Published in Life Sci on July 11, 1983
Developmental studies of phospholipid-sensitive Ca2+-dependent protein kinase and its substrates and of phosphoprotein phosphatases in rat brain. Proc Natl Acad Sci U S A (1984) 0.83
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet (1996) 26.06
Cyclic nucleotide-dependent protein kinases. IV. Widespread occurrence of adenosine 3',5'-monophosphate-dependent protein kinase in various tissues and phyla of the animal kingdom. Proc Natl Acad Sci U S A (1969) 6.02
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Treatment of advanced Parkinson's disease by posterior GPi pallidotomy: 1-year results of a pilot study. Ann Neurol (1996) 3.45
Role of the posterior parietal cortex in updating reaching movements to a visual target. Nat Neurosci (1999) 3.39
HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A (1998) 3.35
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A (1998) 3.23
Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine. Proc Natl Acad Sci U S A (1980) 3.08
Cyclic nucleotide-dependent protein kinases. VI. Isolation and partial purification of a protein kinase activated by guanosine 3',5'-monophosphate. J Biol Chem (1970) 2.89
Functional activation of the T-cell antigen receptor induces tyrosine phosphorylation of phospholipase C-gamma 1. Proc Natl Acad Sci U S A (1991) 2.88
An adenosine 3',5'-monophosphate-dependent protein kinase from Escherichia coli. J Biol Chem (1969) 2.86
The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression. J Biol Chem (1997) 2.62
Cyclic nucleotide-dependent protein kinases. X. An assay method for the measurement of quanosine 3',5'-monophosphate in various biological materials and a study of agents regulating its levels in heart and brain. J Biol Chem (1972) 2.35
Potentiation of epidermal growth factor receptor-mediated oncogenesis by c-Src: implications for the etiology of multiple human cancers. Proc Natl Acad Sci U S A (1995) 2.29
Growth factor-stimulated protein phosphorylation in 3T3-L1 cells. Evidence for protein kinase C-dependent and -independent pathways. J Biol Chem (1985) 2.24
Normalizing motor-related brain activity: subthalamic nucleus stimulation in Parkinson disease. Neurology (2006) 2.05
Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci U S A (1997) 2.03
Spontaneous intracranial hypotension causing reversible frontotemporal dementia. Neurology (2002) 1.89
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. I. Purification and general properties. J Biol Chem (1982) 1.88
Phospholipid-sensitive Ca2+-dependent protein kinase from heart. II. Substrate specificity and inhibition by various agents. J Biol Chem (1982) 1.83
Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting. J Biol Chem (1998) 1.83
A 1.1-Mb transcript map of the hereditary hemochromatosis locus. Genome Res (1997) 1.71
N-terminal methionine-specific peptidase in Salmonella typhimurium. Proc Natl Acad Sci U S A (1987) 1.66
Role of muscarinic cholinergic receptors in regulation of guanosine 3':5'-cyclic monophosphate content in mammalian brain, heart muscle, and intestinal smooth muscle. Proc Natl Acad Sci U S A (1972) 1.66
Phospholipid-sensitive calcium-dependent protein kinase: inhibition by antipsychotic drugs. Biochem Biophys Res Commun (1981) 1.65
Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1. J Biol Chem (1995) 1.64
Adenosine 3',5'-monophosphate-dependent protein kinase from brain. Science (1968) 1.64
Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract. Proc Natl Acad Sci U S A (1997) 1.61
A comparison of the effects of lipolytic and antilipolytic agents on adenosine 3',5'-monophosphate levels in adipose cells as determined by prior labeling with adenine-8-14C. J Biol Chem (1969) 1.56
Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem (1996) 1.49
Adenylate cyclase in islets of Langerhans. Isolation of islets and regulation of adenylate cyclase activity by various hormones and agents. J Biol Chem (1973) 1.45
The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion. J Biol Chem (1998) 1.45
Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci U S A (1993) 1.42
Efficacy of ganciclovir in combination with zidovudine against cytomegalovirus in vitro and in vivo. Antiviral Res (1993) 1.38
Regulation of protein kinase C by lysophospholipids. Potential role in signal transduction. J Biol Chem (1988) 1.38
Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase. Biochem Biophys Res Commun (1982) 1.37
Protein kinases 1988: a current perspective. FASEB J (1988) 1.36
Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites. J Biol Chem (1989) 1.34
Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex. J Biol Chem (1980) 1.32
Tyrosine phosphorylation of phospholipase C-gamma 2 upon cross-linking of membrane Ig on murine B lymphocytes. J Immunol (1992) 1.30
Purification to homogeneity, characterization and monoclonal antibodies of phospholipid-sensitive Ca2+-dependent protein kinase from spleen. Biochem J (1983) 1.27
Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens. J Biol Chem (1987) 1.27
Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. J Biol Chem (1993) 1.26
Guanosine 3':5'-monophosphate-dependent protein kinases in mammalian tissues. Proc Natl Acad Sci U S A (1974) 1.24
Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2. Biochem J (1993) 1.24
Phosphorylation of cardiac troponin inhibitory subunit (troponin I) and tropomyosin-binding subunit (troponin T) by cardiac phospholipid-sensitive Ca2+-dependent protein kinase. Biochem J (1983) 1.24
Cyclic nucleotide-dependent protein kinases. V. Preparation and properties of adenosine 3',5'-monophosphate-dependent protein kinase from various bovine tissues. Biochim Biophys Acta (1970) 1.23
Molecular analysis of the X11-mLin-2/CASK complex in brain. J Neurosci (1999) 1.22
Protein kinase C phosphorylation of cardiac troponin I or troponin T inhibits Ca2(+)-stimulated actomyosin MgATPase activity. J Biol Chem (1991) 1.22
X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J Biol Chem (1998) 1.21
Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry (1996) 1.20
Insulin-like activity of a microbial protease on isolated fat cells. Arch Biochem Biophys (1966) 1.19
Regulation of myocardial cyclic AMP by isoproterenol, glucagon and acetylcholine. Biochem Biophys Res Commun (1971) 1.18
Cyclic nucleotide-dependent protein kinases. 8. An assay method for the measurement of adenosine 3',5'-monophosphate in various tissues and a study of agents influencing its level in adipose cells. J Biol Chem (1970) 1.16
Changes in relative levels of guanosine-3':5'-monophosphate-dependent and adenosine-3':5'-monophosphate-dependent protein kinases in lung, heart, and brain of developing guinea pigs. Proc Natl Acad Sci U S A (1975) 1.16
The chaperone BiP/GRP78 binds to amyloid precursor protein and decreases Abeta40 and Abeta42 secretion. J Biol Chem (1998) 1.16
Phospholipid-sensitive Ca2+-dependent protein kinase and its substrates in human neutrophils. Biochem Biophys Res Commun (1983) 1.15
Polyclonal antibodies to phospholipid/Ca2+-dependent protein kinase and immunocytochemical localization of the enzyme in rat brain. Proc Natl Acad Sci U S A (1985) 1.13
Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines. Neuroscience (2010) 1.11
Dissociation and activation of adenosine 3',5'-monophosphate-dependent and guanosine 3',5'-monophosphate-dependent protein kinases by cyclic nucleotides and by substrate proteins. J Biol Chem (1973) 1.10
An assay method for cyclic AMP and cyclic GMP based upon their abilities to activate cyclic AMP-dependent and cyclic GMP-dependent protein kinases. Adv Cyclic Nucleotide Res (1972) 1.09
Involvement of a carbohydrate group in the active site for surface guided reassociation of animal cells. Nature (1973) 1.09
Polyamines inhibit phospholipid-sensitive and calmodulin-sensitive Ca2+-dependent protein kinases. Biochem J (1983) 1.08
Carmabins A and B, new lipopeptides from the Caribbean cyanobacterium Lyngbya majuscula. J Nat Prod (1998) 1.08
Identification of specific sites in human P-glycoprotein phosphorylated by protein kinase C. J Biol Chem (1993) 1.07
Temporal changes in intracellular distribution of protein kinase C during differentiation of human leukemia HL60 cells induced by phorbol ester. FEBS Lett (1988) 1.07
Substrate proteins for calmodulin-sensitive and phospholipid-sensitive Ca2+-dependent protein kinases in heart, and inhibition of their phosphorylation by palmitoylcarnitine. Proc Natl Acad Sci U S A (1981) 1.06
On-line motor control in patients with Parkinson's disease. Brain (2004) 1.05
Effect of tamoxifen, a nonsteroidal antiestrogen, on phospholipid/calcium-dependent protein kinase and phosphorylation of its endogenous substrate proteins from the rat brain and ovary. Biochem Pharmacol (1985) 1.05
Testing basal ganglia motor functions through reversible inactivations in the posterior internal globus pallidus. J Neurophysiol (2007) 1.05
Large scale transient expression with COS cells. Cytotechnology (1995) 1.05
Purification and characterization of guanosine 3':5'-monophosphate-specific phosphodiesterase from guinea pig lung. J Biol Chem (1977) 1.04
Modulation of amyloid precursor protein metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains. J Biol Chem (2000) 1.03
Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart. J Biol Chem (1986) 1.03
Inhibition of protein kinase C by defensins, antibiotic peptides from human neutrophils. Biochem Pharmacol (1988) 1.02