Published in Nucleic Acids Res on November 11, 1983
Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids. Proc Natl Acad Sci U S A (1986) 1.20
Interaction of dimeric intercalating dyes with single-stranded DNA. Nucleic Acids Res (1995) 0.96
Condensation of nucleic acids by intercalating aromatic cations. Proc Natl Acad Sci U S A (1984) 0.93
The "interceptor" properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin. Biophys Chem (2006) 0.84
DNA-Destabilizing Agents as an Alternative Approach for Targeting DNA: Mechanisms of Action and Cellular Consequences. J Nucleic Acids (2010) 0.81
The molecular theory of polyelectrolyte solutions with applications to the electrostatic properties of polynucleotides. Q Rev Biophys (1978) 14.75
Structural considerations in the interaction of DNA and acridines. J Mol Biol (1961) 7.43
Cation-induced toroidal condensation of DNA studies with Co3+(NH3)6. J Mol Biol (1980) 4.88
A MOLECULAR MECHANISM OF MITOMYCIN ACTION: LINKING OF COMPLEMENTARY DNA STRANDS. Proc Natl Acad Sci U S A (1963) 3.84
AGGREGATION OF DYES BOUND TO POLYANIONS. Proc Natl Acad Sci U S A (1959) 3.75
DNA modification and cancer. Annu Rev Biochem (1981) 3.67
Structural requirements for the binding of ethidium to nucleic acids. Biochim Biophys Acta (1966) 3.44
A neighbor-interaction analysis of the hypochromism and spectra of DNA. J Mol Biol (1965) 3.24
Nanosecond fluorescence spectroscopy of macromolecules. Methods Enzymol (1972) 2.93
The interaction of aminocridines with nucleic acids. Biopolymers (1968) 2.55
Diethyl pyrocarbonate in nucleic acid research. Prog Nucleic Acid Res Mol Biol (1976) 2.27
Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperatively binding ligands. Biopolymers (1976) 2.26
Formaldehyde as a probe of DNA structure. I. Reaction with exocyclic amino groups of DNA bases. Biochemistry (1975) 1.93
Double helical DNA: conformations, physical properties, and interactions with ligands. Annu Rev Biochem (1981) 1.73
Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp Cell Res (1975) 1.66
DNA "melting" proteins. IV. Fluorescence measurements of binding parameters for bacteriophage T4 gene 32-protein to mono-, oligo-, and polynucleotides. J Biol Chem (1976) 1.58
Interaction of daunomycin and its derivatives with DNA. Biochim Biophys Acta (1972) 1.34
Specific recognition of single-stranded nucleic acids. Interaction of tryptophan-containing peptides with native, denatured, and ultraviolet-irradiated DNA. J Biol Chem (1977) 1.20
The interaction between acridine dyes and deoxyribonucleic acid. J Am Chem Soc (1970) 1.10
Intercalative binding of ellipticine to DNA. Cancer Res (1975) 1.09
The interaction of acridine dyes with DNA: an x-ray diffraction and optical investigation. J Mol Biol (1966) 1.08
Interactions of a new antitumor agent, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-9,10-anthracenedione, with nucleic acids. Biochem Pharmacol (1981) 1.04
Physicochemical studies on the interaction of irehdiamine A with bihelical DNA. Biochemistry (1977) 0.99
On the mechanism of the methyl green-pyronin stain for nucleic acids. Histochemie (1967) 0.98
Interaction of molecules with nucleic acids. II. Two pairs of families of intercalation sites, unwinding angles, and the neighbor-exclusion principle. Biopolymers (1979) 0.95
Nuclear chromatin changes during erythroid differentiation of friend virus induced leukemic cells. Exp Cell Res (1976) 0.95
Luminescence of the solid complexes of acridine orange with RNA. Cytometry (1982) 0.95
The solution spectroscopy of drugs and the drug-nucleic acid interactions. Prog Biophys Mol Biol (1978) 0.87
THERMAL DENATURATION OF DEOXYRIBONUCLEIC ACID-ACRIDINE ORANGE COMPLEXES. Biochim Biophys Acta (1964) 0.84
Thermally-induced changes in chromatin of isolated nuclei and of intact cells as revealed by acridine orange staining. Biochem Biophys Res Commun (1974) 0.84
Interaction of crystal violet with nucleic acids. Biochemistry (1981) 0.83
Complex formation of acridine orange with single-stranded polyriboadenylic acid and 5'-AMP: cooperative binding and intercalation between bases. Biophys Struct Mech (1979) 0.83
Quantitative determination of single-stranded sections in DNA using the fluorescent probe acridine orange. Biochim Biophys Acta (1971) 0.82
Carbethoxylation of polynucleotides. Eur J Biochem (1971) 0.81
The nature of strong binding between acridine orange and deoxyribonucleic acid as revealed by equilibrium dialysis and thermal renaturation. Biochim Biophys Acta (1969) 0.79
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays. Cancer Res (1993) 4.11
A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry. Anal Biochem (1994) 2.41
Lymphocyte stimulation: a rapid multiparameter analysis. Proc Natl Acad Sci U S A (1976) 2.37
Simultaneous staining of ribonucleic and deoxyribonucleic acids in unfixed cells using acridine orange in a flow cytofluorometric system. J Histochem Cytochem (1977) 2.23
Human epidermal cell cultures: growth and differentiation in the absence of differentiation in the absence of dermal components or medium supplements. Proc Natl Acad Sci U S A (1979) 2.16
Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis. Cytometry (1998) 2.11
New cell cycle compartments identified by multiparameter flow cytometry. Cytometry (1980) 2.03
Relationship between RNA content and progression of lymphocytes through S phase of cell cycle. Proc Natl Acad Sci U S A (1979) 1.94
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res (1993) 1.88
Activation-induced expression of human programmed death-1 gene in T-lymphocytes. Exp Cell Res (1997) 1.85
Subcompartments of the G1 phase of cell cycle detected by flow cytometry. Proc Natl Acad Sci U S A (1980) 1.76
Constitutive expression of p53 protein in enriched normal human marrow blast cell populations. Blood (1992) 1.69
Segregation of RNA and separate packaging of DNA and RNA in apoptotic bodies during apoptosis. Exp Cell Res (2000) 1.67
Conformation of RNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp Cell Res (1975) 1.66
Activation of caspases measured in situ by binding of fluorochrome-labeled inhibitors of caspases (FLICA): correlation with DNA fragmentation. Exp Cell Res (2000) 1.64
Accessibility of DNA in situ to various fluorochromes: relationship to chromatin changes during erythroid differentiation of Friend leukemia cells. Cytometry (1984) 1.60
Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Prolif (1992) 1.58
Thermal denaturation of DNA in situ as studied by acridine orange staining and automated cytofluorometry. Exp Cell Res (1975) 1.55
Cell cycle-specific effects of lovastatin. Proc Natl Acad Sci U S A (1991) 1.54
Cell cycle-related changes in nuclear chromatin of stimulated lymphocytes as measured by flow cytometry. Cancer Res (1977) 1.53
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell (1989) 1.52
Induction of DNA strand breaks associated with apoptosis during treatment of leukemias. Leukemia (1993) 1.50
Relation of mammalian sperm chromatin heterogeneity to fertility. Science (1980) 1.49
Labelling DNA strand breaks with BrdUTP. Detection of apoptosis and cell proliferation. Cell Prolif (1995) 1.48
Increased mitochondrial uptake of rhodamine 123 during lymphocyte stimulation. Proc Natl Acad Sci U S A (1981) 1.47
Flow cytometric detection of apoptosis: comparison of the assays of in situ DNA degradation and chromatin changes. Cytometry (1994) 1.45
Interactions of acridine orange with double stranded nucleic acids. Spectral and affinity studies. J Biomol Struct Dyn (1987) 1.44
Growth imbalance and altered expression of cyclins B1, A, E, and D3 in MOLT-4 cells synchronized in the cell cycle by inhibitors of DNA replication. Cell Growth Differ (1995) 1.41
Flow cytofluorimetry: discrimination between single cells and cell aggregates by direct size measurements. Acta Cytol (1976) 1.38
Interactions of fluorochrome-labeled caspase inhibitors with apoptotic cells: a caution in data interpretation. Cytometry A (2003) 1.37
Activation of nuclear factor kappa B (NF-kappaB) assayed by laser scanning cytometry (LSC). Cytometry (1998) 1.36
Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes. Cell Prolif (2007) 1.33
Correlation between cell cycle duration and RNA content. J Cell Physiol (1979) 1.33
Induction of H2AX phosphorylation in pulmonary cells by tobacco smoke: a new assay for carcinogens. Cell Cycle (2004) 1.33
Interaction of rhodamine 123 with living cells studied by flow cytometry. Cancer Res (1982) 1.32
Discrimination of human leukemia subtypes by flow cytometric analysis of cellular DNA and RNA. Blood (1980) 1.29
Analysis of apoptosis by laser scanning cytometry. Cytometry (1999) 1.29
Cell cycle-specific effects of tumor necrosis factor. Cancer Res (1984) 1.28
Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor. Cancer (1981) 1.28
Flow cytometry of colorectal carcinoma with three-year follow-up. Dis Colon Rectum (1986) 1.28
Detection of caspases activation by fluorochrome-labeled inhibitors: Multiparameter analysis by laser scanning cytometry. Cytometry (2001) 1.27
Single-step procedure for labeling DNA strand breaks with fluorescein- or BODIPY-conjugated deoxynucleotides: detection of apoptosis and bromodeoxyuridine incorporation. Cytometry (1995) 1.27
Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells. Proc Natl Acad Sci U S A (1995) 1.26
Presence of DNA strand breaks and increased sensitivity of DNA in situ to denaturation in abnormal human sperm cells: analogy to apoptosis of somatic cells. Exp Cell Res (1993) 1.26
Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol (1994) 1.24
Two-chain high molecular weight kininogen induces endothelial cell apoptosis and inhibits angiogenesis: partial activity within domain 5. FASEB J (2000) 1.23
Telomere shortening is an in vivo marker of myocyte replication and aging. Am J Pathol (2000) 1.21
Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines. Cancer Res (1994) 1.20
Relationship between the pharmacological activity of antitumor drugs Ametantrone and mitoxantrone (Novatrone) and their ability to condense nucleic acids. Proc Natl Acad Sci U S A (1986) 1.20
The S-phase cytotoxicity of camptothecin. Exp Cell Res (1991) 1.20
G1 arrest of U937 cells by onconase is associated with suppression of cyclin D3 expression, induction of p16INK4A, p21WAF1/CIP1 and p27KIP and decreased pRb phosphorylation. Leukemia (1998) 1.19
ATM activation and histone H2AX phosphorylation as indicators of DNA damage by DNA topoisomerase I inhibitor topotecan and during apoptosis. Cell Prolif (2006) 1.19
Correlated measurements of DNA, RNA, and protein in individual cells by flow cytometry. Science (1985) 1.18
Myocyte cellular hyperplasia and myocyte cellular hypertrophy contribute to chronic ventricular remodeling in coronary artery narrowing-induced cardiomyopathy in rats. Circ Res (1994) 1.17
Apoptosis in adult retinal ganglion cells after axotomy. J Neurobiol (1994) 1.15
Changes in deoxyribonucleoprotein during spermiogenesis in the bull. Sensitivity of DNA to heat denaturation. Exp Cell Res (1970) 1.15
DNA strand breaks occurring during apoptosis - their early insitu detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol (1992) 1.15
Cell heterogeneity during the cell cycle. J Cell Physiol (1982) 1.15
Detection of apoptosis and DNA replication by differential labeling of DNA strand breaks with fluorochromes of different color. Exp Cell Res (1996) 1.12
BubR1 is involved in regulation of DNA damage responses. Oncogene (2006) 1.11
Immunoseparation and immunodetection of nucleic acids labeled with halogenated nucleotides. Exp Cell Res (1997) 1.11
Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart. Proc Natl Acad Sci U S A (2001) 1.10
Changes in accessibility of DNA to various fluorochromes during spermatogenesis. Cytometry (1986) 1.10
Changes in deoxyribonucleo-protein during spermiogenesis in the bull. 3 H-Actinomycin D binding capacity. Exp Cell Res (1969) 1.08
Onconase and amphinase, the antitumor ribonucleases from Rana pipiens oocytes. Curr Pharm Biotechnol (2008) 1.07
Chromatin condensation and sensitivity of DNA in situ to denaturation during cell cycle and apoptosis--a confocal microscopy study. Micron (2001) 1.06
Interactions of antitumor agents Ametantrone and Mitoxantrone (Novatrone) with double-stranded DNA. Biochem Pharmacol (1985) 1.06
Synchronization in the cell cycle by inhibitors of DNA replication induces histone H2AX phosphorylation: an indication of DNA damage. Cell Prolif (2006) 1.05
A comparison of cell cycle-related changes in postmitotic and quiescent AF8 cells as measured by cytofluorometry after acridine orange staining. Cancer Res (1978) 1.05
Interactions of a new antitumor agent, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]-ethyl]amino]-9,10-anthracenedione, with nucleic acids. Biochem Pharmacol (1981) 1.04
Cleavage of Poly(ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res (2000) 1.03
Actinomycin binding of normal and phytohaemagglutinin stimulated lymphocytes. Exp Cell Res (1969) 1.03
Relationship between DNA damage response, initiated by camptothecin or oxidative stress, and DNA replication, analyzed by quantitative 3D image analysis. Cytometry A (2013) 1.03
HEPES-buffered media in lymphocyte cultures. Proc Soc Exp Biol Med (1971) 1.02
Failure of accumulation of cellular RNA in hamster cells stimulated to synthesize DNA by infection with adenovirus 2. J Biol Chem (1980) 1.02
Flow cytometry of breast carcinoma: II. Relation of tumor cell cycle distribution to histology and estrogen receptor. Cancer (1981) 1.02
The cell cycle effects and induction of apoptosis by 5-bromouridine in cultures of human leukaemic MOLT-4 and HL-60 cell lines and mitogen-stimulated normal lymphocytes. Cell Prolif (1994) 1.01
Cell cycle arrest and apoptosis of melanoma cells by docosahexaenoic acid: association with decreased pRb phosphorylation. Cancer Res (2000) 1.01
Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell Prolif (2001) 1.01
Different effects of staurosporine, an inhibitor of protein kinases, on the cell cycle and chromatin structure of normal and leukemic lymphocytes. Cancer Res (1992) 1.01
Cell cycle effects and control of gene expression by resveratrol in human breast carcinoma cell lines with different metastatic potentials. Int J Oncol (1999) 0.99
Effect of connective tissue intercellular matrix on lymphocyte stimulation. Exp Cell Res (1971) 0.99
Normal and perturbed Chinese hamster ovary cells: correlation of DNA, RNA, and protein content by flow cytometry. J Cell Biol (1985) 0.99
Cytofluorometric studies on conformation of nucleic acids in situ. I. Restriction of acridine orange binding by chromatin proteins. J Histochem Cytochem (1976) 0.98
Extent of constitutive histone H2AX phosphorylation on Ser-139 varies in cells with different TP53 status. Cell Prolif (2006) 0.98
Diverse effects of camptothecin, an inhibitor of topoisomerase I, on the cell cycle of lymphocytic (L1210, MOLT-4) and myelogenous (HL-60, KG1) leukemic cells. Cancer Res (1990) 0.98
Effect of n-butyrate on cell cycle progression and in situ chromatin structure of L1210 cells. Exp Cell Res (1981) 0.97
Different patterns of apoptosis of HL-60 cells induced by cycloheximide and camptothecin. J Cell Physiol (1993) 0.96
Actinomycin binding properties of stimulated human lymphocytes. Exp Cell Res (1969) 0.96
Potentiation of tumor necrosis factor induced apoptosis by onconase. Int J Oncol (1998) 0.96
Caffeine dissociates complexes between DNA and intercalating dyes: application for bleaching fluorochrome-stained cells for their subsequent restaining and analysis by laser scanning cytometry. Cytometry (2001) 0.96