Published in J Biol Chem on November 25, 1983
Metabolic fate of (E)-5-(2-bromovinyl)-2'-deoxyuridine in herpes simplex virus- and mock-infected cells. Antimicrob Agents Chemother (1984) 0.83
Human herpesvirus 8 gene encodes a functional thymidylate synthase. J Virol (2002) 0.81
Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs. Antimicrob Agents Chemother (1986) 0.78
Interaction of tRNA (uracil-5-)-methyltransferase with NO2Ura-tRNA. Nucleic Acids Res (1996) 0.76
Genetic organization and diversity of the hepatitis C virus. Proc Natl Acad Sci U S A (1991) 14.05
Structural identification of autoinducer of Photobacterium fischeri luciferase. Biochemistry (1981) 11.48
Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science (1985) 10.97
Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69
Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44
Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57
(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A (1979) 5.28
Ribosomal RNA sequence shows Pneumocystis carinii to be a member of the fungi. Nature (1988) 5.21
Kinetic and catalytic mechanism of HhaI methyltransferase. J Biol Chem (1987) 4.84
The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem (1995) 4.57
Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (1994) 3.98
Structure of the modified nucleoside Q isolated from Escherichia coli transfer ribonucleic acid. 7-(4,5-cis-Dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-deazaguanosine. Biochemistry (1975) 3.73
Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70
On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell (1983) 3.56
Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine. Proc Natl Acad Sci U S A (1984) 3.22
Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science (1986) 3.11
Antifolate-resistant mutants of Plasmodium falciparum dihydrofolate reductase. Proc Natl Acad Sci U S A (1997) 3.07
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Stable amplified DNA in drug-resistant Leishmania exists as extrachromosomal circles. Science (1986) 2.84
Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 2.74
A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria. Infect Immun (1996) 2.60
Overproduction of a bifunctional thymidylate synthetase-dihydrofolate reductase and DNA amplification in methotrexate-resistant Leishmania tropica. Proc Natl Acad Sci U S A (1983) 2.59
Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei. Cell (1983) 2.53
Atomic structure of thymidylate synthase: target for rational drug design. Science (1987) 2.48
Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A (1990) 2.48
Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (1995) 2.48
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry (1974) 2.42
A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. J Immunol (1992) 2.32
Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem (1988) 2.30
Unstable DNA amplifications in methotrexate-resistant Leishmania consist of extrachromosomal circles which relocalize during stabilization. Cell (1984) 2.28
Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. Proc Natl Acad Sci U S A (1990) 2.16
A rapid and sensitive high pressure liquid chromatography assay for deoxyribonucleoside triphosphates in cell extracts. Anal Biochem (1979) 2.13
A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry (1998) 2.12
Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology (1987) 2.04
Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol (1991) 2.02
Stereochemical modeling of disulfide bridges. Criteria for introduction into proteins by site-directed mutagenesis. Protein Eng (1989) 1.98
Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98
Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3. J Virol (1992) 1.91
Isolation and expression of the Pneumocystis carinii thymidylate synthase gene. Proc Natl Acad Sci U S A (1989) 1.88
Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infect Immun (1994) 1.87
Saturation site-directed mutagenesis of thymidylate synthase. J Biol Chem (1990) 1.85
Plasmid migration using orthogonal-field-alternation gel electrophoresis. Nucleic Acids Res (1987) 1.82
Chemical synthesis of a gene for human epidermal growth factor urogastrone and its expression in yeast. Proc Natl Acad Sci U S A (1983) 1.81
Differential antibody responses of individuals infected with AIDS-associated retroviruses surveyed using the viral core antigen p25gag expressed in bacteria. Virology (1986) 1.81
Isolation and expression of the Pneumocystis carinii dihydrofolate reductase gene. Proc Natl Acad Sci U S A (1989) 1.74
Three-dimensional structure of human basic fibroblast growth factor, a structural homolog of interleukin 1 beta. Proc Natl Acad Sci U S A (1991) 1.73
A bifunctional thymidylate synthetase-dihydrofolate reductase in protozoa. Mol Biochem Parasitol (1984) 1.71
The dihydrofolate reductase domain of Plasmodium falciparum thymidylate synthase-dihydrofolate reductase. Gene synthesis, expression, and anti-folate-resistant mutants. J Biol Chem (1993) 1.71
Purification and characterization of the bifunctional thymidylate synthetase-dihydrofolate reductase from methotrexate-resistant Leishmania tropica. Biochemistry (1985) 1.71
Acidic and basic fibroblast growth factors stimulate tyrosine kinase activity in vivo. J Biol Chem (1988) 1.70
The mechanism of pseudouridine synthase I as deduced from its interaction with 5-fluorouracil-tRNA. Proc Natl Acad Sci U S A (1999) 1.69
Identification of new RNA modifying enzymes by iterative genome search using known modifying enzymes as probes. Nucleic Acids Res (1996) 1.68
The ompA signal peptide directed secretion of Staphylococcal nuclease A by Escherichia coli. J Biol Chem (1985) 1.65
Ligand-affinity cloning and structure of a cell surface heparan sulfate proteoglycan that binds basic fibroblast growth factor. Proc Natl Acad Sci U S A (1990) 1.62
Structure-based discovery of inhibitors of thymidylate synthase. Science (1993) 1.61
Importance of hypervariable regions of HIV-1 gp120 in the generation of virus neutralizing antibodies. AIDS Res Hum Retroviruses (1990) 1.60
Synthetic peptide vaccine confers protection against murine malaria. J Exp Med (1987) 1.58
5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry (1988) 1.57
Human immunodeficiency virus reverse transcriptase expressed in transformed yeast cells. Biochemical properties and interactions with bovine tRNALys. Eur J Biochem (1989) 1.56
High-pressure liquid chromatography--ultraviolet analysis of intracellular nucleotides. Anal Biochem (1982) 1.56
5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase. Proc Natl Acad Sci U S A (1972) 1.54
Role of tyrosine kinase and membrane-spanning domains in signal transduction by the platelet-derived growth factor receptor. Mol Cell Biol (1988) 1.54
Heterologous expression of active thymidylate synthase-dihydrofolate reductase from Plasmodium falciparum. Biochemistry (1990) 1.52
Synthesis in yeast of a functional oxidation-resistant mutant of human alpha-antitrypsin. Nature (1984) 1.46
Sequences homologous to variant antigen mRNA spliced leader in Trypanosomatidae which do not undergo antigenic variation. Nature (1984) 1.45
Biochemical studies on the mode of action of cytochalasin B. Preparation of (3H)cytochalasin B and studies on its binding of cells. J Biol Chem (1974) 1.43
Molecular cloning and characterization of Porphyromonas gingivalis lysine-specific gingipain. A new member of an emerging family of pathogenic bacterial cysteine proteinases. J Biol Chem (1997) 1.43
Molecular recognition of tRNA by tRNA pseudouridine 55 synthase. Biochemistry (1998) 1.42
The structural basis for tRNA recognition and pseudouridine formation by pseudouridine synthase I. Nat Struct Biol (2000) 1.41
The cDNA and derived amino acid sequence for human osteopontin. Nucleic Acids Res (1989) 1.41
Production of a polyketide natural product in nonpolyketide-producing prokaryotic and eukaryotic hosts. Proc Natl Acad Sci U S A (1998) 1.37
Preferential interaction of human immunodeficiency virus reverse transcriptase with two regions of primer tRNA(Lys) as evidenced by footprinting studies and inhibition with synthetic oligoribonucleotides. J Mol Biol (1992) 1.35
Expression in yeast of a Plasmodium vivax antigen of potential use in a human malaria vaccine. J Exp Med (1987) 1.35
Crystal structure of human thymidylate synthase: a structural mechanism for guiding substrates into the active site. Biochemistry (1995) 1.32
The immunostimulatory effect of T cells and T cell lymphokines on murine fetally derived placental cells. J Immunol (1987) 1.32
Bifunctional thymidylate synthase-dihydrofolate reductase in protozoa. FASEB J (1990) 1.31
m5C RNA and m5C DNA methyl transferases use different cysteine residues as catalysts. Proc Natl Acad Sci U S A (2000) 1.30
A filter assay for thymidylate synthetase using 5-fluoro-2'-deoxyuridylate as an active site titrant. Biochemistry (1974) 1.29
Molecular cloning of a functional bovine interleukin 2 cDNA. Proc Natl Acad Sci U S A (1986) 1.29
Inhibition of the p66/p51 form of human immunodeficiency virus reverse transcriptase by tRNA(Lys). Nucleic Acids Res (1990) 1.28
Structure and expression of the gene for Pv200, a major blood-stage surface antigen of Plasmodium vivax. Mol Biochem Parasitol (1992) 1.27
Diphtheria toxin. Site and configuration of ADP-ribosylation of diphthamide in elongation factor 2. J Biol Chem (1981) 1.27
Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis. Proc Natl Acad Sci U S A (1992) 1.26
Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum. Infect Immun (1991) 1.26
Photoaffinity labeling of diphtheria toxin fragment A with NAD: structure of the photoproduct at position 148. Proc Natl Acad Sci U S A (1985) 1.25
Methods for the complete analysis of 5-fluorouracil metabolites in cell extracts. Anal Biochem (1981) 1.25
Lymphocyte proliferative responses to human immunodeficiency virus antigens in vitro. J Clin Invest (1989) 1.25
Bifunctional thymidylate synthase-dihydrofolate reductase from Leishmania tropica: sequence homology with the corresponding monofunctional proteins. Proc Natl Acad Sci U S A (1986) 1.24
Multiple T helper cell epitopes of the circumsporozoite protein of Plasmodium berghei. Eur J Immunol (1988) 1.22
A filter assay for steroid hormone receptors. Biochemistry (1973) 1.21
Exposition of a family of RNA m(5)C methyltransferases from searching genomic and proteomic sequences. Nucleic Acids Res (1999) 1.21
Pharmacokinetics of E-5-(2-bromovinyl)-2'-deoxyuridine in mice. Antimicrob Agents Chemother (1979) 1.20
On the mechanism of DNA-adenine methylase. J Biol Chem (1988) 1.20
Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome. West J Med (1984) 1.19
Identification of the 16S rRNA m5C967 methyltransferase from Escherichia coli. Biochemistry (1999) 1.19