic nucleotide phosphodiesterases. Mol Cell Biochem (1993) 0.90
Local control of breast cancer with tumorectomy plus radiotherapy or radiotherapy alone. Radiology (1976) 0.90
Chronic consumption of alcohol by adult mice: effect on hippocampal cells and synapses. Exp Neurol (1983) 0.90
Does ethanol damage the blood--brain barrier? J Neurol Sci (1981) 0.90
Intracellular trafficking of the vacuolar H+-ATPase accessory subunit Ac45. J Cell Sci (1998) 0.90
Characterization of cyclic nucleotide phosphodiesterases with cyclic AMP analogs: topology of the catalytic sites and comparison with other cyclic AMP-binding proteins. Mol Pharmacol (1995) 0.90