Published in Science on March 23, 1984
Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity. Proc Natl Acad Sci U S A (1987) 2.99
Insulin action is blocked by a monoclonal antibody that inhibits the insulin receptor kinase. Proc Natl Acad Sci U S A (1986) 1.80
Acute insulin action requires insulin receptor kinase activity: introduction of an inhibitory monoclonal antibody into mammalian cells blocks the rapid effects of insulin. Proc Natl Acad Sci U S A (1987) 1.73
Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity. J Clin Invest (1986) 1.67
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
Microinjection of a protein-tyrosine-phosphatase inhibits insulin action in Xenopus oocytes. Proc Natl Acad Sci U S A (1990) 1.27
Monoclonal antibodies to the human insulin receptor that activate glucose transport but not insulin receptor kinase activity. Proc Natl Acad Sci U S A (1987) 1.15
The biochemistry of diabetes. Biochem J (1988) 1.14
Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts. Proc Natl Acad Sci U S A (1989) 1.11
Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor. Biochem J (1987) 1.09
Monoclonal antibodies to the insulin receptor stimulate the intrinsic tyrosine kinase activity by cross-linking receptor molecules. EMBO J (1987) 1.03
The monomeric alpha beta form of the insulin receptor exhibits much higher insulin-dependent tyrosine-specific protein kinase activity than the intact alpha 2 beta 2 form of the receptor. Proc Natl Acad Sci U S A (1985) 1.03
Use of an anti-insulin receptor antibody to discriminate between metabolic and mitogenic effects of insulin: correlation with receptor autophosphorylation. EMBO J (1988) 0.97
Insulin and rabbit anti-insulin receptor antibodies stimulate additively the intrinsic receptor kinase activity. EMBO J (1987) 0.95
Effect of microinjection of a low-Mr human placenta protein tyrosine phosphatase on induction of meiotic cell division in Xenopus oocytes. Mol Cell Biol (1990) 0.95
The insulin-like effect of sodium vanadate on adipocyte glucose transport is mediated at a post-insulin-receptor level. Biochem J (1986) 0.94
Structural analysis of normal and mutant insulin receptors in fibroblasts cultured from families with leprechaunism. Am J Hum Genet (1987) 0.91
Insulin receptors and the clinician. Br Med J (Clin Res Ed) (1986) 0.79
Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA. Biochem J (1990) 0.78
Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. J Biol Chem (1981) 3.28
Insulin-stimulated translocation of glucose transporters in the isolated rat adipose cells: characterization of subcellular fractions. Biochim Biophys Acta (1983) 2.88
Hormonal regulation of mammalian glucose transport. Annu Rev Biochem (1986) 2.84
Cell surface labeling of glucose transporter isoform GLUT4 by bis-mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. J Biol Chem (1990) 2.84
Antibiotic prophylaxis in gastrointestinal endoscopy. Gut (2009) 2.65
Use of bismannose photolabel to elucidate insulin-regulated GLUT4 subcellular trafficking kinetics in rat adipose cells. Evidence that exocytosis is a critical site of hormone action. J Biol Chem (1993) 2.41
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
Glucose transporter proteins in brain: delivery of glucose to neurons and glia. Glia (1997) 1.93
Biosynthetic labeling of insulin receptor: studies of subunits in cultured human IM-9 lymphocytes. Proc Natl Acad Sci U S A (1981) 1.72
Glucose transporter proteins in brain. FASEB J (1994) 1.67
Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Experimental stroke in the female diabetic, db/db, mouse. J Cereb Blood Flow Metab (2001) 1.55
Mechanism of insulin-resistant glucose transport activity in the enlarged adipose cell of the aged, obese rat. J Clin Invest (1982) 1.51
A possible mechanism of insulin resistance in the rat adipose cell in streptozotocin-induced diabetes mellitus. Depletion of intracellular glucose transport systems. J Clin Invest (1981) 1.47
Detection of the rat adipose cell glucose transporter with antibody against the human red cell glucose transporter. Biochem Biophys Res Commun (1982) 1.46
Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochemistry (1981) 1.45
The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor. J Biol Chem (1982) 1.45
Clopidogrel for prevention of major cardiac events after coronary stent implantation: 30-day and 6-month results in patients with smaller stents. Am Heart J (2000) 1.43
Regulation of insulin-stimulated glucose transport in the isolated rat adipocyte. cAMP-independent effects of lipolytic and antilipolytic agents. J Biol Chem (1987) 1.42
Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat. J Neurosci Res (2001) 1.38
Ventricular fibrillation in hypertrophic cardiomyopathy is associated with increased fractionation of paced right ventricular electrograms. Circulation (1992) 1.38
Myristyl and palmityl acylation of the insulin receptor. J Biol Chem (1987) 1.34
Divergent mechanisms for the insulin resistant and hyperresponsive glucose transport in adipose cells from fasted and refed rats. Alterations in both glucose transporter number and intrinsic activity. J Clin Invest (1988) 1.32
Insulin-stimulated glucose transport in rat adipose cells. Modulation of transporter intrinsic activity by isoproterenol and adenosine. J Biol Chem (1986) 1.32
Activity and phosphorylation state of glucose transporters in plasma membranes from insulin-, isoproterenol-, and phorbol ester-treated rat adipose cells. J Biol Chem (1987) 1.29
Counter-regulation of insulin-stimulated glucose transport by catecholamines in the isolated rat adipose cell. J Biol Chem (1984) 1.29
Sex differences in investigation results and treatment in subjects referred for investigation of chest pain. Heart (2001) 1.29
Ferritin: a novel mechanism for delivery of iron to the brain and other organs. Am J Physiol Cell Physiol (2007) 1.29
Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain. Brain Res Mol Brain Res (1999) 1.28
Monocarboxylate transporter expression in mouse brain. Am J Physiol (1998) 1.27
A simple, rapid, and sensitive method for measuring protein concentration in subcellular membrane fractions prepared by sucrose density ultracentrifugation. Anal Biochem (1982) 1.22
Substrate specificity and kinetic parameters of GLUT3 in rat cerebellar granule neurons. Biochem J (1996) 1.22
Cell surface accessibility of GLUT4 glucose transporters in insulin-stimulated rat adipose cells. Modulation by isoprenaline and adenosine. Biochem J (1992) 1.21
Doppler ultrasound in the assessment of severity of coarctation of the aorta and interruption of the aortic arch. Br Heart J (1987) 1.19
Kinetics of GLUT1 and GLUT4 glucose transporters expressed in Xenopus oocytes. J Biol Chem (1993) 1.15
A possible mechanism of insulin resistance in the rat adipose cell with high-fat/low-carbohydrate feeding. Depletion of intracellular glucose transport systems. Diabetes (1982) 1.13
Echocardiographic study of the morphology and growth of the aortic arch in the human fetus. Observations related to the prenatal diagnosis of coarctation. Circulation (1992) 1.11
Ultrafiltration in the management of refractory congestive heart failure. Br Heart J (1986) 1.11
GLUT4 glucose transporter expression in rodent brain: effect of diabetes. Brain Res (1998) 1.10
Clinical value of Doppler echocardiography in the assessment of adults with aortic stenosis. Br Heart J (1985) 1.10
The severity of pulmonary valve or artery obstruction in children estimated by Doppler ultrasound. Eur Heart J (1985) 1.10
A new method for quantification of regurgitant flow rate using color Doppler flow imaging of the flow convergence region proximal to a discrete orifice. An in vitro study. Circulation (1991) 1.10
Biochemical and functional heterogeneity of rat adipocyte glucose transporters. J Biol Chem (1986) 1.08
Insulin, oxytocin, and vasopressin stimulate protein kinase C activity in adipocyte plasma membranes. Proc Natl Acad Sci U S A (1990) 1.06
Distinct localization of GLUT-1, -3, and -5 in human monocyte-derived macrophages: effects of cell activation. Am J Physiol (1998) 1.05
Activation of adenylate cyclase and inhibition of glucose transport in rat adipocytes by forskolin analogues: structural determinants for distinct sites of action. Mol Pharmacol (1988) 1.05
Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance. J Clin Endocrinol Metab (1982) 1.03
Glucose transporter expression in brain: relationship to cerebral glucose utilization. Dev Neurosci (1998) 1.02
Insulin receptor biosynthesis in cultured lymphocytes from insulin-resistant patients. J Clin Invest (1985) 1.00
Expression of mouse-GLUT3 and human-GLUT3 glucose transporter proteins in brain. Biochem Biophys Res Commun (1992) 0.98
Dehydroascorbic acid transport by GLUT4 in Xenopus oocytes and isolated rat adipocytes. J Biol Chem (2000) 0.98
Defects in human insulin receptor gene expression. Mol Endocrinol (1988) 0.98
Doppler ultrasound in the estimation of the severity of pulmonary infundibular stenosis in infants and children. Br Heart J (1986) 0.97
Phosphorylation state of the GLUT4 isoform of the glucose transporter in subfractions of the rat adipose cell: effects of insulin, adenosine, and isoproterenol. Proc Natl Acad Sci U S A (1991) 0.96
Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor. J Clin Endocrinol Metab (1982) 0.95
Detection of the GLUT3 facilitative glucose transporter in rat L6 muscle cells: regulation by cellular differentiation, insulin and insulin-like growth factor-I. Biochem Biophys Res Commun (1992) 0.95
Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. Am J Physiol (1997) 0.95
Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin. J Biol Chem (1983) 0.95
Alterations in GLUT1 and GLUT3 glucose transporter gene expression following unilateral hypoxia-ischemia in the immature rat brain. Brain Res Dev Brain Res (1998) 0.94
The GLUT3 glucose transporter is the predominant isoform in primary cultured neurons: assessment by biosynthetic and photoaffinity labelling. Biochem J (1994) 0.94
Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes. J Biol Chem (1982) 0.93
Alcohol ablation of atrioventricular conduction. Br Heart J (1991) 0.92
Effects of castanospermine and 1-deoxynojirimycin on insulin receptor biogenesis. Evidence for a role of glucose removal from core oligosaccharides. J Biol Chem (1987) 0.91
Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits. J Biol Chem (1984) 0.91
Identification and characterization of the rat adipocyte glucose transporter by photoaffinity crosslinking. FEBS Lett (1983) 0.91
Role of protein kinase C in the regulation of glucose transport in the rat adipose cell. Translocation of glucose transporters without stimulation of glucose transport activity. J Biol Chem (1991) 0.90
Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance. J Clin Invest (1984) 0.90
Glucose transporter isoforms in brain: absence of GLUT3 from the blood-brain barrier. J Cereb Blood Flow Metab (1993) 0.89
Biosynthesis of the insulin receptor. Horm Metab Res (1985) 0.89
Expression of two glucose transporters, GLUT1 and GLUT3, in cultured cerebellar neurons: Evidence for neuron-specific expression of GLUT3. Mol Cell Neurosci (1991) 0.88
Insulin-induced translocation of intracellular glucose transporters in the isolated rat adipose cell. Fed Proc (1984) 0.88
Staurosporine inhibits phorbol 12-myristate 13-acetate- and insulin-stimulated translocation of GLUT1 and GLUT4 glucose transporters in rat adipose cells. Biochem J (1994) 0.87
Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts. J Clin Endocrinol Metab (1983) 0.86
Thrombin-induced translocation of GLUT3 glucose transporters in human platelets. Biochem J (1997) 0.85
Glucose transporter recycling in rat adipose cells. Effects of potassium depletion. J Biol Chem (1993) 0.85
Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of both major receptor subunits following their biosynthetic labeling in culture. Diabetes (1984) 0.85
Non-invasive assessment by Doppler ultrasound of 155 patients with bioprosthetic valves: a comparison of the Wessex porcine, low profile Ionescu-Shiley, and Hancock pericardial bioprostheses. Br Heart J (1986) 0.85
Biosynthesis of the insulin receptor in rat adipose cells. Intracellular processing of the Mr-190 000 pro-receptor. Biochem J (1985) 0.85
Insulin-stimulated phosphorylation of the insulin receptor precursor. Biochem Biophys Res Commun (1983) 0.84
Plasma glucagon immunoreactivity in a totally pancreatectomized patient. Diabetologia (1976) 0.84
Effects of long-term oral magnesium chloride replacement in congestive heart failure secondary to coronary artery disease. Am J Cardiol (1993) 0.84
Functional desensitisation of beta-adrenergic receptors of avian erythrocytes by catecholamines and adenosine 3',5'-phosphate. Eur J Biochem (1980) 0.84
Induction of the insulin proreceptor by hydrocortisone in cultured lymphocytes (IM-9 line). J Clin Invest (1985) 0.84
Modulation of expression of glucose transporters GLUT3 and GLUT1 by potassium and N-methyl-D-aspartate in cultured cerebellar granule neurons. Mol Cell Neurosci (1994) 0.83
Human immunodeficiency virus type 1 infection of H9 cells induces increased glucose transporter expression. J Virol (1996) 0.83
Color flow Doppler mapping studies of "physiologic" pulmonary and tricuspid regurgitation: evidence for true regurgitation as opposed to a valve closing volume. J Am Soc Echocardiogr (1992) 0.83
Cholera and pertussis toxins modify regulation of glucose transport activity in rat adipose cells: evidence for mediation of a cAMP-independent process by G-proteins. Cell Signal (1992) 0.83
Improved membrane protein solubilization and clean-up for optimum two-dimensional electrophoresis utilizing GLUT-1 as a classic integral membrane protein. J Neurosci Methods (2009) 0.83
Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues. J Biol Chem (1988) 0.83
Effects of pressure and volume of the receiving chamber on the spatial distribution of regurgitant jets as imaged by color Doppler flow mapping. An in vitro study. Circulation (1991) 0.83
Intravascular ultrasound imaging of the coronary arteries: an in vitro evaluation of measurement of area of the lumen and atheroma characterisation. Br Heart J (1992) 0.83
Subcellular distribution and phosphorylation state of insulin receptors from insulin- and isoproterenol-treated rat adipose cells. Cell Signal (1991) 0.82
Receptors for insulin and growth hormone on lymphoid cells. Methods Enzymol (1987) 0.82