Published in Anal Biochem on May 01, 1983
Evidence for role of hydroxyl radical in complement and neutrophil-dependent tissue injury. J Clin Invest (1983) 2.52
Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. J Clin Invest (1988) 1.18
Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in the murine Meth A sarcoma model. Proc Natl Acad Sci U S A (1987) 1.17
Hydrochalarones: a novel endohedral metallofullerene platform for enhancing magnetic resonance imaging contrast. J Med Chem (2008) 1.07
Protein conjugation with amphiphilic block copolymers for enhanced cellular delivery. Bioconjug Chem (2008) 0.99
Thermosensitive liposomes for localized delivery and triggered release of chemotherapy. J Control Release (2013) 0.98
Polyethylene glycol modification of a galactosylated streptavidin clearing agent: effects on immunogenicity and clearance of a biotinylated anti-tumour antibody. Br J Cancer (1996) 0.96
Alpha 2-macroglobulin is the primary inhibitor of miniplasmin in vitro and in vivo in the mouse. Comparison with alpha 2-antiplasmin in simultaneous reaction experiments. Biochem J (1988) 0.86
Antigenic peptides containing large PEG loops designed to extend out of the HLA-A2 binding site form stable complexes with class I major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1996) 0.83
Tailoring structure-function properties of L-asparaginase: engineering resistance to trypsin cleavage. Biochem J (2007) 0.80
A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. J Clin Invest (1985) 0.79
Isozymes of superoxide dismutase from wheat germ. Biochim Biophys Acta (1973) 3.17
Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin. J Biol Chem (1973) 2.45
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol (1999) 2.35
Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. J Biol Chem (1981) 2.15
Angiostatin binds ATP synthase on the surface of human endothelial cells. Proc Natl Acad Sci U S A (1999) 1.95
Hepatic receptor that specifically binds oligosaccharides containing fucosyl alpha1 leads to 3 N-acetylglucosamine linkages. Proc Natl Acad Sci U S A (1978) 1.87
Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases. J Immunol (1980) 1.85
Endothelial cell surface F1-F0 ATP synthase is active in ATP synthesis and is inhibited by angiostatin. Proc Natl Acad Sci U S A (2001) 1.83
Physical conditioning augments the fibrinolytic response to venous occlusion in healthy adults. N Engl J Med (1980) 1.81
Model of alpha 2-macroglobulin structure and function. Proc Natl Acad Sci U S A (1985) 1.79
Binding of urokinase-type plasminogen activator to its receptor in MCF-7 cells activates extracellular signal-regulated kinase 1 and 2 which is required for increased cellular motility. J Biol Chem (1998) 1.78
Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990. Acad Med (1996) 1.58
Demonstration and characterization of specific binding sites for factor VIII/von Willebrand factor on human platelets. J Clin Invest (1979) 1.55
Oxidative dissociation of human alpha 2-macroglobulin tetramers into dysfunctional dimers. J Biol Chem (1994) 1.53
Endogenously produced urokinase-type plasminogen activator is a major determinant of the basal level of activated ERK/MAP kinase and prevents apoptosis in MDA-MB-231 breast cancer cells. J Cell Sci (2001) 1.52
Physical properties of human alpha 2-macroglobulin following reaction with methylamine and trypsin. Biochim Biophys Acta (1982) 1.49
Relationship of sialic acid to function and in vivo survival of human factor VIII/von Willebrand factor protein. J Biol Chem (1977) 1.47
Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain. Am J Pathol (1992) 1.47
The subunit structure of normal and hemophilic factor VIII. J Clin Invest (1973) 1.46
Selective diminution of the binding of mannose by murine macrophages in the late stages of activation. J Biol Chem (1982) 1.45
A cytokeratin 8-like protein with plasminogen-binding activity is present on the external surfaces of hepatocytes, HepG2 cells and breast carcinoma cell lines. J Cell Sci (1995) 1.44
The effect of plasmin on the subunit structure of human fibrinogen. J Biol Chem (1972) 1.44
Immunochemical and biochemical characterization of a glioma-associated extracellular matrix glycoprotein. J Cell Biochem (1985) 1.42
alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. Lab Invest (1994) 1.33
Receptors for maleylated proteins regulate secretion of neutral proteases by murine macrophages. Science (1982) 1.31
The subunit structures of human plasma and platelet factor XIII (fibrin-stabilizing factor). J Biol Chem (1971) 1.30
Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. Exp Neurol (2001) 1.29
Analysis of inter-alpha-trypsin inhibitor and a novel trypsin inhibitor, pre-alpha-trypsin inhibitor, from human plasma. Polypeptide chain stoichiometry and assembly by glycan. J Biol Chem (1989) 1.29
Further characterization of the cellular plasminogen binding site: evidence that plasminogen 2 and lipoprotein a compete for the same site. Biochemistry (1989) 1.28
Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface. J Biol Chem (1994) 1.28
The effect of fibrin-stabilizing factor on the subunit structure of human fibrin. J Clin Invest (1971) 1.22
Methionine sulfoxide and the oxidative regulation of plasma proteinase inhibitors. J Leukoc Biol (1988) 1.20
Regulation of macrophage alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-gamma. J Clin Invest (1993) 1.20
Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. J Immunol (1987) 1.19
Evidence for preferential adhesion of ovarian epithelial carcinoma cells to type I collagen mediated by the alpha2beta1 integrin. Int J Cancer (1996) 1.19
Immunohistochemical detection of factor VIII/von Willebrand factor in hyperplastic endothelial cells in glioblastoma multiforme and mixed glioma-sarcoma. J Neuropathol Exp Neurol (1982) 1.18
Embryonic fibroblasts that are genetically deficient in low density lipoprotein receptor-related protein demonstrate increased activity of the urokinase receptor system and accelerated migration on vitronectin. J Biol Chem (1997) 1.17
Chondroitin 4-sulfate covalently cross-links the chains of the human blood protein pre-alpha-inhibitor. J Biol Chem (1991) 1.16
An alpha 2-macroglobulin receptor-dependent mechanism for the plasma clearance of transforming growth factor-beta 1 in mice. J Clin Invest (1991) 1.15
Cell-surface cytokeratin 8 is the major plasminogen receptor on breast cancer cells and is required for the accelerated activation of cell-associated plasminogen by tissue-type plasminogen activator. J Biol Chem (1996) 1.14
Cytokine binding and clearance properties of proteinase-activated alpha 2-macroglobulins. Lab Invest (1991) 1.14
Inhibition of cell surface receptor-bound plasmin by alpha 2-antiplasmin and alpha 2-macroglobulin. J Biol Chem (1991) 1.12
Plasminogen activator inhibitor 1 functions as a urokinase response modifier at the level of cell signaling and thereby promotes MCF-7 cell growth. J Cell Biol (2001) 1.12
Classification of alpha 2-macroglobulin-cytokine interactions based on affinity of noncovalent association in solution under apparent equilibrium conditions. J Biol Chem (1994) 1.11
Specificity and sensitivity of immunohistochemical detection of factor VIII/von Willebrand factor antigen in formalin-fixed paraffin-embedded tissue. J Histochem Cytochem (1982) 1.10
Urokinase receptor primes cells to proliferate in response to epidermal growth factor. Oncogene (2006) 1.10
Precipitation of fibrinogen, fibrinogen degradation products and fibrin monomer by histone H3. Thromb Res (1985) 1.09
The conformation-dependent interaction of alpha 2-macroglobulin with vascular endothelial growth factor. A novel mechanism of alpha 2-macroglobulin/growth factor binding. J Biol Chem (2000) 1.08
Ligand binding, conformational change and plasma elimination of human, mouse and rat alpha-macroglobulin proteinase inhibitors. Biochem J (1983) 1.08
Cytokeratin 8 released by breast carcinoma cells in vitro binds plasminogen and tissue-type plasminogen activator and promotes plasminogen activation. Biochem J (1996) 1.08
Secretion of extracellular matrix-degrading proteinases is increased in epithelial ovarian carcinoma. Int J Cancer (1994) 1.08
Binding of alpha 2-macroglobulin to hepatocytes: mechanism of in vivo clearance. Biochem Biophys Res Commun (1985) 1.07
Presence of the protein-glycosaminoglycan-protein covalent cross-link in the inter-alpha-inhibitor-related proteinase inhibitor heavy chain 2/bikunin. J Biol Chem (1993) 1.05
Catabolism of human tissue plasminogen activator in mice. Blood (1985) 1.05
The very low density lipoprotein receptor regulates urokinase receptor catabolism and breast cancer cell motility in vitro. J Biol Chem (1999) 1.05
The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. J Biol Chem (1993) 1.05
Murine gamma interferon fails to inhibit Toxoplasma gondii growth in murine fibroblasts. Infect Immun (1990) 1.04
Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. Mol Psychiatry (2007) 1.04
The effect of plasmin on the subunit structure of human fibrin. J Biol Chem (1973) 1.03
The in vivo metabolism of antithrombin III and antithrombin III complexes. J Biol Chem (1982) 1.03
Binding of the antitumor drug platinum uracil blue to closed and nicked circular duplex DNAs. Biochemistry (1978) 1.02
Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. J Clin Invest (1982) 1.01
Selective upregulated expression of the alpha2-macroglobulin signaling receptor in highly metastatic 1-LN prostate carcinoma cells. Arch Biochem Biophys (2000) 1.00
Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells. J Immunol (1993) 0.99
Soluble fibrin preparations inhibit the reaction of plasmin with alpha 2-macroglobulin. Comparison with alpha 2-antiplasmin and leupeptin. Biochem J (1991) 0.99
Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. Apoptosis (2010) 0.98
In vivo catabolism of alpha 1-proteinase inhibitor-trypsin, antithrombin III-thrombin and alpha 2-macroglobulin-methylamine. Biochim Biophys Acta (1982) 0.98
Proteolytic activation of single-chain precursor macrophage-stimulating protein by nerve growth factor-gamma and epidermal growth factor-binding protein, members of the kallikrein family. J Biol Chem (1994) 0.97
Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. J Leukoc Biol (2001) 0.97
Structure of inter-alpha-inhibitor (inter-alpha-trypsin inhibitor) and pre-alpha-inhibitor: current state and proposition of a new terminology. Biol Chem Hoppe Seyler (1990) 0.97
The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. J Biol Chem (1994) 0.97
Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. Biochemistry (1983) 0.96
Atrophie blanche. A disorder associated with defective release of tissue plasminogen activator. Arch Pathol Lab Med (1986) 0.96
Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. Biochemistry (1991) 0.96
Binding of tumor necrosis factor alpha to activated forms of human plasma alpha 2 macroglobulin. Am J Pathol (1991) 0.95
Functional inactivation and structural disruption of human alpha 2-macroglobulin by neutrophils and eosinophils. J Biol Chem (1989) 0.95
Plasmin binding to the plasminogen receptor enhances catalytic efficiency and activates the receptor for subsequent ligand binding. Arch Biochem Biophys (1991) 0.95
A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2. J Biol Chem (1995) 0.95
The potential role of alpha 2-macroglobulin in the control of cysteine proteinases (gingipains) from Porphyromonas gingivalis. J Periodontal Res (1997) 0.95
Colony-stimulating factor-1 modulates alpha 2-macroglobulin receptor expression in murine bone marrow macrophages. J Biol Chem (1990) 0.94
Conformation and protease binding activity of binary and ternary human alpha 2-macroglobulin-protease complexes. J Biol Chem (1983) 0.94
Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. Ann N Y Acad Sci (1983) 0.94
Oxidized alpha2-macroglobulin (alpha2M) differentially regulates receptor binding by cytokines/growth factors: implications for tissue injury and repair mechanisms in inflammation. J Immunol (1998) 0.94
Alpha-macroglobulin from Limulus polyphemus exhibits proteinase inhibitory activity and participates in a hemolytic system. Biochemistry (1990) 0.94