Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury.

PubWeight™: 2.52‹?› | Rank: Top 2%

🔗 View Article (PMC 1129244)

Published in J Clin Invest on September 01, 1983

Authors

P A Ward, G O Till, R Kunkel, C Beauchamp

Articles citing this

Oxygen toxicity, oxygen radicals, transition metals and disease. Biochem J (1984) 13.20

Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A (1991) 2.49

Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J Clin Invest (1989) 1.86

Prevention of granulocyte-mediated oxidant lung injury in rats by a hydroxyl radical scavenger, dimethylthiourea. J Clin Invest (1984) 1.74

Those nasty radicals. West J Med (1986) 1.39

The specificity of thiourea, dimethylthiourea and dimethyl sulphoxide as scavengers of hydroxyl radicals. Their protection of alpha 1-antiproteinase against inactivation by hypochlorous acid. Biochem J (1987) 1.32

Proteases and oxidants in experimental pulmonary inflammatory injury. J Clin Invest (1984) 1.30

Acute lung injury in rat caused by immunoglobulin A immune complexes. J Clin Invest (1984) 1.29

Mediators of lung injury in mice following systemic activation of complement. Am J Pathol (1985) 1.28

Roles of histamine, complement and xanthine oxidase in thermal injury of skin. Am J Pathol (1989) 1.27

Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice. J Clin Invest (1985) 1.27

Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest (1988) 1.26

Oxidants increase paracellular permeability in a cultured epithelial cell line. J Clin Invest (1985) 1.25

Role of hydrogen peroxide and hydroxyl radical formation in the killing of Ehrlich tumor cells by anticancer quinones. Proc Natl Acad Sci U S A (1986) 1.22

The pulmonary physician in critical care * 6: The pathogenesis of ALI/ARDS. Thorax (2002) 1.22

Platelets mediate neutrophil-dependent immune complex nephritis in the rat. J Clin Invest (1988) 1.20

Pseudomonas and neutrophil products modify transferrin and lactoferrin to create conditions that favor hydroxyl radical formation. J Clin Invest (1991) 1.20

Lipid peroxidation and acute lung injury after thermal trauma to skin. Evidence of a role for hydroxyl radical. Am J Pathol (1985) 1.18

Possible role of bacterial siderophores in inflammation. Iron bound to the Pseudomonas siderophore pyochelin can function as a hydroxyl radical catalyst. J Clin Invest (1990) 1.14

Systemic complement activation, lung injury, and products of lipid peroxidation. J Clin Invest (1985) 1.13

Evidence for the role of platelet-activating factor in immune complex vasculitis in the rat. J Clin Invest (1989) 1.09

Protease cleavage of iron-transferrin augments pyocyanin-mediated endothelial cell injury via promotion of hydroxyl radical formation. Infect Immun (1996) 1.09

Activation of C5 by cobra venom factor is required in neutrophil-mediated lung injury in the rat. Am J Pathol (1987) 1.06

Preservation of complement-induced lung injury in mice with deficiency of NADPH oxidase. J Clin Invest (1996) 1.05

Antioxidant macromolecules in the epithelial lining fluid of the normal human lower respiratory tract. J Clin Invest (1990) 1.04

Evidence for a role of hydroxyl radical in immune-complex-induced vasculitis. Am J Pathol (1984) 1.01

Deficiency of vitamin E in the alveolar fluid of cigarette smokers. Influence on alveolar macrophage cytotoxicity. J Clin Invest (1986) 1.00

Protease-cleaved iron-transferrin augments oxidant-mediated endothelial cell injury via hydroxyl radical formation. J Clin Invest (1995) 0.99

Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock. Infect Immun (1993) 0.97

Intravascular release of intact cellular fibronectin during oxidant-induced injury of the in vitro perfused rabbit lung. J Clin Invest (1986) 0.96

Additive effect of intravascular complement activation and brief episodes of hypoxia in producing increased permeability in the rabbit lung. J Clin Invest (1985) 0.96

Activation of complement in normal serum by hydrogen peroxide and hydrogen peroxide-related oxygen radicals produced by activated neutrophils. Clin Exp Immunol (1992) 0.93

Iron sequestration by macrophages decreases the potential for extracellular hydroxyl radical formation. J Clin Invest (1993) 0.92

Dimethyl sulfoxide modulates NF-kappa B and cytokine activation in lipopolysaccharide-treated murine macrophages. Infect Immun (1994) 0.92

Walker carcinosarcoma cells damage endothelial cells by the generation of reactive oxygen species. Am J Pathol (1989) 0.92

Degradation of Japanese encephalitis virus by neutrophils. Int J Exp Pathol (1999) 0.91

Experimental pulmonary inflammatory injury in the monkey. J Clin Invest (1985) 0.91

Role of xanthine oxidase in thermal injury of skin. Am J Pathol (1989) 0.91

Chemotactic activity generated in human serum from the fifth component of complement by hydrogen peroxide. Am J Pathol (1984) 0.91

Thermal injury, intravascular hemolysis, and toxic oxygen products. J Clin Invest (1986) 0.90

Alveolar macrophage procoagulant activity is increased in acute hyperoxic lung injury. Am J Pathol (1988) 0.90

Arterial endothelial barrier dysfunction: actions of homocysteine and the hypoxanthine-xanthine oxidase free radical generating system. Br J Pharmacol (1993) 0.90

Detachment of cultured cells from the substratum induced by the neutrophil-derived oxidant NH2Cl: synergistic role of phosphotyrosine and intracellular Ca2+ concentration. J Cell Biol (1995) 0.89

Investigation of the anti-inflammatory properties of hydroxypyridinones. Ann Rheum Dis (1989) 0.88

Differing patterns of P-selectin expression in lung injury. Am J Pathol (1998) 0.86

Glomerular injury and proteinuria in rats after intrarenal injection of cobra venom factor. Evidence for the role of neutrophil-derived oxygen free radicals. Am J Pathol (1986) 0.85

Neutrophil-endothelial cell interaction. Evidence for and mechanisms of the self-protection of bovine microvascular endothelial cells from hydrogen peroxide-induced oxidative stress. J Clin Invest (1986) 0.84

Neutrophil chemotactic activity and C5a following systemic activation of complement in rats. Inflammation (1997) 0.84

Experimental obliterative cholangitis. A model for the study of biliary atresia. Ann Surg (1991) 0.84

Activation of the complement system in patients with porphyrias after irradiation in vivo. J Clin Invest (1984) 0.83

Neutrophil-derived Oxidants and Proteinases as Immunomodulatory Mediators in Inflammation. Mediators Inflamm (1994) 0.82

Ibuprofen prevents oxidant lung injury and in vitro lipid peroxidation by chelating iron. J Clin Invest (1990) 0.80

Self-limiting enhancement by nitric oxide of oxygen free radical-induced endothelial cell injury: evidence against the dual action of NO as hydroxyl radical donor/scavenger. Br J Pharmacol (1996) 0.79

Localization of antiglomerular basement membrane-binding polyclonal antibodies in rat lung and kidney using post-embedding immunogold electron microscopy. Br J Exp Pathol (1989) 0.79

Benoxaprofen activates membrane-associated oxidative metabolism in human polymorphonuclear leucocytes by apparent modulation of protein kinase C. Br J Pharmacol (1988) 0.77

Desensitization of beta-adrenergic receptors in lung injury induced by 2-chloroethyl ethyl sulfide, a mustard analog. J Biochem Mol Toxicol (2009) 0.77

A new experimental model of in-situ immune complex disease of the lung. Clin Exp Immunol (1988) 0.75

Oxygen radicals, cytokines, adhesion molecules, and lung injury. Environ Health Perspect (1994) 0.75

Articles cited by this

BOUND COMPLEMENT AND IMMUNOLOGIC INJURY OF BLOOD VESSELS. J Exp Med (1965) 7.16

A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem (1970) 5.26

Superoxide-dependent production of hydroxyl radical catalyzed by iron-EDTA complex. FEBS Lett (1978) 5.12

Quantitative immunoelectrophoresis of human serum proteins. Clin Sci (1968) 4.98

Protein iodination with solid state lactoperoxidase. Biochemistry (1974) 4.52

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol (1982) 4.38

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites. J Clin Invest (1982) 3.49

Macrophage oxygen-dependent antimicrobial activity. I. Susceptibility of Toxoplasma gondii to oxygen intermediates. J Exp Med (1979) 2.93

Metal-combining properties of human lactoferrin (red milk protein). 1. The involvement of bicarbonate in the reaction. Eur J Biochem (1968) 2.80

Lactoferrin enhances hydroxyl radical production by human neutrophils, neutrophil particulate fractions, and an enzymatic generating system. J Clin Invest (1981) 2.66

Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria. Infect Immun (1983) 2.59

Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. J Clin Invest (1979) 2.40

Role of oxygen metabolites in immune complex injury of lung. J Immunol (1981) 2.39

Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J Biol Chem (1981) 2.16

Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. Biochem J (1981) 1.85

Lactoferrin: a promoter of polymorphonuclear leukocyte adhesiveness. Blood (1981) 1.57

Modulation of classical C3 convertase of complement by tear lactoferrin. Immunology (1982) 1.25

Isolation of lactoferrin from human whey by a single chromatographic step. FEBS Lett (1980) 1.20

A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. Anal Biochem (1983) 1.19

Neutropenia induced by systemic infusion of lactoferrin. J Lab Clin Med (1982) 1.11

The iron-H2O2-iodide cytotoxic system. J Exp Med (1982) 1.09

Complement in acute experimental malaria. I. Total hemolytic activity. Mil Med (1966) 1.08

The requirement for ferric in the initiation of lipid peroxidation by chelated ferrous iron. Biochem Biophys Res Commun (1983) 1.07

Effects of ferrous chloride and iron dextran on lipid peroxidation in vivo in vitamin E and selenium adequate and deficient rats. J Nutr (1981) 1.05

The complement profile in babesiosis. J Immunol (1976) 0.92

Articles by these authors

Superoxide dismutase: improved assays and an assay applicable to acrylamide gels. Anal Biochem (1971) 28.59

Further studies on the chemotactic factor of complement and its formation in vivo. Immunology (1966) 7.59

Bacterial factors chemotactic for polymorphonuclear leukocytes. Am J Pathol (1968) 5.77

A mechanism for the production of ethylene from methional. The generation of the hydroxyl radical by xanthine oxidase. J Biol Chem (1970) 5.26

Endothelial cell gene expression of a neutrophil chemotactic factor by TNF-alpha, LPS, and IL-1 beta. Science (1989) 4.99

A plasmin-split fragment of C'3 as a new chemotactic factor. J Exp Med (1967) 4.94

The deactivation of rabbit neutrophils by chemotactic factor and the nature of the activatable esterase. J Exp Med (1968) 4.79

A neutrophil chemotactic factor from human C'5. J Immunol (1969) 4.46

Role of oxygen-derived free radicals and metabolites in leukocyte-dependent inflammatory reactions. Am J Pathol (1982) 4.38

Improving residents' compliance with standards of ambulatory care: results from the VA Cooperative Study on Computerized Reminders. JAMA (2000) 3.96

Leukotactic factor produced by sensitized lymphocytes. Science (1969) 3.95

Mechanisms of the inhibition of chemotaxis by phosphonate esters. J Exp Med (1967) 3.87

C5 chemotactic fragments produced by an enzyme in lysosomal granules of neutrophils. J Immunol (1970) 3.75

Cellular and molecular regulation of tumor necrosis factor-alpha production by pentoxifylline. Biochem Biophys Res Commun (1988) 3.63

Adhesion molecules and inflammatory injury. FASEB J (1994) 3.53

Acute immunologic pulmonary alveolitis. J Clin Invest (1974) 3.53

The isolation and partial characterization of neutrophil chemotactic factors from Escherichia coli. J Immunol (1975) 3.50

Intravascular activation of complement and acute lung injury. Dependency on neutrophils and toxic oxygen metabolites. J Clin Invest (1982) 3.49

Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo. Proc Natl Acad Sci U S A (1999) 3.49

Purification and identification of formyl-methionyl-leucyl-phenylalanine as the major peptide neutrophil chemotactic factor produced by Escherichia coli. J Biol Chem (1984) 3.32

Length of uninterrupted CGG repeats determines instability in the FMR1 gene. Nat Genet (1994) 3.22

The production by antigen-stimulated lymphocytes of a leukotactic factor distinct from migration inhibitory factor. Cell Immunol (1970) 3.17

Partial biochemical characterization of the activated esterase required in the complement-dependent chemotaxis of rabbit polymorphonuclear leukocytes. J Exp Med (1967) 3.15

The phlogistic role of C3 leukotactic fragments in myocardial infarcts of rats. J Exp Med (1971) 2.95

Chemotoxis of mononuclear cells. J Exp Med (1968) 2.95

Involvement of platelet-endothelial cell adhesion molecule-1 in neutrophil recruitment in vivo. Science (1993) 2.71

The chemosuppression of chemotaxis. J Exp Med (1966) 2.62

Protective effects of C5a blockade in sepsis. Nat Med (1999) 2.50

Role of endothelial-leukocyte adhesion molecule 1 (ELAM-1) in neutrophil-mediated lung injury in rats. J Clin Invest (1991) 2.50

Tissue injury caused by deposition of immune complexes is L-arginine dependent. Proc Natl Acad Sci U S A (1991) 2.49

Neutrophil-dependent acute lung injury. Requirement for P-selectin (GMP-140). J Clin Invest (1992) 2.47

Model system for the management of nitrogen leaching at the scale of river basins and regions. Water Sci Technol (2001) 2.41

Role of oxygen metabolites in immune complex injury of lung. J Immunol (1981) 2.39

Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin. J Biol Chem (1990) 2.37

In vitro and in vivo activity of a lymphocyte and immune complex-dependent chemotactic factor for eosinophils. J Exp Med (1971) 2.36

Complement-derived leukotactic factors in inflammatory synovial fluids of humans. J Clin Invest (1971) 2.35

Neutrophil aggregation and swelling induced by chemotactic agents. J Immunol (1977) 2.26

Evidence for soluble immune complexes in the pathogenesis of the glomerulonephritis of quartan malaria. Lancet (1969) 2.22

C3 leukotactic factors produced by a tissue protease. J Exp Med (1969) 2.19

Human herpesvirus 6 in salivary glands. Lancet (1990) 2.15

Biochemical demonstration of the activatable esterase of the rabbit netrophil involved in the chemotactic response. J Immunol (1970) 2.12

In vivo damage of rat lungs by oxygen metabolites. J Clin Invest (1981) 2.10

In vivo suppression of NF-kappa B and preservation of I kappa B alpha by interleukin-10 and interleukin-13. J Clin Invest (1997) 2.04

Pulmonary endothelial cell killing by human neutrophils. Possible involvement of hydroxyl radical. Lab Invest (1985) 2.01

Bleomycin-induced pulmonary fibrosis in the rat: inhibition by indomethacin. Am J Pathol (1979) 1.96

Role for macrophage inflammatory protein-2 in lipopolysaccharide-induced lung injury in rats. J Immunol (1996) 1.95

C5a-induced expression of P-selectin in endothelial cells. J Clin Invest (1994) 1.93

Chemotactic factor inactivator in normal human serum. J Clin Invest (1973) 1.93

Chemotactic factor influences on the aggregation, swelling, and foreign surface adhesiveness of human leukocytes. Am J Pathol (1978) 1.91

Generation of chemotactic activity in rabbit serum by plasminogen-streptokinase mixtures. J Exp Med (1967) 1.90

Leukotactic factors elaborated by virus-infected tissues. J Exp Med (1972) 1.89

Neutropenia induced by systemic infusion of chemotactic factors. J Immunol (1977) 1.89

Molecular and clinical correlations of deletions leading to Duchenne and Becker muscular dystrophies. Neurology (1989) 1.88

Defective regulation of inflammatory mediators in Hodgkin's disease. Supernormal levels of chemotactic-factor inactivator. N Engl J Med (1974) 1.88

Tumor necrosis factor participates in the pathogenesis of acute immune complex alveolitis in the rat. J Clin Invest (1989) 1.86

Acute inflammatory pulmonary reactions induced by chemotactic factors. Am J Pathol (1979) 1.79

Impaired leucotactic responsiveness in a child with recurrent infections. Lancet (1969) 1.78

Selective neutrophil desensitization to chemotactic factors. J Cell Biol (1979) 1.77

Requirement and role of C5a in acute lung inflammatory injury in rats. J Clin Invest (1996) 1.77

Tumor necrosis factor alpha regulates in vivo intrapulmonary expression of ICAM-1. Am J Pathol (1993) 1.74

Leukotactic factors in health and disease. Am J Pathol (1971) 1.71

Impaired neutrophil chemotaxis in patients with juvenile and rapidly progressing periodontitis. J Periodontal Res (1979) 1.70

Inhibition of lung inflammatory reactions in rats by an anti-human IL-8 antibody. J Immunol (1993) 1.68

Neutrophil chemotactic factors and related clinical disorders. Arthritis Rheum (1970) 1.68

Molecular cloning and characterization of DEFCAP-L and -S, two isoforms of a novel member of the mammalian Ced-4 family of apoptosis proteins. J Biol Chem (2000) 1.66

Lung and dermal vascular injury produced by preformed immune complexes. Am Rev Respir Dis (1978) 1.64

Pathogenesis of the granulomatous lung diseases. Am Rev Respir Dis (1984) 1.64

Replicative Legionella pneumophila lung infection in intratracheally inoculated A/J mice. A murine model of human Legionnaires' disease. Am J Pathol (1994) 1.63

C5 chemotactic fragment induces leukocyte production of tissue factor activity: a link between complement and coagulation. J Clin Invest (1979) 1.63

Isolation from human serum of an inactivator of bacterial lipopolysaccharide. Am J Pathol (1977) 1.58

Influence of inhibitors of cellular function on chemotactic factor-induced neutrophil aggregation. J Immunol (1977) 1.57

Two distinct chemotactic factor inactivators in human serum. J Immunol (1975) 1.55

Inhibition of in vivo and in vitro neutrophil responses to chemotactic factors by a competitive antagonist. J Immunol (1978) 1.55

The role of complement in experimental bullous pemphigoid. J Clin Invest (1995) 1.55

Endothelial cell killing by neutrophils. Synergistic interaction of oxygen products and proteases. Am J Pathol (1989) 1.55

Chemotaxis of human eosinophils. Am J Pathol (1969) 1.54

A major role for neutrophils in experimental bullous pemphigoid. J Clin Invest (1997) 1.53

Role of C5a in multiorgan failure during sepsis. J Immunol (2001) 1.53

Chemotaxis of rat lymphocytes. J Immunol (1977) 1.53

Enhancement by the complement membrane attack complex of tumor necrosis factor-alpha-induced endothelial cell expression of E-selectin and ICAM-1. J Immunol (1995) 1.53

Role of macrophage inflammatory protein-1 alpha (MIP-1 alpha) in acute lung injury in rats. J Immunol (1995) 1.52

Biologic role of complement products. Complement-derived leukotactic activity extractable from lesions of immunologic vasculitis. J Immunol (1972) 1.51

Leukotactic dystunction in sarcoidosis. Ann Intern Med (1976) 1.50

Suppression by superoxide dismutase of immune-complex--induced pulmonary alveolitis and dermal inflammation. Am J Pathol (1981) 1.50

Requirements for leukocyte adhesion molecules in nephrotoxic nephritis. J Clin Invest (1993) 1.49

Long-term low-dose cyclosporine therapy for severe psoriasis: effects on renal function and structure. J Am Acad Dermatol (1996) 1.49

Mediator-induced activation of xanthine oxidase in endothelial cells. FASEB J (1989) 1.49

Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest (2000) 1.49

Sublytic concentrations of the membrane attack complex of complement induce endothelial interleukin-8 and monocyte chemoattractant protein-1 through nuclear factor-kappa B activation. Am J Pathol (1997) 1.49

Chemoattractants of leukocytes, with special reference to lymphocytes. Fed Proc (1972) 1.48

Biochemical quantitation of the chemotactic factor inactivator activity in human serum. J Lab Clin Med (1979) 1.46

In vitro and in vivo stimulation of rat neutrophils and alveolar macrophages by immune complexes. Production of O-2 and H2O2. Am J Pathol (1983) 1.46

Congenital 21-hydroxylase deficiency as a new deletion mutation. Detection in a proband during subsequent prenatal diagnosis by HLA typing and DNA analysis. Hum Immunol (1992) 1.45

Anti-L-selectin antibody treatment of hemorrhagic-traumatic shock in baboons. Crit Care Med (1999) 1.45