W G Hol

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Prediction of the occurrence of the ADP-binding beta alpha beta-fold in proteins, using an amino acid sequence fingerprint. J Mol Biol 1986 9.13
2 The alpha-helix dipole and the properties of proteins. Nature 1978 4.59
3 Crystal structures of human topoisomerase I in covalent and noncovalent complexes with DNA. Science 1998 4.51
4 Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature 1991 4.11
5 A model for the mechanism of human topoisomerase I. Science 1998 4.10
6 Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant. Nature 1983 3.94
7 The role of the alpha-helix dipole in protein function and structure. Prog Biophys Mol Biol 1985 3.42
8 Crystal structure of cholera toxin B-pentamer bound to receptor GM1 pentasaccharide. Protein Sci 1994 3.19
9 Dipoles of the alpha-helix and beta-sheet: their role in protein folding. Nature 1981 2.56
10 Synergistic effects of substrate-induced conformational changes in phosphoglycerate kinase activation. Nature 1997 2.23
11 Refined structure of Escherichia coli heat-labile enterotoxin, a close relative of cholera toxin. J Mol Biol 1993 2.17
12 Lactose binding to heat-labile enterotoxin revealed by X-ray crystallography. Nature 1992 2.08
13 Structure of the heat shock protein chaperonin-10 of Mycobacterium leprae. Science 1996 2.03
14 Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures. Acta Crystallogr D Biol Crystallogr 1999 2.01
15 Dihydrofolate reductase from Lactobacillus casei. X-ray structure of the enzyme methotrexate.NADPH complex. J Biol Chem 1978 1.94
16 Computer simulation of the dynamics of hydrated protein crystals and its comparison with x-ray data. Proc Natl Acad Sci U S A 1983 1.69
17 Structure of bovine liver rhodanese. I. Structure determination at 2.5 A resolution and a comparison of the conformation and sequence of its two domains. J Mol Biol 1978 1.67
18 The intact and cleaved human antithrombin III complex as a model for serpin-proteinase interactions. Nat Struct Biol 1994 1.63
19 Crystal structure of hexameric haemocyanin from Panulirus interruptus refined at 3.2 A resolution. J Mol Biol 1989 1.63
20 Crystallographic analysis of oxygenated and deoxygenated states of arthropod hemocyanin shows unusual differences. Proteins 1994 1.58
21 Crystal structure of p-hydroxybenzoate hydroxylase. J Mol Biol 1979 1.53
22 Three-dimensional structure of the diphtheria toxin repressor in complex with divalent cation co-repressors. Structure 1995 1.53
23 Refined 1.83 A structure of trypanosomal triosephosphate isomerase crystallized in the presence of 2.4 M-ammonium sulphate. A comparison with the structure of the trypanosomal triosephosphate isomerase-glycerol-3-phosphate complex. J Mol Biol 1991 1.50
24 High-resolution structure of the diphtheria toxin repressor complexed with cobalt and manganese reveals an SH3-like third domain and suggests a possible role of phosphate as co-corepressor. Biochemistry 1996 1.47
25 Crystal structure of a cobalt-activated diphtheria toxin repressor-DNA complex reveals a metal-binding SH3-like domain. J Mol Biol 1999 1.46
26 Glycolysis as a target for the design of new anti-trypanosome drugs. Drug Resist Updat 2001 1.45
27 Crystal structure of the p-hydroxybenzoate hydroxylase-substrate complex refined at 1.9 A resolution. Analysis of the enzyme-substrate and enzyme-product complexes. J Mol Biol 1989 1.44
28 Structure of bovine pancreatic phospholipase A2 at 1.7A resolution. J Mol Biol 1981 1.44
29 Atomic structure of the cubic core of the pyruvate dehydrogenase multienzyme complex. Science 1992 1.44
30 Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT). Mol Microbiol 1994 1.43
31 Crystal structure of a new heat-labile enterotoxin, LT-IIb. Structure 1996 1.42
32 Crystal structure of deoxygenated Limulus polyphemus subunit II hemocyanin at 2.18 A resolution: clues for a mechanism for allosteric regulation. Protein Sci 1993 1.41
33 The covalent and tertiary structure of bovine liver rhodanese. Nature 1978 1.41
34 The 2.0 A crystal structure of cephalosporin acylase. Structure 2000 1.37
35 Molecular dynamics refinement of a thermitase-eglin-c complex at 1.98 A resolution and comparison of two crystal forms that differ in calcium content. J Mol Biol 1989 1.34
36 A rapid method for positioning small flexible molecules, nucleic acids, and large protein fragments in experimental electron density maps. Proteins 1999 1.33
37 Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. J Mol Biol 2000 1.32
38 Crystal structure of the iron-dependent regulator (IdeR) from Mycobacterium tuberculosis shows both metal binding sites fully occupied. J Mol Biol 1999 1.32
39 Overcoming codon bias: a method for high-level overexpression of Plasmodium and other AT-rich parasite genes in Escherichia coli. Int J Parasitol 2000 1.32
40 Principles of quasi-equivalence and Euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A 1999 1.31
41 Refined crystal structure of lipoamide dehydrogenase from Azotobacter vinelandii at 2.2 A resolution. A comparison with the structure of glutathione reductase. J Mol Biol 1991 1.27
42 Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J Mol Biol 2000 1.27
43 Novel insights into catalytic mechanism from a crystal structure of human topoisomerase I in complex with DNA. Biochemistry 2000 1.27
44 AB5 toxins. Curr Opin Struct Biol 1995 1.26
45 A flash-annealing technique to improve diffraction limits and lower mosaicity in crystals of glycerol kinase. Acta Crystallogr D Biol Crystallogr 1998 1.26
46 Structure of quinoprotein methylamine dehydrogenase at 2.25 A resolution. EMBO J 1989 1.25
47 Structural flexibility in human topoisomerase I revealed in multiple non-isomorphous crystal structures. J Mol Biol 1999 1.24
48 The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site. J Mol Biol 1998 1.24
49 Crystal structure of recombinant human triosephosphate isomerase at 2.8 A resolution. Triosephosphate isomerase-related human genetic disorders and comparison with the trypanosomal enzyme. Protein Sci 1994 1.23
50 Effects of the alpha-helix dipole upon the functioning and structure of proteins and peptides. Adv Biophys 1985 1.23
51 Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase. Structure 1996 1.22
52 Comparison of the hemocyanin beta-barrel with other Greek key beta-barrels: possible importance of the "beta-zipper" in protein structure and folding. Proteins 1992 1.21
53 A comparison of the three-dimensional structures of subtilisin BPN' and subtilisin novo. Cold Spring Harb Symp Quant Biol 1972 1.21
54 Inclusion of thermal motion in crystallographic structures by restrained molecular dynamics. Science 1990 1.20
55 AB(5) toxins: structures and inhibitor design. Curr Opin Struct Biol 2000 1.19
56 The refined crystal structure of Pseudomonas putida lipoamide dehydrogenase complexed with NAD+ at 2.45 A resolution. Proteins 1992 1.19
57 Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat Struct Biol 1999 1.18
58 The crystal structure of the "open" and the "closed" conformation of the flexible loop of trypanosomal triosephosphate isomerase. Proteins 1991 1.17
59 Structure of porcine pancreatic phospholipase A2 at 2.6 A resolution and comparison with bovine phospholipase A2. J Mol Biol 1983 1.16
60 Crystal structure of the iron-dependent regulator from Mycobacterium tuberculosis at 2.0-A resolution reveals the Src homology domain 3-like fold and metal binding function of the third domain. J Biol Chem 2000 1.15
61 A very fast program for visualizing protein surfaces, channels and cavities. J Mol Graph 1989 1.14
62 Structural insights into the function of type IB topoisomerases. Curr Opin Struct Biol 1999 1.13
63 Structure-based drug design: progress, results and challenges. Structure 1994 1.13
64 The adaptability of the active site of trypanosomal triosephosphate isomerase as observed in the crystal structures of three different complexes. Proteins 1991 1.12
65 Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A 1999 1.12
66 Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit. Immunology 1998 1.11
67 Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease. Structure 2000 1.11
68 Motion of the DNA-binding domain with respect to the core of the diphtheria toxin repressor (DtxR) revealed in the crystal structures of apo- and holo-DtxR. J Biol Chem 1998 1.11
69 Structure of the native cysteine-sulfenic acid redox center of enterococcal NADH peroxidase refined at 2.8 A resolution. Biochemistry 1996 1.10
70 Crystal structure of p-hydroxybenzoate hydroxylase complexed with its reaction product 3,4-dihydroxybenzoate. J Mol Biol 1988 1.10
71 Selective inhibition of trypanosomal glyceraldehyde-3-phosphate dehydrogenase by protein structure-based design: toward new drugs for the treatment of sleeping sickness. J Med Chem 1994 1.10
72 Three-dimensional structure of the human 'protective protein': structure of the precursor form suggests a complex activation mechanism. Structure 1995 1.09
73 A mutant cholera toxin B subunit that binds GM1- ganglioside but lacks immunomodulatory or toxic activity. Proc Natl Acad Sci U S A 2001 1.09
74 Subtilisin Novo. The three-dimensional structure and its comparison with subtilisin BPN'. Eur J Biochem 1972 1.08
75 Structure determination of the glycosomal triosephosphate isomerase from Trypanosoma brucei brucei at 2.4 A resolution. J Mol Biol 1987 1.08
76 Crystal structure of recombinant triosephosphate isomerase from Bacillus stearothermophilus. An analysis of potential thermostability factors in six isomerases with known three-dimensional structures points to the importance of hydrophobic interactions. Protein Sci 1995 1.07
77 Three-dimensional structure of the quinoprotein methylamine dehydrogenase from Paracoccus denitrificans determined by molecular replacement at 2.8 A resolution. Proteins 1992 1.07
78 Crystal structure of glycosomal glyceraldehyde-3-phosphate dehydrogenase from Leishmania mexicana: implications for structure-based drug design and a new position for the inorganic phosphate binding site. Biochemistry 1995 1.06
79 Mutants of the Escherichia coli heat-labile enterotoxin with reduced ADP-ribosylation activity or no activity retain the immunogenic properties of the native holotoxin. Infect Immun 1996 1.06
80 Crystal structure of fructose-1,6-bisphosphate aldolase from the human malaria parasite Plasmodium falciparum. Biochemistry 1998 1.05
81 Structural studies of receptor binding by cholera toxin mutants. Protein Sci 1997 1.05
82 Three hTIM mutants that provide new insights on why TIM is a dimer. J Mol Biol 1996 1.05
83 Crystal structures of wild-type p-hydroxybenzoate hydroxylase complexed with 4-aminobenzoate,2,4-dihydroxybenzoate, and 2-hydroxy-4-aminobenzoate and of the Tyr222Ala mutant complexed with 2-hydroxy-4-aminobenzoate. Evidence for a proton channel and a new binding mode of the flavin ring. Biochemistry 1994 1.04
84 Structure determination of Panulirus interruptus haemocyanin at 3.2 A resolution. Successful phase extension by sixfold density averaging. J Mol Biol 1986 1.03
85 Structures of type 2 peroxisomal targeting signals in two trypanosomatid aldolases. J Mol Biol 2000 1.01
86 Structure-based exploration of the ganglioside GM1 binding sites of Escherichia coli heat-labile enterotoxin and cholera toxin for the discovery of receptor antagonists. Biochemistry 1999 1.00
87 Purification, crystallization and preliminary X-ray investigation of quinoprotein methylamine dehydrogenase from Thiobacillus versutus. Eur J Biochem 1986 1.00
88 Adenosine analogues as selective inhibitors of glyceraldehyde-3-phosphate dehydrogenase of Trypanosomatidae via structure-based drug design. J Med Chem 2001 1.00
89 Anion-coordinating residues at binding site 1 are essential for the biological activity of the diphtheria toxin repressor. Infect Immun 1999 0.99
90 Crystal structure of the reduced form of p-hydroxybenzoate hydroxylase refined at 2.3 A resolution. Proteins 1992 0.98
91 Calcium binding to thermitase. Crystallographic studies of thermitase at 0, 5, and 100 mM calcium. J Biol Chem 1991 0.98
92 Mutational analysis of the role of ADP-ribosylation activity and GM1-binding activity in the adjuvant properties of the Escherichia coli heat-labile enterotoxin towards intranasally administered keyhole limpet hemocyanin. Eur J Immunol 1998 0.97
93 Crystallographic and enzymatic investigations on the role of Ser558, His610, and Asn614 in the catalytic mechanism of Azotobacter vinelandii dihydrolipoamide acetyltransferase (E2p). Biochemistry 1995 0.97
94 In search of new lead compounds for trypanosomiasis drug design: a protein structure-based linked-fragment approach. J Comput Aided Mol Des 1992 0.97
95 Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution. J Mol Biol 1993 0.97
96 An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma brucei. J Mol Biol 2001 0.96
97 Crystallographic investigations of the tryptophan-derived cofactor in the quinoprotein methylamine dehydrogenase. FEBS Lett 1991 0.96
98 Active site structure of methylamine dehydrogenase: hydrazines identify C6 as the reactive site of the tryptophan-derived quinone cofactor. Biochemistry 1992 0.96
99 A potential target enzyme for trypanocidal drugs revealed by the crystal structure of NAD-dependent glycerol-3-phosphate dehydrogenase from Leishmania mexicana. Structure 2000 0.96
100 Intermolecular interactions between the A and B subunits of heat-labile enterotoxin from Escherichia coli promote holotoxin assembly and stability in vivo. Proc Natl Acad Sci U S A 1992 0.95
101 Crystallographic analysis of substrate binding and catalysis in dihydrolipoyl transacetylase (E2p). Biochemistry 1993 0.95
102 The Arg7Lys mutant of heat-labile enterotoxin exhibits great flexibility of active site loop 47-56 of the A subunit. Biochemistry 1995 0.95
103 Protein crystallography and infectious diseases. Protein Sci 1994 0.95
104 Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin. Structure 1997 0.94
105 Pseudo 2-fold symmetry in the copper-binding domain of arthropodan haemocyanins. Possible implications for the evolution of oxygen transport proteins. J Mol Biol 1989 0.94
106 The role of waters in docking strategies with incremental flexibility for carbohydrate derivatives: heat-labile enterotoxin, a multivalent test case. J Med Chem 1999 0.94
107 Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants. Structure 1995 0.93
108 The high resolution three-dimensional structure of bovine liver rhodanese. Fundam Appl Toxicol 1984 0.93
109 Conformational changes in Leishmania mexicana glyceraldehyde-3-phosphate dehydrogenase induced by designed inhibitors. J Mol Biol 2001 0.93
110 Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: elucidation of a novel binding mode for a 2-amino-N(6)-substituted adenosine. J Med Chem 2000 0.93
111 Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. J Med Chem 1998 0.92
112 Comparison of the B-pentamers of heat-labile enterotoxin and verotoxin-1: two structures with remarkable similarity and dissimilarity. Biochemistry 1993 0.92
113 Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity. Chem Biol 2001 0.92
114 Analysis of the active site of the flavoprotein p-hydroxybenzoate hydroxylase and some ideas with respect to its reaction mechanism. Biochemistry 1990 0.91
115 Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution. FEBS Lett 1994 0.91
116 Synthesis and structure-activity relationships of analogs of 2'-deoxy-2'-(3-methoxybenzamido)adenosine, a selective inhibitor of trypanosomal glycosomal glyceraldehyde-3-phosphate dehydrogenase. J Med Chem 1995 0.91
117 A bisubstrate analog induces unexpected conformational changes in phosphoglycerate kinase from Trypanosoma brucei. J Mol Biol 1998 0.90
118 Preliminary crystallographic studies of triosephosphate isomerase from the blood parasite Trypanosoma brucei brucei. J Mol Biol 1984 0.89
119 Heat-labile enterotoxin of Escherichia coli. Characterization of different crystal forms. J Biol Chem 1985 0.89
120 On the role of the active site helix in papain, an ab initio molecular orbital study. Biophys Chem 1979 0.89
121 Three-dimensional structure of lipoamide dehydrogenase from Pseudomonas fluorescens at 2.8 A resolution. Analysis of redox and thermostability properties. J Mol Biol 1993 0.89
122 Comparison of high-resolution structures of the diphtheria toxin repressor in complex with cobalt and zinc at the cation-anion binding site. Protein Sci 1997 0.89
123 The catalytic domain of the dihydrolipoyl transacetylase component of the pyruvate dehydrogenase complex from Azotobacter vinelandii and Escherichia coli. Expression, purification, properties and preliminary X-ray analysis. Eur J Biochem 1991 0.88
124 Protein engineering studies of A-chain loop 47-56 of Escherichia coli heat-labile enterotoxin point to a prominent role of this loop for cytotoxicity. Mol Microbiol 1996 0.88
125 Use of electron microscopy in the examination of lattice defects in crystals of alcohol oxidase. FEBS Lett 1989 0.87
126 Crystallographic and molecular modeling studies on trypanosomal triosephosphate isomerase: a critical assessment of the predicted and observed structures of the complex with 2-phosphoglycerate. J Med Chem 1991 0.87
127 Structures of three diphtheria toxin repressor (DtxR) variants with decreased repressor activity. Acta Crystallogr D Biol Crystallogr 2001 0.87
128 Structure of the complex between trypanosomal triosephosphate isomerase and N-hydroxy-4-phosphono-butanamide: binding at the active site despite an "open" flexible loop conformation. Protein Sci 1992 0.86
129 Anion binding at the active site of trypanosomal triosephosphate isomerase. Monohydrogen phosphate does not mimic sulphate. Eur J Biochem 1991 0.86
130 Crystal structure of a non-toxic mutant of heat-labile enterotoxin, which is a potent mucosal adjuvant. Protein Sci 1997 0.85
131 X-ray structure of lipoamide dehydrogenase from Azotobacter vinelandii determined by a combination of molecular and isomorphous replacement techniques. J Mol Biol 1989 0.85
132 Solid-phase synthesis of N-acyl-N'-alkyl/aryl disubstituted guanidines. J Org Chem 2001 0.85
133 Improvement of diffraction quality upon rehydration of dehydrated icosahedral Enterococcus faecalis pyruvate dehydrogenase core crystals. Protein Sci 1997 0.85
134 The coenzyme analogue adenosine 5-diphosphoribose displaces FAD in the active site of p-hydroxybenzoate hydroxylase. An x-ray crystallographic investigation. Biochemistry 1989 0.84
135 The atomic model of the human protective protein/cathepsin A suggests a structural basis for galactosialidosis. Proc Natl Acad Sci U S A 1998 0.84
136 Tumor marker disaccharide D-Gal-beta 1, 3-GalNAc complexed to heat-labile enterotoxin from Escherichia coli. Protein Sci 1996 0.84
137 Crystal structure of heat-labile enterotoxin from Escherichia coli with increased thermostability introduced by an engineered disulfide bond in the A subunit. Protein Sci 1997 0.84
138 Papain in water-rich and in methanol-rich media; crystallization and conformation. J Mol Biol 1968 0.83
139 Probing the limits of the molecular replacement method: the case of Trypanosoma brucei phosphoglycerate kinase. Acta Crystallogr D Biol Crystallogr 1997 0.83
140 Refined 3.2 A structure of glycosomal holo glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei. Acta Crystallogr D Biol Crystallogr 1995 0.83
141 Differences in the binding of sulfate, selenate and thiosulfate ions to bovine liver rhodanese, and a description of a binding site for ammonium and sodium ions. An X-ray diffraction study. Eur J Biochem 1984 0.83
142 A database method for automated map interpretation in protein crystallography. Proteins 1999 0.83
143 Hexamers of subunit II from Limulus hemocyanin (a 48-mer) have the same quaternary structure as whole Panulirus hemocyanin molecules. Proteins 1991 0.83
144 The structure of bovine liver rhodanese. II. The active site in the sulfur-substituted and the sulfur-free enzyme. J Mol Biol 1979 0.83
145 Cloning and overexpression of the triosephosphate isomerase genes from psychrophilic and thermophilic bacteria. Structural comparison of the predicted protein sequences. J Mol Biol 1993 0.83
146 Structure determination of the human protective protein: twofold averaging reveals the three-dimensional structure of a domain which was entirely absent in the initial model. Acta Crystallogr D Biol Crystallogr 1996 0.82
147 Crystallographic refinement by incorporation of molecular dynamics: thermostable serine protease thermitase complexed with eglin c. Acta Crystallogr B 1989 0.82
148 Nitrate binding to Limulus polyphemus subunit type II hemocyanin and its functional implications. J Mol Biol 1996 0.82
149 Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli. Nat Struct Biol 1995 0.82
150 X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa. EMBO J 1997 0.82
151 The double domain structure of rhodanese. J Mol Biol 1975 0.81
152 An accurate numerical model for calculating the equilibration rate of a hanging-drop experiment. Acta Crystallogr D Biol Crystallogr 1999 0.81
153 Structure determination of quinoprotein methylamine dehydrogenase from Thiobacillus versutus. Acta Crystallogr B 1990 0.81
154 Structural diversity in a conserved cholera toxin epitope involved in ganglioside binding. Protein Sci 1995 0.81
155 Crystal structures of substrates and products bound to the phosphoglycerate kinase active site reveal the catalytic mechanism. Biochemistry 1998 0.81
156 Using a galactose library for exploration of a novel hydrophobic pocket in the receptor binding site of the Escherichia coli heat-labile enterotoxin. J Biol Chem 1999 0.81
157 Exploration of the GM1 receptor-binding site of heat-labile enterotoxin and cholera toxin by phenyl-ring-containing galactose derivatives. Acta Crystallogr D Biol Crystallogr 2001 0.80
158 Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure. J Mol Biol 1998 0.80
159 Stabilization of human triosephosphate isomerase by improvement of the stability of individual alpha-helices in dimeric as well as monomeric forms of the protein. Biochemistry 1996 0.80
160 Crystallographic analyses of NADH peroxidase Cys42Ala and Cys42Ser mutants: active site structures, mechanistic implications, and an unusual environment of Arg 303. Biochemistry 1995 0.79
161 Primary and tertiary structures of the first domain of Panulirus interruptus hemocyanin and comparison of arthropod hemocyanins. Eur J Biochem 1987 0.79
162 Preliminary crystallographic studies of glycosomal glyceraldehyde phosphate dehydrogenase from Trypanosoma brucei brucei. J Mol Biol 1987 0.79
163 Structure-based discovery of a pore-binding ligand: towards assembly inhibitors for cholera and related AB5 toxins. J Mol Biol 1999 0.79
164 Soaking in Cs2SO4 reveals a caesium-aromatic interaction in bovine-liver rhodanese. Eur J Biochem 1988 0.79
165 The influence of purification and protein heterogeneity on the crystallization of p-hydroxybenzoate hydroxylase. Eur J Biochem 1989 0.79
166 An L40C mutation converts the cysteine-sulfenic acid redox center in enterococcal NADH peroxidase to a disulfide. Biochemistry 1995 0.78
167 Heat-labile enterotoxin crystal forms with variable A/B5 orientation. Analysis of conformational flexibility. FEBS Lett 1992 0.78
168 The importance of dynamic light scattering in obtaining multiple crystal forms of Trypanosoma brucei PGK. Protein Sci 1998 0.78
169 Engineering of microheterogeneity-resistant p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. FEBS Lett 1990 0.78
170 Structure of m-carboxyphenyl-alpha-D-galactopyranoside complexed to heat-labile enterotoxin at 1.3 A resolution: surprising variations in ligand-binding modes. Acta Crystallogr D Biol Crystallogr 2000 0.77
171 Binding of metal cyanide complexes to bovine liver rhodanese in the crystalline state. Biochemistry 1983 0.77
172 Stepwise transplantation of an active site loop between heat-labile enterotoxins LT-II and LT-I and characterization of the obtained hybrid toxins. Protein Eng 1998 0.77
173 Spectroscopic investigations of Panulirus interruptus hemocyanin in the crystalline state. Eur J Biochem 1989 0.77
174 Effects of eglin-c binding to thermitase: three-dimensional structure comparison of native thermitase and thermitase eglin-c complexes. Proteins 1992 0.76
175 Molecular modeling reveals the possible importance of a carbonyl oxygen binding pocket for the catalytic mechanism of p-hydroxybenzoate hydroxylase. J Biol Chem 1988 0.76
176 Automated protein crystallization and a new crystal form of a subtilisin:eglin complex. Protein Eng 1989 0.76
177 Structure of Panulirus interruptus hemocyanin at 5 A resolution. J Mol Biol 1982 0.75
178 Crystals containing a single subunit type of Panulirus interruptus haemocyanin. J Mol Biol 1983 0.75
179 Structure of arthropodan hemocyanin. Prog Clin Biol Res 1988 0.75
180 Crystallization of thermitase, a thermostable subtilisin, from a sodium formate solution by means of an automated procedure. J Mol Biol 1989 0.75
181 Crystallization and preliminary x-ray investigation of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens. J Biol Chem 1975 0.75
182 A general method of domain closure is applied to phosphoglycerate kinase and the result compared with the crystal structure of a closed conformation of the enzyme. Proteins 1998 0.75
183 X-ray studies reveal lanthanide binding sites at the A/B5 interface of E. coli heat labile enterotoxin. FEBS Lett 1992 0.75
184 Crystallographic study of eglin-C binding to thermitase. Adv Exp Med Biol 1996 0.75
185 A comparison of crystallographic data of the subtilopeptidases B and C. J Mol Biol 1967 0.75