Published in Nature on August 20, 1984
Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91
Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J (1985) 3.60
The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med (2013) 3.20
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol (2002) 2.54
Involvement of ras in sexual differentiation but not in growth control in fission yeast. EMBO J (1986) 2.31
Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A (1984) 2.12
Accumulation of p21ras.GTP in response to stimulation with epidermal growth factor and oncogene products with tyrosine kinase activity. Proc Natl Acad Sci U S A (1990) 2.08
The oncogenic forms of N-ras or H-ras prevent skeletal myoblast differentiation. Mol Cell Biol (1987) 1.95
A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets. Proc Natl Acad Sci U S A (1989) 1.64
Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor. Mol Cell Biol (1986) 1.57
Transformation and stimulation of DNA synthesis in NIH-3T3 cells are a titratable function of normal p21N-ras expression. EMBO J (1986) 1.46
Induction of neurite formation in PC12 cells by microinjection of proto-oncogenic Ha-ras protein preincubated with guanosine-5'-O-(3-thiotriphosphate). Mol Cell Biol (1987) 1.41
Ras activation by insulin and epidermal growth factor through enhanced exchange of guanine nucleotides on p21ras. Mol Cell Biol (1993) 1.41
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes. Biochem J (1985) 1.35
Regulation of hepatitis B virus replication by the ras-mitogen-activated protein kinase signaling pathway. J Virol (2003) 1.26
Role of calcium and phosphoinositides in the actions of certain hormones and neurotransmitters. J Clin Invest (1985) 1.21
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas. Virchows Arch (2005) 1.20
Immunohistochemical detection of the ras oncogene p21 product in an experimental tumour and in human colorectal neoplasms. Br J Cancer (1985) 1.15
Retroviral oncogenes: a historical primer. Nat Rev Cancer (2012) 1.10
Dexamethasone-dependent inhibition of differentiation of C2 myoblasts bearing steroid-inducible N-ras oncogenes. J Cell Biol (1988) 1.09
Effects of ras-encoded proteins and platelet-derived growth factor on inositol phospholipid turnover in NRK cells. Proc Natl Acad Sci U S A (1988) 1.00
Possible involvement of normal p21 H-ras in the insulin/insulinlike growth factor 1 signal transduction pathway. Mol Cell Biol (1989) 0.99
Immunocytochemical demonstration of p21 ras family oncogene product in normal mucosa and in premalignant and malignant tumours of the colorectum. Br J Cancer (1985) 0.99
Immunohistochemical detection of ras oncogene p21 product in benign and malignant mammary tissue in man. J Clin Pathol (1986) 0.88
Modulation of maturation and ribosomal protein S6 phosphorylation in Xenopus oocytes by microinjection of oncogenic ras protein and protein kinase C. Mol Cell Biol (1990) 0.88
Malignant transformation of murine fibroblasts by a human c-Ha-ras-1 oncogene does not require a functional epidermal growth factor receptor. Mol Cell Biol (1986) 0.88
C3G regulates the size of the cerebral cortex neural precursor population. EMBO J (2006) 0.85
Dietary lipids and calorie restriction affect mammary tumor incidence and gene expression in mouse mammary tumor virus/v-Ha-ras transgenic mice. Proc Natl Acad Sci U S A (1995) 0.82
Is there a critical target gene for the first step in carcinogenesis? Environ Health Perspect (1991) 0.81
Cardiac Hormones Target the Ras-MEK 1/2-ERK 1/2 Kinase Cancer Signaling Pathways. Cancers (Basel) (2011) 0.78
Induction of differentiation in v-Ha-ras-transformed MDCK cells by prostaglandin E2 and 8-bromo-cyclic AMP is associated with a decrease in steady-state level of inositol 1,4,5-trisphosphate. Mol Cell Biol (1990) 0.76
Total Chemical Synthesis and Folding of All-L and All-D Variants of Oncogenic KRas(G12V). J Am Chem Soc (2017) 0.75
Identification of clones that encode chicken tropomyosin by direct immunological screening of a cDNA expression library. Proc Natl Acad Sci U S A (1983) 6.00
Induction of membrane ruffling and fluid-phase pinocytosis in quiescent fibroblasts by ras proteins. Science (1986) 4.99
Microinjection and localization of a 130K protein in living fibroblasts: a relationship to actin and fibronectin. Cell (1980) 4.87
Rapid purification of mammalian 70,000-dalton stress proteins: affinity of the proteins for nucleotides. Mol Cell Biol (1985) 4.75
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (1984) 4.61
A rapid purification of alpha-actinin, filamin, and a 130,000-dalton protein from smooth muscle. J Biol Chem (1980) 4.50
Co-existence of vinculin and a vinculin-like protein of higher molecular weight in smooth muscle. J Biol Chem (1982) 4.42
Nuclear and nucleolar localization of the 72,000-dalton heat shock protein in heat-shocked mammalian cells. J Biol Chem (1984) 4.20
Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell (1984) 3.81
Microinjection of the ras oncogene protein into PC12 cells induces morphological differentiation. Cell (1985) 3.73
Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med (2001) 3.69
10-nm filaments are induced to collapse in living cells microinjected with monoclonal and polyclonal antibodies against tubulin. J Cell Biol (1984) 3.51
Three human transforming genes are related to the viral ras oncogenes. Proc Natl Acad Sci U S A (1983) 3.06
p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps. Mol Cell Biol (2000) 2.96
Purification of the major mammalian heat shock proteins. J Biol Chem (1982) 2.79
Biochemical characterization of the mammalian stress proteins and identification of two stress proteins as glucose- and Ca2+-ionophore-regulated proteins. J Biol Chem (1983) 2.78
Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase. J Cell Biol (1988) 2.72
The common 90-kd protein component of non-transformed '8S' steroid receptors is a heat-shock protein. EMBO J (1985) 2.50
Adenovirus interaction with distinct integrins mediates separate events in cell entry and gene delivery to hematopoietic cells. J Virol (1996) 2.38
Non-muscle alpha actinins are calcium-sensitive actin-binding proteins. Nature (1981) 2.35
Isolation of phosphorylated peptides and proteins on ion exchange papers. Anal Biochem (1978) 2.33
Direct visualization of fluorescein-labeled microtubules in vitro and in microinjected fibroblasts. J Cell Biol (1981) 2.33
Induction of terminal differentiation by constitutive activation of p38 MAP kinase in human rhabdomyosarcoma cells. Genes Dev (2000) 2.21
Molecular and cellular effects of heat-shock and related treatments of mammalian tissue-culture cells. Cold Spring Harb Symp Quant Biol (1982) 2.18
Fluorescent localization of contractile proteins in tissue culture cells. Methods Enzymol (1982) 2.12
RB-dependent S-phase response to DNA damage. Mol Cell Biol (2000) 2.08
Microinjection of fos-specific antibodies blocks DNA synthesis in fibroblast cells. Mol Cell Biol (1988) 2.00
Inhibition of DNA synthesis by RB: effects on G1/S transition and S-phase progression. Genes Dev (1998) 1.99
Disruption of the in vivo distribution of the intermediate filaments in fibroblasts through the microinjection of a specific monoclonal antibody. Cell (1981) 1.98
Solvolytic desulfation of glycosaminoglycuronan sulfates with dimethyl sulfoxide containing water or methanol. Carbohydr Res (1977) 1.96
Microinjection of fluorescently labeled alpha-actinin into living fibroblasts. Proc Natl Acad Sci U S A (1979) 1.95
Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells. Oncogene (2006) 1.94
HRas-dependent pathways can activate morphological and genetic markers of cardiac muscle cell hypertrophy. J Biol Chem (1993) 1.91
A Rab1 mutant affecting guanine nucleotide exchange promotes disassembly of the Golgi apparatus. J Cell Biol (1994) 1.91
Optimal spatial requirements for the location of basic residues in peptide substrates for the cyclic AMP-dependent protein kinase. J Biol Chem (1980) 1.88
Inhibition of T helper cell type 2 cell differentiation and immunoglobulin E response by ligand-activated Valpha14 natural killer T cells. J Exp Med (1999) 1.88
A novel membrane factor stimulates guanine nucleotide exchange reaction of ras proteins. FEBS Lett (1990) 1.76
Elevation of tubulin levels by microinjection suppresses new tubulin synthesis. Nature (1983) 1.68
The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP-responsive enhancer elements. Nature (1988) 1.66
The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest (1991) 1.66
Transient reversion of ras oncogene-induced cell transformation by antibodies specific for amino acid 12 of ras protein. Nature (1985) 1.61
Studies on the kinetic mechanism of the catalytic subunit of the cAMP-dependent protein kinase. J Biol Chem (1983) 1.61
Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cells. Proc Natl Acad Sci U S A (1981) 1.55
A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum. Proc Natl Acad Sci U S A (1994) 1.53
Effect of genetic differences in omeprazole metabolism on cure rates for Helicobacter pylori infection and peptic ulcer. Ann Intern Med (1998) 1.51
Late onset diabetes mellitus in patients with hereditary aceruloplasminemia. Intern Med (1996) 1.47
Changing ligand specificities of alphavbeta1 and alphavbeta3 integrins by swapping a short diverse sequence of the beta subunit. J Biol Chem (1997) 1.45
Megakaryocytes derived from human embryonic stem cells: a genetically tractable system to study megakaryocytopoiesis and integrin function. J Thromb Haemost (2006) 1.45
Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation. J Biol Chem (1994) 1.41
Transport of microinjected proteins into peroxisomes of mammalian cells: inability of Zellweger cell lines to import proteins with the SKL tripeptide peroxisomal targeting signal. Mol Cell Biol (1992) 1.39
Nerve growth factor stimulation of the Ras-guanine nucleotide exchange factor and GAP activities. Science (1992) 1.39
Regulation of cell cycle progression and nuclear affinity of the retinoblastoma protein by protein phosphatases. Proc Natl Acad Sci U S A (1993) 1.38
Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3. J Biol Chem (1998) 1.35
Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins. Proc Natl Acad Sci U S A (1990) 1.32
Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. J Biol Chem (2000) 1.32
Alpha-actinin and vinculin from nonmuscle cells: calcium-sensitive interactions with actin. Cold Spring Harb Symp Quant Biol (1982) 1.32
Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. J Cell Biol (1989) 1.28
Simian virus 40 small t antigen cooperates with mitogen-activated kinases to stimulate AP-1 activity. Mol Cell Biol (1994) 1.27
Signal transduction through the cAMP-dependent protein kinase. Mol Cell Biochem (1993) 1.27
Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proc Natl Acad Sci U S A (1990) 1.26
Distribution of fluorescently labeled alpha-actinin in living and fixed fibroblasts. J Cell Biol (1980) 1.26
Multiple discontinuous ligand-mimetic antibody binding sites define a ligand binding pocket in integrin alpha(IIb)beta(3). J Biol Chem (2000) 1.25
NADPH oxidase 1 plays a critical mediating role in oncogenic Ras-induced vascular endothelial growth factor expression. Oncogene (2008) 1.23
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus. J Biol Chem (1994) 1.22
Upper cervical spine movement during intubation: fluoroscopic comparison of the AirWay Scope, McCoy laryngoscope, and Macintosh laryngoscope. Br J Anaesth (2008) 1.22
Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway. J Biol Chem (1996) 1.20
Oncogenic Ras upregulates NADPH oxidase 1 gene expression through MEK-ERK-dependent phosphorylation of GATA-6. Oncogene (2008) 1.19
G12 requirement for thrombin-stimulated gene expression and DNA synthesis in 1321N1 astrocytoma cells. J Biol Chem (1995) 1.18
Critical amino acid residues for ligand binding are clustered in a predicted beta-turn of the third N-terminal repeat in the integrin alpha 4 and alpha 5 subunits. EMBO J (1995) 1.18
Immunohistochemical diagnosis of Cryptococcus neoformans var. gattii infection in chronic meningoencephalitis: the first case in Japan. Intern Med (2001) 1.17
Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. Mol Cell Biol (1994) 1.17
Prognostic factors in primary gastrointestinal leiomyosarcoma: a retrospective study. World J Surg (1992) 1.15
A novel regulatory epitope defined by a murine monoclonal antibody to the platelet GPIIb-IIIa complex (alpha IIb beta 3 integrin). Thromb Haemost (1996) 1.15
Metabolism of the recently encountered designer drug, methylone, in humans and rats. Xenobiotica (2006) 1.14
Expression of c-fos and AP-1 activity in senescent human fibroblasts is not sufficient for DNA synthesis. J Cell Biol (1992) 1.12
Mouse models for BRAF-induced cancers. Biochem Soc Trans (2007) 1.11
Inhibition of cyclic AMP-dependent protein kinase by analogues of a synthetic peptide substrate. J Biol Chem (1978) 1.10
Protein phosphatase 2A potentiates activity of promoters containing AP-1-binding elements. Mol Cell Biol (1993) 1.09
Transmembrane calcium influx associated with von Willebrand factor binding to GP Ib in the initiation of shear-induced platelet aggregation. Thromb Haemost (1993) 1.09
Transport of microinjected alcohol oxidase from Pichia pastoris into vesicles in mammalian cells: involvement of the peroxisomal targeting signal. J Cell Biol (1992) 1.08
12/15-lipoxygenase translocation enhances site-specific actin polymerization in macrophages phagocytosing apoptotic cells. J Biol Chem (2001) 1.08
Construction of mammalian cell lines with indicator genes driven by regulated promoters. Ciba Found Symp (1990) 1.08
Isolation and sequence of a cDNA clone that contains the entire coding region for chicken smooth-muscle alpha-tropomyosin. J Biol Chem (1984) 1.07
Human cytomegalovirus-induced chromatin factors responsible for changes in template activity and structure of infected cell chromatin. Virology (1978) 1.07
Interference with endogenous ras function inhibits cellular responses to wounding. J Cell Biol (1993) 1.07
Use of desferrioxamine in the treatment of aceruloplasminemia. Ann Neurol (1997) 1.06
The mammalian stress response and the cytoskeleton: alterations in intermediate filaments. Ann N Y Acad Sci (1985) 1.06
Disruption of the three cytoskeletal networks in mammalian cells does not affect transcription, translation, or protein translocation changes induced by heat shock. Mol Cell Biol (1985) 1.06
Mediation of growth factor induced DNA synthesis and calcium mobilization by Gq and Gi2. J Cell Biol (1993) 1.04
A requirement for Ras protein function in thrombin-stimulated mitogenesis in astrocytoma cells. J Biol Chem (1993) 1.04
RalGDS functions in Ras- and cAMP-mediated growth stimulation. J Biol Chem (1997) 1.03
T cell receptor-induced calcineurin activation regulates T helper type 2 cell development by modifying the interleukin 4 receptor signaling complex. J Exp Med (2000) 1.02
The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death. Oncogene (1999) 1.02
Intracellular mediators of c-fos induction. Cold Spring Harb Symp Quant Biol (1988) 1.01
Expression of c-myc gene product in gastric carcinoma. Oncology (1991) 1.00
An inherited prion disease with a PrP P105L mutation: clinicopathologic and PrP heterogeneity. Neurology (1999) 1.00
Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J Biol Chem (1994) 1.00