By searching processively RecA protein pairs DNA molecules that share a limited stretch of homology.

PubWeight™: 3.07‹?› | Rank: Top 1%

🔗 View Article (PMID 6616624)

Published in Cell on September 01, 1983

Authors

D K Gonda, C M Radding

Articles citing this

Homologous recombination in Escherichia coli: dependence on substrate length and homology. Genetics (1986) 7.97

Homologous recombination in procaryotes. Microbiol Rev (1988) 7.06

Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation. Mol Cell Biol (1992) 5.71

Homology requirements for recombination in Escherichia coli. Proc Natl Acad Sci U S A (1985) 4.46

The minimum amount of homology required for homologous recombination in mammalian cells. Mol Cell Biol (1984) 4.39

Homology requirement for efficient gene conversion between duplicated chromosomal sequences in mammalian cells. Genetics (1987) 3.40

Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol (1997) 3.27

Sequence homology requirements for intermolecular recombination in mammalian cells. Proc Natl Acad Sci U S A (1986) 2.50

Stable DNA heteroduplex formation catalyzed by the Escherichia coli RecA protein in the absence of ATP hydrolysis. Proc Natl Acad Sci U S A (1990) 2.44

Distance-independence of mitotic intrachromosomal recombination in Saccharomyces cerevisiae. Genetics (1990) 2.15

The synapsis event in the homologous pairing of DNAs: RecA recognizes and pairs less than one helical repeat of DNA. Proc Natl Acad Sci U S A (1992) 2.03

DNA homology requirements for mitotic gap repair in Drosophila. Proc Natl Acad Sci U S A (1993) 1.66

Mechanism of the concerted action of recA protein and helix-destabilizing proteins in homologous recombination. Proc Natl Acad Sci U S A (1984) 1.65

Recombination between poly[d(GT).d(CA)] sequences in simian virus 40-infected cultured cells. Mol Cell Biol (1985) 1.61

Isolation and visualization of active presynaptic filaments of recA protein and single-stranded DNA. Proc Natl Acad Sci U S A (1984) 1.60

Single-molecule imaging of DNA pairing by RecA reveals a three-dimensional homology search. Nature (2012) 1.60

Processes of copy-number change in human DNA: the dynamics of {alpha}-globin gene deletion. Proc Natl Acad Sci U S A (2006) 1.57

Stable three-stranded DNA made by RecA protein. Proc Natl Acad Sci U S A (1991) 1.55

Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev (2007) 1.51

Ionic inhibition of formation of RecA nucleoprotein networks blocks homologous pairing. Proc Natl Acad Sci U S A (1985) 1.29

Mechanism of intramolecular recyclization and deletion formation following transformation of Escherichia coli with linearized plasmid DNA. Nucleic Acids Res (1986) 1.26

The frequency of gene targeting in yeast depends on the number of target copies. Proc Natl Acad Sci U S A (1994) 1.24

Ordered intracellular RecA-DNA assemblies: a potential site of in vivo RecA-mediated activities. Proc Natl Acad Sci U S A (2000) 1.13

E. coli recA protein possesses a strand separating activity on short duplex DNAs. EMBO J (1985) 1.12

Interaction of the RecA protein of Escherichia coli with single-stranded oligodeoxyribonucleotides. Nucleic Acids Res (1996) 1.04

A Rad51 presynaptic filament is sufficient to capture nucleosomal homology during recombinational repair of a DNA double-strand break. Mol Cell (2008) 1.00

The REC2 gene encodes the homologous pairing protein of Ustilago maydis. Mol Cell Biol (1994) 1.00

Integration of narrow-host-range vectors from Escherichia coli into the genomes of amino acid-producing corynebacteria after intergeneric conjugation. J Bacteriol (1996) 0.98

A role for RNA synthesis in homologous pairing events. Mol Cell Biol (1994) 0.95

Requirements for ectopic homologous recombination in mammalian somatic cells. Mol Cell Biol (1996) 0.95

Spiroplasma citri virus SpV1-derived cloning vector: deletion formation by illegitimate and homologous recombination in a spiroplasmal host strain which probably lacks a functional recA gene. J Bacteriol (1996) 0.93

Efficient incorporation of large (>2 kb) heterologies into heteroduplex DNA: Pms1/Msh2-dependent and -independent large loop mismatch repair in Saccharomyces cerevisiae. Genetics (2001) 0.93

Recombinational DNA repair in a cellular context: a search for the homology search. Nat Rev Microbiol (2009) 0.93

Mini-Mu-duction as a test for genetic complementation in Escherichia coli. J Bacteriol (1984) 0.92

Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell (2015) 0.92

Increased expression of LD1 genes transcribed by RNA polymerase I in Leishmania donovani as a result of duplication into the rRNA gene locus. Mol Cell Biol (1995) 0.90

Stimulation of IS1 excision by bacteriophage P1 ref function. J Bacteriol (1989) 0.89

Marker-dependent recombination in T4 bacteriophage. III. Structural prerequisites for marker discrimination. Genetics (1991) 0.86

Drosophila bloom helicase maintains genome integrity by inhibiting recombination between divergent DNA sequences. Nucleic Acids Res (2008) 0.86

Homologous pairing of single-stranded circular DNAs catalyzed by recA protein. Nucleic Acids Res (1984) 0.86

RecA.oligonucleotide filaments bind in the minor groove of double-stranded DNA. Proc Natl Acad Sci U S A (1995) 0.84

Homothallic switching of Saccharomyces cerevisiae mating type genes by using a donor containing a large internal deletion. Mol Cell Biol (1985) 0.80

DNA Sequence Alignment during Homologous Recombination. J Biol Chem (2016) 0.78

RecA: Regulation and Mechanism of a Molecular Search Engine. Trends Biochem Sci (2016) 0.78

RecA-independent recombination at gamma delta termini and at IS3 producing inverted repetition in F' plasmids. Proc Natl Acad Sci U S A (1984) 0.75

ATP hydrolysis Promotes Duplex DNA Release by the RecA Presynaptic Complex. J Biol Chem (2016) 0.75

Articles by these authors

A general model for genetic recombination. Proc Natl Acad Sci U S A (1975) 20.85

A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science (1989) 9.68

Homologous pairing and strand exchange in genetic recombination. Annu Rev Genet (1982) 6.18

Purified Escherichia coli recA protein catalyzes homologous pairing of superhelical DNA and single-stranded fragments. Proc Natl Acad Sci U S A (1979) 5.91

Genetic recombination: strand transfer and mismatch repair. Annu Rev Biochem (1978) 5.79

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes. Proc Natl Acad Sci U S A (1995) 4.60

Nucleotide sequence of a ribonucleic acid transcribed in vitro from lambda phage deoxyribonucleic acid. J Biol Chem (1971) 4.38

The role of exonuclease and beta protein of phage lambda in genetic recombination. II. Substrate specificity and the mode of action of lambda exonuclease. J Biol Chem (1971) 3.92

Specificity of the S1 nuclease from Aspergillus oryzae. J Biol Chem (1975) 3.57

Regulation of lambda exonuclease. I. Properties of lambda exonuclease purified from lysogens of lambda T11 and wild type. J Mol Biol (1966) 3.39

Uptake of homologous single-stranded fragments by superhelical DNA: a possible mechanism for initiation of genetic recombination. Proc Natl Acad Sci U S A (1975) 3.19

Nonessential functions of bacteriophage lambda. Virology (1969) 3.11

Molecular mechanisms in genetic recombination. Annu Rev Genet (1973) 2.77

Uptake of homologous single-stranded fragments by superhelical DNA. II. Characterization of the reaction. J Mol Biol (1977) 2.68

Mechanism for the action of lambda exonuclease in genetic recombination. Nat New Biol (1971) 2.61

Homologous pairing in genetic recombination: complexes of recA protein and DNA. Proc Natl Acad Sci U S A (1979) 2.53

Homologous pairing in genetic recombination: recA protein makes joint molecules of gapped circular DNA and closed circular DNA. Cell (1980) 2.43

Activities of human recombination protein Rad51. Proc Natl Acad Sci U S A (1997) 2.39

Recombination promoted by superhelical DNA and the recA gene of Escherichia coli. Proc Natl Acad Sci U S A (1976) 2.38

The homologous recombination system of phage lambda. Pairing activities of beta protein. J Biol Chem (1986) 2.35

Uptake of homologous single-stranded fragments by superhelical DNA. IV. Branch migration. J Mol Biol (1977) 2.20

The topology of homologous pairing promoted by RecA protein. Cell (1980) 2.16

Role of exonuclease and beta protein of phage lambda in genetic recombination. V. Recombination of lambda DNA in vitro. Proc Natl Acad Sci U S A (1971) 2.15

Single strands induce recA protein to unwind duplex DNA for homologous pairing. Nature (1979) 2.14

Synapsis and the formation of paranemic joints by E. coli RecA protein. Cell (1983) 2.14

Regulation of lambda exonuclease. II. Joint regulation of exonuclease and a new lambda antigen. J Mol Biol (1966) 2.09

Interaction of human rad51 recombination protein with single-stranded DNA binding protein, RPA. Nucleic Acids Res (1998) 2.08

Insertions, deletions and mismatches in heteroduplex DNA made by recA protein. Cell (1983) 2.00

cis-trans recognition and subunit-specific degradation of short-lived proteins. Nature (1990) 2.00

Homologous pairing in genetic recombination. Purification and characterization of Escherichia coli recA protein. J Biol Chem (1981) 1.89

Polarity of heteroduplex formation promoted by Escherichia coli recA protein. Proc Natl Acad Sci U S A (1981) 1.82

Rings and filaments of beta protein from bacteriophage lambda suggest a superfamily of recombination proteins. Proc Natl Acad Sci U S A (1999) 1.81

Recombination activities of HsDmc1 protein, the meiotic human homolog of RecA protein. Proc Natl Acad Sci U S A (1997) 1.79

Nuclease activity in defective lysogens of phage lambda. Biochem Biophys Res Commun (1964) 1.77

Networks of DNA and RecA protein are intermediates in homologous pairing. Biochemistry (1985) 1.75

Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes. Proc Natl Acad Sci U S A (1996) 1.74

The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A (1998) 1.72

The beta protein of phage lambda promotes strand exchange. J Mol Biol (1998) 1.70

The beta protein of phage lambda binds preferentially to an intermediate in DNA renaturation. J Mol Biol (1998) 1.67

Homologous pairing and topological linkage of DNA molecules by combined action of E. coli RecA protein and topoisomerase I. Cell (1981) 1.67

Mechanism of the concerted action of recA protein and helix-destabilizing proteins in homologous recombination. Proc Natl Acad Sci U S A (1984) 1.65

Homologous pairing in genetic recombination: formation of D loops by combined action of recA protein and a helix-destabilizing protein. Proc Natl Acad Sci U S A (1980) 1.64

The pairing activity of stable nucleoprotein filaments made from recA protein, single-stranded DNA, and adenosine 5'-(gamma-thio)triphosphate. J Biol Chem (1985) 1.60

Concerted strand exchange and formation of Holliday structures by E. coli RecA protein. Cell (1981) 1.59

Visualization of recA protein and its association with DNA: a priming effect of single-strand-binding protein. Cell (1982) 1.58

Polar branch migration promoted by recA protein: effect of mismatched base pairs. Proc Natl Acad Sci U S A (1982) 1.56

Formation of nascent heteroduplex structures by RecA protein and DNA. Cell (1982) 1.56

Stable three-stranded DNA made by RecA protein. Proc Natl Acad Sci U S A (1991) 1.55

Separation of the presynaptic and synaptic phases of homologous pairing promoted by recA protein. J Biol Chem (1984) 1.55

Interaction of human recombination proteins Rad51 and Rad54. Nucleic Acids Res (1997) 1.54

Identification of a portable determinant of cell cycle function within the carboxyl-terminal domain of the yeast CDC34 (UBC3) ubiquitin conjugating (E2) enzyme. EMBO J (1992) 1.54

Human Dmc1 protein binds DNA as an octameric ring. Proc Natl Acad Sci U S A (1999) 1.53

Uptake of homologous single-stranded fragments by superhelical DNA. III. The product and its enzymic conversion to a recombinant molecule. J Mol Biol (1977) 1.51

The mechanism of the search for homology promoted by recA protein. Facilitated diffusion within nucleoprotein networks. J Biol Chem (1986) 1.50

Rad51 expression and localization in B cells carrying out class switch recombination. Proc Natl Acad Sci U S A (1996) 1.50

Human Rad52 protein promotes single-strand DNA annealing followed by branch migration. Mutat Res (1997) 1.42

Ability of RecA protein to promote a search for rare sequences in duplex DNA. Proc Natl Acad Sci U S A (1986) 1.36

The specificity of lambda exonuclease. Interactions with single-stranded DNA. J Biol Chem (1975) 1.35

Rapid exchange of A:T base pairs is essential for recognition of DNA homology by human Rad51 recombination protein. Mol Cell (1999) 1.33

Sequestration of mammalian Rad51-recombination protein into micronuclei. J Cell Biol (1999) 1.33

Recombination activities of E. coli recA protein. Cell (1981) 1.33

Homologous recognition and triplex formation promoted by RecA protein between duplex oligonucleotides and single-stranded DNA. J Mol Biol (1993) 1.31

Ionic inhibition of formation of RecA nucleoprotein networks blocks homologous pairing. Proc Natl Acad Sci U S A (1985) 1.29

Hybrids of bacteriophages lambda and phi 80: a study of nonvegetative functions. Virology (1969) 1.28

The role of exonuclease and beta protein of phage lambda in genetic recombination. 3. Binding to deoxyribonucleic acid. J Biol Chem (1971) 1.28

Homologous pairing in genetic recombination. The pairing reaction catalyzed by Escherichia coli recA protein. J Biol Chem (1981) 1.27

Three phases in homologous pairing: polymerization of recA protein on single-stranded DNA, synapsis, and polar strand exchange. Cold Spring Harb Symp Quant Biol (1983) 1.20

Polarity of DNA strand exchange promoted by recombination proteins of the RecA family. Proc Natl Acad Sci U S A (1998) 1.19

Topography of the interaction of recA protein with single-stranded deoxyoligonucleotides. J Biol Chem (1986) 1.19

Escherichia coli recA protein protects single-stranded DNA or gapped duplex DNA from degradation by RecBC DNase. J Biol Chem (1981) 1.18

Kinetic analysis of pairing and strand exchange catalyzed by RecA. Detection by fluorescence energy transfer. J Biol Chem (1997) 1.18

Intermediates in homologous pairing promoted by RecA protein and correlations of recombination in vitro and in vivo. Cold Spring Harb Symp Quant Biol (1984) 1.18

The mechanism of conversion of deletions and insertions. Cold Spring Harb Symp Quant Biol (1979) 1.17

RecA tests homology at both pairing and strand exchange. Proc Natl Acad Sci U S A (1997) 1.17

A possible role of the C-terminal domain of the RecA protein. A gateway model for double-stranded DNA binding. J Biol Chem (1996) 1.16

A partially deficient mutant, recA1730, that fails to form normal nucleoprotein filaments. Mol Gen Genet (1992) 1.14

RNA-DNA hybridization promoted by E. coli RecA protein. Nucleic Acids Res (1992) 1.14

Intermediates in homologous pairing promoted by recA protein. Isolation and characterization of active presynaptic complexes. J Mol Biol (1985) 1.13

The role of exonuclease and beta protein of bacteriophage lambda in genetic recombination. I. Effects of red mutants on protein structure. J Mol Biol (1970) 1.13

RecA protein reinitiates strand exchange on isolated protein-free DNA intermediates. An ADP-resistant process. J Mol Biol (1990) 1.13

How specific is the first recognition step of homologous recombination? Trends Biochem Sci (1995) 1.13

Homologous recognition promoted by RecA protein via non-Watson-Crick bonds between identical DNA strands. Proc Natl Acad Sci U S A (1993) 1.13

A novel nucleic acid-binding protein that interacts with human rad51 recombinase. Nucleic Acids Res (1997) 1.12

Transfection by half molecules and inverted molecules of lambda DNA: requirement for exo and -promoted recombination. Virology (1973) 1.11

Unwinding associated with synapsis of DNA molecules by recA protein. Proc Natl Acad Sci U S A (1983) 1.10

Partial purification and properties of an exonuclease inhibitor induced by bacteriophage Mu-1. J Virol (1981) 1.08

Purification of recA protein from Escherichia coli. Methods Enzymol (1983) 1.07

Formation in vitro of infective joint molecules of lambda DNA by T4 gene-32 protein. Proc Natl Acad Sci U S A (1974) 1.07

Kinetics and topology of homologous pairing promoted by Escherichia coli recA-gene protein. Cold Spring Harb Symp Quant Biol (1981) 1.05

The role of the N gene of phage lambda in the synthesis of two phage-specific proteins. Proc Natl Acad Sci U S A (1968) 1.04

Lower fidelity of RecA protein catalysed homologous pairing with a superhelical substrate. Nature (1982) 1.04

The mechanics of winding and unwinding helices in recombination: torsional stress associated with strand transfer promoted by RecA protein. Cell (1988) 1.04

Kinetics of homologous pairing promoted by RecA protein: effects of ends and internal sites in DNA. Biochemistry (1985) 1.04

Interactions of three strands in joints made by RecA protein. Biochemistry (1993) 1.04

The effects on strand exchange of 5' versus 3' ends of single-stranded DNA in RecA nucleoprotein filaments. J Mol Biol (1991) 1.03