1
|
The Burlington randomized trial of the nurse practitioner.
|
N Engl J Med
|
1974
|
17.02
|
2
|
Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism.
|
JAMA
|
1999
|
12.75
|
3
|
Controversy in counting and attributing events in clinical trials.
|
N Engl J Med
|
1979
|
7.25
|
4
|
Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin.
|
N Engl J Med
|
1995
|
6.86
|
5
|
Canadian Atrial Fibrillation Anticoagulation (CAFA) Study.
|
J Am Coll Cardiol
|
1991
|
6.55
|
6
|
A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism.
|
N Engl J Med
|
1999
|
5.14
|
7
|
Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer.
|
Thromb Haemost
|
2000
|
4.81
|
8
|
A comparison of low-molecular-weight heparin administered primarily at home with unfractionated heparin administered in the hospital for proximal deep-vein thrombosis.
|
N Engl J Med
|
1996
|
4.70
|
9
|
PROACT: a phase II randomized trial of recombinant pro-urokinase by direct arterial delivery in acute middle cerebral artery stroke. PROACT Investigators. Prolyse in Acute Cerebral Thromboembolism.
|
Stroke
|
1998
|
4.52
|
10
|
The Burlington randomized trial of the nurse practitioner: health outcomes of patients.
|
Ann Intern Med
|
1974
|
4.37
|
11
|
Canadian implantable defibrillator study (CIDS) : a randomized trial of the implantable cardioverter defibrillator against amiodarone.
|
Circulation
|
2000
|
4.12
|
12
|
Subcutaneous fondaparinux versus intravenous unfractionated heparin in the initial treatment of pulmonary embolism.
|
N Engl J Med
|
2003
|
3.94
|
13
|
Meta-analysis of the implantable cardioverter defibrillator secondary prevention trials. AVID, CASH and CIDS studies. Antiarrhythmics vs Implantable Defibrillator study. Cardiac Arrest Study Hamburg . Canadian Implantable Defibrillator Study.
|
Eur Heart J
|
2000
|
3.71
|
14
|
A comparison of aspirin with placebo in patients treated with warfarin after heart-valve replacement.
|
N Engl J Med
|
1993
|
3.67
|
15
|
Double-blind randomised trial of a very-low-dose warfarin for prevention of thromboembolism in stage IV breast cancer.
|
Lancet
|
1994
|
3.51
|
16
|
Treatment of warfarin-associated coagulopathy with oral vitamin K: a randomised controlled trial.
|
Lancet
|
2000
|
3.50
|
17
|
Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.
|
Science
|
1984
|
3.47
|
18
|
Randomised trial of outcome after myocardial infarction in patients with frequent or repetitive ventricular premature depolarisations: CAMIAT. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Investigators.
|
Lancet
|
1997
|
3.40
|
19
|
Effect of bromhexine on ventilatory capacity in patients with a variety of chest diseases.
|
Lancet
|
1969
|
3.34
|
20
|
Effects of physiologic pacing versus ventricular pacing on the risk of stroke and death due to cardiovascular causes. Canadian Trial of Physiologic Pacing Investigators.
|
N Engl J Med
|
2000
|
3.32
|
21
|
Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis.
|
N Engl J Med
|
1982
|
3.16
|
22
|
Aspirin, sulfinpyrazone, or both in unstable angina. Results of a Canadian multicenter trial.
|
N Engl J Med
|
1985
|
2.99
|
23
|
Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis.
|
N Engl J Med
|
1979
|
2.91
|
24
|
Significance testing to establish equivalence between treatments, with special reference to data in the form of 2X2 tables.
|
Biometrics
|
1977
|
2.87
|
25
|
Prognostic importance of myocardial ischemia detected by ambulatory monitoring early after acute myocardial infarction.
|
N Engl J Med
|
1996
|
2.69
|
26
|
Use of a clinical model for safe management of patients with suspected pulmonary embolism.
|
Ann Intern Med
|
1998
|
2.49
|
27
|
The North American Vasovagal Pacemaker Study (VPS). A randomized trial of permanent cardiac pacing for the prevention of vasovagal syncope.
|
J Am Coll Cardiol
|
1999
|
2.44
|
28
|
Randomised comparison of two intensities of oral anticoagulant therapy after tissue heart valve replacement.
|
Lancet
|
1988
|
2.44
|
29
|
Incidence of recurrent thromboembolic and bleeding complications among patients with venous thromboembolism in relation to both malignancy and achieved international normalized ratio: a retrospective analysis.
|
J Clin Oncol
|
2000
|
2.35
|
30
|
Ultrasonographic screening before hospital discharge for deep venous thrombosis after arthroplasty: the post-arthroplasty screening study. A randomized, controlled trial.
|
Ann Intern Med
|
1997
|
2.28
|
31
|
Comparison of high-dose with low-dose subcutaneous heparin to prevent left ventricular mural thrombosis in patients with acute transmural anterior myocardial infarction.
|
N Engl J Med
|
1989
|
2.28
|
32
|
Platelet-active drugs : the relationships among dose, effectiveness, and side effects.
|
Chest
|
2001
|
2.25
|
33
|
How should results from completed studies influence ongoing clinical trials? The CAFA Study experience.
|
Ann Intern Med
|
1991
|
2.06
|
34
|
Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study.
|
Circulation
|
2000
|
2.05
|
35
|
Quality of life in stage II breast cancer: an instrument for clinical trials.
|
J Clin Oncol
|
1988
|
1.93
|
36
|
Oral rivaroxaban for the prevention of symptomatic venous thromboembolism after elective hip and knee replacement.
|
J Bone Joint Surg Br
|
2009
|
1.91
|
37
|
Prevention of deep vein thrombosis after elective hip surgery. A randomized trial comparing low molecular weight heparin with standard unfractionated heparin.
|
Ann Intern Med
|
1991
|
1.81
|
38
|
Depression and risk of sudden cardiac death after acute myocardial infarction: testing for the confounding effects of fatigue.
|
Psychosom Med
|
2000
|
1.80
|
39
|
Ardeparin sodium for extended out-of-hospital prophylaxis against venous thromboembolism after total hip or knee replacement. A randomized, double-blind, placebo-controlled trial.
|
Ann Intern Med
|
2000
|
1.71
|
40
|
Cost-effectiveness of the implantable cardioverter-defibrillator: results from the Canadian Implantable Defibrillator Study (CIDS).
|
Circulation
|
2001
|
1.70
|
41
|
Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study.
|
Circulation
|
1991
|
1.68
|
42
|
Expectorant action of bromhexine in chronic obstructive bronchitis.
|
Br Med J
|
1970
|
1.67
|
43
|
A randomized controlled trial of a low-molecular-weight heparin (enoxaparin) to prevent deep-vein thrombosis in patients undergoing elective hip surgery.
|
N Engl J Med
|
1986
|
1.67
|
44
|
A prospective, randomized trial of high-dose intravenous immune globulin G therapy, oral prednisone therapy, and no therapy in childhood acute immune thrombocytopenic purpura.
|
J Pediatr
|
1993
|
1.64
|
45
|
Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis.
|
N Engl J Med
|
1982
|
1.64
|
46
|
Active-control trials: how would a new agent compare with placebo? A method illustrated with clopidogrel, aspirin, and placebo.
|
Am Heart J
|
2001
|
1.62
|
47
|
BAY 59-7939: an oral, direct factor Xa inhibitor for the prevention of venous thromboembolism in patients after total knee replacement. A phase II dose-ranging study.
|
J Thromb Haemost
|
2005
|
1.60
|
48
|
Fibrinolytic variables in patients with recurrent venous thrombosis: a prospective cohort study.
|
Thromb Haemost
|
2001
|
1.58
|
49
|
The effect of thrombocytopenia on experimental arteriosclerotic lesion formation in rabbits. Smooth muscle cell proliferation and re-endothelialization.
|
J Clin Invest
|
1977
|
1.58
|
50
|
Low-dose cyclosporin versus placebo in patients with rheumatoid arthritis.
|
Lancet
|
1990
|
1.56
|
51
|
Dual-chamber versus ventricular pacing. Critical appraisal of current data.
|
Circulation
|
1996
|
1.55
|
52
|
Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: the PROACT II trial.
|
Neurology
|
2001
|
1.55
|
53
|
Emergency department use at two Hamilton hospitals.
|
Can Med Assoc J
|
1975
|
1.55
|
54
|
Effectiveness of intermittent pneumatic leg compression for preventing deep vein thrombosis after total hip replacement.
|
JAMA
|
1990
|
1.55
|
55
|
Low-molecular-weight heparin in the treatment of patients with venous thromboembolism. The Columbus Investigators.
|
N Engl J Med
|
1997
|
1.54
|
56
|
Intermittent compression units for severe post-phlebitic syndrome: a randomized crossover study.
|
CMAJ
|
1999
|
1.52
|
57
|
Cyclophosphamide and plasma exchange in multiple sclerosis.
|
Lancet
|
1991
|
1.50
|
58
|
The occurrence of subsequent malignancy in patients presenting with deep vein thrombosis: results from a historical cohort study.
|
Thromb Haemost
|
1998
|
1.49
|
59
|
Comparative safety and tolerability of clopidogrel and aspirin: results from CAPRIE. CAPRIE Steering Committee and Investigators. Clopidogrel versus aspirin in patients at risk of ischaemic events.
|
Drug Saf
|
1999
|
1.46
|
60
|
Relationship between acute respiratory illness and air pollution levels in an industrial city.
|
Am Rev Respir Dis
|
1977
|
1.46
|
61
|
Coronary patency, infarct size and left ventricular function after thrombolytic therapy for acute myocardial infarction: results from the tissue plasminogen activator: Toronto (TPAT) placebo-controlled trial. TPAT Study Group.
|
J Am Coll Cardiol
|
1991
|
1.45
|
62
|
Optimal duration of oral anticoagulant therapy: a randomized trial comparing four weeks with three months of warfarin in patients with proximal deep vein thrombosis.
|
Thromb Haemost
|
1995
|
1.44
|
63
|
Poor adherence to placebo or amiodarone therapy predicts mortality: results from the CAMIAT study. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial.
|
Psychosom Med
|
1999
|
1.40
|
64
|
The thrombogenic effect of anticancer drug therapy in women with stage II breast cancer.
|
N Engl J Med
|
1988
|
1.39
|
65
|
1965-1990: 25th anniversary of nurse practitioners. A classic manuscript reprinted in celebration of 25 years of progress. The Burlington randomized trial of the nurse practitioner. 1971-2.
|
J Am Acad Nurse Pract
|
1990
|
1.38
|
66
|
A randomized trial of a single bolus dosage regimen of recombinant tissue plasminogen activator in patients with acute pulmonary embolism.
|
Chest
|
1990
|
1.32
|
67
|
An emergency department triage model based on presenting complaints.
|
Can J Public Health
|
1973
|
1.29
|
68
|
Prevention and treatment of postphlebitic syndrome: results of a 3-part study.
|
Arch Intern Med
|
2001
|
1.28
|
69
|
Double-blind randomised trial of Org 10172 low-molecular-weight heparinoid in prevention of deep-vein thrombosis in thrombotic stroke.
|
Lancet
|
1987
|
1.25
|
70
|
Sensitivity and specificity of a rapid whole-blood assay for D-dimer in the diagnosis of pulmonary embolism.
|
Ann Intern Med
|
1998
|
1.24
|
71
|
The stroke prognosis instrument II (SPI-II) : A clinical prediction instrument for patients with transient ischemia and nondisabling ischemic stroke.
|
Stroke
|
2000
|
1.24
|
72
|
The relationship between anti-factor Xa level and clinical outcome in patients receiving enoxaparine low molecular weight heparin to prevent deep vein thrombosis after hip replacement.
|
Thromb Haemost
|
1989
|
1.22
|
73
|
When is a prognostic factor useful? A guide for the perplexed.
|
J Clin Oncol
|
1991
|
1.20
|
74
|
Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery.
|
Br J Surg
|
2005
|
1.19
|
75
|
Progression to chronic atrial fibrillation after pacing: the Canadian Trial of Physiologic Pacing. CTOPP Investigators.
|
J Am Coll Cardiol
|
2001
|
1.19
|
76
|
Methotrexate in rheumatoid arthritis. Indications, contraindications, efficacy, and safety.
|
Ann Intern Med
|
1987
|
1.16
|
77
|
Comparison of 1 month with 3 months of anticoagulation for a first episode of venous thromboembolism associated with a transient risk factor.
|
J Thromb Haemost
|
2004
|
1.14
|
78
|
Prevention of venous thrombosis with small, subcutaneous doses of heparin.
|
JAMA
|
1976
|
1.13
|
79
|
Colchicine in the treatment of cirrhosis of the liver.
|
N Engl J Med
|
1988
|
1.13
|
80
|
Relevance of preoperative and postoperative blood tests to postoperative leg-vein thrombosis.
|
Lancet
|
1973
|
1.11
|
81
|
The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparin in rabbits.
|
Blood
|
1982
|
1.10
|
82
|
A randomized trial comparing activated thromboplastin time with heparin assay in patients with acute venous thromboembolism requiring large daily doses of heparin.
|
Arch Intern Med
|
1994
|
1.09
|
83
|
Low molecular weight heparin and compression stockings in the prevention of venous thromboembolism in neurosurgery.
|
Thromb Haemost
|
1996
|
1.09
|
84
|
Replacement of venography in suspected venous thrombosis by impedance plethysmography and 125I-fibrinogen leg scanning: a less invasive approach.
|
Ann Intern Med
|
1981
|
1.09
|
85
|
The qualification and disqualification of patients and events in long-term cardiovascular clinical trials.
|
Thromb Haemost
|
1979
|
1.08
|
86
|
Adjusted subcutaneous heparin or continuous intravenous heparin in patients with acute deep vein thrombosis. A randomized trial.
|
Ann Intern Med
|
1987
|
1.08
|
87
|
Relationship between the anticoagulant and antithrombotic effects of heparin in experimental venous thrombosis.
|
Blood
|
1977
|
1.04
|
88
|
A randomized trial comparing 12 weeks versus 36 weeks of adjuvant chemotherapy in stage II breast cancer.
|
J Clin Oncol
|
1990
|
1.04
|
89
|
Amiodarone interaction with beta-blockers: analysis of the merged EMIAT (European Myocardial Infarct Amiodarone Trial) and CAMIAT (Canadian Amiodarone Myocardial Infarction Trial) databases. The EMIAT and CAMIAT Investigators.
|
Circulation
|
1999
|
1.03
|
90
|
Arteriovenous-shunt thrombosis. Prevention by sulfinpyrazone.
|
N Engl J Med
|
1974
|
1.02
|
91
|
Fondaparinux combined with intermittent pneumatic compression vs. intermittent pneumatic compression alone for prevention of venous thromboembolism after abdominal surgery: a randomized, double-blind comparison.
|
J Thromb Haemost
|
2007
|
1.02
|
92
|
Effect of obesity on outcomes after fondaparinux, enoxaparin, or heparin treatment for acute venous thromboembolism in the Matisse trials.
|
J Thromb Haemost
|
2007
|
1.01
|
93
|
A low-molecular-weight heparinoid compared with unfractionated heparin in the prevention of deep vein thrombosis in patients with acute ischemic stroke. A randomized, double-blind study.
|
Ann Intern Med
|
1992
|
1.00
|
94
|
The role of sulfinpyrazone in the prevention of arterio-venous shunt thrombosis.
|
Circulation
|
1975
|
0.99
|
95
|
Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis.
|
Circulation
|
1981
|
0.99
|
96
|
The effects of rivaroxaban on the complications of surgery after total hip or knee replacement: results from the RECORD programme.
|
J Bone Joint Surg Br
|
2012
|
0.98
|
97
|
A randomized trial of less intense postoperative warfarin or aspirin therapy in the prevention of venous thromboembolism after surgery for fractured hip.
|
Arch Intern Med
|
1989
|
0.98
|
98
|
Social class and emergency department utilization.
|
Can Fam Physician
|
1975
|
0.97
|
99
|
Impedance plethysmography using the occlusive cuff technique in the diagnosis of venous thrombosis.
|
Circulation
|
1976
|
0.97
|
100
|
Controversy in neurology: the Canadian study on TIA and aspirin. A critique of the Canadian TIA study. Reply.
|
Ann Neurol
|
1979
|
0.97
|
101
|
An alternative to the use of two-sided tests in clinical trials.
|
Stat Med
|
1996
|
0.97
|
102
|
Wound botulism in injectors of drugs: upsurge in cases in England during 2004.
|
Euro Surveill
|
2005
|
0.96
|
103
|
Platelet-active drugs: the relationships among dose, effectiveness, and side effects.
|
Chest
|
1998
|
0.96
|
104
|
The diagnosis of acute, recurrent, deep-vein thrombosis: a diagnostic challenge.
|
Circulation
|
1983
|
0.94
|
105
|
Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group.
|
N Engl J Med
|
2000
|
0.94
|
106
|
Dose-response study of recombinant human soluble thrombomodulin (ART-123) in the prevention of venous thromboembolism after total hip replacement.
|
J Thromb Haemost
|
2005
|
0.94
|
107
|
A secondary prevention, randomized trial of suloctidil in patients with a recent history of thromboembolic stroke.
|
Stroke
|
1985
|
0.93
|
108
|
The incidence of symptomatic venous thromboembolism during and after prophylaxis with enoxaparin: a multi-institutional cohort study of patients who underwent hip or knee arthroplasty. Canadian Collaborative Group.
|
Arch Intern Med
|
1998
|
0.93
|
109
|
Canadian Implantable Defibrillator Study (CIDS): study design and organization. CIDS Co-Investigators.
|
Am J Cardiol
|
1993
|
0.92
|
110
|
Dose-response study of recombinant factor VIIa/tissue factor inhibitor recombinant nematode anticoagulant protein c2 in prevention of postoperative venous thromboembolism in patients undergoing total knee replacement.
|
Circulation
|
2001
|
0.92
|
111
|
Absorption and antidysrhythmic activity of oral disopyramide phosphate after acute myocardial infarction.
|
Br J Clin Pharmacol
|
1982
|
0.91
|
112
|
Effectiveness of intermittent pulsatile elastic stockings for the prevention of calf and thigh vein thrombosis in patients undergoing elective knee surgery.
|
Thromb Res
|
1979
|
0.91
|
113
|
Effect of clinical risk stratification on cost-effectiveness of the implantable cardioverter-defibrillator: the Canadian implantable defibrillator study.
|
Circulation
|
2001
|
0.91
|
114
|
Synergism between ipratropium and theophylline in asthma.
|
Thorax
|
1981
|
0.91
|
115
|
Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (third of three parts).
|
N Engl J Med
|
1975
|
0.90
|
116
|
On the probability of a committee meeting.
|
Br Med J
|
1976
|
0.90
|
117
|
Regression of injury-induced atheromatous lesions in rabbits.
|
Arch Pathol Lab Med
|
1976
|
0.88
|
118
|
Tissue plasminogen activator (rt-PA) vs heparin in deep vein thrombosis. Results of a randomized trial.
|
Chest
|
1990
|
0.88
|
119
|
Intra-uterine infection and cord immunoglobulin M. II. Clinical analysis of infants with elevated cord serum immunoglobulin M.
|
Can Med Assoc J
|
1974
|
0.86
|
120
|
Coronary care unit utilization in Hamilton, Ontario, a city of 375,000 people.
|
Can J Cardiol
|
1988
|
0.86
|
121
|
Accuracy of screening compression ultrasonography and clinical examination for the diagnosis of deep vein thrombosis after total hip or knee arthroplasty.
|
Can J Surg
|
1998
|
0.86
|
122
|
Methotrexate in rheumatoid arthritis. Feedback on American College of Physicians guidelines.
|
Ann Intern Med
|
1989
|
0.86
|
123
|
North American Vasovagal Pacemaker Study: study design and organization.
|
Pacing Clin Electrophysiol
|
1997
|
0.84
|
124
|
Economic evaluation of outpatient treatment with low-molecular-weight heparin for proximal vein thrombosis.
|
Arch Intern Med
|
1999
|
0.84
|
125
|
Prevention of deep vein thrombosis in potential neurosurgical patients. A randomized trial comparing graduated compression stockings alone or graduated compression stockings plus intermittent pneumatic compression with control.
|
Arch Intern Med
|
1989
|
0.84
|
126
|
Relationship between pacemaker dependency and the effect of pacing mode on cardiovascular outcomes.
|
Circulation
|
2001
|
0.84
|
127
|
Adverse haematological effects of ticlopidine. Prevention, recognition and management.
|
Drug Saf
|
1998
|
0.84
|
128
|
Early treatment of stroke with monosialoganglioside GM-1. Efficacy and safety results of the Early Stroke Trial.
|
Stroke
|
1994
|
0.83
|
129
|
Canadian American ticlopidine study (cats) in thromboembolic stroke.
|
Agents Actions Suppl
|
1984
|
0.83
|
130
|
Relationship between the antithrombotic and anticoagulant effects of low molecular weight heparin.
|
Thromb Res
|
1981
|
0.83
|
131
|
Tissue plasminogen activator: Toronto (TPAT) placebo-controlled randomized trial in acute myocardial infarction.
|
J Am Coll Cardiol
|
1989
|
0.83
|
132
|
The influence of red blood cells on the effects of aspirin or sulphinpyrazone on platelet adherence to damaged rabbit aorta.
|
Br J Haematol
|
1979
|
0.83
|
133
|
Platelet-inhibiting drugs in the prevention of clinical thrombotic disease (first of three parts).
|
N Engl J Med
|
1975
|
0.83
|
134
|
Antithrombotic therapy for cerebrovascular disorders. An update.
|
Chest
|
1995
|
0.82
|
135
|
An evaluation of impedance plethysmography and 125I-fibrinogen leg scanning in patients following hip surgery.
|
Thromb Haemost
|
1989
|
0.82
|
136
|
The defibrillator in acute myocardial infarction trial (DINAMIT): study protocol.
|
Am Heart J
|
2000
|
0.82
|
137
|
A randomized trial of aspirin and sulfinpyrazone in patients with threatened stroke. Results and methodologic issues.
|
Circulation
|
1980
|
0.82
|
138
|
XIV. Cerebral ischemia: the role of thrombosis and of antithrombotic therapy. Study group on antithrombotic therapy.
|
Stroke
|
1977
|
0.82
|
139
|
Failure of aspirin plus dipyridamole to prevent restenosis after carotid endarterectomy.
|
Ann Intern Med
|
1992
|
0.82
|
140
|
Evaluation of disodium cromoglycate in intrinsic and extrinsic asthma.
|
Am Rev Respir Dis
|
1972
|
0.81
|
141
|
The relation between the activated partial thromboplastin time response and recurrence in patients with venous thrombosis treated with continuous intravenous heparin.
|
Arch Intern Med
|
1996
|
0.81
|
142
|
Intrauterine infection and cord immunoglobulin M. I. Analysis of methods of assay and levels of immunoglobulin M in normal newborns.
|
Can Med Assoc J
|
1972
|
0.81
|
143
|
One year mortality outcomes of all coronary and intensive care unit patients with acute myocardial infarction, unstable angina or other chest pain in Hamilton, Ontario, a city of 375,000 people.
|
Can J Cardiol
|
1989
|
0.81
|
144
|
Anticholinergic and sympathomimetic combination therapy of asthma.
|
J Allergy Clin Immunol
|
1983
|
0.81
|
145
|
Bilateral vs. ipsilateral venography as the primary efficacy outcome measure in thromboprophylaxis clinical trials: a systematic review.
|
J Thromb Haemost
|
2004
|
0.81
|
146
|
Single studies and overview analyses: is aspirin of value in cerebral ischemia?
|
Stroke
|
1987
|
0.81
|
147
|
Recurrent venous thrombosis and heparin therapy: an evaluation of the importance of early activated partial thromboplastin times.
|
Arch Intern Med
|
1999
|
0.81
|
148
|
Resolution of lipid-containing atherosclerotic lesions induced by injury.
|
Blood Vessels
|
1977
|
0.81
|
149
|
An evaluation of suloctidil in the prevention of deep vein thrombosis in neurosurgical patients.
|
Thromb Res
|
1985
|
0.81
|
150
|
Fish oils and low-molecular-weight heparin for the reduction of restenosis after percutaneous transluminal coronary angioplasty. The EMPAR Study.
|
Circulation
|
1996
|
0.81
|
151
|
Ardeparin (low-molecular-weight heparin) vs graduated compression stockings for the prevention of venous thromboembolism. A randomized trial in patients undergoing knee surgery.
|
Arch Intern Med
|
1996
|
0.81
|
152
|
Prevention of venous thrombosis by intermittent sequential calf compression in patients with intracranial disease.
|
Thromb Res
|
1979
|
0.80
|
153
|
Differing patterns of cholesterol accumulation and 3-H-cholesterol influx in areas of the cholesterol-fed pig aorta identified by evans blue dye.
|
Exp Mol Pathol
|
1975
|
0.80
|
154
|
A meta-analysis of the studies of dihydroergotamine plus heparin in the prophylaxis of deep vein thrombosis.
|
Chest
|
1986
|
0.80
|
155
|
The diagnostic value of the fibrinogen/fibrin fragment E antigen assay in clinically suspected deep vein thrombosis.
|
Blood
|
1982
|
0.80
|
156
|
Maprotiline (Ludiomil, Ciba 34,276-BA) and imipramine in depressed outpatients: a double-blind clinical study.
|
Curr Ther Res Clin Exp
|
1976
|
0.80
|
157
|
Low dose cyclosporine in rheumatoid arthritis: a pilot study.
|
J Rheumatol
|
1987
|
0.80
|
158
|
Combination therapy of cyclosporine with methotrexate and gold in rheumatoid arthritis (2 pilot studies).
|
J Rheumatol
|
1994
|
0.79
|
159
|
Enhanced platelet accumulation onto injured carotid arteries in rabbits after aspirin treatment.
|
J Clin Invest
|
1981
|
0.79
|
160
|
The osmotic fragility of mammalian erythrocytes in hypotonic solutions of sodium chloride.
|
Comp Biochem Physiol
|
1969
|
0.79
|
161
|
Design and baseline results of the monosialoganglioside early stroke trial. The EST Study Group.
|
Stroke
|
1992
|
0.79
|
162
|
The current status of platelet suppressive drugs in the treatment of thrombosis.
|
Thromb Diath Haemorrh
|
1975
|
0.79
|
163
|
Use of Hirulog in the prevention of venous thrombosis after major hip or knee surgery.
|
Circulation
|
1994
|
0.79
|
164
|
Sex-related differences in platelet aggregation: influence of the hematocrit.
|
Blood
|
1980
|
0.79
|
165
|
Effects of immunosuppression with cyclosporine in insulin-dependent diabetes mellitus of recent onset: the Canadian open study at 44 months.
|
Transplant Proc
|
1988
|
0.78
|
166
|
Antithrombotic therapy for cerebrovascular disorders.
|
Chest
|
1992
|
0.78
|
167
|
Ultrasonographic screening for deep vein thrombosis following arthroplasty fails to reduce posthospital thromboembolic complications: the Postarthroplasty Screening Study (PASS).
|
Chest
|
1998
|
0.78
|
168
|
Very low-dose warfarin prophylaxis to prevent thromboembolism in women with metastatic breast cancer receiving chemotherapy: an economic evaluation.
|
J Clin Oncol
|
1995
|
0.78
|
169
|
Salmon calcitonin nasal spray in the prevention of corticosteroid-induced osteoporosis.
|
Br J Rheumatol
|
1997
|
0.78
|
170
|
A placebo-controlled study to determine the efficacy of oral disopyramide phosphate for the prophylaxis of ventricular dysrhythmias after acute myocardial infarction.
|
Br J Clin Pharmacol
|
1982
|
0.78
|
171
|
Critical evaluation of platelet-inhibiting drugs in thrombotic disease.
|
Prog Hematol
|
1975
|
0.78
|
172
|
Alanine transport across the human placental brush border membrane and the role of SH groups in carrier function.
|
Z Ernahrungswiss
|
1995
|
0.77
|
173
|
The incidence of symptomatic venous thromboembolism after enoxaparin prophylaxis in lower extremity arthroplasty: a cohort study of 1,984 patients. Canadian Collaborative Group.
|
Chest
|
1998
|
0.77
|
174
|
Increased dipyridamole plasma concentrations associated with salicylate administration. Relationship to effects on platelet aggregation in vivo.
|
Thromb Res
|
1979
|
0.77
|
175
|
Comparison of mortality from acute myocardial infarction between 1979 and 1992 in a geographically defined stable population.
|
Am J Cardiol
|
1996
|
0.77
|
176
|
Metoprolol prophylaxis against postoperative atrial fibrillation increases length of hospital stay in patients not on pre-operative beta blockers: the beta blocker length of stay (BLOS) trial.
|
Heart
|
2004
|
0.77
|
177
|
Utility of ultrasound imaging of the lower extremities in the diagnostic approach in patients with suspected pulmonary embolism.
|
J Intern Med
|
2001
|
0.76
|
178
|
Interaction between cyclosporin A and nonsteroidal antiinflammatory drugs.
|
J Rheumatol
|
1997
|
0.76
|
179
|
Platelet-inhibiting drugs iee parts).
|
N Engl J Med
|
1975
|
0.76
|
180
|
Resolution of experimental pulmonary emboli with heparin and streptokinase in different dosage regimens.
|
J Clin Invest
|
1974
|
0.76
|
181
|
Clinical trials of cyclosporin in IDDM.
|
Diabetes Care
|
1989
|
0.76
|
182
|
Randomized trial of therapy with platelet antiaggregants for threatened stroke. 2: Observations on the pathogenesis and natural history of threatened stroke.
|
Can Med Assoc J
|
1980
|
0.75
|
183
|
Amiodarone for patients with ventricular premature depolarizations after myocardial infarction. Is it safe to stop treatment at one year?
|
Circulation
|
1993
|
0.75
|
184
|
The effect of systemic adjuvant chemotherapy on local breast recurrence in node positive breast cancer patients treated by lumpectomy without radiation.
|
Br J Cancer
|
1992
|
0.75
|
185
|
Effects of cyclosporine in recent-onset juvenile type 1 diabetes: impact of age and duration of disease.
|
J Pediatr
|
1987
|
0.75
|
186
|
1. Design and main results of the trial.
|
Can Med Assoc J
|
1980
|
0.75
|
187
|
Effect of suloctidil on platelet function in patients with shortened platelet survival time.
|
Thromb Res
|
1984
|
0.75
|
188
|
The effect of ipratropium on exercise-induced bronchoconstriction.
|
Ann Allergy
|
1981
|
0.75
|
189
|
The 'parent/child game': an innovative approach to parenting assessment and training with relevance to child abuse cases.
|
Nurs Stand Spec Suppl
|
1991
|
0.75
|
190
|
Impact of tissue plasminogen activator and heparin versus heparin alone on quantitative coronary angiographic findings in myocardial infarction. The Toronto Tissue Plasminogen Activator Trial Study Group.
|
Am J Cardiol
|
1993
|
0.75
|
191
|
Heparin therapy for deep vein thrombosis: from hospital to home.
|
Am J Med
|
2001
|
0.75
|
192
|
Clopidogrel, aspirin, and first line therapy.
|
Cerebrovasc Dis
|
1998
|
0.75
|
193
|
Antibiotics in sinus secretions.
|
Lancet
|
1968
|
0.75
|
194
|
Lidocaine and the reduction of post-venographic pain.
|
Aust N Z J Med
|
1984
|
0.75
|
195
|
Graded exercise testing following thrombolytic therapy for acute myocardial infarction: the importance of timing and infarct location. TPAT Study Group.
|
Can J Cardiol
|
1994
|
0.75
|
196
|
The identical effect of electrolyte and non-electrolyte on the osmotic fragility of mammalian erythrocytes.
|
Comp Biochem Physiol
|
1970
|
0.75
|
197
|
Parenting assessment: the parent/child game.
|
Nurs Stand
|
1992
|
0.75
|
198
|
Definition of high risk/high response population for stroke in patients with transient ischemic attacks.
|
Thromb Haemost
|
1979
|
0.75
|
199
|
Making research relevant: experience in a Canadian health region.
|
Med J Aust
|
1977
|
0.75
|
200
|
Clomipramine HCL--a double-blind study of a new antidepressant drug.
|
Can Psychiatr Assoc J
|
1973
|
0.75
|
201
|
Kids and car seats.
|
Can Nurse
|
1993
|
0.75
|
202
|
Relationships between osmotic fragility and other species-specific variables of mammalian erythrocytes.
|
Comp Biochem Physiol
|
1970
|
0.75
|
203
|
Platelet tests and antiplatelet drugs in coronary artery disease.
|
Circulation
|
1983
|
0.75
|
204
|
Problem oriented medical records: their impact on staff communication, attitudes and decision making.
|
Arch Phys Med Rehabil
|
1975
|
0.75
|
205
|
Clomipramine (Anafranil) in depressive patients with obsessive neurosis.
|
J Int Med Res
|
1977
|
0.75
|
206
|
Thrombolysis with a combination of small doses of streptokinase and full doses of heparin.
|
Semin Thromb Hemost
|
1975
|
0.75
|
207
|
Canadian Amiodarone Myocardial Infarction Arrhythmia Trial (CAMIAT): rationale and protocol. CAMIAT Investigators.
|
Am J Cardiol
|
1993
|
0.75
|
208
|
The spectrum of ABO hemolytic disease of the newborn infant.
|
J Pediatr
|
1979
|
0.75
|
209
|
Guidelines on the management of secondary prophylaxis of vascular events in stable patients in primary care.
|
Int J Clin Pract
|
2004
|
0.75
|
210
|
The Canadian cooperative study of platelet suppressant therapy in threatened stroke.
|
Thromb Haemost
|
1979
|
0.75
|
211
|
Effects on thrombin generation of single injections of Hirulog in patients with calf vein thrombosis.
|
Thromb Haemost
|
1994
|
0.75
|
212
|
Antiplatelet therapy: views from the experts.
|
Neurology
|
1999
|
0.75
|
213
|
Colchicine treatment of cirrhosis: answers.
|
Hepatology
|
1989
|
0.75
|
214
|
The relationship between basic biomedical research and the design and analysis of clinical trials.
|
Thromb Res Suppl
|
1983
|
0.75
|
215
|
Immunosuppression and type I diabetes.
|
Lancet
|
1987
|
0.75
|