Published in J Biol Chem on May 30, 1997
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab (2009) 3.78
HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A (1998) 3.35
The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci U S A (1998) 3.23
Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci U S A (1997) 2.06
Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc Natl Acad Sci U S A (1997) 2.03
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Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum. Proc Natl Acad Sci U S A (1999) 1.60
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Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. Blood (2010) 1.03
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Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci U S A (2002) 1.01
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Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci U S A (2002) 0.93
Increased susceptibility to Mycobacterium avium in hemochromatosis protein HFE-deficient mice. Infect Immun (2008) 0.92
The 16189 variant of mitochondrial DNA occurs more frequently in C282Y homozygotes with haemochromatosis than those without iron loading. J Med Genet (2004) 0.91
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HFE H63D mutation frequency shows an increase in Turkish women with breast cancer. BMC Cancer (2006) 0.87
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The haemochromatosis protein HFE induces an apparent iron-deficient phenotype in H1299 cells that is not corrected by co-expression of beta 2-microglobulin. Biochem J (2003) 0.85
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An association study of HFE gene mutation with idiopathic male infertility in the Chinese Han population. Asian J Androl (2012) 0.78
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The Q283P amino-acid change in HFE leads to structural and functional consequences similar to those described for the mutated 282Y HFE protein. Hum Genet (2005) 0.77
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C282Y-HFE gene variant affects cholesterol metabolism in human neuroblastoma cells. PLoS One (2014) 0.76
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Targeted disruption of the HFE gene. Proc Natl Acad Sci U S A (1998) 0.76
Association Studies of HFE C282Y and H63D Variants with Oral Cancer Risk and Iron Homeostasis Among Whites and Blacks. Cancers (Basel) (2015) 0.75
HFE Variants and the Expression of Iron-Related Proteins in Breast Cancer-Associated Lymphocytes and Macrophages. Cancer Microenviron (2016) 0.75
The role of MHC class Ib-restricted T cells during infection. Immunogenetics (2016) 0.75
Analysis of single nucleotide variants of HFE gene and association to survival in The Cancer Genome Atlas GBM data. PLoS One (2017) 0.75
Effects of strain and age on hepatic gene expression profiles in murine models of HFE-associated hereditary hemochromatosis. Genes Nutr (2014) 0.75
The hemochromatosis protein HFE 20 years later: An emerging role in antigen presentation and in the immune system. Immun Inflamm Dis (2017) 0.75
The Effects of HFE Polymorphisms on Biochemical Parameters of Iron Status in Arab Beta-Thalassemia Patients. Indian J Hematol Blood Transfus (2017) 0.75
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