Published in J Cereb Blood Flow Metab on March 01, 1983
Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clin Cancer Res (2010) 3.35
Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc Natl Acad Sci U S A (2004) 1.97
Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Brain Behav Immun (2009) 1.41
Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model. Neoplasia (2007) 1.33
Lipopolysaccharide alters the blood-brain barrier transport of amyloid beta protein: a mechanism for inflammation in the progression of Alzheimer's disease. Brain Behav Immun (2009) 1.32
Early beneficial effect of matrix metalloproteinase inhibition on blood-brain barrier permeability as measured by magnetic resonance imaging countered by impaired long-term recovery after stroke in rat brain. J Cereb Blood Flow Metab (2007) 1.30
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1999) 1.26
Polypeptide point modifications with fatty acid and amphiphilic block copolymers for enhanced brain delivery. Bioconjug Chem (2005) 1.26
Dynamic-contrast-enhanced-MRI with extravasating contrast reagent: rat cerebral glioma blood volume determination. J Magn Reson (2010) 1.23
Transcytosis of macromolecules through the blood-brain barrier: a cell biological perspective and critical appraisal. Acta Neuropathol (1989) 1.19
Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor. Proc Natl Acad Sci U S A (2007) 1.18
Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition. J Alzheimers Dis (2009) 1.17
Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment. Exp Neurol (2007) 1.16
Transport of human immunodeficiency virus type 1 pseudoviruses across the blood-brain barrier: role of envelope proteins and adsorptive endocytosis. J Virol (2001) 1.04
Transport across the blood-brain barrier of pluronic leptin. J Pharmacol Exp Ther (2010) 1.01
Nitric oxide isoenzymes regulate lipopolysaccharide-enhanced insulin transport across the blood-brain barrier. Endocrinology (2008) 1.01
Decreased blood-brain barrier permeability to fluorescein in streptozotocin-treated rats. Neurosci Lett (2006) 1.00
Transport of prion protein across the blood-brain barrier. Exp Neurol (2009) 0.95
How to measure drug transport across the blood-brain barrier. NeuroRx (2005) 0.93
Nociceptive inhibition prevents inflammatory pain induced changes in the blood-brain barrier. Brain Res (2008) 0.93
Antagonists of growth hormone-releasing hormone cross the blood-brain barrier: a potential applicability to treatment of brain tumors. Proc Natl Acad Sci U S A (2005) 0.92
Impact of L-DOPA treatment on regional cerebral blood flow and metabolism in the basal ganglia in a rat model of Parkinson's disease. Neuroimage (2012) 0.91
Permeability of the murine blood-brain barrier to some octapeptide analogs of somatostatin. Proc Natl Acad Sci U S A (1990) 0.91
P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier. Antimicrob Agents Chemother (1998) 0.90
Tracer kinetic model of blood-brain barrier transport of plasma protein-bound ligands. Empiric testing of the free hormone hypothesis. J Clin Invest (1984) 0.90
In vitro blood-brain barrier models using brain capillary endothelial cells isolated from neonatal and adult rats retain age-related barrier properties. PLoS One (2013) 0.89
Rapid transport of CCL11 across the blood-brain barrier: regional variation and importance of blood cells. J Pharmacol Exp Ther (2014) 0.87
Multiparametric magnetic resonance imaging and repeated measurements of blood-brain barrier permeability to contrast agents. Methods Mol Biol (2011) 0.86
A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration. J Pharmacol Exp Ther (2010) 0.86
Cerebral energy metabolism and microdialysis in neurocritical care. Childs Nerv Syst (2010) 0.84
Bacterial melanin crosses the blood-brain barrier in rat experimental model. Fluids Barriers CNS (2014) 0.83
Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia. Neurobiol Dis (2014) 0.82
Alpha synuclein is transported into and out of the brain by the blood-brain barrier. Peptides (2014) 0.81
Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity. J Control Release (2014) 0.81
Transport of an antifungal trypsin inhibitor isolated from corn across the blood-brain barrier. Antimicrob Agents Chemother (2002) 0.80
Permeability of the blood-brain barrier to a rhenacarborane. J Pharmacol Exp Ther (2009) 0.80
Quantitative Fluorescent Microscopy to Measure Vascular Pore Sizes in Primary and Metastatic Brain Tumors. Cancer Res (2016) 0.80
Water exchange-minimizing DCE-MRI protocol to detect changes in tumor vascular parameters: effect of bevacizumab/paclitaxel combination therapy. MAGMA (2013) 0.80
Agile delivery of protein therapeutics to CNS. J Control Release (2014) 0.79
The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model. Magn Reson Med (2011) 0.79
Quantitative fluorescence microscopy provides high resolution imaging of passive diffusion and P-gp mediated efflux at the in vivo blood-brain barrier. J Neurosci Methods (2013) 0.79
Protective effects of an anti-melanocortin-4 receptor scFv derivative in lipopolysaccharide-induced cachexia in rats. J Cachexia Sarcopenia Muscle (2012) 0.79
The quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher. Fluids Barriers CNS (2015) 0.77
A Basic ApoE-Based Peptide Mediator to Deliver Proteins across the Blood-Brain Barrier: Long-Term Efficacy, Toxicity, and Mechanism. Mol Ther (2017) 0.77
Sleep fragmentation and sepsis differentially impact blood-brain barrier integrity and transport of tumor necrosis factor-α in aging. Brain Behav Immun (2015) 0.76
Nano-particle delivery of brain derived neurotrophic factor after focal cerebral ischemia reduces tissue injury and enhances behavioral recovery. Pharmacol Biochem Behav (2016) 0.75
Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier. PLoS One (2015) 0.75
Experimental intracerebral haemorrhage: the effect of nimodipine pretreatment. J Neurol Neurosurg Psychiatry (1988) 0.75
Peritumoral tissue compression is predictive of exudate flux in a rat model of cerebral tumor: an MRI study in an embedded tumor. NMR Biomed (2015) 0.75
Transmission of α-synuclein-containing erythrocyte-derived extracellular vesicles across the blood-brain barrier via adsorptive mediated transcytosis: another mechanism for initiation and progression of Parkinson's disease? Acta Neuropathol Commun (2017) 0.75
Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis. FASEB J (2017) 0.75
The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem (1977) 11.55
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab (1983) 9.59
Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab (1985) 5.99
The flow of solute and solvent across a two-membrane system. J Theor Biol (1963) 4.70
Comparison of bolus and infusion methods for receptor quantitation: application to [18F]cyclofoxy and positron emission tomography. J Cereb Blood Flow Metab (1993) 2.28
Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy. Cancer Res (1996) 2.22
Imaging the expression of transfected genes in vivo. Cancer Res (1995) 2.05
Fate of cerebrospinal fluid-borne amyloid beta-peptide: rapid clearance into blood and appreciable accumulation by cerebral arteries. J Neurochem (1996) 1.96
Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke (2000) 1.77
Intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion. J Pharmacol Exp Ther (1975) 1.63
Efflux of radiolabeled polyethylene glycols and albumin from rat brain. Am J Physiol (1981) 1.62
Drainage of interstitial fluid from different regions of rat brain. Am J Physiol (1984) 1.58
Measurements of dog blood-brain transfer constants by ventriculocisternal perfusion. Am J Physiol (1975) 1.56
Striatal 18F-dopa uptake: absence of an aging effect. J Cereb Blood Flow Metab (1993) 1.52
Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology. Stroke (2000) 1.52
Local cerebral glucose utilization in controlled graded levels of hyperglycemia in the conscious rat. J Cereb Blood Flow Metab (1988) 1.49
Effects of postnatal dexamethasone on blood-brain barrier permeability and brain water content in newborn lambs. Am J Physiol Regul Integr Comp Physiol (2001) 1.44
Characteristics of p-aminohippurate transport in proximal renal tubules. Am J Physiol (1969) 1.43
Specificity of cerebral amino acid transport: a kinetic analysis. Prog Brain Res (1968) 1.38
Filtration and reflection coefficients of the rabbit blood-brain barrier. Am J Physiol (1966) 1.33
Sucrose and inulin space measurements of cerebral cortex in four mammalian species. Am J Physiol (1970) 1.32
Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats. Ann Neurol (2000) 1.27
Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A (1999) 1.26
Midazolam changes cerebral blood flow in discrete brain regions: an H2(15)O positron emission tomography study. Anesthesiology (1997) 1.25
A general approach to the non-invasive imaging of transgenes using cis-linked herpes simplex virus thymidine kinase. Neoplasia (1999) 1.25
Imaging adenoviral-mediated herpes virus thymidine kinase gene transfer and expression in vivo. Cancer Res (1999) 1.24
Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol (1991) 1.23
Tumor-specific transcriptional targeting of suicide gene therapy. Gene Ther (2002) 1.16
A method to obtain infusion schedules for prescribed blood concentration time courses. J Appl Physiol (1976) 1.15
Cerebrospinal fluid production by the choroid plexus and brain. Science (1971) 1.14
A component of fluid absorption linked to passive ion flows in the superficial pars recta. J Gen Physiol (1975) 1.13
Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res (2001) 1.12
Ontogeny of blood-brain barrier function in ovine fetuses, lambs, and adults. Am J Physiol (1996) 1.11
Rapid distribution of intraventricularly administered sucrose into cerebrospinal fluid cisterns via subarachnoid velae in rat. Neuroscience (1996) 1.11
Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. J Physiol (1991) 1.10
Theoretical analysis of net tracer flux due to volume circulation in a membrane with pores of different sizes. Relation to solute drag model. J Gen Physiol (1971) 1.10
Mutant herpes simplex virus induced regression of tumors growing in immunocompetent rats. J Neurooncol (1994) 1.09
Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction. Childs Brain (1976) 1.07
Quantification and pharmacokinetics of blood-brain barrier disruption in humans. J Neurosurg (1996) 1.06
An evaluation of errors in the determination of blood flow by the indicator fractionation and tissue equilibration (Kety) methods. J Cereb Blood Flow Metab (1984) 1.05
Volume absorption in the pars recta. II. Hydraulic conductivity coefficient. Am J Physiol (1978) 1.03
Monoclonal antibody localization in subcutaneous and intracranial human glioma xenografts: paired-label and imaging analysis. Anticancer Res (1984) 1.03
Quantitative autoradiographic studies of brain edema and a comparison of multi-isotope autoradiographic techniques. Adv Neurol (1980) 1.03
Nigrostriatal function in humans studied with positron emission tomography. Ann Neurol (1989) 1.03
Regional measurements of blood flow in experimental RG-2 rat gliomas. Cancer Res (1983) 1.01
Volume regulatory loss of Na, Cl, and K from rat brain during acute hyponatremia. Am J Physiol (1987) 1.00
Transport of material between brain extracellular fluid, brain cells and blood. Fed Proc (1974) 1.00
Methods for Quantifying the transport of drugs across brain barrier systems. Pharmacol Ther (1981) 0.99
A critical evaluation of the principles governing the advantages of intra-arterial infusions. J Pharmacokinet Biopharm (1974) 0.98
Regional measurements of blood-to-tissue transport in experimental RG-2 rat gliomas. Cancer Res (1983) 0.97
Selection of experimental conditions for the accurate determination of blood--brain transfer constants from single-time experiments: a theoretical analysis. J Cereb Blood Flow Metab (1983) 0.97
Extracellular space of the cerebral cortex of normothermic and hypothermic cats. Exp Neurol (1970) 0.96
Convection of cerebral interstitial fluid and its role in brain volume regulation. Ann N Y Acad Sci (1986) 0.95
Increased blood-brain transfer in a rabbit model of acute liver failure. Gastroenterology (1983) 0.95
Volume regulatory influx of electrolytes from plasma to brain during acute hyperosmolality. Am J Physiol (1987) 0.94
Regional blood flow in RT-9 brain tumors. J Neurosurg (1983) 0.94
Antenatal steroids decrease blood-brain barrier permeability in the ovine fetus. Am J Physiol (1999) 0.94
Effect of intravascular-to-extravascular water exchange on the determination of blood-to-tissue transfer constant by magnetic resonance imaging. Magn Reson Med (2005) 0.93
Chemotherapy of brain tumors: physiological and pharmacokinetic considerations. Semin Oncol (1986) 0.93
Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imaging. AJNR Am J Neuroradiol (2010) 0.93
Dexamethasone effects on [125I]albumin distribution in experimental RG-2 gliomas and adjacent brain. J Cereb Blood Flow Metab (1987) 0.93
Regional variations in the apparent diffusion coefficient and the intracellular distribution of water in rat brain during acute focal ischemia. Stroke (2001) 0.93
Susceptibility changes following bolus injections. Magn Reson Med (1993) 0.93
Fluid absorption and active and passive ion flows in the rabbit superficial pars recta. Am J Physiol (1977) 0.91
Intravascular streaming during carotid artery infusions. Demonstration in humans and reduction using diastole-phased pulsatile administration. J Neurosurg (1991) 0.91
Differences in function and structure of the capillary endothelium in gray matter, white matter and a circumventricular organ of rat brain. Blood Vessels (1986) 0.91
Topography of capillary density, glucose metabolism, and microvascular function within the rat inferior colliculus. J Cereb Blood Flow Metab (1987) 0.91
Local cerebral blood flow during the first hour following acute ligation of multiple arterioles in rat whisker barrel cortex. Neurobiol Dis (1998) 0.91
Drug streaming during intra-arterial chemotherapy. J Neurosurg (1986) 0.91
Peritoneal absorption of macromolecules studied by quantitative autoradiography. Am J Physiol (1985) 0.90
Osmosis in cortical collecting tubules. A theoretical and experimental analysis of the osmotic transient phenomenon. J Gen Physiol (1974) 0.89
Quantitative evaluation of the loss of human platelet dense bodies following stimulation by thrombin or A23187. J Physiol (1977) 0.89
Local blood-to-tissue transport in Walker 256 metastatic brain tumors. J Neurooncol (1984) 0.89
Regulation of brain water and electrolytes during acute hyperosmolality in rats. Am J Physiol (1987) 0.88