Published in J Biol Chem on October 10, 1982
Modification of cytokinins by cauliflower microsomal enzymes. Plant Physiol (1984) 1.18
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450. J Clin Invest (1985) 1.15
Cross-linking mass spectrometry and mutagenesis confirm the functional importance of surface interactions between CYP3A4 and holo/apo cytochrome b(5). Biochemistry (2012) 0.95
Characterization of pig kidney microsomal cytochrome P-450 catalysing 25-hydroxylation of vitamin D3 and C27 steroids. Biochem J (1990) 0.83
Integrated analysis of COX-2 and iNOS derived inflammatory mediators in LPS-stimulated RAW macrophages pre-exposed to Echium plantagineum L. bee pollen extract. PLoS One (2013) 0.77
Comparison of CYP3A4 and CYP3A5: the effects of cytochrome b5 and NADPH-cytochrome P450 reductase on testosterone hydroxylation activities. Drug Metab Pharmacokinet (2012) 0.77
Camphor hydroxylase of Pseudomonas putida: vestiges of sequence homology in cytochrome P-450CAM, putidaredoxin, and related proteins. Proc Natl Acad Sci U S A (1984) 0.75
How do risk factors work together? Mediators, moderators, and independent, overlapping, and proxy risk factors. Am J Psychiatry (2001) 7.73
P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics (1996) 6.12
The P450 superfamily: update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA Cell Biol (1993) 4.92
The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature. DNA Cell Biol (1991) 3.73
Oxygen activation by cytochrome P-450. Annu Rev Biochem (1980) 3.44
The P450 superfamily: updated listing of all genes and recommended nomenclature for the chromosomal loci. DNA (1989) 3.03
Inactivation of key metabolic enzymes by mixed-function oxidation reactions: possible implication in protein turnover and ageing. Proc Natl Acad Sci U S A (1983) 2.98
The P450 gene superfamily: recommended nomenclature. DNA (1987) 2.95
Enzymatic omega-oxidation. IV. Purification and properties of the omega-hydroxylase of Pseudomonas oleovorans. J Biol Chem (1970) 2.89
Enzymatic omega-oxidation. I. Electon carriers in fatty acid and hydrocarbon hydroxylation. J Biol Chem (1966) 2.83
How can we learn about developmental processes from cross-sectional studies, or can we? Am J Psychiatry (2000) 2.70
Cytochrome P-450. Multiplicity of isoforms, substrates, and catalytic and regulatory mechanisms. J Biol Chem (1991) 2.68
Enzymatic omega-oxidation. II. Function of rubredoxin as the electron carrier in omega-hydroxylation. J Biol Chem (1967) 2.62
Effect of superoxide generation and dismutation on hydroxylation reactions catalyzed by liver microsomal cytochrome P-450. J Biol Chem (1971) 2.35
Structure of the gene for human butyrylcholinesterase. Evidence for a single copy. Biochemistry (1990) 2.26
Role of hemoprotein P-450 in fatty acid omega-hydroxylation in a soluble enzyme system from liver microsomes. J Biol Chem (1968) 1.92
Resolution of the cytochrome P-450-containing omega-hydroxylation system of liver microsomes into three components. J Biol Chem (1969) 1.84
Gene expression during development of Myxococcus xanthus. Analysis of the genes for protein S. J Mol Biol (1984) 1.79
Phosphatidylcholine requirement in the enzymatic reduction of hemoprotein P-450 and in fatty acid, hydrocarbon, and drug hydroxylation. J Biol Chem (1970) 1.76
Purification and characterization of a unique isozyme of cytochrome P-450 from liver microsomes of ethanol-treated rabbits. J Biol Chem (1982) 1.71
Preparation and properties of partially purified cytochrome P-450 and reduced nicotinamide adenine dinucleotide phosphate-cytochrome P-450 reductase from rabbit liver microsomes. J Biol Chem (1974) 1.69
Purified liver microsomal NADPH-cytochrome P-450 reductase. Spectral characterization of oxidation-reduction states. J Biol Chem (1978) 1.68
Enzymatic omega-oxidation. 3. Purification and properties of rubredoxin, a component of the omega-hydroxylation system of Pseudomonas oleovorans. J Biol Chem (1968) 1.56
Separate roles for FMN and FAD in catalysis by liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1981) 1.56
Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1976) 1.54
On the stoichiometry of the oxidase and monooxygenase reactions catalyzed by liver microsomal cytochrome P-450. Products of oxygen reduction. J Biol Chem (1984) 1.52
Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450. J Biol Chem (1976) 1.50
Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation. Biochem Pharmacol (1978) 1.49
Structural features of liver microsomal NADPH-cytochrome P-450 reductase. Hydrophobic domain, hydrophilic domain, and connecting region. J Biol Chem (1982) 1.45
Two forms of liver microsomal cytochrome P-450, P-450lm2 and P-450LM4 (rabbit liver). Methods Enzymol (1978) 1.42
Interactions of cytochrome P-450, NADPH-cytochrome P-450 reductase, phospholipid, and substrate in the reconstituted liver microsomal enzyme system. J Biol Chem (1980) 1.40
Epoxidation of olefins by cytochrome P450: evidence from site-specific mutagenesis for hydroperoxo-iron as an electrophilic oxidant. Proc Natl Acad Sci U S A (1998) 1.40
Purified liver microsomal cytochrome P-450. Separation and characterization of multiple forms. J Biol Chem (1975) 1.39
Peroxo-iron and oxenoid-iron species as alternative oxygenating agents in cytochrome P450-catalyzed reactions: switching by threonine-302 to alanine mutagenesis of cytochrome P450 2B4. Proc Natl Acad Sci U S A (1996) 1.39
Stereospecificity and other properties of highly purified beta-hydroxy-beta-methylglutaryl coenzyme A cleavage enzyme from bovine liver. J Biol Chem (1968) 1.36
Identification of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein requiring phospholipid for catalytic activity. Biochem Biophys Res Commun (1974) 1.35
Identification of the high and low potential flavins of liver microsomal NADPH-cytochrome P-450 reductase. J Biol Chem (1978) 1.35
Complete amino acid sequence and predicted membrane topology of phenobarbital-induced cytochrome P-450 (isozyme 2) from rabbit liver microsomes. Proc Natl Acad Sci U S A (1983) 1.30
Enzymatic omega-oxidation. V. Forms of Pseudomonas oleovorans rubredoxin containing one or two iron atoms: structure and function in omega-hydroxylation. J Biol Chem (1971) 1.30
Subunit structure of rabbit muscle pyruvate kinase. J Biol Chem (1969) 1.29
Interaction of methoxychlor and related compounds with estrogen receptor alpha and beta, and androgen receptor: structure-activity studies. Mol Pharmacol (2000) 1.28
Properties of NADPH-cytochrome P-450 reductase purified from rabbit liver microsomes. Arch Biochem Biophys (1979) 1.25
Analysis of expressed sequence tags from two starvation, time-of-day-specific libraries of Neurospora crassa reveals novel clock-controlled genes. Genetics (2001) 1.22
CYP2D6 catalyzes tamoxifen 4-hydroxylation in human liver. Cancer Res (1997) 1.20
Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital. J Biol Chem (1976) 1.19
An analysis of the electron paramagnetic resonance spectrum of pseudomonas oleovorans rubredoxin. A method for determination of the liganids of ferric iron in completely rhombic sites. J Biol Chem (1971) 1.17
Isolation of artemisinin (qinghaosu) from Artemisia annua growing in the United States. J Nat Prod (1984) 1.17
Mechanism of C-5 double bond introduction in the biosynthesis of cholesterol by rat liver microsomes. J Biol Chem (1977) 1.17
P-450 cytochromes: structure and function. Adv Enzymol Relat Areas Mol Biol (1987) 1.16
Role of a hydrophobic polypeptide in the N-terminal region of NADPH-cytochrome P-450 reductase in complex formation with P-450LM. Biochem Biophys Res Commun (1979) 1.15
Enzymatic oxidation. VII. Reduced diphosphopyridine nucleotide-rubredoxin reductase: properties and function as an electron carrier in hydroxylation. J Biol Chem (1972) 1.15
Effects of pesticides and related compounds on steroid metabolism and function. CRC Crit Rev Toxicol (1975) 1.14
Hydrogen peroxide formation and stoichiometry of hydroxylation reactions catalyzed by highly purified liver microsomal cytochrome P-450. Arch Biochem Biophys (1977) 1.11
Immunochemical characterization of multiple forms of cytochrome P-450 in rabbit nasal microsomes and evidence for tissue-specific expression of P-450s NMa and NMb. Mol Pharmacol (1990) 1.11
Catalysis by cytochrome P-450 of an oxidative reaction in xenobiotic aldehyde metabolism: deformylation with olefin formation. Proc Natl Acad Sci U S A (1991) 1.11
Oxidation-reduction states of FMN and FAD in NADPH-cytochrome P-450 reductase during reduction by NADPH. J Biol Chem (1982) 1.09
Immunochemical evidence for induction of the alcohol-oxidizing cytochrome P-450 of rabbit liver microsomes by diverse agents: ethanol, imidazole, trichloroethylene, acetone, pyrazole, and isoniazid. Proc Natl Acad Sci U S A (1985) 1.08
Alcohol-inducible cytochrome P-450IIE1 lacking the hydrophobic NH2-terminal segment retains catalytic activity and is membrane-bound when expressed in Escherichia coli. J Biol Chem (1991) 1.07
The effect of o,p'DDD on cortisol and hexobarbital metabolism. Biochem Pharmacol (1966) 1.07
Changes in cell surface hydrophobicity of Myxococcus xanthus are correlated with sporulation-related events in the developmental program. J Bacteriol (1984) 1.06
Characterization of the omega-hydroxylase of Pseudomonas oleovorans as a nonheme iron protein. Arch Biochem Biophys (1977) 1.06
Properties of a solubilized form of the cytochrome P-450-containing mixed-function oxidase of liver microsomes. Mol Pharmacol (1970) 1.05
Role of lysyl epsilon-amino groups in adenosine diphosphate binding and catalytic activity of pyruvate kinase. J Biol Chem (1971) 1.05
Highly purified detergent-solubilized NADPH-cytochrome P-450 reductase from phenobarbital-induced rat liver microsomes. Biochem Biophys Res Commun (1974) 1.05
Reduction of alkyl hydroperoxides to alcohols: role of rubredoxin, an electron carrier in the bacterial hydroxylation of hydrocarbons. Biochem Biophys Res Commun (1971) 1.04
Catalytic activity of cytochrome P-450 isozyme 3a isolated from liver microsomes of ethanol-treated rabbits. Oxidation of alcohols. J Biol Chem (1982) 1.03
Amino-terminal sequence of phenobarbital-inducible cytochrome P-450 from rabbit liver microsomes: similarity to hydrophobic amino-terminal segments of preproteins. Biochem Biophys Res Commun (1977) 1.03
Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood. Pharmacogenetics (1993) 1.03
Fatty acid and hydrocarbon hydroxylation in yeast: role of cytochrome P-450 in Candida tropicalis. Biochem Biophys Res Commun (1971) 1.02
Simple, rapid, and highly efficient separation of amino acid phenylthiohydantoins by reversed-phase high-performance liquid chromatography. Anal Biochem (1982) 1.02
Estrogenic action of DDT analogs. Am J Ind Med (1983) 1.02
Structure-activity relationships of putative primaquine metabolites causing methemoglobin formation in canine hemolysates. Toxicol Appl Pharmacol (1985) 1.02
Structural resemblance of cytochrome P-450 isolated from Pseudomonas putida and from rabbit liver microsomes. Biochem Biophys Res Commun (1974) 1.01
Effects of cytochrome b5 on cytochrome P-450-catalyzed reactions. Studies with manganese-substituted cytochrome b5. Drug Metab Dispos (1984) 1.01
Effect of different recruitment sources on the composition of a bipolar disorder case registry. Soc Psychiatry Psychiatr Epidemiol (2000) 1.01
Mechanism of action of pyruvate kinase. Role of sulfhydryl groups in catalytic activity as determined by disulfide interchange. J Biol Chem (1972) 1.01
Properties of a yeast cytochrome P-450-containing enzyme system which catalyzes the hydroxylation of fatty acids, alkanes, and drugs. Eur J Biochem (1973) 1.01
Endogenous substrates of monooxygenases: fatty acids and prostaglandins. Pharmacol Ther (1980) 0.99
Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1. Mol Pharmacol (2000) 0.98
Comparison of six rabbit liver cytochrome P-450 isozymes in formation of a reactive metabolite of acetaminophen. Biochem Biophys Res Commun (1983) 0.98
Determination of the antimalarial arteether and its deethylated metabolite dihydroartemisinin in plasma by high-performance liquid chromatography with reductive electrochemical detection. J Pharm Sci (1991) 0.98
Monospecific antipeptide antibody to cytochrome P-450 2B6. Drug Metab Dispos (1999) 0.98
Structural features of isozyme 2 of liver microsomal cytochrome P-450. Identification of a highly conserved cysteine-containing peptide. J Biol Chem (1982) 0.97
Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes. Proc Natl Acad Sci U S A (1993) 0.97
Purification and properties of a shortened form of cytochrome P-450 2E1: deletion of the NH2-terminal membrane-insertion signal peptide does not alter the catalytic activities. Proc Natl Acad Sci U S A (1991) 0.97
Interactions of chlorinated hydrocarbon pesticides with the 8S estrogen-binding protein in rat testes. Steroids (1978) 0.97
Biochemical studies on cytochrome P-450 solubilized from liver microsomes: partial purification and mechanism of catalysis. Ann N Y Acad Sci (1973) 0.96
Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes. Cancer Res (1985) 0.96
Purification and characterization of two unique forms of cytochrome P-450 from rabbit nasal microsomes. Biochemistry (1988) 0.96
Spectral intermediates in the reaction of oxygen with purified liver microsomal cytochrome P-450. Biochem Biophys Res Commun (1976) 0.95
Effects of conditions for reconstitution with cytochrome b5 on the formation of products in cytochrome P-450-catalyzed reactions. Drug Metab Dispos (1986) 0.95
Kinetics of reduction of cytochrome P-450LM4 in a reconstituted liver microsomal enzyme system. J Biol Chem (1979) 0.95
Heme ligand replacement reactions of cytochrome P-450. Characterization of the bonding atom of the axial ligand trans to thiolate as oxygen. J Biol Chem (1982) 0.93
Membrane topology of cytochrome P450 2B4 in Langmuir-Blodgett monolayers. Arch Biochem Biophys (1998) 0.93
Metabolism of a potential 8-aminoquinoline antileishmanial drug in rat liver microsomes. Biochem Pharmacol (1985) 0.93
Further studies on the properties of liver propionyl coenzyme A holocarboxylase synthetase and the specificity of holocarboxylase formation. J Biol Chem (1966) 0.93
Hydroxylation of prostaglandins A1 and E1 by liver microsomal monooxygenase. Characteristics of the enzyme system in the guinea pig. J Biol Chem (1978) 0.92
Role of isozymes of rabbit microsomal cytochrome P-450 in the metabolism of retinoic acid, retinol, and retinal. Mol Pharmacol (1992) 0.92
Metabolic activation of pesticides with proestrogenic activity. Fed Proc (1987) 0.91