Published in Biochem J on May 01, 1986
An analysis of vertebrate mRNA sequences: intimations of translational control. J Cell Biol (1991) 12.00
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F. Mol Cell Biol (1990) 7.33
Mechanism and regulation of eukaryotic protein synthesis. Microbiol Rev (1992) 6.27
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol Cell Biol (1989) 4.81
Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2. EMBO J (1992) 3.65
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology. Proc Natl Acad Sci U S A (1990) 2.66
Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI. Mol Cell Biol (1989) 2.48
Modulation of tRNA(iMet), eIF-2, and eIF-2B expression shows that GCN4 translation is inversely coupled to the level of eIF-2.GTP.Met-tRNA(iMet) ternary complexes. Mol Cell Biol (1995) 2.37
Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Proc Natl Acad Sci U S A (1991) 2.34
mRNA cap-binding protein: cloning of the gene encoding protein synthesis initiation factor eIF-4E from Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.21
Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control. Mol Cell Biol (1994) 2.17
An essential yeast protein, encoded by duplicated genes TIF1 and TIF2 and homologous to the mammalian translation initiation factor eIF-4A, can suppress a mitochondrial missense mutation. Proc Natl Acad Sci U S A (1989) 2.10
A putative ATP-dependent RNA helicase involved in Saccharomyces cerevisiae ribosome assembly. Proc Natl Acad Sci U S A (1992) 1.94
Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.88
A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity. EMBO J (1993) 1.80
A protein complex of translational regulators of GCN4 mRNA is the guanine nucleotide-exchange factor for translation initiation factor 2 in yeast. Proc Natl Acad Sci U S A (1993) 1.78
Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system. Proc Natl Acad Sci U S A (1989) 1.73
Beta-globin mRNAs capped with m7G, m2.7(2)G or m2.2.7(3)G differ in intrinsic translation efficiency. Nucleic Acids Res (1988) 1.72
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol Cell Biol (1988) 1.69
Translation in Saccharomyces cerevisiae: initiation factor 4E-dependent cell-free system. Mol Cell Biol (1989) 1.68
ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. Biochem Biophys Res Commun (2008) 1.63
Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F. Proc Natl Acad Sci U S A (1990) 1.58
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proc Natl Acad Sci U S A (1989) 1.51
ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1992) 1.46
Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI. Mol Cell Biol (1995) 1.46
Translation of a polycistronic mRNA in the presence of the cauliflower mosaic virus transactivator protein. EMBO J (1991) 1.42
Divergent genes for translation initiation factor eIF-4A are coordinately expressed in tobacco. Nucleic Acids Res (1991) 1.39
Guanine nucleotide exchange factor for eukaryotic translation initiation factor 2 in Saccharomyces cerevisiae: interactions between the essential subunits GCD2, GCD6, and GCD7 and the regulatory subunit GCN3. Mol Cell Biol (1993) 1.39
Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Nucleic Acids Res (1992) 1.38
Molecular cloning of the cDNA for stimulatory GDP/GTP exchange protein for smg p21s (ras p21-like small GTP-binding proteins) and characterization of stimulatory GDP/GTP exchange protein. Mol Cell Biol (1991) 1.36
Mutations in the GCD7 subunit of yeast guanine nucleotide exchange factor eIF-2B overcome the inhibitory effects of phosphorylated eIF-2 on translation initiation. Mol Cell Biol (1994) 1.35
Multidomain organization of eukaryotic guanine nucleotide exchange translation initiation factor eIF-2B subunits revealed by analysis of conserved sequence motifs. Protein Sci (1995) 1.34
A second maternally expressed Drosophila gene encodes a putative RNA helicase of the "DEAD box" family. Proc Natl Acad Sci U S A (1991) 1.32
Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation. Proc Natl Acad Sci U S A (1988) 1.25
Role of an upstream open reading frame in the translation of polycistronic mRNAs in plant cells. Nucleic Acids Res (1992) 1.21
Amino acid microsequencing of internal tryptic peptides of heme-regulated eukaryotic initiation factor 2 alpha subunit kinase: homology to protein kinases. Proc Natl Acad Sci U S A (1991) 1.12
Regulation of protein turnover in skeletal and cardiac muscle. Biochem J (1991) 1.11
The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2. Biochem J (1989) 1.10
Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle. Mol Med (2007) 1.06
Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha. Biochem J (1999) 1.06
Structural features of adenovirus 2 virus-associated RNA required for binding to the protein kinase DAI. Nucleic Acids Res (1994) 1.06
Activity of protein phosphatases against initiation factor-2 and elongation factor-2. Biochem J (1990) 1.06
The La antigen inhibits the activation of the interferon-inducible protein kinase PKR by sequestering and unwinding double-stranded RNA. Nucleic Acids Res (1994) 1.01
Initiation factor protein modifications and inhibition of protein synthesis. Mol Cell Biol (1987) 0.96
Phosphorylation of the alpha subunit of initiation factor 2 correlates with the inhibition of translation following transient cerebral ischaemia in the rat. Biochem J (1994) 0.95
Regulation of in vitro translation by double-stranded RNA in mammalian cell mRNA preparations. Nucleic Acids Res (1988) 0.92
Purification and characterization of mRNA cap-binding protein from Drosophila melanogaster embryos. Mol Cell Biol (1989) 0.91
The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNA-dependent, interferon-induced protein kinase, PKR. Nucleic Acids Res (1993) 0.91
PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease. J Cell Mol Med (2009) 0.90
Nucleotide sequence of human cDNA encoding eukaryotic initiation factor 4AI. Nucleic Acids Res (1993) 0.89
GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. Biochem J (1987) 0.89
Effects of dexamethasone on lung protein turnover. Biochem J (1991) 0.88
Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins. Neurotox Res (2010) 0.87
Phosphorylation controls binding of acidic proteins to the ribosome. Proc Natl Acad Sci U S A (1991) 0.86
Phosphorylation of mammalian translation initiation factor 5 (eIF5) in vitro and in vivo. Nucleic Acids Res (2002) 0.86
Structural analysis of the 5' domain of the HeLa 18S ribosomal RNA by chemical and enzymatic probing. Nucleic Acids Res (1990) 0.86
Mechanism of inhibition of polypeptide chain initiation in calcium-depleted Ehrlich ascites tumor cells. J Cell Biol (1989) 0.84
The alpha subunit of eucaryotic initiation factor 2 is phosphorylated in mengovirus-infected mouse L cells. J Virol (1990) 0.83
Haem inhibits iron uptake subsequent to endocytosis of transferrin in reticulocytes. Biochem J (1988) 0.80
Age-dependent decrease in the amount of eukaryotic initiation factor 2 in various rat tissues. Biochem J (1992) 0.79
Inhibitor of eukaryotic initiation factor 4F activity in unfertilized sea urchin eggs. Proc Natl Acad Sci U S A (1987) 0.79
Acute alterations in sodium flux in vitro lead to decreased myofibrillar protein breakdown in rat skeletal muscle. Biochem J (1987) 0.78
Presence of haemin-controlled eIF-2 alpha kinases in both undifferentiated and differentiating mouse erythroleukaemia cells. Biochem J (1989) 0.77
Inhibition of polypeptide chain initiation in Daudi cells by interferons. Evidence that activity of initiation factor eIF-2 and availability of mRNA are unimpaired. Biochem J (1986) 0.77
Identification of a Kinase in Wheat Germ that Phosphorylates the Large Subunit of Initiation Factor 4F. Plant Physiol (1988) 0.75
Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res (1984) 39.52
Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles. Microbiol Rev (1983) 24.58
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res (1981) 18.27
How do eucaryotic ribosomes select initiation regions in messenger RNA? Cell (1978) 12.04
Capping of eucaryotic mRNAs. Cell (1976) 10.84
Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell (1985) 7.95
Point mutations close to the AUG initiator codon affect the efficiency of translation of rat preproinsulin in vivo. Nature (1984) 7.54
Biochemistry of interferons and their actions. Annu Rev Biochem (1982) 6.89
Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis. Cell (1977) 6.22
Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin. Nucleic Acids Res (1984) 5.96
A cytoskeletal structure with associated polyribosomes obtained from HeLa cells. Cell (1977) 5.22
Poliovirus mutant that does not selectively inhibit host cell protein synthesis. Mol Cell Biol (1985) 4.94
ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors. J Biol Chem (1985) 4.62
Inhibition of translation by poliovirus: inactivation of a specific initiation factor. Proc Natl Acad Sci U S A (1978) 4.59
A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proc Natl Acad Sci U S A (1978) 4.45
Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells. Cell (1981) 4.34
New initiation factor activity required for globin mRNA translation. J Biol Chem (1983) 4.31
The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. J Biol Chem (1978) 4.26
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
Eukaryotic protein synthesis. Annu Rev Biochem (1985) 3.48
Two forms of purified m7G-cap binding protein with different effects on capped mRNA translation in extracts of uninfected and poliovirus-infected HeLa cells. J Biol Chem (1981) 3.41
Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors. J Mol Biol (1977) 3.30
Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus. Proc Natl Acad Sci U S A (1982) 3.26
Adenovirus VAI RNA prevents phosphorylation of the eukaryotic initiation factor 2 alpha subunit subsequent to infection. Proc Natl Acad Sci U S A (1985) 3.09
Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proc Natl Acad Sci U S A (1979) 2.81
Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNA. Nature (1985) 2.80
Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis. Proc Natl Acad Sci U S A (1985) 2.53
RNA-stimulated ATPase activity of eukaryotic initiation factors. J Biol Chem (1984) 2.49
Control of protein synthesis in reticulocyte lysates by haemin. Nat New Biol (1973) 2.39
2B or not 2B: regulation of the catalytic utilization of eIF-2. Cell (1983) 2.32
Purification of the eukaryotic initiation factor 2-eukaryotic initiation factor 2B complex and characterization of its guanine nucleotide exchange activity during protein synthesis initiation. J Biol Chem (1983) 2.31
Inhibition of host translation in encephalomyocarditis virus-infected L cells: a novel mechanism. J Virol (1982) 2.13
Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. Cell (1984) 2.08
Regulation of protein synthesis initiation in eucaryotes. Arch Biochem Biophys (1983) 2.00
Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation. J Biol Chem (1984) 1.99
Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis. J Biol Chem (1983) 1.97
Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: effect of mRNA 5' secondary structure. Mol Cell Biol (1985) 1.93
Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells. J Virol (1984) 1.87
A GDP/GTP exchange factor essential for eukaryotic initiation factor 2 cycling in Ehrlich ascites tumor cells and its regulation by eukaryotic initiation factor 2 phosphorylation. J Biol Chem (1983) 1.84
Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. J Biol Chem (1985) 1.83
Role of ATP in binding and migration of 40S ribosomal subunits. Cell (1980) 1.82
Role of mRNA competition in regulating translation: further characterization of mRNA discriminatory initiation factors. Proc Natl Acad Sci U S A (1983) 1.81
Adenovirus VA RNAI mediates a translational stimulation which is not restricted to the viral mRNAs. EMBO J (1985) 1.80
Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro. J Virol (1985) 1.79
Poliovirus-induced inhibition of host-cell protein synthesis. Cell (1982) 1.79
Mechanism of polypeptide chain initiation in eukaryotes and its control by phosphorylation of the alpha subunit of initiation factor 2. Proc Natl Acad Sci U S A (1982) 1.78
Initiation factors in protein biosynthesis. Annu Rev Biochem (1982) 1.76
Alterations in initiation factor activity from poliovirus-infected HeLa cells. J Biol Chem (1979) 1.75
Purification and characterization of initiation factor IF-E3 from rabbit reticulocytes. Proc Natl Acad Sci U S A (1976) 1.73
Characterization of eukaryotic initiation factor 4A, a protein involved in ATP-dependent binding of globin mRNA. J Biol Chem (1982) 1.73
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2. Nature (1982) 1.70
Effect of phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 on the function of reversing factor in the initiation of protein synthesis. Proc Natl Acad Sci U S A (1983) 1.69
Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo. J Biol Chem (1984) 1.61
Initiation of mammalian protein synthesis. The multiple functions of the initiation factor eIF-3. Biochim Biophys Acta (1979) 1.59
False starts in translational control of gene expression. Nature (1985) 1.57
Mechanism of translational control by partial phosphorylation of the alpha subunit of eukaryotic initiation factor 2. Proc Natl Acad Sci U S A (1984) 1.57
Analysis of phosphorylation of protein synthesis initiation factor eIF-2 by two-dimensional gel electrophoresis. Eur J Biochem (1978) 1.54
Nucleotide regulation of a eukaryotic protein synthesis initiation complex;. Biochim Biophys Acta (1975) 1.52
Competition between globin messenger ribonucleic acids for a discriminating initiation factor. J Biol Chem (1977) 1.51
Isolation and structural characterization of cap-binding proteins from poliovirus-infected HeLa cells. J Virol (1985) 1.51
Eukaryotic ribosomal subunit anti-association activity of calf liver is contained in a single polypeptide chain protein of Mr = 25,500 (eukaryotic initiation factor 6). J Biol Chem (1982) 1.50
Binding and release of radiolabeled eukaryotic initiation factors 2 and 3 during 80 S initiation complex formation. J Biol Chem (1979) 1.50
Phosphorylation of initiation factor eIF-2 alpha, binding of mRNA to 48 S complexes, and its reutilization in initiation of protein synthesis. J Biol Chem (1983) 1.50
Functional characterization of eukaryotic mRNA cap binding protein complex: effects on translation of capped and naturally uncapped RNAs. Biochemistry (1984) 1.48
On the association of mRNA with the cytoskeleton in uninfected and adenovirus-infected human KB cells. Exp Cell Res (1981) 1.48
Partial purification of a translational repressor mediating hemin control of globin synthesis and implication of results on the site of inhibition. Biochem Biophys Res Commun (1973) 1.47
Mechanism of inhibition of polypeptide chain initiation in heat-shocked Ehrlich cells involves reduction of eukaryotic initiation factor 4F activity. J Biol Chem (1985) 1.46
The interferon-induced protein kinase PK-i from mouse L cells. J Biol Chem (1979) 1.45
Purification and characterization of a ribosome dissociation factor (eukaryotic initiation factor 6) from wheat germ. J Biol Chem (1979) 1.45
Characterization of double-stranded-RNA-activated kinase that phosphorylates alpha subunit of eukaryotic initiation factor 2 (eIF-2 alpha) in reticulocyte lysates. Proc Natl Acad Sci U S A (1980) 1.42
Mode of action of the heme-controlled translational inhibitor: relationship of eukaryotic initiation factor 2-stimulating protein to translation restoring factor. Proc Natl Acad Sci U S A (1981) 1.42
Protein synthesis in rabbit reticulocytes: mechanism of protein synthesis inhibition by heme-regulated inhibitor. Proc Natl Acad Sci U S A (1979) 1.41
The mechanism of action of eukaryotic initiation factor 4C in protein synthesis. Eur J Biochem (1980) 1.37
Regulation of protein synthesis by phosphorylation of eukaryotic initiation factor 2 alpha in intact reticulocytes and reticulocyte lysates. Proc Natl Acad Sci U S A (1982) 1.32
Regulation of protein synthesis in rabbit reticulocyte lysates: preparation of efficient protein synthesis lysates and the purification and characterization of the heme-regulated translational inhibitory protein kinase. Methods Enzymol (1979) 1.31
The ribosome cycle in mammalian protein synthesis. II. Association of the native smaller ribosomal subunit with protein factors. J Biol Chem (1973) 1.30
Unusual requirements for optimum translation of polio viral RNA in vitro. J Biol Chem (1983) 1.28
Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells. J Virol (1985) 1.24
Distribution of reversing factor in reticulocyte lysates during active protein synthesis and on inhibition by heme deprivation or double-stranded RNA. Proc Natl Acad Sci U S A (1984) 1.23
Site-specific phosphorylation of the alpha subunit of eukaryotic initiation factor eIF-2 by the heme-regulated and double-stranded RNA-activated eIF-2 alpha kinases from rabbit reticulocyte lysates. Proc Natl Acad Sci U S A (1980) 1.23
Purification and characterization of a protein factor that reverses the inhibition of protein synthesis by the heme-regulated translational inhibitor in rabbit reticulocyte lysates. Eur J Biochem (1979) 1.22
Evidence that glucose 6-phosphate regulates protein synthesis initiation in reticulocyte lysates. J Biol Chem (1978) 1.22
Role of eukaryotic initiation factor 5 in the formation of 80 S initiation complexes. J Biol Chem (1979) 1.21
The preparation and properties of gel-filtered rabbit-reticulocyte lysate protein-synthesis systems. Eur J Biochem (1983) 1.18
Regulation of protein synthesis in vesicular stomatitis virus-infected mouse L-929 cells by decreased protein synthesis initiation factor 2 activity. J Virol (1982) 1.16
In situ phosphorylation of the alpha subunit of eukaryotic initiation factor 2 in reticulocyte lysates inhibited by heme deficiency, double-stranded RNA, oxidized glutathione, or the heme-regulated protein kinase. Proc Natl Acad Sci U S A (1979) 1.13
Protein synthesis eukaryotic initiation factors 4A and 4B are not altered by poliovirus infection of HeLa cells. J Biol Chem (1983) 1.13
Ribosomal subunit antiassociation activity in rabbit reticulocyte lysates. Evidence for a low molecular weight ribosomal subunit antiassociation protein factor (Mr = 25,000). J Biol Chem (1984) 1.11
The role of eIF-4C in protein synthesis initiation complex formation. Biochim Biophys Acta (1980) 1.11
The regulation of initiation of protein synthesis by phosphorylation of eIF-2(alpha) and the role of reversing factor in the recycling of eIF-2. J Biol Chem (1984) 1.10
The effects of amino acid starvation on regulation of polypeptide chain initiation in Ehrlich ascites tumor cells. J Biol Chem (1980) 1.09
The 60 S ribosomal subunit as a carrier of eukaryotic initiation factor 2 and the site of reversing factor activity during protein synthesis. J Biol Chem (1985) 1.08
Characterization of GTP-dependent Met-tRNAf binding protein. J Biol Chem (1977) 1.07
The roles of sugar phosphates and thiol-reducing systems in the control of reticulocyte protein synthesis. Eur J Biochem (1983) 1.07
Polypeptide chain initiation in eukaryotes: reversibility of the ternary complex-forming reaction. Proc Natl Acad Sci U S A (1983) 1.07
Studies on the role of eukaryotic nucleotide exchange factor in polypeptide chain initiation. J Biol Chem (1984) 1.05
The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. EMBO J (1996) 2.75
eIF4G: translation's mystery factor begins to yield its secrets. RNA (1997) 2.33
Translation initiation factor modifications and the regulation of protein synthesis in apoptotic cells. Cell Death Differ (2000) 2.00
A reevaluation of the cap-binding protein, eIF4E, as a rate-limiting factor for initiation of translation in reticulocyte lysate. J Biol Chem (1996) 1.82
Proteolytic cleavage of initiation factor eIF-4 gamma in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs. Nucleic Acids Res (1995) 1.72
Effect of streptozotocin diabetes and insulin treatment on the rate of protein synthesis in tissues of the rat in vivo. J Biol Chem (1974) 1.71
Phosphorylation inhibits guanine nucleotide exchange on eukaryotic initiation factor 2. Nature (1982) 1.70
The influence of electrical stimulation in vitro on protein synthesis and other metabolic parameters of rat extensor digitorum longus muscle. Biochem J (1970) 1.63
The proteolytic cleavage of eukaryotic initiation factor (eIF) 4G is prevented by eIF4E binding protein (PHAS-I; 4E-BP1) in the reticulocyte lysate. EMBO J (1997) 1.54
Protein metabolism in skeletal muscle, diaphragm, and heart of diabetic rats. Am J Physiol (1983) 1.25
Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. J Biol Chem (2001) 1.22
Protein synthesis in a postmitochondrial supernatant system from rat liver. An effect of diabetes at the level of peptide chain initiation. FEBS Lett (1973) 1.13
Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo. J Biol Chem (1986) 1.11
Translation initiation factor 4E. Int J Biochem Cell Biol (1999) 1.10
The effects of amino acid starvation on regulation of polypeptide chain initiation in Ehrlich ascites tumor cells. J Biol Chem (1980) 1.09
Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation. J Cell Sci (1995) 1.05
Increased phosphorylation of eukaryotic initiation factor 4 alpha during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation. Eur J Biochem (1993) 1.04
The association of initiation factor 4F with poly(A)-binding protein is enhanced in serum-stimulated Xenopus kidney cells. J Biol Chem (1999) 1.03
Effects of starvation, diabetes and acute insulin treatment on the regulation of polypeptide-chain initiation in rat skeletal muscle. Biochem J (1984) 1.03
Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo. Eur J Biochem (2001) 0.99
The role of 5'-leader length, secondary structure and PABP concentration on cap and poly(A) tail function during translation in Xenopus oocytes. Nucleic Acids Res (2000) 0.98
Protein synthesis in liver and skeletal muscle of mice bearing an ascites tumor. Cancer Res (1984) 0.98
Assembly and breakdown of mammalian protein synthesis initiation complexes: regulation by guanine nucleotides and by phosphorylation of initiation factor eIF-2. Biochemistry (1983) 0.97
Cellular stress in xenopus kidney cells enhances the phosphorylation of eukaryotic translation initiation factor (eIF)4E and the association of eIF4F with poly(A)-binding protein. Biochem J (1999) 0.95
Investigation of the role of uncharged tRNA in the regulation of polypeptide chain initiation by amino acid starvation in cultured mammalian cells; a reappraisal. Eur J Biochem (1982) 0.94
Initiation of protein synthesis in Ehrlich ascites tumour cells. Evidence for physiological variation in the association of methionyl-tRNAf with native 40-S ribosomal subunits in vivo. Eur J Biochem (1975) 0.93
Characterization of a macromolecular inhibitor of polypeptide chain initiation from Ehrlich ascites tumor cells. Biochem Biophys Res Commun (1976) 0.93
Regulation of binding of initiator tRNA to eukaryotic initiation factor eIF-2. Effects of the haem-controlled repressor on the kinetics of ternary complex formation. FEBS Lett (1982) 0.92
Preparation and characterization of cell-free protein synthesis systems from oocytes and eggs of Xenopus laevis. Development (1989) 0.91
Conditions that alter rates of tissue protein synthesis in vivo. Biochem Soc Trans (1980) 0.90
Comparison of rates of protein synthesis in skeletal muscle measured in vivo and in the perfused hemicorpus [proceedings]. Biochem Soc Trans (1979) 0.89
Translational regulation during activation of porcine peripheral blood lymphocytes: association and phosphorylation of the alpha and gamma subunits of the initiation factor complex eIF-4F. Biochem J (1995) 0.87
The metabolic state of muscle in the isolated perfused rat hemicorpus in relation to rates of protein synthesis. Biochem J (1984) 0.86
The effect of dietary protein deficiency on albumin synthesis and on the concentration of active albumin messenger ribonucleic acid in rat liver. Biochem J (1978) 0.85
The effect of glucagon on muscle protein synthesis in the perfused rat hemicorpus [proceedings]. Biochem Soc Trans (1980) 0.84
Protein metabolism in the tumour-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumour at different stages in tumour growth. Biochem J (1989) 0.83
Purification and phosphorylation of initiation factor eIF-2 from rabbit skeletal muscle. FEBS Lett (1982) 0.83
Insulin stimulation of growth in diabetic rats. Synthesis and degradation of ribosomes and total tissue protein in skeletal muscle and heart. J Biol Chem (1986) 0.82
Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle. Biochimie (1990) 0.82
Protein turnover in tissues of diabetic rats. Acta Biol Med Ger (1981) 0.81
The role of soluble protein factors in the translational control of protein synthesis in eukaryotic cells. FEBS Lett (1973) 0.81
Effect of diabetes on the ultrastructure of the hepatocyte and on the distribution and activity of ribosomes in the free and membrane-bound populations. Biochim Biophys Acta (1974) 0.81
Protein metabolism in the mouse during pregnancy and lactation. Biochem J (1987) 0.81
Stimulation of initiation factor eIF-2 by a rat liver protein with GDPase activity. Biochem Biophys Res Commun (1980) 0.78
Inhibition of protein synthesis by the heme-controlled eIF-2 alpha kinase leads to the appearance of mRNA-containing 48S complexes that contain eIF-4E but lack methionyl-tRNA(f). Eur J Biochem (1995) 0.78
A fractionated reticulocyte lysate system for studies on protein synthesis initiation factors. Methods Mol Biol (1998) 0.77
Proteasome inhibitors and immunosuppressive drugs promote the cleavage of eIF4GI and eIF4GII by caspase-8-independent mechanisms in Jurkat T cell lines. FEBS Lett (2001) 0.77
Hormonal requirements for acute stimulation of rat liver polysome formation by amino acid feeding. Biochim Biophys Acta (1974) 0.77
Stimulation by insulin of protein synthesis in cultured chick embryo fibroblasts. Biochimie (1993) 0.76
Association of initiation factor eIF-2 with a rapidly sedimenting fraction from Ehrlich ascites-tumour cells. Biochem J (1981) 0.76
An intact muscle preparation suitable for studies of the metabolic effects of electrical stimulation. Biochem J (1971) 0.75
Radioactive puromycin formation as an assay for the proportion of active ribosomes in mammalian cells: correlation with polysome profiles under different physiological conditions. Life Sci (1983) 0.75
Effect of insulin treatment on protein turnover in adult diabetics. Proc Nutr Soc (1979) 0.75
40S ribosomal complexes in reticulocyte lysates treated with the haem-controlled eIF-2 alpha kinase. Biochem Soc Trans (1991) 0.75
Increased phosphorylation of eukaryotic initiation factor 4 alpha during activation of T lymphocytes correlates with increased eIF-4F complex formation. Biochem Soc Trans (1993) 0.75
Influence of streptozotocin diabetes on the ability of muscle cell sap to support protein synthesis by ribosomes in cell-free systems. Biochim Biophys Acta (1973) 0.75
Stimulation of rat liver initiation factor eIF-2 by a factor with guanosine diphosphase activity [proceedings]. Biochem Soc Trans (1980) 0.75
Hormonal control of protein synthesis in rat mammary explants. Biochem Soc Trans (1990) 0.75
The effect of streptozotocin diabetes on liver protein metabolism. Proc Nutr Soc (1980) 0.75
Micro-injection of p21ras into Xenopus oocytes, or incubation of oocyte S-100 with ATP, induces the activation of eIF-4 alpha kinase(s). Biochem Soc Trans (1995) 0.75
Effect of cleavage of the p220 subunit of eukaryotic translation initiation factor eIF-4F on protein synthesis in vitro. Biochem Soc Trans (1995) 0.75
Regulation of polypeptide-chain initiation in Ehrlich ascites-tumour cells by amino acid starvation [proceedings]. Biochem Soc Trans (1980) 0.75
Synthesis of albumin and of total plasma proteins by liver of fed and starved rats. Proc Nutr Soc (1978) 0.75
Whole-body protein synthesis and oxidation rates in streptozotocin diabetic rats. Proc Nutr Soc (1979) 0.75
The effect of an Ehrlich ascites tumour on the rate of protein synthesis in muscle and liver of the host [proceedings]. Biochem Soc Trans (1980) 0.75
Protein synthesis and breakdown in muscle and kidney of diabetic and insulin treated rats. Proc Nutr Soc (1980) 0.75
Effect of streptozotocin diabetes on protein synthesis in the liver, kidney and intestinal mucosa of young rats [proceedings]. Proc Nutr Soc (1978) 0.75
Effect of dietary protein on liver protein synthesis [proceedings]. Biochem Soc Trans (1980) 0.75