Genetic organization and diversity of the hepatitis C virus.

PubWeight™: 14.05‹?› | Rank: Top 0.1% | All-Time Top 10000

🔗 View Article (PMC 51250)

Published in Proc Natl Acad Sci U S A on March 15, 1991

Authors

Q L Choo1, K H Richman, J H Han, K Berger, C Lee, C Dong, C Gallegos, D Coit, R Medina-Selby, P J Barr

Author Affiliations

1: Chiron Corporation, Emeryville, CA 94608.

Articles citing this

(truncated to the top 100)

Internal ribosome entry site within hepatitis C virus RNA. J Virol (1992) 9.14

Expression and identification of hepatitis C virus polyprotein cleavage products. J Virol (1993) 8.47

Characterization of the hepatitis C virus-encoded serine proteinase: determination of proteinase-dependent polyprotein cleavage sites. J Virol (1993) 6.36

Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: quasispecies nature of HCV genome distribution. J Virol (1992) 6.09

Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus. EMBO J (1996) 5.47

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41

Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. J Virol (1993) 5.08

Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci U S A (1996) 4.82

NS3 is a serine protease required for processing of hepatitis C virus polyprotein. J Virol (1993) 4.60

Secondary structure of the 5' nontranslated regions of hepatitis C virus and pestivirus genomic RNAs. Nucleic Acids Res (1992) 4.58

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions. J Virol (1993) 4.57

Evidence for immune selection of hepatitis C virus (HCV) putative envelope glycoprotein variants: potential role in chronic HCV infections. Proc Natl Acad Sci U S A (1992) 4.47

Unique features of internal initiation of hepatitis C virus RNA translation. EMBO J (1995) 4.44

Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. Hepatology (2014) 4.15

Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76

Sequence analysis of the 5' noncoding region of hepatitis C virus. Proc Natl Acad Sci U S A (1992) 3.72

Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev (2000) 3.70

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc Natl Acad Sci U S A (1993) 3.68

Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini. J Virol (1994) 3.61

Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci U S A (1994) 3.56

Evidence for in vitro replication of hepatitis C virus genome in a human T-cell line. Proc Natl Acad Sci U S A (1992) 3.55

Both NS3 and NS4A are required for proteolytic processing of hepatitis C virus nonstructural proteins. J Virol (1994) 3.51

Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif. J Clin Invest (1995) 3.47

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

At least 12 genotypes of hepatitis C virus predicted by sequence analysis of the putative E1 gene of isolates collected worldwide. Proc Natl Acad Sci U S A (1993) 3.37

Genomic structure of the human prototype strain H of hepatitis C virus: comparison with American and Japanese isolates. Proc Natl Acad Sci U S A (1991) 3.34

Expression of virus-encoded proteinases: functional and structural similarities with cellular enzymes. Microbiol Rev (1993) 3.33

An RNA pseudoknot is an essential structural element of the internal ribosome entry site located within the hepatitis C virus 5' noncoding region. RNA (1995) 3.30

Human monoclonal antibodies that inhibit binding of hepatitis C virus E2 protein to CD81 and recognize conserved conformational epitopes. J Virol (2000) 3.26

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25

Second-generation line probe assay for hepatitis C virus genotyping. J Clin Microbiol (1996) 3.22

A natural intergenotypic recombinant of hepatitis C virus identified in St. Petersburg. J Virol (2002) 3.20

Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. Proc Natl Acad Sci U S A (1995) 3.20

Biosynthesis and biochemical properties of the hepatitis C virus core protein. J Virol (1994) 3.19

Geographical distribution of hepatitis C virus genotypes in blood donors: an international collaborative survey. J Clin Microbiol (1994) 2.90

Sequence analysis of the core gene of 14 hepatitis C virus genotypes. Proc Natl Acad Sci U S A (1994) 2.83

New hepatitis C virus (HCV) genotyping system that allows for identification of HCV genotypes 1a, 1b, 2a, 2b, 3a, 3b, 4, 5a, and 6a. J Clin Microbiol (1997) 2.78

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J Virol (1993) 2.74

Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles. J Virol (2006) 2.68

HLA class I-restricted cytotoxic T lymphocytes specific for hepatitis C virus. Identification of multiple epitopes and characterization of patterns of cytokine release. J Clin Invest (1995) 2.66

Quantitative analysis of the peripheral blood cytotoxic T lymphocyte response in patients with chronic hepatitis C virus infection. J Clin Invest (1996) 2.65

Hepatitis C virus NS3 serine proteinase: trans-cleavage requirements and processing kinetics. J Virol (1994) 2.64

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58

Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation. J Virol (1995) 2.57

Hepatitis C virus (HCV)-specific cytotoxic T lymphocytes recognize epitopes in the core and envelope proteins of HCV. J Virol (1993) 2.57

At least five related, but distinct, hepatitis C viral genotypes exist. Proc Natl Acad Sci U S A (1992) 2.56

Hepatitis C virus glycoprotein folding: disulfide bond formation and association with calnexin. J Virol (1996) 2.53

The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation. Proc Natl Acad Sci U S A (1997) 2.43

Genomic organization of GB viruses A and B: two new members of the Flaviviridae associated with GB agent hepatitis. J Virol (1995) 2.38

Two hepatitis C virus glycoprotein E2 products with different C termini. J Virol (1994) 2.38

Topology of the membrane-associated hepatitis C virus protein NS4B. J Virol (2003) 2.37

A cis-acting replication element in the sequence encoding the NS5B RNA-dependent RNA polymerase is required for hepatitis C virus RNA replication. J Virol (2004) 2.36

Mapping of serotype-specific, immunodominant epitopes in the NS-4 region of hepatitis C virus (HCV): use of type-specific peptides to serologically differentiate infections with HCV types 1, 2, and 3. J Clin Microbiol (1993) 2.36

A conserved helical element is essential for internal initiation of translation of hepatitis C virus RNA. J Virol (1994) 2.35

Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules. J Virol (1995) 2.34

Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe (2009) 2.33

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3). J Virol (1996) 2.30

Importance of primer selection for the detection of hepatitis C virus RNA with the polymerase chain reaction assay. Proc Natl Acad Sci U S A (1992) 2.30

The GB viruses: a review and proposed classification of GBV-A, GBV-C (HGV), and GBV-D in genus Pegivirus within the family Flaviviridae. J Gen Virol (2010) 2.26

Accurate quantification of hepatitis C virus (HCV) RNA from all HCV genotypes by using branched-DNA technology. J Clin Microbiol (1996) 2.26

Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease. Proc Natl Acad Sci U S A (1992) 2.18

Inhibition of intracellular hepatitis C virus replication by synthetic and vector-derived small interfering RNAs. EMBO Rep (2003) 2.16

Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol (1993) 2.16

Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J Virol (2002) 2.05

Comprehensive analysis of CD8(+)-T-cell responses against hepatitis C virus reveals multiple unpredicted specificities. J Virol (2002) 2.03

Synthesis of a novel hepatitis C virus protein by ribosomal frameshift. EMBO J (2001) 2.03

A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci U S A (2002) 2.02

Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol (1996) 2.02

Acute hepatitis C virus structural gene sequences as predictors of persistent viremia: hypervariable region 1 as a decoy. J Virol (1999) 1.98

Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus. J Virol (1999) 1.93

The native form and maturation process of hepatitis C virus core protein. J Virol (1998) 1.91

Compartmentalization of T lymphocytes to the site of disease: intrahepatic CD4+ T cells specific for the protein NS4 of hepatitis C virus in patients with chronic hepatitis C. J Exp Med (1993) 1.90

Identification of a naturally occurring recombinant genotype 2/6 hepatitis C virus. J Virol (2006) 1.90

Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma. J Clin Microbiol (1991) 1.87

5' and 3' untranslated regions of pestivirus genome: primary and secondary structure analyses. Nucleic Acids Res (1993) 1.86

Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol (1997) 1.84

Classification of hepatitis C viruses based on phylogenetic analysis of the envelope 1 and nonstructural 5B regions and identification of five additional subtypes. Proc Natl Acad Sci U S A (1994) 1.82

Hepatitis C virus genotyping: interrogation of the 5' untranslated region cannot accurately distinguish genotypes 1a and 1b. J Clin Microbiol (2002) 1.78

An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A. J Virol (1995) 1.78

Mutational analysis of the hepatitis C virus RNA helicase. J Virol (1997) 1.77

Proteasome activator PA28gamma-dependent nuclear retention and degradation of hepatitis C virus core protein. J Virol (2003) 1.76

Hyperphosphorylation of the hepatitis C virus NS5A protein requires an active NS3 protease, NS4A, NS4B, and NS5A encoded on the same polyprotein. J Virol (1999) 1.75

Virus-host cell interactions during hepatitis C virus RNA replication: impact of polyprotein expression on the cellular transcriptome and cell cycle association with viral RNA synthesis. J Virol (2004) 1.74

Functional analysis of the interaction between HCV 5'UTR and putative subunits of eukaryotic translation initiation factor eIF3. Nucleic Acids Res (1998) 1.72

Transfection of a differentiated human hepatoma cell line (Huh7) with in vitro-transcribed hepatitis C virus (HCV) RNA and establishment of a long-term culture persistently infected with HCV. J Virol (1995) 1.70

Expression of processed envelope protein of hepatitis C virus in mammalian and insect cells. J Virol (1992) 1.68

Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture. J Virol (2010) 1.64

Interaction of hepatitis C virus core protein with viral sense RNA and suppression of its translation. J Virol (1999) 1.63

Hepatitis C virus core protein interacts with cellular putative RNA helicase. J Virol (1999) 1.63

Sequence evolution of the hypervariable region in the putative envelope region E2/NS1 of hepatitis C virus is correlated with specific humoral immune responses. J Virol (1995) 1.63

Regulated processing of hepatitis C virus core protein is linked to subcellular localization. J Virol (1997) 1.63

Clinical evaluation of two methods for genotyping hepatitis C virus based on analysis of the 5' noncoding region. J Clin Microbiol (2003) 1.62

Specific interaction of polypyrimidine tract-binding protein with the extreme 3'-terminal structure of the hepatitis C virus genome, the 3'X. J Virol (1997) 1.61

The NS2 protein of hepatitis C virus is a transmembrane polypeptide. J Virol (1995) 1.61

Self-assembly of nucleocapsid-like particles from recombinant hepatitis C virus core protein. J Virol (2001) 1.59

Molecular model of the specificity pocket of the hepatitis C virus protease: implications for substrate recognition. Proc Natl Acad Sci U S A (1994) 1.57

Genetic drift in hypervariable region 1 of the viral genome in persistent hepatitis C virus infection. J Virol (1994) 1.57

Hepatitis C virus genotyping based on 5' noncoding sequence analysis (Trugene). J Clin Microbiol (2001) 1.56

Detection of intrahepatic replication of hepatitis C virus RNA by in situ hybridization and comparison with histopathology. Proc Natl Acad Sci U S A (1992) 1.56

Articles cited by this

A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65

Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08

New M13 vectors for cloning. Methods Enzymol (1983) 90.74

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89

An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis. Science (1989) 18.79

Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes. Nucleic Acids Res (1989) 10.03

Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proc Natl Acad Sci U S A (1990) 8.92

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end. Proc Natl Acad Sci U S A (1991) 7.13

Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology (1988) 5.92

The 5'-terminal sequence of the hepatitis C virus genome. Jpn J Exp Med (1990) 5.46

Molecular cloning and nucleotide sequence of the genome of hog cholera virus. Virology (1989) 5.29

Nucleotide sequence of dengue 2 RNA and comparison of the encoded proteins with those of other flaviviruses. Virology (1988) 4.78

A cDNA fragment of hepatitis C virus isolated from an implicated donor of post-transfusion non-A, non-B hepatitis in Japan. Nucleic Acids Res (1989) 4.29

N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases. Nucleic Acids Res (1989) 4.27

Hepatitis C virus: the major causative agent of viral non-A, non-B hepatitis. Br Med Bull (1990) 4.16

Evolution of RNA viruses. Annu Rev Microbiol (1988) 3.34

Comparisons of the pestivirus bovine viral diarrhoea virus with members of the flaviviridae. J Gen Virol (1988) 3.31

The putative nucleocapsid and envelope protein genes of hepatitis C virus determined by comparison of the nucleotide sequences of two isolates derived from an experimentally infected chimpanzee and healthy human carriers. J Gen Virol (1990) 3.18

Flaviviridae. Intervirology (1985) 3.06

Yellow fever virus proteins NS2A, NS2B, and NS4B: identification and partial N-terminal amino acid sequence analysis. Virology (1989) 2.87

Nucleotide sequence of core and envelope genes of the hepatitis C virus genome derived directly from human healthy carriers. Nucleic Acids Res (1990) 2.76

Recent advances in pestivirus research. J Gen Virol (1989) 2.67

Nucleotide sequence and genome organization of carnation mottle virus RNA. Nucleic Acids Res (1985) 2.32

Experimental infection of chimpanzees with antihemophilic (factor VIII) materials: recovery of virus-like particles associated with non-A, non-B hepatitis. J Med Virol (1979) 1.64

The agents of non-A, non-B viral hepatitis. J Virol Methods (1985) 1.56

Articles by these authors

Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science (1989) 37.89

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: VII. Factors Causing Acidosis in Chronic Nephritis. A Preliminary Report. J Clin Invest (1926) 14.83

Nucleotide sequence and expression of an AIDS-associated retrovirus (ARV-2). Science (1985) 10.97

Characterization of ribosomal frameshifting in HIV-1 gag-pol expression. Nature (1988) 10.69

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: X. The Acidosis of Nephritis. J Clin Invest (1929) 10.24

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: VI. Studies of Diabetes. J Clin Invest (1925) 9.92

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell (1999) 9.84

Boron nitride substrates for high-quality graphene electronics. Nat Nanotechnol (2010) 9.72

Detection of hepatitis C viral sequences in non-A, non-B hepatitis. Lancet (1990) 8.56

Haplotype variation and linkage disequilibrium in 313 human genes. Science (2001) 8.52

Cell-specific expression of the rat insulin gene: evidence for role of two distinct 5' flanking elements. Science (1985) 8.44

Genome-wide detection of alternative splicing in expressed sequences of human genes. Nucleic Acids Res (2001) 7.27

Characterization of the terminal regions of hepatitis C viral RNA: identification of conserved sequences in the 5' untranslated region and poly(A) tails at the 3' end. Proc Natl Acad Sci U S A (1991) 7.13

Real-space observation of a two-dimensional skyrmion crystal. Nature (2010) 7.08

Elevated levels of mRNA can account for the trans-activation of human immunodeficiency virus. Proc Natl Acad Sci U S A (1986) 6.57

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XII. A Study of Renal Edema. J Clin Invest (1929) 6.48

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene (2007) 5.79

(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a potent and selective anti-herpes agent. Proc Natl Acad Sci U S A (1979) 5.28

Variable and hypervariable domains are found in the regions of HCV corresponding to the flavivirus envelope and NS1 proteins and the pestivirus envelope glycoproteins. Virology (1991) 4.47

Prevalence of Kaposi's sarcoma associated herpesvirus infection measured by antibodies to recombinant capsid protein and latent immunofluorescence antigen. Lancet (1996) 4.05

Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule. Science (1994) 3.98

Fragile X premutation is a significant risk factor for premature ovarian failure: the International Collaborative POF in Fragile X study--preliminary data. Am J Med Genet (1999) 3.82

Vaccination of chimpanzees against infection by the hepatitis C virus. Proc Natl Acad Sci U S A (1994) 3.76

Redesigning trypsin: alteration of substrate specificity. Science (1985) 3.70

Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature (2007) 3.69

On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell (1983) 3.56

Isolation of full-length putative rat lysophospholipase cDNA using improved methods for mRNA isolation and cDNA cloning. Biochemistry (1987) 3.48

Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron (1999) 3.37

A quantitative test to estimate neutralizing antibodies to the hepatitis C virus: cytofluorimetric assessment of envelope glycoprotein 2 binding to target cells. Proc Natl Acad Sci U S A (1996) 3.25

Expression, identification and subcellular localization of the proteins encoded by the hepatitis C viral genome. J Gen Virol (1993) 3.18

Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus. Science (1986) 3.11

C-terminal domain of the hepatitis C virus NS3 protein contains an RNA helicase activity. Biochem Biophys Res Commun (1995) 3.09

Cloning and characterization of a cDNA for murine macrophage inflammatory protein (MIP), a novel monokine with inflammatory and chemokinetic properties. J Exp Med (1988) 3.06

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03

Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area. J Comp Neurol (1998) 3.01

Multiple transcription start sites, DNase I-hypersensitive sites, and an opposite-strand exon in the 5' region of the CHO dhfr gene. Mol Cell Biol (1986) 2.82

Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology (2005) 2.79

Criteria for diagnosing Parkinson's disease. Ann Neurol (1992) 2.78

Alpha-factor-directed synthesis and secretion of mature foreign proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 2.74

Targeted disruption of the mPer3 gene: subtle effects on circadian clock function. Mol Cell Biol (2000) 2.69

The hepatitis C virus encodes a serine protease involved in processing of the putative nonstructural proteins from the viral polyprotein precursor. Biochem Biophys Res Commun (1993) 2.67

TOTAL ACID-BASE EQUILIBRIUM OF PLASMA IN HEALTH AND DISEASE: XI. Hypochloremia and Total Salt Deficiency in Nephritis. J Clin Invest (1929) 2.64

A recombinant baculovirus 42-kilodalton C-terminal fragment of Plasmodium falciparum merozoite surface protein 1 protects Aotus monkeys against malaria. Infect Immun (1996) 2.60

Characterization of hepatitis C virus envelope glycoprotein complexes expressed by recombinant vaccinia viruses. J Virol (1993) 2.58

Characterization of the hepatitis C virus E2/NS1 gene product expressed in mammalian cells. Virology (1992) 2.58

Anterior paralimbic mediation of procaine-induced emotional and psychosensory experiences. Arch Gen Psychiatry (1996) 2.53

Sequences homologous to the variant antigen mRNA spliced leader are located in tandem repeats and variable orphons in trypanosoma brucei. Cell (1983) 2.53

Amplification of EGFR T790M causes resistance to an irreversible EGFR inhibitor. Oncogene (2010) 2.53

Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene (1995) 2.50

Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48

Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A (1990) 2.48

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak. Nature (1995) 2.48

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev (2001) 2.48

Leptin activates hypothalamic CART neurons projecting to the spinal cord. Neuron (1998) 2.46

Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology (2000) 2.45

Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J Exp Med (1990) 2.44

A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus. Hum Genet (1998) 2.44

Structure of cloned DNA complementary to rat prolactin messenger RNA. J Biol Chem (1980) 2.44

Psychiatric epidemiology in Korea. Part I: Gender and age differences in Seoul. J Nerv Ment Dis (1990) 2.42

Evolution of the genome and the genetic code: selection at the dinucleotide level by methylation and polyribonucleotide cleavage. Proc Natl Acad Sci U S A (1989) 2.42

Developing and deploying a patient safety program in a large health care delivery system: you can't fix what you don't know about. Jt Comm J Qual Improv (2001) 2.42

Validity of the Migraine Disability Assessment (MIDAS) score in comparison to a diary-based measure in a population sample of migraine sufferers. Pain (2000) 2.41

Gastric distention: a mechanism for postprandial gastroesophageal reflux. Gastroenterology (1985) 2.37

Prevalence of diabetes and impaired fasting glucose in Korea: Korean National Health and Nutrition Survey 2001. Diabetes Care (2006) 2.35

Prevalence and risk factors of RLS in an elderly population: the MEMO study. Memory and Morbidity in Augsburg Elderly. Neurology (2000) 2.34

The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study. BJU Int (2003) 2.32

A carboxyl-terminal fragment of Plasmodium falciparum gp195 expressed by a recombinant baculovirus induces antibodies that completely inhibit parasite growth. J Immunol (1992) 2.32

Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y). J Biol Chem (1988) 2.30

Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Res (2000) 2.28

Leukocyte relaxation properties. Biophys J (1988) 2.27

Srg3, a mouse homolog of yeast SWI3, is essential for early embryogenesis and involved in brain development. Mol Cell Biol (2001) 2.26

Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology (2010) 2.21

Human prolactin. cDNA structural analysis and evolutionary comparisons. J Biol Chem (1981) 2.19

Diagnosis of hepatitis C virus (HCV) infection using an immunodominant chimeric polyprotein to capture circulating antibodies: reevaluation of the role of HCV in liver disease. Proc Natl Acad Sci U S A (1992) 2.18

Defective antigen processing in GILT-free mice. Science (2001) 2.16

Cloning of three human multifunctional de novo purine biosynthetic genes by functional complementation of yeast mutations. Proc Natl Acad Sci U S A (1990) 2.16

Women's Health Australia: recruitment for a national longitudinal cohort study. Women Health (1998) 2.16

Vertical transmission of hepatitis C virus. Lancet (1991) 2.08

Evidence-based recommendations for the use of Negative Pressure Wound Therapy in traumatic wounds and reconstructive surgery: steps towards an international consensus. Injury (2011) 2.07

Premedication with intravenous dexmedetomidine-midazolam suppresses fentanyl-induced cough. Ir J Med Sci (2012) 2.06

Sequence relationships of type D retroviruses which cause simian acquired immunodeficiency syndrome. Virology (1987) 2.04

Recombinant polypeptide from the endonuclease region of the acquired immune deficiency syndrome retrovirus polymerase (pol) gene detects serum antibodies in most infected individuals. J Virol (1986) 2.04

Analgesia nociception index: evaluation as a new parameter for acute postoperative pain. Br J Anaesth (2013) 2.04

Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol (1991) 2.02

Neoadjuvant chemoradiation for localized adenocarcinoma of the pancreas. Ann Surg Oncol (2001) 2.01

Molecular cloning and structural characterization of the Arg-gingipain proteinase of Porphyromonas gingivalis. Biosynthesis as a proteinase-adhesin polyprotein. J Biol Chem (1995) 1.98

Healing of arterial prostheses in man: its incompleteness. Ann Surg (1972) 1.97

Circadian regulation of a Drosophila homolog of the mammalian Clock gene: PER and TIM function as positive regulators. Mol Cell Biol (1998) 1.96

Interleukin-6 as a paracrine and autocrine growth factor in human prostatic carcinoma cells in vitro. Cancer Res (1997) 1.95

Mammalian subtilisin-related proteinases in cleavage activation of the paramyxovirus fusion glycoprotein: superiority of furin/PACE to PC2 or PC1/PC3. J Virol (1992) 1.91

The impact of nocturnal symptoms associated with gastroesophageal reflux disease on health-related quality of life. Arch Intern Med (2001) 1.88

Difficult extubation due to transfixation of a nasotracheal tube by a Kirschner wire. Anesthesiology (1977) 1.88

Saccharomyces cerevisiae recombinant Pfs25 adsorbed to alum elicits antibodies that block transmission of Plasmodium falciparum. Infect Immun (1994) 1.87

Use of a signature nucleotide sequence of hepatitis C virus for detection of viral RNA in human serum and plasma. J Clin Microbiol (1991) 1.87