Published in J Clin Invest on December 01, 1985
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Multiple restriction fragment length polymorphisms at the insulin receptor locus: a highly informative marker for linkage analysis. Proc Natl Acad Sci U S A (1986) 1.59
A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J (1989) 1.24
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. J Clin Invest (1990) 1.17
Defective processing of insulin-receptor precursor in cultured lymphocytes from a patient with extreme insulin resistance. J Clin Invest (1988) 0.75
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Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Defect in phosphorylation of insulin receptors in cells from an insulin-resistant patient with normal insulin binding. Science (1984) 1.44
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Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance. J Clin Endocrinol Metab (1982) 1.03
Primary defect of insulin receptors in skin fibroblasts cultured from an infant with leprechaunism and insulin resistance. Proc Natl Acad Sci U S A (1979) 1.02
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Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. Proc Natl Acad Sci U S A (1981) 0.96
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Characterization of insulin receptors in patients with the syndromes of insulin resistance and acanthosis nigricans. Diabetologia (1980) 0.89
Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. J Clin Invest (1983) 0.88
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Decreased insulin binding to cultured cells from a patient with the Rabson-Mendenhall syndrome: dichotomy between studies with cultured lymphocytes and cultured fibroblasts. J Clin Endocrinol Metab (1983) 0.86
Insulin-stimulated receptor phosphorylation appears normal in cultured Epstein-Barr virus-transformed lymphocyte cell lines derived from patients with extreme insulin resistance. J Clin Endocrinol Metab (1985) 0.82
Downregulation occurs normally in cultured Epstein-Barr virus-transformed lymphocytes from patients with extreme insulin resistance. Discrepancy between downregulation in vivo and in vitro. Diabetes (1984) 0.81
The intraovarian sites of androgen and estrogen formation in women with normal and hyperandrogenic ovaries as judged by in vitro experiments. J Clin Endocrinol Metab (1980) 0.79
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Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell (1997) 4.20
Efficacy and safety of troglitazone in the treatment of lipodystrophy syndromes. Ann Intern Med (2000) 3.44
Early neonatal death in mice homozygous for a null allele of the insulin receptor gene. Nat Genet (1996) 3.40
Use of polymerase chain reaction catalyzed by Taq DNA polymerase for site-specific mutagenesis. Gene (1989) 3.11
Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes (2000) 3.01
Identification of a family of sorting nexin molecules and characterization of their association with receptors. Mol Cell Biol (1998) 2.97
Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. Mol Biol Cell (2000) 2.69
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol (1997) 2.51
Insulin-induced receptor loss in cultured human lymphocytes is due to accelerated receptor degradation. Proc Natl Acad Sci U S A (1981) 2.18
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Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. Am J Hum Genet (2000) 1.76
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Direct demonstration of glycosylation of insulin receptor subunits by biosynthetic and external labeling: evidence for heterogeneity. Proc Natl Acad Sci U S A (1981) 1.64
Biosynthesis and glycosylation of the insulin receptor. Evidence for a single polypeptide precursor of the two major subunits. J Biol Chem (1983) 1.62
Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science (1988) 1.56
Studies on the mechanism of activation of adipose tissue pyruvate dehydrogenase by insulin. J Biol Chem (1973) 1.47
Binding of insulin receptors to lectins: evidence for common carbohydrate determinants on several membrane receptors. Biochemistry (1981) 1.45
The structure of insulin receptor and its subunits. Evidence for multiple nonreduced forms and a 210,000 possible proreceptor. J Biol Chem (1982) 1.45
A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab (1999) 1.44
The role of antireceptor antibodies in stimulating phosphorylation of the insulin receptor. J Biol Chem (1984) 1.43
An endogenous substrate for the insulin receptor-associated tyrosine kinase. J Biol Chem (1985) 1.42
Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem (2001) 1.38
Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mol Cell Biol (1995) 1.36
Insulin receptor phosphorylation may not be a prerequisite for acute insulin action. Science (1984) 1.35
Myristyl and palmityl acylation of the insulin receptor. J Biol Chem (1987) 1.34
Tyrosine kinase-deficient mutant human insulin receptors (Met1153-->Ile) overexpressed in transfected rat adipose cells fail to mediate translocation of epitope-tagged GLUT4. Proc Natl Acad Sci U S A (1994) 1.29
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Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells. J Biol Chem (1994) 1.26
A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. EMBO J (1989) 1.24
Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking. J Biol Chem (2000) 1.24
Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology (1997) 1.22
Involvement of dileucine motifs in the internalization and degradation of the insulin receptor. J Biol Chem (1994) 1.21
Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance. J Clin Invest (1991) 1.18
Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance. J Clin Invest (1990) 1.17
Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1994) 1.14
Transfection of DNA into isolated rat adipose cells by electroporation: evaluation of promoter activity in transfected adipose cells which are highly responsive to insulin after one day in culture. Biochem Biophys Res Commun (1993) 1.14
Localization of an occult insulinoma by intraoperative ultrasonography. Surgery (1985) 1.12
Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J Biol Chem (1995) 1.12
Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking. Traffic (2000) 1.11
Insulin resistance associated with androgen excess in women with autoantibodies to the insulin receptor. Ann Intern Med (1982) 1.09
Subcellular localization and internalization of the four human leptin receptor isoforms. J Biol Chem (1999) 1.09
Hypoglycemia associated with antibodies to the insulin receptor. N Engl J Med (1982) 1.05
Homozygous deletion of the human insulin receptor gene results in leprechaunism. Nat Genet (1993) 1.05
Activation of serum- and glucocorticoid-induced protein kinase (Sgk) by cyclic AMP and insulin. J Biol Chem (2000) 1.05
Clinical disorders associated with autoantibodies to the insulin receptor. Simulation by passive transfer of immunoglobulins to rats. J Clin Invest (1983) 1.05
Insulin stimulates phosphorylation of a 120-kDa glycoprotein substrate (pp120) for the receptor-associated protein kinase in intact H-35 hepatoma cells. Proc Natl Acad Sci U S A (1987) 1.04
Decreased insulin binding in cultured lymphocytes from two patients with extreme insulin resistance. J Clin Endocrinol Metab (1982) 1.03
Streptavidin blotting: a sensitive technique to study cell surface proteins; application to investigate autophosphorylation and endocytosis of biotin-labeled insulin receptors. Endocrinology (1993) 1.02
Receptor defects in patients with extreme insulin resistance. Diabetes Metab Rev (1985) 1.00
Anti-receptor antibodies mimic the effect of insulin to down-regulate insulin receptors in cultured human lymphoblastoid (IM-9) cells. J Clin Endocrinol Metab (1984) 1.00
Tyrosine kinase activity of the insulin receptor of patients with type A extreme insulin resistance: studies with circulating mononuclear cells and cultured lymphocytes. J Clin Endocrinol Metab (1984) 0.99
Non-insulin-mediated glucose disappearance in subjects with IDDM. Discordance between experimental results and minimal model analysis. Diabetes (1994) 0.99
Defects in human insulin receptor gene expression. Mol Endocrinol (1988) 0.98
Insulin-stimulated phosphorylation of recombinant pp120/HA4, an endogenous substrate of the insulin receptor tyrosine kinase. Biochemistry (1995) 0.98
Normal coding sequence of insulin gene in Pima Indians and Nauruans, two groups with highest prevalence of type II diabetes. Diabetes (1991) 0.98
Cloning, tissue expression, and chromosomal localization of the mouse IRS-3 gene. Endocrinology (1997) 0.97
Hepatocyte plasma membrane ECTO-ATPase (pp120/HA4) is a substrate for tyrosine kinase activity of the insulin receptor. Biochem Biophys Res Commun (1990) 0.97
Substitution of isoleucine for methionine at position 1153 in the beta-subunit of the human insulin receptor. A mutation that impairs receptor tyrosine kinase activity, receptor endocytosis, and insulin action. J Biol Chem (1992) 0.97
Interaction of insulin receptor substrate 3 with insulin receptor, insulin receptor-related receptor, insulin-like growth factor-1 receptor, and downstream signaling proteins. J Biol Chem (1999) 0.96
Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH. Proc Natl Acad Sci U S A (1981) 0.96
Extreme insulin resistance in association with abnormally high binding affinity of insulin receptors from a patient with leprechaunism: evidence for a defect intrinsic to the receptor. J Clin Endocrinol Metab (1982) 0.95
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Insulin-induced internalization of the insulin receptor in the isolated rat adipose cell. Detection of the internalized 138-kilodalton receptor subunit using a photoaffinity 125I-insulin. J Biol Chem (1983) 0.95
pp120/ecto-ATPase, an endogenous substrate of the insulin receptor tyrosine kinase, is expressed as two variably spliced isoforms. J Biol Chem (1993) 0.94
A novel human insulin receptor gene mutation uniquely inhibits insulin binding without impairing posttranslational processing. Diabetes (1994) 0.94
Two patients with insulin resistance due to decreased levels of insulin-receptor mRNA. Diabetes (1991) 0.93
Mechanism of glucocorticoid-induced increase in insulin receptors of cultured human lymphocytes. J Biol Chem (1982) 0.93
Immunoglobulin heavy chain-binding protein binds to misfolded mutant insulin receptors with mutations in the extracellular domain. J Biol Chem (1992) 0.93
Effects of castanospermine and 1-deoxynojirimycin on insulin receptor biogenesis. Evidence for a role of glucose removal from core oligosaccharides. J Biol Chem (1987) 0.91
Internalization of insulin receptors in the isolated rat adipose cell. Demonstration of the vectorial disposition of receptor subunits. J Biol Chem (1984) 0.91
Insulin-induced activation of phosphatidyl inositol 3-kinase. Demonstration that the p85 subunit binds directly to the COOH terminus of the insulin receptor in intact cells. J Biol Chem (1994) 0.90
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor. J Biol Chem (1987) 0.90
Action of insulin receptor substrate-3 (IRS-3) and IRS-4 to stimulate translocation of GLUT4 in rat adipose cells. Mol Endocrinol (1999) 0.90
A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman. J Clin Endocrinol Metab (1991) 0.90
Insulin receptor degradation is accelerated in cultured lymphocytes from patients with genetic syndromes of extreme insulin resistance. J Clin Invest (1984) 0.90
Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT4 to the cell surface in rat adipose cells. J Biol Chem (1997) 0.89
Deletion of C-terminal 113 amino acids impairs processing and internalization of human insulin receptor: comparison of receptors expressed in CHO and NIH-3T3 cells. Biochim Biophys Acta (1993) 0.89
Molecular scanning of beta-3-adrenergic receptor gene in total congenital lipoatrophic diabetes mellitus. J Clin Endocrinol Metab (1997) 0.89
Mutagenesis of lysine 460 in the human insulin receptor. Effects upon receptor recycling and cooperative interactions among binding sites. J Biol Chem (1990) 0.89
Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identification of the mutation by direct sequencing of genomic deoxyribonucleic acid amplified by polymerase chain reaction. J Clin Endocrinol Metab (1990) 0.89
Tissue distribution and subcellular localization of an endogenous substrate (pp 120) for the insulin receptor-associated tyrosine kinase. Endocrinology (1986) 0.89
Biosynthesis of the insulin receptor. Horm Metab Res (1985) 0.89
Homozygosity for a null allele of the insulin receptor gene in a patient with leprechaunism. Hum Mutat (1995) 0.88
Tumor-promoting phorbol ester stimulates tyrosine phosphorylation in U-937 monocytes. Proc Natl Acad Sci U S A (1984) 0.88
Defect in cooperativity in insulin receptors from a patient with a congenital form of extreme insulin resistance. J Clin Invest (1983) 0.88
Specific glycosylation site mutations of the insulin receptor alpha subunit impair intracellular transport. Biochemistry (1993) 0.88
The insulin-stimulated receptor kinase is a tyrosine-specific casein kinase. Eur J Biochem (1983) 0.87
Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab (1997) 0.87
Binding of hormones to receptors. An alternative explanation of nonlinear Scatchard plots. Biochemistry (1975) 0.87
Insulin stimulates phosphorylation of serine residues in soluble insulin receptors. Biochem Biophys Res Commun (1983) 0.87
Rat liver membranes contain a 120 kDa glycoprotein which serves as a substrate for the tyrosine kinases of the receptors for insulin and epidermal growth factor. FEBS Lett (1987) 0.87
Unique features of the insulin receptor in rat brain. J Neurochem (1984) 0.86