Published in Cell on May 01, 1983
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol Cell Biol (1989) 4.81
The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A (1992) 4.74
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2. EMBO J (1992) 3.65
Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc Natl Acad Sci U S A (1993) 3.62
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci U S A (1985) 3.09
Initiation of protein synthesis in mammalian cells. Biochem J (1986) 2.99
Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system. Mol Cell Biol (1991) 2.55
Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene. J Virol (1995) 2.55
Translational control mediated by eucaryotic initiation factor-2 is restricted to specific mRNAs in transfected cells. Mol Cell Biol (1987) 2.29
Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci U S A (1992) 2.20
Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity. EMBO J (1987) 2.17
Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells. Proc Natl Acad Sci U S A (1990) 2.05
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J Virol (1989) 1.96
Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase. J Virol (1988) 1.77
Inhibition of translation in cells infected with a poliovirus 2Apro mutant correlates with phosphorylation of the alpha subunit of eucaryotic initiation factor 2. J Virol (1989) 1.77
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol Cell Biol (1988) 1.69
Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F. Mol Cell Biol (1991) 1.68
Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA. J Virol (1993) 1.67
Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol Cell Biol (1986) 1.61
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proc Natl Acad Sci U S A (1989) 1.51
Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2. J Virol (1992) 1.44
Species-specific signals for the splicing of a short Drosophila intron in vitro. Mol Cell Biol (1993) 1.39
Reversible phosphorylation of eukaryotic initiation factor 2 alpha in response to endoplasmic reticular signaling. Mol Cell Biochem (1993) 1.36
Functional dissection of adenovirus VAI RNA. J Virol (1989) 1.26
Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region. Biochem J (1996) 1.24
An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines. Mol Cell Biol (1986) 1.22
Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase. Proc Natl Acad Sci U S A (1994) 1.22
Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies. EMBO J (1987) 1.17
Adenovirus VAI-RNA regulates gene expression by controlling stability of ribosome-bound RNAs. EMBO J (1989) 1.14
Roles of a 67-kDa polypeptide in reversal of protein synthesis inhibition in heme-deficient reticulocyte lysate. Proc Natl Acad Sci U S A (1988) 0.99
Phosphorylation of wheat germ initiation factors and ribosomal proteins. Plant Physiol (1985) 0.96
Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Biochem J (1994) 0.95
Expression of mutant eukaryotic initiation factor 2 alpha subunit (eIF-2 alpha) reduces inhibition of guanine nucleotide exchange activity of eIF-2B mediated by eIF-2 alpha phosphorylation. Mol Cell Biol (1994) 0.94
Mutations that affect phosphorylation of the adenovirus DNA-binding protein alter its ability to enhance its own synthesis. J Virol (1989) 0.85
A novel translational regulation function for the simian virus 40 large-T antigen gene. J Virol (1995) 0.85
The alpha subunit of initiation factor 2 is phosphorylated in vivo in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1986) 0.84
The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells. J Virol (1990) 0.83
The adenovirus E1B 55-kilodalton and E4 open reading frame 6 proteins limit phosphorylation of eIF2alpha during the late phase of infection. J Virol (2009) 0.83
Identification of a Kinase in Wheat Germ that Phosphorylates the Large Subunit of Initiation Factor 4F. Plant Physiol (1988) 0.75
The Ambystoma tigrinum virus (ATV) RNase III gene can modulate host PKR activation and interferon production. Virology (2017) 0.75
Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2 alpha kinase. Cell (1986) 4.72
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci U S A (1985) 3.09
Cloning of adeno-associated virus type 4 (AAV4) and generation of recombinant AAV4 particles. J Virol (1997) 2.91
The regulation of initiation of mammalian protein synthesis. Prog Nucleic Acid Res Mol Biol (1981) 2.81
Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli. J Virol (1994) 2.32
Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation. J Biol Chem (1983) 2.31
Asymmetric replication in vitro from a human sequence element is dependent on adeno-associated virus Rep protein. J Virol (1995) 2.23
Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity. EMBO J (1987) 2.17
Competition between cellular and viral mRNAs in vitro is regulated by a messenger discriminatory initiation factor. Proc Natl Acad Sci U S A (1976) 2.12
Evidence for role of m7G5'-phosphate group in recognition of eukaryotic mRNA by initiation factor IF-M3. Nature (1976) 2.09
Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. Mol Cell Biol (1993) 2.05
Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats. J Virol (1994) 1.98
The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation. J Virol (1989) 1.96
Purification and physical properties of homogeneous initiation factor MP from rabbit reticulocytes. J Biol Chem (1975) 1.83
Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase. J Virol (1988) 1.77
Identification of the hypusine-containing protein hy+ as translation initiation factor eIF-4D. Proc Natl Acad Sci U S A (1983) 1.76
Inhibition of protein synthesis in rabbit reticulocyte lysates by double-stranded RNA and oxidized glutathione: indirect mode of action on polypeptide chain initiation. Proc Natl Acad Sci U S A (1975) 1.68
Translational control by influenza virus: suppression of the kinase that phosphorylates the alpha subunit of initiation factor eIF-2 and selective translation of influenza viral mRNAs. Mol Cell Biol (1986) 1.61
Adeno-associated virus DNA replication in vitro: activation by a maltose binding protein/Rep 68 fusion protein. J Virol (1994) 1.56
High-efficiency transfer of the T cell co-stimulatory molecule B7-2 to lymphoid cells using high-titer recombinant adeno-associated virus vectors. Hum Gene Ther (1995) 1.52
Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation. J Biol Chem (1979) 1.50
Factors involved in initiation of haemoglobin synthesis can be phosphorylated in vitro. Nature (1976) 1.47
Effect of hemin on site-specific phosphorylation of eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1978) 1.46
Mitochondrial-cytosolic interactions in perfused rat heart. Role of coupled transamination in repletion of citric acid cycle intermediates. J Biol Chem (1973) 1.41
Isolation of an active transcription initiation complex from HeLa cell-free extract. Proc Natl Acad Sci U S A (1984) 1.40
Purification and characterization of two initiation factors required for maximal activity of a highly fractionated globin mRNA translation system. Proc Natl Acad Sci U S A (1976) 1.36
Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection. J Virol (1995) 1.31
Eukaryotic initiation complex formation. Evidence for two distinct pathways. J Biol Chem (1975) 1.27
Functional dissection of adenovirus VAI RNA. J Virol (1989) 1.26
Regulation of gene expression for translation initiation factor eIF-2 alpha: importance of the 3' untranslated region. Biochem J (1996) 1.24
An adenovirus mutant unable to express VAI RNA displays different growth responses and sensitivity to interferon in various host cell lines. Mol Cell Biol (1986) 1.22
Morphological and biochemical studies of isolated mitochondria from fetal, neonatal, and adult liver and from neoplastic tissues. J Cell Biol (1967) 1.21
Role of eukaryotic initiation factor 5 in the formation of 80 S initiation complexes. J Biol Chem (1979) 1.21
T-cell activation leads to rapid stimulation of translation initiation factor eIF2B and inactivation of glycogen synthase kinase-3. J Biol Chem (1996) 1.16
Reduced activity of the interferon-induced double-stranded RNA-dependent protein kinase during a heat shock stress. J Biol Chem (1989) 1.14
Analysis of initiation factor function in highly fractionated and unfractionated reticulocyte lysate systems. Methods Enzymol (1979) 1.14
Identification of a downstream sequence and binding protein that regulate adenovirus major late promoter transcription in vitro. J Biol Chem (1988) 1.13
Identification of a 48 S preinitiation complex in reticulocyte lysate. J Biol Chem (1978) 1.12
Increased eIF-2 alpha expression in mitogen-activated primary T lymphocytes. EMBO J (1990) 1.11
Mitochondrial-cytosolic interactions in cardiac tissue: role of the malate-aspartate cycle in the removal of glycolytic NADH from the cytosol. Symp Soc Exp Biol (1973) 1.09
Compensatory increase in levels of beta minor globin in murine beta-thalassemia is under translational control. J Biol Chem (1986) 1.08
Regulation of translation initiation factor gene expression during human T cell activation. J Biol Chem (1992) 1.08
Binding of MET-TRNAf and GTP to homogeneous initiation factor MP. J Biol Chem (1975) 1.08
Coordination of citric acid cycle activity with electron transport flux. Circ Res (1976) 1.07
Role of sequences within the first intron in the regulation of expression of eukaryotic initiation factor 2 alpha. J Biol Chem (1992) 1.07
Polypeptide chain initiation in eukaryotes: mechanism of formation of initiation complex. Proc Natl Acad Sci U S A (1976) 1.05
The Metabolic Significance of the Malate-Aspartate Cycle in Heart. Circ Res (1975) 1.04
The molecular mechanism of hemoglobin synthesis and its regulation in the reticulocyte. CRC Crit Rev Biochem (1978) 1.03
A key transcription factor for eukaryotic initiation factor-2 alpha is strongly homologous to developmental transcription factors and may link metabolic genes to cellular growth and development. J Biol Chem (1994) 1.03
Control of the transport of reducing equivalents across the mitochondrial membrane in perfused rat heart. J Mol Cell Cardiol (1971) 1.03
Homologous globin cell-free transcription system with comparison of heterologous factors. Mol Cell Biol (1984) 1.00
Identification and characterization of a novel transcription factor participating in the expression of eukaryotic initiation factor 2 alpha. J Biol Chem (1989) 0.98
Efficient gene targeting in mouse embryonic stem cells. Gene Ther (1997) 0.98
The roles of AAV Rep proteins in gene expression and targeted integration. Curr Top Microbiol Immunol (1996) 0.98
Isolation and characterization of the promoter and flanking regions of the gene encoding the human protein-synthesis-initiation factor 2 alpha. Gene (1989) 0.97
Active transport of potassium ion in heart mitochondria. Circ Res (1967) 0.97
Isolation of stable preinitiation, initiation, and elongation complexes from RNA polymerase II-directed transcription. Proc Natl Acad Sci U S A (1985) 0.97
Control of eIF-2 phosphatase activity in rabbit reticulocyte lysate. Proc Natl Acad Sci U S A (1979) 0.97
Use of heparin-Sepharose for the rapid isolation of initiation and elongation factors. Methods Enzymol (1979) 0.96
The effects of histones and other polycations on cellular energetics. IV. Further studies on the stimulation of mitochondrial oxygen consumption. J Biol Chem (1966) 0.93
Mode of action of the calcium ionophores X-537A and A23187 on cardiac contractility. Biochem Pharmacol (1974) 0.92
Identification and characterization of an adenovirus 2 major late promoter CAP sequence DNA-binding protein. J Biol Chem (1990) 0.91
Effects of acidosis on myocardial contractility and metabolism. Acta Med Scand Suppl (1976) 0.90
Contribution of tissue acidosis to ischemic injury in the perfused rat heart. Circulation (1976) 0.90
The association of eIF-2 with Met-tRNAi or eIF-2B alters the specificity of eIF-2 phosphatase. J Biol Chem (1984) 0.89
Characteristics of eukaryotic initiation factor 2 and its subunits. J Biol Chem (1980) 0.88
Characterization of an antisense Inr element in the eIF-2 alpha gene. J Biol Chem (1994) 0.87
Purification and properties of eIF-2 phosphatase. J Biol Chem (1980) 0.86
Regulation of eukaryotic translation initiation factor expression during T-cell activation. Biochim Biophys Acta (1993) 0.85
Classification of an eIF-2phosphatase as a type-2 protein phosphatase. FEBS Lett (1980) 0.83
Double-stranded RNA-dependent phosphorylation of protein P1 and eukaryotic initiation factor 2 alpha does not correlate with protein synthesis inhibition in a cell-free system from interferon-treated mouse L cells. Proc Natl Acad Sci U S A (1983) 0.83
Respiratory acidosis and its reversibility in perfused rat heart: regulation of citric acid cycle activity. Am J Physiol (1978) 0.83
Quantitation and localization of globin messenger RNA in rabbit reticulocyte lysate. J Biol Chem (1979) 0.82
Indirect inactivation of eukaryotic initiation factor 2 in reticulocyte lysate by selenite. J Biol Chem (1980) 0.81
The role of phosphorylation in the regulation of eukaryotic initiation factor 2 activity. Curr Top Cell Regul (1982) 0.81
Investigation of the calcium cycle in perfused rat and frog hearts. Recent Adv Stud Cardiac Struct Metab (1974) 0.81
Signal transduction pathways that contribute to increased protein synthesis during T-cell activation. Biochim Biophys Acta (2000) 0.80
Investigation of the role of mitochondria in the cardiac contraction--relaxation cycle. FEBS Lett (1972) 0.80
Transcriptional regulation of E2F-1 and eIF-2 genes by alpha-pal: a potential mechanism for coordinated regulation of protein synthesis, growth, and the cell cycle. Biochim Biophys Acta (2000) 0.80
Second phosphorylation site on alpha subunit of eIF-2 in rabbit reticulocyte lysate. J Cyclic Nucleotide Protein Phosphor Res (1988) 0.79
Reducing artifact and increasing the yield of specific DNA target fragments during PCR-RACE or anchor PCR. Biotechniques (1993) 0.78
Formation of alpha-Pal/Max heterodimers synergistically activates the eIF2-alpha promoter. J Biol Chem (1998) 0.78
International symposium on translational/transcriptional regulation of gene expression. Highlights of the Fogarty International Center Meeting held in Bethesda, Maryland on 7-9 April, 1982. FEBS Lett (1982) 0.78
Genomic cloning and characterization of the human eukaryotic initiation factor-2beta promoter. J Biol Chem (1999) 0.78
Manometric changes during retrograde biliary infusion in mice. Am J Physiol Gastrointest Liver Physiol (2000) 0.78
Detection of early gene expression changes during activation of human primary lymphocytes by in vitro synthesis of proteins from polysome-associated mRNAs. Protein Sci (2001) 0.78
Comparison of fMet-tRNAf and Met-tRNAf from Escherichia coli and rabbit liver in initiation of hemoglobin synthesis. J Biol Chem (1975) 0.76
Immunosuppressants FK506 and rapamycin have different effects on the biosynthesis of cytoplasmic actin during the early period of T cell activation. Biochem J (1999) 0.76
A difference in the rate of ribosomal elongation balances the synthesis of eukaryotic translation initiation factor (eIF)-2 alpha and eIF-2 beta. J Biol Chem (1993) 0.76
The binding of transfer ribonucleic acids to 5 S and 5.8 S eukaryotic ribosomal ribonucleic acid-protein complexes. J Biol Chem (1982) 0.76
The purification and characterization of subunits alpha, beta, and gamma from the rabbit reticulocyte eukaryotic initiation factor 2. Arch Biochem Biophys (1987) 0.76
The use of [14C]eukaryotic initiation factor 2 to measure the endogenous pool size of eukaryotic initiation factor 2 in rabbit reticulocyte lysate. J Biol Chem (1979) 0.75
The regulation of eIF-2 function protein synthesis initiation. Biochimie (1982) 0.75