Published in J Neurophysiol on March 01, 1983
TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J (1997) 3.60
Proton-induced transformation of calcium channel in chick dorsal root ganglion cells. J Physiol (1987) 1.80
Pharmacological properties and H+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurones. J Physiol (1991) 1.60
Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab (1987) 1.47
Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol (1990) 1.46
Simultaneous imaging of cerebral partial pressure of oxygen and blood flow during functional activation and cortical spreading depression. Appl Opt (2009) 1.41
Carbonic anhydrase IV and XIV knockout mice: roles of the respective carbonic anhydrases in buffering the extracellular space in brain. Proc Natl Acad Sci U S A (2005) 1.33
Intracellular pH of astrocytes increases rapidly with cortical stimulation. Am J Physiol (1987) 1.33
Carbonic acid buffer changes during complete brain ischemia. Am J Physiol (1986) 1.32
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci U S A (2009) 1.31
Intracellular pH transients of mammalian astrocytes. J Neurosci (1989) 1.24
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol (2002) 1.24
Regulation of intracellular pH in reticulospinal neurones of the lamprey, Petromyzon marinus. J Physiol (1986) 1.24
An intracellular analysis of gamma-aminobutyric-acid-associated ion movements in rat sympathetic neurones. J Physiol (1985) 1.23
The regulation of intracellular pH by identified glial cells and neurones in the central nervous system of the leech. J Physiol (1987) 1.20
Hydrogen ion buffering during complete brain ischemia. Brain Res (1985) 1.20
pH transients evoked by excitatory synaptic transmission are increased by inhibition of extracellular carbonic anhydrase. Proc Natl Acad Sci U S A (1992) 1.20
Proton sensitivity of the GABA(A) receptor is associated with the receptor subunit composition. J Physiol (1996) 1.16
Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia. Prog Brain Res (1985) 1.15
Ionic control of intracellular pH in rat cerebellar Purkinje cells maintained in culture. J Physiol (1990) 1.10
Intracellular pH regulation in cultured mouse oligodendrocytes. J Physiol (1988) 1.09
Electrically evoked dendritic pH transients in rat cerebellar Purkinje cells. J Physiol (2002) 1.09
The effect of external pH changes on responses to excitatory amino acids in mouse hippocampal neurones. J Physiol (1990) 1.05
Extracellular pH in the isolated retina of the toad in darkness and during illumination. J Physiol (1989) 1.04
Synaptic acidification enhances GABAA signaling. J Neurosci (2010) 1.02
Changes in the surface pH of voltage-clamped snail neurones apparently caused by H+ fluxes through a channel. J Physiol (1988) 1.01
Spreading Depression, Spreading Depolarizations, and the Cerebral Vasculature. Physiol Rev (2015) 0.99
δ ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol (2012) 0.98
Rapid rise of extracellular pH evoked by neural activity is generated by the plasma membrane calcium ATPase. J Neurophysiol (2009) 0.96
Mechanism of action of GABA on intracellular pH and on surface pH in crayfish muscle fibres. J Physiol (1990) 0.96
Mapping brain glucose uptake with chemical exchange-sensitive spin-lock magnetic resonance imaging. J Cereb Blood Flow Metab (2014) 0.95
Bicarbonate and ammonia changes in brain during spreading depression. Can J Physiol Pharmacol (1987) 0.95
Alkalinization in the isolated and perfused anterior midgut of the larval mosquito, Aedes aegypti. J Insect Sci (2008) 0.94
Modification of activity-dependent increases in cerebellar blood flow by extracellular potassium in anaesthetized rats. J Physiol (1999) 0.92
Acid-induced changes of brain protein buffering. Brain Res (1987) 0.92
Proton-induced sodium current in freshly dissociated hypothalamic neurones of the rat. J Physiol (1992) 0.90
Modulation of a sustained calcium current by intracellular pH in horizontal cells of fish retina. J Gen Physiol (1993) 0.87
Electrophysiological properties of rat CA1 pyramidal neurones in vitro modified by changes in extracellular bicarbonate. J Physiol (1989) 0.87
Arterially perfused neurosphere-derived cells distribute outside the ischemic core in a model of transient focal ischemia and reperfusion in vitro. PLoS One (2008) 0.84
Upregulation of the hyperpolarization-activated cation current in rat thalamic relay neurones by acetazolamide. J Physiol (1999) 0.84
Loss of Acid sensing ion channel-1a and bicarbonate administration attenuate the severity of traumatic brain injury. PLoS One (2013) 0.84
Acidosis and blockade of orthodromic responses caused by anoxia in rat hippocampal slices at different temperatures. J Physiol (1990) 0.84
A circadian clock regulates the pH of the fish retina. J Physiol (2000) 0.83
Determination of extracellular bicarbonate and carbon dioxide concentrations in brain slices using carbonate and pH-selective microelectrodes. J Neurosci Methods (1994) 0.82
Modulation of neuronal voltage-activated calcium and sodium channels by polyamines and pH. Channels (Austin) (2007) 0.82
A steady-state model of spreading depression predicts the importance of an unknown conductance in specific dendritic domains. Biophys J (2007) 0.81
Extracellular alkalinization evoked by GABA and its relationship to activity-dependent pH shifts in turtle cerebellum. J Physiol (1991) 0.81
The Molecular Mechanisms of Neural Flow Coupling: A New Concept. J Neuroimaging (2015) 0.80
In vivo measurement of regional brain and tumor pH using [14C]dimethyloxazolidinedione and quantitative autoradiography. II: Characterization of the extracellular fluid compartment using pH-sensitive microelectrodes and [14C]sucrose. J Cereb Blood Flow Metab (1986) 0.78
Extracellular acidic pH inhibits oligodendrocyte precursor viability, migration, and differentiation. PLoS One (2013) 0.78
Commentary: The Spinal Cord Has an Intrinsic System for the Control of pH. Front Physiol (2016) 0.75
Monitoring ion activities in and around cells using ion-selective liquid-membrane microelectrodes. Sensors (Basel) (2013) 0.75
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19. Br J Pharmacol (2016) 0.75
Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. J Physiol (1981) 4.05
Bedout: a possible end-Permian impact crater offshore of northwestern Australia. Science (2004) 3.65
Electrophysiological properties of dendrites and somata in alligator Purkinje cells. J Neurophysiol (1971) 3.27
Theory of current source-density analysis and determination of conductivity tensor for anuran cerebellum. J Neurophysiol (1975) 2.72
The emerging epidemic of skin cancer. Br J Dermatol (1994) 2.53
Calcium role in depolarization-secretion coupling: an aequorin study in squid giant synapse. Proc Natl Acad Sci U S A (1975) 2.40
Modulation by applied electric fields of Purkinje and stellate cell activity in the isolated turtle cerebellum. J Physiol (1986) 2.00
Calcium and potassium changes in extracellular microenvironment of cat cerebellar cortex. J Neurophysiol (1978) 1.98
Diffusion from an injected volume of a substance in brain tissue with arbitrary volume fraction and tortuosity. Brain Res (1985) 1.97
Characterization of inducible cyclooxygenase in rat brain. J Comp Neurol (1995) 1.94
Mothers' reports of childhood vaccinations and infections and their concordance with general practitioner records. J Public Health Med (1991) 1.87
Calcium transient in presynaptic terminal of squid giant synapse: detection with aequorin. Science (1972) 1.86
Experimental optimization of current source-density technique for anuran cerebellum. J Neurophysiol (1975) 1.81
A model for the polarization of neurons by extrinsically applied electric fields. Biophys J (1986) 1.75
Effects of electric fields on transmembrane potential and excitability of turtle cerebellar Purkinje cells in vitro. J Physiol (1988) 1.75
Field potentials in the alligator cerebellum and theory of their relationship to Purkinje cell dendritic spikes. J Neurophysiol (1971) 1.71
Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge. Proc Natl Acad Sci U S A (2000) 1.69
Neocortical spreading depression provokes the expression of c-fos protein-like immunoreactivity within trigeminal nucleus caudalis via trigeminovascular mechanisms. J Neurosci (1993) 1.50
Magnetic localization of neuronal activity in the human brain. Proc Natl Acad Sci U S A (1988) 1.48
Hydrogen ions kill brain at concentrations reached in ischemia. J Cereb Blood Flow Metab (1987) 1.47
Maximum geometrical hindrance to diffusion in brain extracellular space surrounding uniformly spaced convex cells. J Theor Biol (2004) 1.45
Calcium modulation in brain extracellular microenvironment demonstrated with ion-selective micropipette. Proc Natl Acad Sci U S A (1977) 1.44
Dynamics of interstitial and intracellular pH in evolving brain infarct. Am J Physiol (1991) 1.43
Extracellular space parameters in the rat neocortex and subcortical white matter during postnatal development determined by diffusion analysis. Neuroscience (1993) 1.42
Optimization of multiplexed bead-based cytokine immunoassays for rat serum and brain tissue. J Neurosci Methods (2004) 1.41
Dendritic spikes and their inhibition in alligator Purkinje cells. Science (1968) 1.40
Changes of extracellular potassium activity induced by electric current through brain tissue in the rat. J Physiol (1983) 1.39
Extracellular ionic variations during spreading depression. Neuroscience (1978) 1.37
Equilibrium potential for the postsynaptic response in the squid giant synapse. J Gen Physiol (1974) 1.37
Intracellular pH of astrocytes increases rapidly with cortical stimulation. Am J Physiol (1987) 1.33
Carbonic acid buffer changes during complete brain ischemia. Am J Physiol (1986) 1.32
Search for new particles in two-jet final states in 7 TeV proton-proton collisions with the ATLAS detector at the LHC. Phys Rev Lett (2010) 1.32
Theoretical analysis of field potentials in anisotropic ensembles of neuronal elements. IEEE Trans Biomed Eng (1973) 1.27
Cell cavities increase tortuosity in brain extracellular space. J Theor Biol (2005) 1.27
Extracellular potassium, volume fraction, and tortuosity in rat hippocampal CA1, CA3, and cortical slices during ischemia. J Neurophysiol (1995) 1.24
Intracellular pH transients of mammalian astrocytes. J Neurosci (1989) 1.24
Diffusion of albumins in rat cortical slices and relevance to volume transmission. Neuroscience (1996) 1.24
Perspectives on spreading depression. Brain Res Brain Res Rev (2000) 1.24
Reactive astrocytosis from excitotoxic injury in hippocampal organ culture parallels that seen in vivo. J Cereb Blood Flow Metab (1997) 1.22
Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes. J Comp Neurol (1996) 1.22
Diffusion characteristics and extracellular volume fraction during normoxia and hypoxia in slices of rat neostriatum. J Neurophysiol (1991) 1.22
Development and validation of computed tomography derived anthropometric regression equations for estimating abdominal adipose tissue distribution. Obes Res (1994) 1.21
Ascorbate inhibits edema in brain slices. J Neurochem (2000) 1.20
Reversal properties of climbing fiber potential in cat Purkinje cells: an example of a distributed synapse. J Neurophysiol (1976) 1.20
Dopamine-mediated volume transmission in midbrain is regulated by distinct extracellular geometry and uptake. J Neurophysiol (2001) 1.20
Hydrogen ion buffering during complete brain ischemia. Brain Res (1985) 1.20
Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production. J Neurochem (1999) 1.19
Potassium accumulation around individual purkinje cells in cerebellar slices from the guinea-pig. J Physiol (1983) 1.17
Diffusion from an iontophoretic point source in the brain: role of tortuosity and volume fraction. Brain Res (1979) 1.16
Heterogeneous distribution of hydrogen and bicarbonate ions during complete brain ischemia. Prog Brain Res (1985) 1.15
Anisotropic and heterogeneous diffusion in the turtle cerebellum: implications for volume transmission. J Neurophysiol (1993) 1.15
Origin of the apparent tissue conductivity in the molecular and granular layers of the in vitro turtle cerebellum and the interpretation of current source-density analysis. J Neurophysiol (1994) 1.14
Patient comorbidity: relationship to outcomes of total knee arthroplasty. Clin Orthop Relat Res (1998) 1.12
Spatial buffering of potassium ions in brain extracellular space. Biophys J (2000) 1.11
Calcium waves precede electrophysiological changes of spreading depression in hippocampal organ cultures. J Neurosci (1998) 1.11
Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. J Physiol (1991) 1.10
Extracellular dopamine concentration in the retina of the clawed frog, Xenopus laevis. Proc Natl Acad Sci U S A (1993) 1.08
Therapeutic treatment of DMBA-induced mammary tumors with PPAR ligands. Anticancer Res (2001) 1.07
Measurement of nanomolar dopamine diffusion using low-noise perfluorinated ionomer coated carbon fiber microelectrodes and high-speed cyclic voltammetry. Anal Chem (1989) 1.06
Large potassium signals and slow potentials evoked during aminopyridine or barium superfusion in cat cerebellum. Brain Res (1976) 1.06
Observation of a charged charmoniumlike structure in e+ e- → π+ π- J/ψ at sqrt[s] = 4.26 GeV. Phys Rev Lett (2013) 1.05
The migration of substances in the neuronal microenvironment. Ann N Y Acad Sci (1986) 1.03
Dynamics of the brain cell microenvironment. Neurosci Res Program Bull (1980) 1.02
The effects of strength conditioning on older women's ability to perform daily tasks. J Am Geriatr Soc (1995) 1.02
Poly[N-(2-hydroxypropyl)methacrylamide] polymers diffuse in brain extracellular space with same tortuosity as small molecules. Biophys J (2001) 1.02
Long-term elevation of cyclooxygenase-2, but not lipoxygenase, in regions synaptically distant from spreading depression. J Comp Neurol (1996) 1.02
The three-dimensional point spread functions of a microscope objective in image and object space. J Microsc (1995) 1.02
Calcium diffusion in the brain cell microenvironment. Can J Physiol Pharmacol (1987) 1.01
Diffusion in the slice microenvironment and implications for physiological studies. Fed Proc (1983) 1.01
Water compartmentalization and extracellular tortuosity after osmotic changes in cerebellum of Trachemys scripta. J Physiol (1996) 1.01
Direct monitoring of dopamine and 5-HT release in substantia nigra and ventral tegmental area in vitro. Exp Brain Res (1994) 1.00
Fat distribution, physical activity, and cardiovascular risk factors. Med Sci Sports Exerc (1997) 1.00
Quisqualate, kainate and NMDA can initiate spreading depression in the turtle cerebellum. Brain Res (1988) 0.99
MEG source models and physiology. Phys Med Biol (1987) 0.97
Dextran decreases extracellular tortuosity in thick-slice ischemia model. J Cereb Blood Flow Metab (2000) 0.97
Intra-abdominal adipose tissue values associated with risk of possessing elevated blood lipids and blood pressure. Obes Res (1994) 0.96
Astrocytic clasmatodendrosis in hippocampal organ culture. Glia (2001) 0.96
Preferred centripetal conduction of dendritic spikes in alligator Purkinje cells. Science (1969) 0.96
Modulation of extracellular calcium and its functional implications. Fed Proc (1980) 0.96
Bicarbonate and ammonia changes in brain during spreading depression. Can J Physiol Pharmacol (1987) 0.95
Multimodal characterization of population responses evoked by applied electric field in vitro: extracellular potential, magnetic evoked field, transmembrane potential, and current-source density analysis. J Neurosci (1991) 0.95
Regulation of intracellular pH in vertebrate central neurons. Brain Res (1985) 0.95
The effects of extracellular acidosis on neurons and glia in vitro. J Cereb Blood Flow Metab (1989) 0.93
Acid-induced changes of brain protein buffering. Brain Res (1987) 0.92
Magnetic field associated with spreading depression: a model for the detection of migraine. Brain Res (1988) 0.91
Anion permeability in spreading depression investigated with ion-sensitive microelectrodes. Brain Res (1979) 0.90
Management of acute otitis media. Evid Rep Technol Assess (Summ) (2000) 0.90
Behavior of extracellular K+ and pH in skate (Raja erinacea) cerebellum. Brain Res (1988) 0.89
Whole-cell chloride currents in rat astrocytes accompany changes in cell morphology. J Neurosci (1996) 0.88
Prostaglandin E2 and 4-aminopyridine prevent the lipopolysaccharide-induced outwardly rectifying potassium current and interleukin-1beta production in cultured rat microglia. J Neurochem (1998) 0.87
Diffusion of anions and cations in the extracellular micro-environment of the brain [proceedings]. J Physiol (1979) 0.87
Diffusion measurements for drug design. Nat Mater (2005) 0.86
Light and electron microscopic evaluation of hydrogen ion-induced brain necrosis. J Cereb Blood Flow Metab (1987) 0.86
Magnetic field associated with neural activities in an isolated cerebellum. Brain Res (1987) 0.86
Cytoskeletal actin gates a Cl- channel in neocortical astrocytes. J Neurosci (1998) 0.86
First observation of the M1 transition ψ(3686)→γη(c)(2S). Phys Rev Lett (2012) 0.86
Cholestatic liver injury down-regulates hepatic glutathione synthesis. J Surg Res (1996) 0.85
Magnetic evoked field associated with transcortical currents in turtle cerebellum. Biophys J (1988) 0.85
Observation of two new N* resonances in the decay ψ(3686)→ppπ0. Phys Rev Lett (2013) 0.85