Published in Appl Environ Microbiol on April 01, 1997
Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon. Antimicrob Agents Chemother (1997) 4.40
Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. J Bacteriol (1997) 3.81
Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J Bacteriol (2000) 3.27
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections. Antimicrob Agents Chemother (2003) 3.00
Evolutionary paths to antibiotic resistance under dynamically sustained drug selection. Nat Genet (2011) 2.86
Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coli. Antimicrob Agents Chemother (1998) 2.59
Complete sequence of a 184-kilobase catabolic plasmid from Sphingomonas aromaticivorans F199. J Bacteriol (1999) 2.52
Interactions among strategies associated with bacterial infection: pathogenicity, epidemicity, and antibiotic resistance. Clin Microbiol Rev (2002) 2.20
Role of the multidrug efflux systems of Pseudomonas aeruginosa in organic solvent tolerance. J Bacteriol (1998) 2.04
Involvement of outer membrane protein TolC, a possible member of the mar-sox regulon, in maintenance and improvement of organic solvent tolerance of Escherichia coli K-12. J Bacteriol (1998) 1.98
Functional genomic study of exogenous n-butanol stress in Escherichia coli. Appl Environ Microbiol (2010) 1.69
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coli. Antimicrob Agents Chemother (2000) 1.69
Evidence for an efflux pump mediating multiple antibiotic resistance in Salmonella enterica serovar Typhimurium. Antimicrob Agents Chemother (2000) 1.58
Insights into the environmental resistance gene pool from the genome sequence of the multidrug-resistant environmental isolate Escherichia coli SMS-3-5. J Bacteriol (2008) 1.49
Comparison of gyrA mutations, cyclohexane resistance, and the presence of class I integrons in Salmonella enterica from farm animals in England and Wales. J Clin Microbiol (2002) 1.43
Cell surface properties of organic solvent-tolerant mutants of Escherichia coli K-12. Appl Environ Microbiol (1997) 1.39
The transcriptional regulator SoxS is required for resistance of Salmonella typhimurium to paraquat but not for virulence in mice. Infect Immun (1997) 1.31
RamA confers multidrug resistance in Salmonella enterica via increased expression of acrB, which is inhibited by chlorpromazine. Antimicrob Agents Chemother (2008) 1.31
Multiple antibiotic resistance (mar) locus in Salmonella enterica serovar typhimurium DT104. Appl Environ Microbiol (2001) 1.18
Membrane stresses induced by overproduction of free fatty acids in Escherichia coli. Appl Environ Microbiol (2011) 1.18
Suppression of hypersensitivity of Escherichia coli acrB mutant to organic solvents by integrational activation of the acrEF operon with the IS1 or IS2 element. J Bacteriol (2001) 1.16
Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli. Antimicrob Agents Chemother (2015) 1.07
Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs. Antimicrob Agents Chemother (1997) 1.03
Quinolone resistance of Salmonella enterica serovar Virchow isolates from humans and poultry in Israel: evidence for clonal expansion. J Clin Microbiol (2007) 0.94
Screening of genes involved in isooctane tolerance in Saccharomyces cerevisiae by using mRNA differential display. Appl Environ Microbiol (2000) 0.92
Escherichia coli mar and acrAB mutants display no tolerance to simple alcohols. Int J Mol Sci (2010) 0.88
Directed evolution of an E. coli inner membrane transporter for improved efflux of biofuel molecules. Biotechnol Biofuels (2013) 0.88
Microarray analyses of the metabolic responses of Saccharomyces cerevisiae to organic solvent dimethyl sulfoxide. J Ind Microbiol Biotechnol (2003) 0.86
Discovery of glpC, an organic solvent tolerance-related gene in Escherichia coli, using gene expression profiles from DNA microarrays. Appl Environ Microbiol (2005) 0.86
Using transcriptomics to improve butanol tolerance of Synechocystis sp. strain PCC 6803. Appl Environ Microbiol (2013) 0.85
The marC gene of Escherichia coli is not involved in multiple antibiotic resistance. Antimicrob Agents Chemother (2007) 0.83
Discovery of a modified transcription factor endowing yeasts with organic-solvent tolerance and reconstruction of an organic-solvent-tolerant Saccharomyces cerevisiae strain. Appl Environ Microbiol (2008) 0.82
Genetic evidence for a novel interaction between transcriptional activator SoxS and region 4 of the σ(70) subunit of RNA polymerase at class II SoxS-dependent promoters in Escherichia coli. J Mol Biol (2010) 0.82
Contributions of mutations in acrR and marR genes to organic solvent tolerance in Escherichia coli. AMB Express (2012) 0.81
Organic solvent tolerance of Escherichia coli is independent of OmpF levels in the membrane. Appl Environ Microbiol (1999) 0.81
Study of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants. Iran J Pharm Res (2012) 0.80
Increase of organic solvent tolerance of Escherichia coli by the deletion of two regulator genes, fadR and marR. Appl Microbiol Biotechnol (2012) 0.80
Improvement of n-butanol tolerance in Escherichia coli by membrane-targeted tilapia metallothionein. Biotechnol Biofuels (2013) 0.78
Improved n-butanol production via co-expression of membrane-targeted tilapia metallothionein and the clostridial metabolic pathway in Escherichia coli. BMC Biotechnol (2017) 0.75
A predominant multidrug-resistant Salmonella enterica serovar Saintpaul clonal line in German turkey and related food products. Appl Environ Microbiol (2010) 0.75
Studies on transformation of Escherichia coli with plasmids. J Mol Biol (1983) 116.81
The physical map of the whole E. coli chromosome: application of a new strategy for rapid analysis and sorting of a large genomic library. Cell (1987) 46.35
Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol (1980) 41.18
Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol Microbiol (1995) 8.41
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J Bacteriol (1993) 6.02
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. J Bacteriol (1988) 4.97
marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli. J Bacteriol (1991) 3.83
The XylS/AraC family of regulators. Nucleic Acids Res (1993) 3.18
Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. J Bacteriol (1994) 3.13
Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences. Proc Natl Acad Sci U S A (1995) 3.09
Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. J Bacteriol (1993) 2.88
Replication in Saccharomyces cerevisiae of plasmid pBR313 carrying DNA from the yeast trpl region. Gene (1979) 2.73
Characterization of MarR, the repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli. J Bacteriol (1995) 2.55
Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein. J Bacteriol (1995) 2.53
Charomids: cosmid vectors for efficient cloning and mapping of large or small restriction fragments. Proc Natl Acad Sci U S A (1986) 2.42
P1 transduction map spanning the replication terminus of Escherichia coli K12. Mol Gen Genet (1981) 2.37
Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl Environ Microbiol (1995) 2.18
Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli. J Bacteriol (1994) 2.16
Active efflux of toluene in a solvent-resistant bacterium. J Bacteriol (1996) 2.11
Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli. J Bacteriol (1996) 2.07
Direction of travel of RecBC recombinase through bacteriophage lambda DNA. Genetics (1986) 1.98
Purification and regulatory properties of MarA protein, a transcriptional activator of Escherichia coli multiple antibiotic and superoxide resistance promoters. J Bacteriol (1995) 1.95
Identification of new genes regulated by the marRAB operon in Escherichia coli. J Bacteriol (1995) 1.75
Active efflux of chloramphenicol in susceptible Escherichia coli strains and in multiple-antibiotic-resistant (Mar) mutants. Antimicrob Agents Chemother (1994) 1.71
Cloning of an organic solvent-resistance gene in Escherichia coli: the unexpected role of alkylhydroperoxide reductase. Proc Natl Acad Sci U S A (1995) 1.57
A close correlation between improvement of organic solvent tolerance levels and alteration of resistance toward low levels of multiple antibiotics in Escherichia coli. Biosci Biotechnol Biochem (1995) 1.51
soxRS gene increased the level of organic solvent tolerance in Escherichia coli. Biosci Biotechnol Biochem (1995) 1.23
Cloning of organic solvent tolerance gene ostA that determines n-hexane tolerance level in Escherichia coli. Appl Environ Microbiol (1994) 1.07
Expression monitoring by hybridization to high-density oligonucleotide arrays. Nat Biotechnol (1996) 72.84
A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (1988) 27.60
A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc (1987) 8.45
Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med (1992) 8.27
Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat Med (1999) 8.01
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms. Nature (1999) 7.86
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med (1991) 7.52
Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell (2001) 6.37
Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. J Immunol (1991) 6.30
Green revolution: a mutant gibberellin-synthesis gene in rice. Nature (2002) 5.84
Randomised trial of effects of interferon-alpha on incidence of hepatocellular carcinoma in chronic active hepatitis C with cirrhosis. Lancet (1995) 5.03
Identification of CRE1 as a cytokinin receptor from Arabidopsis. Nature (2001) 4.77
Hepatitis B virus (HBV) particles are produced in a cell culture system by transient expression of transfected HBV DNA. Proc Natl Acad Sci U S A (1987) 4.72
Crystal structure of human serum albumin at 2.5 A resolution. Protein Eng (1999) 4.37
Standard steroid treatment for autoimmune pancreatitis. Gut (2009) 4.33
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Salicylic acid potentiates an agonist-dependent gain control that amplifies pathogen signals in the activation of defense mechanisms. Plant Cell (1997) 4.08
Effects of environmental tobacco smoke on urinary cotinine excretion in nonsmokers. Evidence for passive smoking. N Engl J Med (1984) 3.98
Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis. Plant J (2001) 3.92
Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli. J Bacteriol (1990) 3.78
Detection of serum hepatitis B virus DNA in patients with chronic hepatitis using the polymerase chain reaction assay. Proc Natl Acad Sci U S A (1989) 3.67
Glial growth factors are alternatively spliced erbB2 ligands expressed in the nervous system. Nature (1993) 3.42
Interferon beta prevents recurrence of hepatocellular carcinoma after complete resection or ablation of the primary tumor-A prospective randomized study of hepatitis C virus-related liver cancer. Hepatology (2000) 3.42
Results of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan. The Liver Cancer Study Group of Japan. Hepatology (2000) 3.42
Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell (2001) 3.29
Mutation of Jak3 in a patient with SCID: essential role of Jak3 in lymphoid development. Science (1995) 3.15
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene. Proc Natl Acad Sci U S A (1995) 3.06
Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis. Cancer Res (1993) 3.05
Location of stem cells of human hair follicles by clonal analysis. Cell (1994) 2.96
Energy release in the solar corona from spatially resolved magnetic braids. Nature (2013) 2.90
Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int (2001) 2.90
Antigenic drift of equine infectious anemia virus in chronically infected horses. Arch Gesamte Virusforsch (1973) 2.86
Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet (1999) 2.81
Successful treatment of Behçet disease with pentoxifylline. Ann Intern Med (1996) 2.81
Serum matrix metalloproteinase 3 as a predictor of the degree of joint destruction during the six months after measurement, in patients with early rheumatoid arthritis. Arthritis Rheum (2000) 2.72
Natural killer (NK) cell stimulatory factor increases the cytotoxic activity of NK cells from both healthy donors and human immunodeficiency virus-infected patients. J Exp Med (1992) 2.71
Expression of immunoreactive E-cadherin adhesion molecules in human cancers. Am J Pathol (1991) 2.71
Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut (2003) 2.71
Emergence and takeover of YMDD motif mutant hepatitis B virus during long-term lamivudine therapy and re-takeover by wild type after cessation of therapy. Hepatology (1998) 2.67
Prediction of variceal hemorrhage by esophageal endoscopy. Gastrointest Endosc (1981) 2.62
Molecular clock of silent substitution: at least six-fold preponderance of silent changes in mitochondrial genes over those in nuclear genes. J Mol Evol (1982) 2.58
Complete nucleotide sequence of hepatitis B virus DNA of subtype adr and its conserved gene organization. Gene (1984) 2.56
High-resolution endoscopic imaging of the GI tract using optical coherence tomography. Gastrointest Endosc (2000) 2.53
Rice dwarf mutant d1, which is defective in the alpha subunit of the heterotrimeric G protein, affects gibberellin signal transduction. Proc Natl Acad Sci U S A (2000) 2.51
Giant Rashba-type spin splitting in bulk BiTeI. Nat Mater (2011) 2.49
Decreased prefrontal dopamine D1 receptors in schizophrenia revealed by PET. Nature (1997) 2.46
Effects of size and shape (aspect ratio) on the hemodynamics of saccular aneurysms: a possible index for surgical treatment of intracranial aneurysms. Neurosurgery (1999) 2.43
Natural history and risk factors for immunoglobulin A nephropathy in Japan. Research Group on Progressive Renal Diseases. Am J Kidney Dis (1997) 2.40
A woman who trembled, then had chorea. Lancet (1998) 2.40
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression. J Biol Chem (1989) 2.37
Load-bearing mode of the knee joint: physical behavior of the knee joint with or without menisci. Clin Orthop Relat Res (1980) 2.33
Gamma interferon and lymphotoxin, released by activated T cells, synergize to inhibit granulocyte/monocyte colony formation. J Exp Med (1986) 2.33
1/f fluctuation of heartbeat period. IEEE Trans Biomed Eng (1982) 2.32
Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS. Neurology (2006) 2.31
RNA-dependent RNA polymerase activity of the soluble recombinant hepatitis C virus NS5B protein truncated at the C-terminal region. J Biol Chem (1998) 2.29
FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity. J Antibiot (Tokyo) (1994) 2.28
Combined transcriptome and proteome analysis as a powerful approach to study genes under glucose repression in Bacillus subtilis. Nucleic Acids Res (2001) 2.28
Prospective study of alpha-fetoprotein in cirrhotic patients monitored for development of hepatocellular carcinoma. Hepatology (1994) 2.26
Immune interferon enhances functional properties of human granulocytes: role of Fc receptors and effect of lymphotoxin, tumor necrosis factor, and granulocyte-macrophage colony-stimulating factor. J Immunol (1987) 2.24
Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana. FEBS Lett (1999) 2.24
Tumor necrosis factor and lymphotoxin induce differentiation of human myeloid cell lines in synergy with immune interferon. J Exp Med (1986) 2.23
Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. J Biol Chem (1996) 2.22
The essential two-component regulatory system encoded by yycF and yycG modulates expression of the ftsAZ operon in Bacillus subtilis. Microbiology (2000) 2.21
Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol (1998) 2.21
SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell (1999) 2.19
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol Cell Biol (2001) 2.18
Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli. Appl Environ Microbiol (1995) 2.18
Covalent structure of a group-specific protease from rat small intestine. Appendix: crystallographic data for a group specific protease from rat intestine. Biochemistry (1978) 2.17
Administration of thyroxine in treated Graves' disease. Effects on the level of antibodies to thyroid-stimulating hormone receptors and on the risk of recurrence of hyperthyroidism. N Engl J Med (1991) 2.17
Constitutive expression of hypoxia-inducible factor-1alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res (2001) 2.14
Benign and malignant nodules in cirrhotic livers: distinction based on blood supply. Radiology (1991) 2.13
Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study. Clin Exp Immunol (1985) 2.12
Natural killer (NK) cell-derived hematopoietic colony-inhibiting activity and NK cytotoxic factor. Relationship with tumor necrosis factor and synergism with immune interferon. J Exp Med (1985) 2.11
Cloning and functional analysis of two gibberellin 3 beta -hydroxylase genes that are differently expressed during the growth of rice. Proc Natl Acad Sci U S A (2001) 2.09
Enhancement of rice canopy carbon gain by elevated CO(2) is sensitive to growth stage and leaf nitrogen concentration. New Phytol (2006) 2.09
Comparison of various submucosal injection solutions for maintaining mucosal elevation during endoscopic mucosal resection. Endoscopy (2004) 2.08
Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med (1998) 2.07
Morphological changes after steroid therapy in autoimmune pancreatitis. Scand J Gastroenterol (2004) 2.06
IgG4-related sclerosing disease incorporating sclerosing pancreatitis, cholangitis, sialadenitis and retroperitoneal fibrosis with lymphadenopathy. Pancreatology (2005) 2.06
Cell cycle regulation of hepatitis C virus internal ribosomal entry site-directed translation. Gastroenterology (2000) 2.05
Detection of serum hepatitis C virus RNA. Lancet (1990) 2.05
New method of deep brain stimulation therapy with two electrodes implanted in parallel and side by side. J Neurosurg (2001) 2.04
PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis. Lancet (1998) 2.02
A structurally abnormal insulin causing human diabetes. Nature (1979) 1.99
Papillary glioneuronal tumor: a new variant of mixed neuronal-glial neoplasm. Am J Surg Pathol (1998) 1.97
Successful nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. Endoscopy (2006) 1.97
Osteoclast differentiation factor acts as a multifunctional regulator in murine osteoclast differentiation and function. J Immunol (1999) 1.96
Factors predictive of response to interferon-alpha therapy in hepatitis C virus infection. Hepatology (1994) 1.96
Interferon gamma regulates antigen-induced eosinophil recruitment into the mouse airways by inhibiting the infiltration of CD4+ T cells. J Exp Med (1993) 1.95
Molecular cloning of the protocatechuate 4,5-dioxygenase genes of Pseudomonas paucimobilis. J Bacteriol (1990) 1.95
Biological functions of proline in morphogenesis and osmotolerance revealed in antisense transgenic Arabidopsis thaliana. Plant J (1999) 1.95
Upregulation of two death pathways of perforin/granzyme and FasL/Fas in septic acute respiratory distress syndrome. Am J Respir Crit Care Med (2000) 1.94
Rapid diagnosis of adenoviral conjunctivitis by PCR and restriction fragment length polymorphism analysis. J Clin Microbiol (1996) 1.94
Fas/FasL-dependent apoptosis of alveolar cells after lipopolysaccharide-induced lung injury in mice. Am J Respir Crit Care Med (2001) 1.94