Published in Nature on June 17, 1983
Functions of microtubules in the Saccharomyces cerevisiae cell cycle. J Cell Biol (1988) 7.19
Fluorescent actin filaments move on myosin fixed to a glass surface. Proc Natl Acad Sci U S A (1986) 5.67
Mechanical relaxation of the hair bundle mediates adaptation in mechanoelectrical transduction by the bullfrog's saccular hair cell. Proc Natl Acad Sci U S A (1987) 4.02
Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J Cell Biol (1995) 3.74
Gliding movement of and bidirectional transport along single native microtubules from squid axoplasm: evidence for an active role of microtubules in cytoplasmic transport. J Cell Biol (1985) 3.58
The force exerted by a single kinesin molecule against a viscous load. Biophys J (1994) 3.33
Magnetic particle motions within living cells. Measurement of cytoplasmic viscosity and motile activity. Biophys J (1987) 2.62
Smooth muscle myosin cross-bridge interactions modulate actin filament sliding velocity in vitro. J Cell Biol (1990) 2.51
Actin-dependent mitochondrial motility in mitotic yeast and cell-free systems: identification of a motor activity on the mitochondrial surface. J Cell Biol (1995) 2.23
Structure and function of the cytoskeleton of a Dictyostelium myosin-defective mutant. J Cell Biol (1990) 2.12
Microinjected fluorescent polystyrene beads exhibit saltatory motion in tissue culture cells. J Cell Biol (1984) 1.96
Modulation of contraction by gelation/solation in a reconstituted motile model. J Cell Biol (1991) 1.93
Fluorescence visualization of the distribution of microfilaments in gonads and early embryos of the nematode Caenorhabditis elegans. J Cell Biol (1986) 1.85
In pursuit of myosin function. Cell Regul (1989) 1.84
ATP-dependent movement of myosin in vitro: characterization of a quantitative assay. J Cell Biol (1984) 1.84
Optical traps to study properties of molecular motors. Cold Spring Harb Protoc (2011) 1.79
Formation and movement of myosin-containing structures in living fibroblasts. J Cell Biol (1989) 1.72
The 110-kD protein-calmodulin complex of the intestinal microvillus is an actin-activated MgATPase. J Cell Biol (1987) 1.71
Yeast mitochondria contain ATP-sensitive, reversible actin-binding activity. Mol Biol Cell (1994) 1.65
Stress fiber-based movement of Shigella flexneri within cells. Infect Immun (1991) 1.63
Light chain phosphorylation regulates the movement of smooth muscle myosin on actin filaments. J Cell Biol (1985) 1.63
Structural and immunological characterization of the myosin-like 110-kD subunit of the intestinal microvillar 110K-calmodulin complex: evidence for discrete myosin head and calmodulin-binding domains. J Cell Biol (1988) 1.59
The sliding theory of cytoplasmic streaming: fifty years of progress. J Plant Res (2007) 1.57
Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy. J Clin Invest (1996) 1.57
Interaction of actin filaments with microtubules. J Cell Biol (1984) 1.56
Models of motor-assisted transport of intracellular particles. Biophys J (2001) 1.55
The 110-kD protein-calmodulin complex of the intestinal microvillus (brush border myosin I) is a mechanoenzyme. J Cell Biol (1989) 1.54
Myosin-I moves actin filaments on a phospholipid substrate: implications for membrane targeting. J Cell Biol (1992) 1.46
Accelerated sliding of pollen tube organelles along Characeae actin bundles regulated by Ca2+. J Cell Biol (1988) 1.36
Characterization of diverse forms of myosin heavy chain expressed in adult human skeletal muscle. Nucleic Acids Res (1986) 1.34
Organelle-cytoskeletal interactions: actin mutations inhibit meiosis-dependent mitochondrial rearrangement in the budding yeast Saccharomyces cerevisiae. Mol Biol Cell (1995) 1.33
Movement of single myosin filaments and myosin step size on an actin filament suspended in solution by a laser trap. Biophys J (1994) 1.33
Artificial Molecular Machines. Chem Rev (2015) 1.31
Site-specific inhibition of myosin-mediated motility in vitro by monoclonal antibodies. J Cell Biol (1985) 1.31
Regulation of desmosome assembly in MDCK epithelial cells: coordination of membrane core and cytoplasmic plaque domain assembly at the plasma membrane. J Cell Biol (1991) 1.28
Role of myosin in terminal web contraction in isolated intestinal epithelial brush borders. J Cell Biol (1985) 1.28
Cytoskeleton and integration of cellular function in cells of higher plants. J Cell Biol (1984) 1.27
Inhibition of acanthamoeba actomyosin-II ATPase activity and mechanochemical function by specific monoclonal antibodies. J Cell Biol (1984) 1.25
A physical model of ATP-induced actin-myosin movement in vitro. Biophys J (1991) 1.25
Characterization of intestinal microvillar membrane disks: detergent-resistant membrane sheets enriched in associated brush border myosin I (110K-calmodulin). J Cell Biol (1989) 1.23
Movement of scallop myosin on Nitella actin filaments: regulation by calcium. Proc Natl Acad Sci U S A (1984) 1.22
A myosin heavy-chain-like polypeptide is associated with the nuclear envelope in higher eukaryotic cells. J Cell Biol (1986) 1.18
Bidirectional transport of fluorescently labeled vesicles introduced into extruded axoplasm of squid Loligo pealei. J Cell Biol (1984) 1.17
Simultaneous recordings of force and sliding movement between a myosin-coated glass microneedle and actin cables in vitro. Proc Natl Acad Sci U S A (1989) 1.13
Microfilament orientation constrains vesicle flow and spatial distribution in growing pollen tubes. Biophys J (2009) 1.13
Steady-state force-velocity relation in the ATP-dependent sliding movement of myosin-coated beads on actin cables in vitro studied with a centrifuge microscope. Proc Natl Acad Sci U S A (1990) 1.11
Direct physical study of kinetochore-microtubule interactions by reconstitution and interrogation with an optical force clamp. Methods (2010) 1.10
Unidirectional sliding of myosin filaments along the bundle of F-actin filaments spontaneously formed during superprecipitation. J Cell Biol (1985) 1.08
Actin filaments mediate Dictyostelium myosin assembly in vitro. Proc Natl Acad Sci U S A (1989) 1.08
Actin cores of hair-cell stereocilia support myosin motility. Proc Natl Acad Sci U S A (1990) 1.07
Coupled myosin VI motors facilitate unidirectional movement on an F-actin network. J Cell Biol (2009) 1.06
Actin and Myosin in pea tendrils. Plant Physiol (1989) 1.02
The sliding filament model: 1972-2004. J Gen Physiol (2004) 0.99
Reactivation of organelle movements along the cytoskeletal framework of a giant freshwater ameba. J Cell Biol (1986) 0.99
Myosin lever arm directs collective motion on cellular actin network. Proc Natl Acad Sci U S A (2014) 0.99
Movement of actin away from the center of reconstituted rabbit myosin filament is slower than in the opposite direction. Biophys J (1993) 0.94
The Qdot-labeled actin super-resolution motility assay measures low-duty cycle muscle myosin step size. Biochemistry (2013) 0.93
Magnetic phagosome motion in J774A.1 macrophages: influence of cytoskeletal drugs. Biophys J (2000) 0.92
Cytoplasmic streaming in plant cells emerges naturally by microfilament self-organization. Proc Natl Acad Sci U S A (2013) 0.92
Single molecule measurements and molecular motors. Philos Trans R Soc Lond B Biol Sci (2008) 0.91
Probing the role of nonmuscle tropomyosin isoforms in intracellular granule movement by microinjection of monoclonal antibodies. J Cell Biol (1989) 0.90
Measurement of work done by ATP-induced sliding between rabbit muscle myosin and algal cell actin cables in vitro. J Physiol (1991) 0.90
Organelle Movements along Actin Filaments and Microtubules. Plant Physiol (1986) 0.89
The distribution of myosin II in Dictyostelium discoideum slug cells. J Cell Biol (1991) 0.87
Characterization and dynamics of cytoplasmic F-actin in higher plant endosperm cells during interphase, mitosis, and cytokinesis. J Cell Biol (1987) 0.86
Neonatal and adult myosin heavy chains form homodimers during avian skeletal muscle development. J Cell Biol (1991) 0.85
An integrated in vitro and in situ study of kinetics of myosin II from frog skeletal muscle. J Physiol (2011) 0.85
Insights into human beta-cardiac myosin function from single molecule and single cell studies. J Cardiovasc Transl Res (2009) 0.85
Link between the enzymatic kinetics and mechanical behavior in an actomyosin motor. Biophys J (2001) 0.84
How lucky can one be? A perspective from a young scientist at the right place at the right time. Nat Med (2012) 0.84
Future challenges in single-molecule fluorescence and laser trap approaches to studies of molecular motors. Dev Cell (2012) 0.83
One path to understanding energy transduction in biological systems. Nat Med (2012) 0.82
Assembly of avian skeletal muscle myosins: evidence that homodimers of the heavy chain subunit are the thermodynamically stable form. J Cell Biol (1991) 0.82
Actin-crosslinking protein regulation of filament movement in motility assays: a theoretical model. Biophys J (1994) 0.81
The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines. Curr Drug Targets Infect Disord (2002) 0.79
Molecular motors: forty years of interdisciplinary research. Mol Biol Cell (2011) 0.79
In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos. Biomed Opt Express (2014) 0.78
Studies on rat parotid-cell actomyosin. Biochem J (1984) 0.77
Use of fluorescent techniques to study the in vitro movement of myosins. EXS (2014) 0.76
Molecules in motion: Michael Sheetz, James Spudich, and Ronald Vale receive the 2012 Albert Lasker Basic Medical Research Award. J Clin Invest (2012) 0.75
Following nature's challenges. Nat Med (2012) 0.75
The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J Biol Chem (1971) 35.39
Identification of a novel force-generating protein, kinesin, involved in microtubule-based motility. Cell (1985) 13.73
Single myosin molecule mechanics: piconewton forces and nanometre steps. Nature (1994) 13.73
Tracking kinesin-driven movements with nanometre-scale precision. Nature (1988) 13.43
Extracellular matrix rigidity causes strengthening of integrin-cytoskeleton linkages. Cell (1997) 10.22
Single particle tracking. Analysis of diffusion and flow in two-dimensional systems. Biophys J (1991) 9.39
Purification of muscle actin. Methods Enzymol (1982) 9.11
Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination. Science (1987) 8.51
Biological membranes as bilayer couples. A molecular mechanism of drug-erythrocyte interactions. Proc Natl Acad Sci U S A (1974) 7.95
Localization of cytoplasmic dynein to mitotic spindles and kinetochores. Nature (1990) 7.33
Myosin-V is a processive actin-based motor. Nature (1999) 7.13
Pilus retraction powers bacterial twitching motility. Nature (2000) 5.69
Fluorescent actin filaments move on myosin fixed to a glass surface. Proc Natl Acad Sci U S A (1986) 5.67
Force of single kinesin molecules measured with optical tweezers. Science (1993) 5.57
Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction. J Supramol Struct (1976) 5.42
Myosin-V stepping kinetics: a molecular model for processivity. Proc Natl Acad Sci U S A (2000) 5.03
Dynactin, a conserved, ubiquitously expressed component of an activator of vesicle motility mediated by cytoplasmic dynein. J Cell Biol (1991) 5.02
Different axoplasmic proteins generate movement in opposite directions along microtubules in vitro. Cell (1985) 4.61
Lateral mobility of integral membrane proteins is increased in spherocytic erythrocytes. Nature (1980) 4.50
A micromachined device provides a new bend on fibroblast traction forces. Proc Natl Acad Sci U S A (1997) 4.50
Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. Cell (2000) 4.45
Myosin structure and function in cell motility. Annu Rev Cell Biol (1987) 4.33
Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination. Annu Rev Biochem (1977) 4.25
Two activators of microtubule-based vesicle transport. J Cell Biol (1991) 4.06
Lateral movements of membrane glycoproteins restricted by dynamic cytoplasmic barriers. Science (1991) 4.05
Cytoplasmic dynein is a minus end-directed motor for membranous organelles. Cell (1989) 4.05
Myosin VI is a processive motor with a large step size. Proc Natl Acad Sci U S A (2001) 3.95
Biochemical and structural studies of actomyosin-like proteins from non-muscle cells. Isolation and characterization of myosin from amoebae of Dictyostelium discoideum. J Mol Biol (1974) 3.91
Organelle, bead, and microtubule translocations promoted by soluble factors from the squid giant axon. Cell (1985) 3.87
Purification of muscle actin. Methods Cell Biol (1982) 3.87
Origin of proteins in sporulation. Annu Rev Biochem (1968) 3.86
Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin. J Mol Biol (1990) 3.80
Quantitative measurements of force and displacement using an optical trap. Biophys J (1996) 3.78
Transcription by single molecules of RNA polymerase observed by light microscopy. Nature (1991) 3.63
The neck region of the myosin motor domain acts as a lever arm to generate movement. Proc Natl Acad Sci U S A (1996) 3.61
Movement of organelles along filaments dissociated from the axoplasm of the squid giant axon. Cell (1985) 3.59
Single microtubules from squid axoplasm support bidirectional movement of organelles. Cell (1985) 3.55
Assays for actin sliding movement over myosin-coated surfaces. Methods Enzymol (1991) 3.53
Membrane tether formation from blebbing cells. Biophys J (1999) 3.47
Myosin subfragment-1 is sufficient to move actin filaments in vitro. Nature (1987) 3.44
Deformation and flow of membrane into tethers extracted from neuronal growth cones. Biophys J (1996) 3.42
Mechanical properties of neuronal growth cone membranes studied by tether formation with laser optical tweezers. Biophys J (1995) 3.39
Integrin-cytoskeletal interactions in migrating fibroblasts are dynamic, asymmetric, and regulated. J Cell Biol (1993) 3.37
Single-molecule biomechanics with optical methods. Science (1999) 3.35
The microtubule-dependent formation of a tubulovesicular network with characteristics of the ER from cultured cell extracts. Cell (1988) 3.34
Forward transport of glycoproteins on leading lamellipodia in locomoting cells. Nature (1989) 3.34
Control of nonmuscle myosins by phosphorylation. Annu Rev Biochem (1992) 3.34
Capping of surface receptors and concomitant cortical tension are generated by conventional myosin. Nature (1989) 3.24
Cell spreading and lamellipodial extension rate is regulated by membrane tension. J Cell Biol (2000) 3.18
Gene replacement in Dictyostelium: generation of myosin null mutants. EMBO J (1989) 3.04
Matrix control of protein diffusion in biological membranes. Proc Natl Acad Sci U S A (1981) 2.96
Effect of sonication on the structure of lecithin bilayers. Biochemistry (1972) 2.94
Characteristics of a membrane reservoir buffering membrane tension. Biophys J (1999) 2.93
Biochemical and structural studies of actomyosin-like proteins from non-muscle cells. II. Purification, properties, and membrane association of actin from amoebae of Dictyostelium discoideum. J Biol Chem (1974) 2.87
Targeting of motor proteins. Science (1996) 2.80
Cytochalasin B, its interaction with actin and actomyosin from muscle (cell movement-microfilaments-rabbit striated muscle). Proc Natl Acad Sci U S A (1972) 2.68
Cytochalasin inhibits the rate of elongation of actin filament fragments. J Cell Biol (1979) 2.67
Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo. Cell (1993) 2.61
Actin microheterogeneity in chick embryo fibroblasts. Proc Natl Acad Sci U S A (1977) 2.57
Calcium control of actin-activated myosin adenosine triphosphatase from Dictyostelium discoideum. Proc Natl Acad Sci U S A (1976) 2.45
Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1. Nature (1993) 2.44
Cell migration does not produce membrane flow. J Cell Biol (1990) 2.42
Selective regulation of integrin--cytoskeleton interactions by the tyrosine kinase Src. Nat Cell Biol (1999) 2.41
Chemical subdomains within the kinetochore domain of isolated CHO mitotic chromosomes. J Cell Biol (1991) 2.40
Ligand binding regulates the directed movement of beta1 integrins on fibroblasts. Nature (1996) 2.40
Biochemical and structural characterization of actin from Dictyostelium discoideum. J Biol Chem (1978) 2.39
Mechanism of action of cytochalasin: evidence that it binds to actin filament ends. J Cell Biol (1981) 2.36
Regulation of myosin self-assembly: phosphorylation of Dictyostelium heavy chain inhibits formation of thick filaments. Proc Natl Acad Sci U S A (1980) 2.35
Pyk2 regulates multiple signaling events crucial for macrophage morphology and migration. Proc Natl Acad Sci U S A (2003) 2.34
Truncation mutants define and locate cytoplasmic barriers to lateral mobility of membrane glycoproteins. Proc Natl Acad Sci U S A (1994) 2.32
Quantized velocities at low myosin densities in an in vitro motility assay. Nature (1991) 2.28
Modulation of membrane protein lateral mobility by polyphosphates and polyamines. Proc Natl Acad Sci U S A (1980) 2.27
The role of kinesin and other soluble factors in organelle movement along microtubules. J Cell Biol (1988) 2.27
On the production of deletions in the chromosome of Escherichia coli. J Mol Biol (1970) 2.26
Forces on adhesive contacts affect cell function. Curr Opin Cell Biol (1998) 2.26
Biochemical studies of bacterial sporulation and germaination. VII. Protein turnover during sporulation of Bacillus subtilis. J Biol Chem (1968) 2.26
Membrane damage caused by irradiation of fluorescent concanavalin A. Proc Natl Acad Sci U S A (1979) 2.21
On the mechanism of ATP-induced shape changes in human erythrocyte membranes. I. The role of the spectrin complex. J Cell Biol (1977) 2.20
Visualization of actin fibers associated with the cell membrane in amoebae of Dictyostelium discoideum. Proc Natl Acad Sci U S A (1975) 2.19
Membrane tension in swelling and shrinking molluscan neurons. J Neurosci (1998) 2.18
Regulation of skeletal muscle contraction. II. Structural studies of the interaction of the tropomyosin-troponin complex with actin. J Mol Biol (1972) 2.17
Membrane skeletal dynamics: role in modulation of red cell deformability, mobility of transmembrane proteins, and shape. Semin Hematol (1983) 2.17
Functions of microtubule-based motors. Annu Rev Physiol (1991) 2.13
Structure and function of the cytoskeleton of a Dictyostelium myosin-defective mutant. J Cell Biol (1990) 2.12
Single cytoplasmic dynein molecule movements: characterization and comparison with kinesin. Biophys J (1995) 2.11
Role of highly conserved lysine 130 of myosin motor domain. In vivo and in vitro characterization of site specifically mutated myosin. J Biol Chem (1994) 2.11
Myosin dynamics in live Dictyostelium cells. Proc Natl Acad Sci U S A (1996) 2.10
Mechanism of K+-induced actin assembly. J Cell Biol (1982) 2.08
Biochemical studies of bacterial sporulation and germination. VI. Origin of spore core and coat proteins. J Biol Chem (1968) 2.06
Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum. Proc Natl Acad Sci U S A (1986) 2.05
In vitro assays of processive myosin motors. Methods (2000) 2.03
Integral membrane protein interaction with Triton cytoskeletons of erythrocytes. Biochim Biophys Acta (1979) 2.00
Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. J Cell Biol (1996) 1.98
Towards a molecular understanding of cytokinesis. Trends Cell Biol (2000) 1.98
Chemoattractant-elicited increases in myosin phosphorylation in Dictyostelium. Cell (1985) 1.93
Characterization of the microtubule movement produced by sea urchin egg kinesin. J Biol Chem (1987) 1.92
On the role of myosin-II in cytokinesis: division of Dictyostelium cells under adhesive and nonadhesive conditions. Mol Biol Cell (1997) 1.91
Biochemical studies of bacterial sporulation and germination. XII. A sulfonic acid as a major sulfur compound of Bacillus subtilis spores. J Bacteriol (1969) 1.89
Myosin I contributes to the generation of resting cortical tension. Biophys J (1999) 1.88
Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences. Proc Natl Acad Sci U S A (1993) 1.88