Published in J Biol Chem on June 10, 1983
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol Cell Biol (1989) 4.81
Adenovirus virus-associated RNA and translation control. J Virol (1991) 3.77
Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26
The mouse protein synthesis initiation factor 4A gene family includes two related functional genes which are differentially expressed. EMBO J (1988) 3.17
Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. Nucleic Acids Res (1985) 3.00
Initiation of protein synthesis in mammalian cells. Biochem J (1986) 2.99
Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors. Nucleic Acids Res (2004) 2.55
Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. EMBO J (1990) 2.12
A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. Mol Cell Biol (1996) 2.01
Computational modeling of eukaryotic mRNA turnover. RNA (2001) 1.79
Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system. Proc Natl Acad Sci U S A (1989) 1.73
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol Cell Biol (1988) 1.69
Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition. Nucleic Acids Res (1997) 1.56
Microinjection of ubiquitin: changes in protein degradation in HeLa cells subjected to heat-shock. J Cell Biol (1987) 1.52
hnRNP K binds a core polypyrimidine element in the eukaryotic translation initiation factor 4E (eIF4E) promoter, and its regulation of eIF4E contributes to neoplastic transformation. Mol Cell Biol (2005) 1.50
Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation. J Cell Biol (1989) 1.43
Biochemical characterisation of cap-poly(A) synergy in rabbit reticulocyte lysates: the eIF4G-PABP interaction increases the functional affinity of eIF4E for the capped mRNA 5'-end. Nucleic Acids Res (2000) 1.42
Proteomic data from human cell cultures refine mechanisms of chaperone-mediated protein homeostasis. Cell Stress Chaperones (2013) 1.41
RNA binding targets aminoacyl-tRNA synthetases to translating ribosomes. J Biol Chem (2011) 1.41
Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J (2000) 1.39
The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity. EMBO J (1995) 1.33
IRES interaction with translation initiation factors: functional characterization of novel RNA contacts with eIF3, eIF4B, and eIF4GII. RNA (2001) 1.30
p97/DAP5 is a ribosome-associated factor that facilitates protein synthesis and cell proliferation by modulating the synthesis of cell cycle proteins. EMBO J (2006) 1.28
Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells. J Virol (1985) 1.24
Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Res (2015) 1.23
A cellular response linking eIF4AI activity to eIF4AII transcription. RNA (2012) 1.13
The human translation initiation multi-factor complex promotes methionyl-tRNAi binding to the 40S ribosomal subunit. Nucleic Acids Res (2011) 1.09
Development of a novel system to study hepatitis delta virus genome replication. J Virol (2005) 1.09
Initiation factor protein modifications and inhibition of protein synthesis. Mol Cell Biol (1987) 0.96
The DEAD-box helicase eIF4A: paradigm or the odd one out? RNA Biol (2012) 0.95
Non-coding RNA: what is functional and what is junk? Front Genet (2015) 0.92
Translational initiation factor expression and ribosomal protein gene expression are repressed coordinately but by different mechanisms in murine lymphosarcoma cells treated with glucocorticoids. Mol Cell Biol (1989) 0.92
The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic Acids Res (2012) 0.92
Quantitative proteomics of heat-treated human cells show an across-the-board mild depletion of housekeeping proteins to massively accumulate few HSPs. Cell Stress Chaperones (2015) 0.88
eIF4F: A Retrospective. J Biol Chem (2015) 0.84
Ubiquitination of newly synthesized proteins at the ribosome. Biochimie (2015) 0.83
Structural analysis of the DAP5 MIF4G domain and its interaction with eIF4A. Structure (2013) 0.82
Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status. Mol Cancer Ther (2015) 0.81
Human eukaryotic initiation factor 2 (eIF2)-GTP-Met-tRNAi ternary complex and eIF3 stabilize the 43 S preinitiation complex. J Biol Chem (2014) 0.79
LOOP IIId of the HCV IRES is essential for the structural rearrangement of the 40S-HCV IRES complex. Nucleic Acids Res (2015) 0.79
Quantitative studies of mRNA recruitment to the eukaryotic ribosome. Biochimie (2015) 0.78
Hippuristanol - A potent steroid inhibitor of eukaryotic initiation factor 4A. Translation (Austin) (2016) 0.78
Quantitative proteomics of rat livers shows that unrestricted feeding is stressful for proteostasis with implications on life span. Aging (Albany NY) (2016) 0.76
Qualitative and Quantitative Protein Complex Prediction Through Proteome-Wide Simulations. PLoS Comput Biol (2015) 0.75
Membranes, energetics, and evolution across the prokaryote-eukaryote divide. Elife (2017) 0.75
A unique enhancer boundary complex on the mouse ribosomal RNA genes persists after loss of Rrn3 or UBF and the inactivation of RNA polymerase I transcription. PLoS Genet (2017) 0.75
The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol Cell Biol (1989) 4.81
Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F. J Biol Chem (1987) 4.48
The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes. J Biol Chem (1978) 4.26
Involvement of eukaryotic initiation factor 4A in the cap recognition process. J Biol Chem (1983) 3.70
Translation initiation factor 5A and its hypusine modification are essential for cell viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1991) 3.26
Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl)methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin Cancer Res (1999) 3.24
Dendrimers: relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125I-labelled polyamidoamine dendrimers in vivo. J Control Release (2000) 3.07
Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells. EMBO J (1995) 2.78
Effect of initiation factor eIF-5A depletion on protein synthesis and proliferation of Saccharomyces cerevisiae. J Biol Chem (1994) 2.77
Sequence of the initiation factor IF2 gene: unusual protein features and homologies with elongation factors. Proc Natl Acad Sci U S A (1984) 2.72
Feedback regulation of rRNA synthesis in Escherichia coli. Requirement for initiation factor IF2. J Mol Biol (1987) 2.70
A sensitive immunoblotting method for measuring protein synthesis initiation factor levels in lysates of Escherichia coli. J Biol Chem (1981) 2.59
An eIF-4A-like protein is a suppressor of an Escherichia coli mutant defective in 50S ribosomal subunit assembly. Nature (1988) 2.55
Methyl 4-mercaptobutyrimidate as a cleavable cross-linking reagent and its application to the Escherichia coli 30S ribosome. Biochemistry (1973) 2.14
Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. EMBO J (1990) 2.12
Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. Cell (1984) 2.08
General practice computing in Scotland. BMJ (1990) 2.06
Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein. J Biol Chem (1994) 2.06
Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ (2002) 2.05
Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation. J Biol Chem (1984) 1.99
Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly. J Biol Chem (1997) 1.98
Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells. J Virol (1984) 1.87
GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3. Genes Dev (1995) 1.86
The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Mol Cell Biol (1994) 1.85
Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification. J Biol Chem (1985) 1.83
Role of mRNA competition in regulating translation: further characterization of mRNA discriminatory initiation factors. Proc Natl Acad Sci U S A (1983) 1.81
A competitive inhibitor of the GTP reaction in protein synthesis. J Mol Biol (1966) 1.76
The translation initiation factor eIF3-p48 subunit is encoded by int-6, a site of frequent integration by the mouse mammary tumor virus genome. J Biol Chem (1997) 1.76
Cloning and mapping of a gene for translational initiation factor IF2 in Escherichia coli. Proc Natl Acad Sci U S A (1982) 1.75
Alterations in initiation factor activity from poliovirus-infected HeLa cells. J Biol Chem (1979) 1.75
Conservation and diversity of eukaryotic translation initiation factor eIF3. J Biol Chem (1997) 1.75
Purification and characterization of initiation factor IF-E3 from rabbit reticulocytes. Proc Natl Acad Sci U S A (1976) 1.73
Structure of the beta subunit of translational initiation factor eIF-2. Cell (1988) 1.71
Heterogeneous nuclear ribonucleoprotein A1 binds to the transcription-regulatory region of mouse hepatitis virus RNA. Proc Natl Acad Sci U S A (1997) 1.70
Initiation factor and ribosome levels are coordinately controlled in Escherichia coli growing at different rates. J Biol Chem (1983) 1.70
Disability, distress and unemployment in neurology outpatients with symptoms 'unexplained by organic disease'. J Neurol Neurosurg Psychiatry (2011) 1.69
Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases. Mol Cell Biol (1988) 1.69
Immunochemical characterization of mammalian protein synthesis initiation factors. Biochemistry (1982) 1.68
Early phase tumor accumulation of macromolecules: a great difference in clearance rate between tumor and normal tissues. Jpn J Cancer Res (1998) 1.68
Dendrimer-platinate: a novel approach to cancer chemotherapy. Anticancer Drugs (1999) 1.67
Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cells. Virology (1989) 1.66
A new class of fusion-associated small transmembrane (FAST) proteins encoded by the non-enveloped fusogenic reoviruses. EMBO J (2000) 1.66
Purification and characterization of initiation factor IF-E2 from rabbit reticulocytes. J Biol Chem (1976) 1.66
The major protein of messenger ribonucleoprotein particles in somatic cells is a member of the Y-box binding transcription factor family. J Biol Chem (1995) 1.65
Purification and characterization of protein synthesis initiation factors eIF-1, eIF-4C, eIF-4D, and eIF-5 from rabbit reticulocytes. J Biol Chem (1978) 1.62
Seizure risk from cavernous or arteriovenous malformations: prospective population-based study. Neurology (2011) 1.62
Preferential utilization of phosphorylated 40-S ribosomal subunits during initiation complex formation. Eur J Biochem (1982) 1.62
Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo. J Biol Chem (1984) 1.61
Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal, and intravenous administration to rats. J Biomed Mater Res (1987) 1.60
Eukaryotic initiation factor 3 is required for poliovirus 2A protease-induced cleavage of the p220 component of eukaryotic initiation factor 4F. Proc Natl Acad Sci U S A (1990) 1.58
Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E. J Biol Chem (1991) 1.56
Overexpression in COS cells of p50, the major core protein associated with mRNA, results in translation inhibition. Nucleic Acids Res (1997) 1.56
Cloning and sequencing of complementary DNAs encoding the alpha-subunit of translational initiation factor eIF-2. Characterization of the protein and its messenger RNA. J Biol Chem (1987) 1.55
Psychopathology in people with epilepsy and intellectual disability; an investigation of potential explanatory variables. J Neurol Neurosurg Psychiatry (2003) 1.53
The safety of antiepileptic drug withdrawal in patients with non-epileptic seizures. J Neurol Neurosurg Psychiatry (2005) 1.52
Complementation of adenovirus virus-associated RNA I gene deletion by expression of a mutant eukaryotic translation initiation factor. Proc Natl Acad Sci U S A (1989) 1.51
SUI1/p16 is required for the activity of eukaryotic translation initiation factor 3 in Saccharomyces cerevisiae. Mol Cell Biol (1996) 1.49
The nucleotide sequence of infectious pancreatic necrosis virus (IPNV) dsRNA segment A reveals one large ORF encoding a precursor polyprotein. Nucleic Acids Res (1986) 1.47
Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation. J Cell Biol (1989) 1.43
Sequence determination and cDNA cloning of eukaryotic initiation factor 4D, the hypusine-containing protein. J Biol Chem (1989) 1.42
Long-term danazol therapy in autoimmune thrombocytopenia: unmaintained remission and age-dependent response in women. Ann Intern Med (1989) 1.41
Comparison of bimanual examination with ultrasound examination before hysterectomy for uterine leiomyoma. Obstet Gynecol (1998) 1.41
Two structural domains of initiation factor eIF-4B are involved in binding to RNA. J Biol Chem (1994) 1.39
Many universities do teach professionalism. Br J Nurs (2002) 1.39
Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells. J Virol (1982) 1.38
The major core protein of messenger ribonucleoprotein particles (p50) promotes initiation of protein biosynthesis in vitro. J Biol Chem (1998) 1.34
The existence of two genes between infB and rpsO in the Escherichia coli genome: DNA sequencing and S1 nuclease mapping. Nucleic Acids Res (1988) 1.32
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine. J Biol Chem (1991) 1.32
Protein synthesis initiation factors from human HeLa cells and rabbit reticulocytes are similar: comparison of protein structure, activities, and immunochemical properties. Biochemistry (1982) 1.32
Clinical classification criteria for knee osteoarthritis: performance in the general population and primary care. Ann Rheum Dis (2006) 1.32
Prevalence of evidence of prior myocardial infarction, hypertension, diabetes and obesity in three neighboring communities in Pennsylvania. Am J Med Sci (1967) 1.31
Protein synthesis initiation factor eIF-4D. Functional comparison of native and unhypusinated forms of the protein. J Biol Chem (1989) 1.30
Simple methods for assessing haplotype-environment interactions in case-only and case-control studies. Genet Epidemiol (2007) 1.29
A 110-kilodalton subunit of translation initiation factor eIF3 and an associated 135-kilodalton protein are encoded by the Saccharomyces cerevisiae TIF32 and TIF31 genes. J Biol Chem (1999) 1.29
Expression of a phosphorylation-resistant eukaryotic initiation factor 2 alpha-subunit mitigates heat shock inhibition of protein synthesis. J Biol Chem (1993) 1.29
Protein synthesis initiation factors from rabbit reticulocytes: purification, characterization, and radiochemical labeling. Methods Enzymol (1979) 1.28
Guanosine 5'-triphosphatase activity of initiation factor f2. Proc Natl Acad Sci U S A (1968) 1.27
In vitro study of two dominant inhibitory GTPase mutants of Escherichia coli translation initiation factor IF2. Direct evidence that GTP hydrolysis is necessary for factor recycling. J Biol Chem (1999) 1.26
Influence of molecular weight on passive tumour accumulation of a soluble macromolecular drug carrier. Eur J Cancer (1995) 1.26
Biochemical and biophysical characterization of the reovirus cell attachment protein sigma 1: evidence that it is a homotrimer. Virology (1991) 1.25
The 39-kilodalton subunit of eukaryotic translation initiation factor 3 is essential for the complex's integrity and for cell viability in Saccharomyces cerevisiae. Mol Cell Biol (1997) 1.25
Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. J Biol Chem (1994) 1.24
Double-stranded RNA-dependent protein kinase and 2-5A system are both activated in interferon-treated, encephalomyocarditis virus-infected HeLa cells. J Virol (1985) 1.24
Translation initiation factor IF1 is essential for cell viability in Escherichia coli. J Bacteriol (1994) 1.24
Purification and characterization of initiation factors IF-E4 and IF-E6 from rabbit reticulocytes. J Biol Chem (1977) 1.23
Rapid alterations in initiation rate and recruitment of inactive RNA are temporally correlated with S6 phosphorylation. Eur J Biochem (1982) 1.23
Two translational initiation sites in the infB gene are used to express initiation factor IF2 alpha and IF2 beta in Escherichia coli. EMBO J (1985) 1.22
AGC kinases regulate phosphorylation and activation of eukaryotic translation initiation factor 4B. Oncogene (2008) 1.22
Selection of the 5'-proximal translation initiation site is influenced by mRNA and eIF-2 concentrations. Eur J Biochem (1990) 1.21
Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption. J Cell Biol (1990) 1.21