Published in Gene on October 01, 1984
Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc Natl Acad Sci U S A (1987) 4.72
A human hepatitis B viral enhancer element. EMBO J (1985) 3.94
A recombinant hepatitis B core antigen polypeptide with the protamine-like domain deleted self-assembles into capsid particles but fails to bind nucleic acids. J Virol (1989) 2.72
Transcriptional trans-activating function of hepatitis B virus. J Virol (1987) 2.46
Common evolutionary origin of hepatitis B virus and retroviruses. Proc Natl Acad Sci U S A (1986) 2.20
Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sci U S A (1986) 2.18
Detection of multiple, novel reverse transcriptase coding sequences in human nucleic acids: relation to primate retroviruses. J Virol (1989) 2.05
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proc Natl Acad Sci U S A (1990) 1.90
Host-independent evolution and a genetic classification of the hepadnavirus family based on nucleotide sequences. Proc Natl Acad Sci U S A (1989) 1.76
Hepatitis B virus core antigen has two nuclear localization sequences in the arginine-rich carboxyl terminus. J Virol (1991) 1.73
Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site. Proc Natl Acad Sci U S A (1985) 1.57
Constrained evolution with respect to gene overlap of hepatitis B virus. J Mol Evol (1997) 1.49
Enhanced replication of a hepatitis B virus mutant associated with an epidemic of fulminant hepatitis. J Virol (1994) 1.44
Tight clustering of human hepatitis B virus integration sites in hepatomas near a triple-stranded region. J Virol (1987) 1.42
Point mutation in the S gene of hepatitis B virus for a d/y or w/r subtypic change in two blood donors carrying a surface antigen of compound subtype adyr or adwr. J Virol (1987) 1.41
Subtype-independent immature secretion and subtype-dependent replication deficiency of a highly frequent, naturally occurring mutation of human hepatitis B virus core antigen. J Virol (1999) 1.39
Mutations in core nucleotide sequence of hepatitis B virus correlate with fulminant and severe hepatitis. J Clin Invest (1993) 1.38
Hepatitis B virus polypeptide X: expression in Escherichia coli and identification of specific antibodies in sera from hepatitis B virus-infected humans. J Virol (1986) 1.35
A new hepadnavirus endemic in arctic ground squirrels in Alaska. J Virol (1996) 1.26
Inversely repeating integrated hepatitis B virus DNA and cellular flanking sequences in the human hepatoma-derived cell line huSP. Proc Natl Acad Sci U S A (1985) 1.25
A frequent, naturally occurring mutation (P130T) of human hepatitis B virus core antigen is compensatory for immature secretion phenotype of another frequent variant (I97L). J Virol (2000) 1.22
Trans-activation function of a 3' truncated X gene-cell fusion product from integrated hepatitis B virus DNA in chronic hepatitis tissues. Proc Natl Acad Sci U S A (1990) 1.20
Identification of a promoter region for 3.6-kilobase mRNA of hepatitis B virus and specific cellular binding protein. J Virol (1989) 1.19
Variations in codons 84-101 in the core nucleotide sequence correlate with hepatocellular injury in chronic hepatitis B virus infection. J Clin Invest (1992) 1.18
Multiple integration site of hepatitis B virus DNA in hepatocellular carcinoma and chronic active hepatitis tissues from children. J Virol (1987) 1.18
Structural rearrangement of integrated hepatitis B virus DNA as well as cellular flanking DNA is present in chronically infected hepatic tissues. J Virol (1990) 1.17
X-region-specific transcript in mammalian hepatitis B virus-infected liver. J Virol (1988) 1.16
Genotyping by multiplex polymerase chain reaction for detection of endemic hepatitis B virus transmission. J Clin Microbiol (1993) 1.12
The new core promoter element XCPE1 (X Core Promoter Element 1) directs activator-, mediator-, and TATA-binding protein-dependent but TFIID-independent RNA polymerase II transcription from TATA-less promoters. Mol Cell Biol (2007) 1.11
Differential formation of disulfide linkages in the core antigen of extracellular and intracellular hepatitis B virus core particles. J Virol (1991) 1.07
Characterization of transcription from TATA-less promoters: identification of a new core promoter element XCPE2 and analysis of factor requirements. PLoS One (2009) 1.07
Structural analysis of a hepatitis B virus genome integrated into chromosome 17p of a human hepatocellular carcinoma. J Virol (1988) 1.07
Replication advantage and host factor-independent phenotypes attributable to a common naturally occurring capsid mutation (I97L) in human hepatitis B virus. J Virol (2002) 1.06
Sequence of a replication competent hepatitis B virus genome with a preX open reading frame. Nucleic Acids Res (1990) 0.94
Free and integrated forms of hepatitis B virus DNA in human hepatocellular carcinoma cells (PLC/342) propagated in nude mice. J Virol (1987) 0.91
Nuclear respiratory factor 1 plays an essential role in transcriptional initiation from the hepatitis B virus x gene promoter. J Virol (2004) 0.89
Association between frequency of amino acid changes in core region of hepatitis B virus (HBV) and the presence of precore mutation in Japanese HBV carriers. J Gastroenterol (1997) 0.87
A transcription initiation site for the hepatitis B virus X gene is directed by the promoter-binding protein. J Virol (1993) 0.83
Integrated hepatitis B virus DNA preserves the binding sequence of transcription factor Yin and Yang 1 at the virus-cell junction. J Virol (2000) 0.83
The complete nucleotide sequence of hepatitis B virus, subtype adr (SRADR) and phylogenetic analysis. Nucleic Acids Res (1992) 0.81
The two different states of hepatitis B virus DNA in asymptomatic carriers: HBe-antigen-positive versus anti-HBe-positive asymptomatic carriers. Dig Dis Sci (1998) 0.80
Hepatitis B virus infection: An insight into infection outcomes and recent treatment options. Virusdisease (2015) 0.80
Complete nucleotide sequence of a hepatitis B virus, subtype adw2, and identification of three types of C open reading frame. Nucleic Acids Res (1993) 0.78
Association of the core clustering mutations (codon 21-34) and the severity of chronic hepatitis B in Korean patients. Korean J Intern Med (1995) 0.75
Structure and expression of integrated hepatitis B virus genes in an HBs antigen producing human cell line (huGK-14). Cytotechnology (1997) 0.75
The binding site of transcription factor YY1 is required for intramolecular recombination between terminally repeated sequences of linear replicative hepatitis B virus DNA. J Virol (2000) 0.75
Lamivudine-to-entecavir switching treatment in type B chronic hepatitis patients without evidence of lamivudine resistance. J Gastroenterol (2009) 0.75
Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol (1996) 72.84
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc (1987) 8.45
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med (1992) 8.27
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med (1991) 7.52
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol (1991) 6.30
Green revolution: a mutant gibberellin-synthesis gene in rice. Nature (2002) 5.84
HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature (1991) 5.34
Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature (2001) 4.77
Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc Natl Acad Sci U S A (1987) 4.72
The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med (1998) 4.48
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis. Plant J (2001) 3.92
Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology (2000) 3.42
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A (1995) 3.06
Duck hepatitis B virus (DHBV) particles produced by transient expression of DHBV DNA in a human hepatoma cell line are infectious in vitro. J Virol (1988) 3.03
Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol (1997) 2.98
Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90
Successful treatment of Behçet disease with pentoxifylline. Ann Intern Med (1996) 2.81
Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J Exp Med (1992) 2.71
Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology (1998) 2.67
Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc (1981) 2.62
Molecular clock of silent substitution: at least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes. J Mol Evol (1982) 2.58
Rice dwarf mutant d1, which is defective in the alpha subunit of the heterotrimeric G protein, affects gibberellin signal transduction. Proc Natl Acad Sci U S A (2000) 2.51
Identification of 15- to 17-kilodalton antigens associated with virulent Rhodococcus equi. J Clin Microbiol (1991) 2.44
Natural history and risk factors for immunoglobulin A nephropathy in Japan. Research Group on Progressive Renal Diseases. Am J Kidney Dis (1997) 2.40
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem (1989) 2.37
Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation. J Exp Med (1986) 2.33
1/f fluctuation of heartbeat period. IEEE Trans Biomed Eng (1982) 2.32
Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor. J Immunol (1987) 2.24
Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana. FEBS Lett (1999) 2.24
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. J Exp Med (1986) 2.23
Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol (1998) 2.21
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol (2001) 2.18
Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl Environ Microbiol (1995) 2.18
Administration of thyroxine in treated Graves' disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med (1991) 2.17
Frequent presence of HBV in the sera of HBsAg-negative, anti-HBc-positive blood donors. Transfusion (2001) 2.16
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res (2001) 2.14
Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J Exp Med (1985) 2.11
Cloning and functional analysis of two gibberellin 3 beta -hydroxylase genes that are differently expressed during the growth of rice. Proc Natl Acad Sci U S A (2001) 2.09
PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet (1998) 2.02
A structurally abnormal insulin causing human diabetes. Nature (1979) 1.99
Organic solvent tolerance and antibiotic resistance increased by overexpression of marA in Escherichia coli. Appl Environ Microbiol (1997) 1.98
Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol (1998) 1.97
Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology (1994) 1.96
Biological functions of proline in morphogenesis and osmotolerance revealed in antisense transgenic Arabidopsis thaliana. Plant J (1999) 1.95
Can we stop national immunisation days before global eradication of poliomyelitis? Lancet (1999) 1.92
Oxidative stress in the absence of inflammation in a mouse model for hepatitis C virus-associated hepatocarcinogenesis. Cancer Res (2001) 1.91
Mechanisms of IFN-gamma induction by natural killer cell stimulatory factor (NKSF/IL-12). Role of transcription and mRNA stability in the synergistic interaction between NKSF and IL-2. J Immunol (1992) 1.88
Expression of a gibberellin 2-oxidase gene around the shoot apex is related to phase transition in rice. Plant Physiol (2001) 1.86
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS): a correlative study of the clinical features and mitochondrial DNA mutation. Neurology (1992) 1.85
The adverse impact on liver transplantation of using positive cytotoxic crossmatch donors. Transplantation (1992) 1.83
Kawasaki disease in families. Pediatrics (1989) 1.83
A phylogenetically conserved sequence within viral 3' untranslated RNA pseudoknots regulates translation. Mol Cell Biol (1993) 1.82
Effect of hepatitis G virus infection on chronic hepatitis C. Ann Intern Med (1996) 1.81
Amyotrophic lateral sclerosis: T2 shortening in motor cortex at MR imaging. Radiology (1993) 1.81
The dwarf-1 (dt) Mutant of Zea mays blocks three steps in the gibberellin-biosynthetic pathway. Proc Natl Acad Sci U S A (1996) 1.80
Impaired motor facilitation during action observation in individuals with autism spectrum disorder. Curr Biol (2005) 1.80
Composition and structure of articular cartilage: a template for tissue repair. Clin Orthop Relat Res (2001) 1.79
Molecular assembly of the influenza virus RNA polymerase: determination of the subunit-subunit contact sites. J Gen Virol (1996) 1.77
Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D. J Neurochem (1987) 1.77
Visiting a forest, but not a city, increases human natural killer activity and expression of anti-cancer proteins. Int J Immunopathol Pharmacol (2008) 1.76
Two distinct types of repression domain in engrailed: one interacts with the groucho corepressor and is preferentially active on integrated target genes. Mol Cell Biol (1998) 1.76
A stress-inducible gene for 9-cis-epoxycarotenoid dioxygenase involved in abscisic acid biosynthesis under water stress in drought-tolerant cowpea. Plant Physiol (2000) 1.75
The 5' upstream region of mPer1 gene contains two promoters and is responsible for circadian oscillation. Curr Biol (2000) 1.74
Establishment of pure NOTES procedure using a conventional flexible endoscope: review of six cases of gastric gastrointestinal stromal tumors. Endoscopy (2011) 1.73
Inhibition of myocardial endothelin pathway improves long-term survival in heart failure. Nature (1996) 1.73
Amplification of c-myc, K-sam, and c-met in gastric cancers: detection by fluorescence in situ hybridization. Lab Invest (1998) 1.68
Intense superoxide dismutase-1 immunoreactivity in intracytoplasmic hyaline inclusions of familial amyotrophic lateral sclerosis with posterior column involvement. J Neuropathol Exp Neurol (1996) 1.67
Intranasal lidocaine 8% spray for second-division trigeminal neuralgia. Br J Anaesth (2006) 1.64
A glomerular permeability factor produced by human T cell hybridomas. Kidney Int (1991) 1.61
A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjects. J Biol Regul Homeost Agents (2008) 1.61
Glomerulonephritis in autopsy cases with hepatitis C virus infection. Intern Med (1998) 1.61
Amino acid sequence of heat-stable enterotoxin produced by Vibrio cholerae non-01. FEBS Lett (1985) 1.60
Cytokine production regulating Th1 and Th2 cytokines in hemophagocytic lymphohistiocytosis. Blood (1997) 1.60
International prognostic scoring system and TP53 mutations are independent prognostic indicators for patients with myelodysplastic syndrome. Br J Haematol (2001) 1.59
Comparison of the prognostic value of inflammation-based prognostic scores in patients with hepatocellular carcinoma. Br J Cancer (2012) 1.58
Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cdnas and identification of distinct genomic loci. J Biol Chem (1999) 1.58
Hepatitis B virus integration in hepatocellular carcinoma DNA: duplication of cellular flanking sequences at the integration site. Proc Natl Acad Sci U S A (1985) 1.57
IkappaBalpha ubiquitination is catalyzed by an SCF-like complex containing Skp1, cullin-1, and two F-box/WD40-repeat proteins, betaTrCP1 and betaTrCP2. Biochem Biophys Res Commun (1999) 1.56
Normal variations of the temporal bone on high-resolution CT: their incidence and clinical significance. Clin Radiol (1995) 1.55
Transmission of and liver injury by TT virus in patients on maintenance hemodialysis. J Gastroenterol (1999) 1.55
Nucleotide sequences of small ribosomal RNA and adjacent transfer RNA genes in rat mitochondrial DNA. Gene (1981) 1.55
Prognostic factors of hemophagocytic syndrome in adults: analysis of 34 cases. Eur J Haematol (1997) 1.54
The serology of chronic hepatitis B infection revisited. J Clin Invest (1993) 1.54
Salt and salted food intake and subsequent risk of gastric cancer among middle-aged Japanese men and women. Br J Cancer (2004) 1.54
Enhanced mucosal cytokine production in inflammatory bowel disease. Gastroenterology (1992) 1.53
Nitrile hydratase and its application to industrial production of acrylamide. Biosci Biotechnol Biochem (1996) 1.53
A close correlation between improvement of organic solvent tolerance levels and alteration of resistance toward low levels of multiple antibiotics in Escherichia coli. Biosci Biotechnol Biochem (1995) 1.51