Stratification and terminal differentiation of cultured epidermal cells.

PubWeight™: 2.44‹?› | Rank: Top 2%

🔗 View Article (PMID 6895777)

Published in Nature on February 04, 1982

Authors

F M Watt, H Green

Articles citing this

Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67

Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J Cell Biol (1986) 5.96

Epidermal stem cells of the skin. Annu Rev Cell Dev Biol (2006) 3.92

Self-assembly of human papillomavirus type 1 capsids by expression of the L1 protein alone or by coexpression of the L1 and L2 capsid proteins. J Virol (1993) 3.65

Canonical notch signaling functions as a commitment switch in the epidermal lineage. Genes Dev (2006) 3.51

Retinoids as important regulators of terminal differentiation: examining keratin expression in individual epidermal cells at various stages of keratinization. J Cell Biol (1987) 2.62

Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc Natl Acad Sci U S A (1988) 2.53

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol (1994) 2.05

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes. J Cell Biol (1984) 2.00

Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis. J Cell Biol (1984) 1.93

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A (2001) 1.79

Tissue- and stratum-specific expression of the human involucrin promoter in transgenic mice. Proc Natl Acad Sci U S A (1993) 1.57

Epstein-Barr virus infection in ex vivo tonsil epithelial cell cultures of asymptomatic carriers. J Virol (2004) 1.48

Polarized expression of integrin receptors (alpha 6 beta 4, alpha 2 beta 1, alpha 3 beta 1, and alpha v beta 5) and their relationship with the cytoskeleton and basement membrane matrix in cultured human keratinocytes. J Cell Biol (1991) 1.47

Emerging interactions between skin stem cells and their niches. Nat Med (2014) 1.45

The phenotypic heterogeneity of mouse thymic stromal cells. Immunology (1990) 1.37

Effect of growth environment on spatial expression of involucrin by human epidermal keratinocytes. Arch Dermatol Res (1987) 1.36

A matter of life and death: self-renewal in stem cells. EMBO Rep (2012) 1.30

TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells. Cell Regul (1990) 1.28

Molecular biology of keratinocyte differentiation. Environ Health Perspect (1989) 1.16

Mechanisms of adherence of Candida albicans to cultured human epidermal keratinocytes. Infect Immun (1993) 1.14

Role of LIM kinases in normal and psoriatic human epidermis. Mol Biol Cell (2006) 1.14

Marker succession during the development of keratinocytes from cultured human embryonic stem cells. Proc Natl Acad Sci U S A (2003) 1.11

Par3-mInsc and Gαi3 cooperate to promote oriented epidermal cell divisions through LGN. Nat Cell Biol (2014) 1.11

Novel protein in human epidermal keratinocytes: regulation of expression during differentiation. Mol Cell Biol (1988) 1.09

Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation. Br J Cancer (1989) 1.05

Mouse antisera specific for desmosomal adhesion molecules of suprabasal skin cells, meninges, and meningioma. Proc Natl Acad Sci U S A (1986) 0.98

NG2 proteoglycan expression in mouse skin: altered postnatal skin development in the NG2 null mouse. J Histochem Cytochem (2007) 0.97

Commitment to differentiation and expression of early differentiation markers in murine keratinocytes in vitro are regulated independently of extracellular calcium concentrations. J Cell Biol (1993) 0.94

Phorbol ester-stimulated phosphorylation of keratinocyte transglutaminase in the membrane anchorage region. Biochem J (1990) 0.92

Neuregulin3 alters cell fate in the epidermis and mammary gland. BMC Dev Biol (2007) 0.90

Epidermal development in mammals: key regulators, signals from beneath, and stem cells. Int J Mol Sci (2013) 0.90

Characterization of the human spr2 promoter: induction after UV irradiation or TPA treatment and regulation during differentiation of cultured primary keratinocytes. Nucleic Acids Res (1990) 0.89

PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation. Cell Res (2009) 0.88

Differentiation-dependent changes in the solubility of a 195-kD protein in human epidermal keratinocytes. J Cell Biol (1986) 0.88

Switching roles: the functional plasticity of adult tissue stem cells. EMBO J (2015) 0.87

H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. PLoS One (2009) 0.87

A novel mechanism of matrix metalloproteinase-9 gene expression implies a role for keratinization. EMBO Rep (2001) 0.85

Expression of EGF receptor, involucrin, and cytokeratins in basal cell carcinomas and squamous cell carcinomas of the skin. Arch Dermatol Res (1989) 0.85

Human keratinocytes have two interconvertible modes of proliferation. Nat Cell Biol (2015) 0.85

Differential expression of TGF-beta isoforms during differentiation of HaCaT human keratinocyte cells: implication for the separate role in epidermal differentiation. J Korean Med Sci (2004) 0.83

Ancient origin of the gene encoding involucrin, a precursor of the cross-linked envelope of epidermis and related epithelia. Proc Natl Acad Sci U S A (2008) 0.82

Mimicking normal tissue architecture and perturbation in cancer with engineered micro-epidermis. Biomaterials (2012) 0.82

Computational modelling of epidermal stratification highlights the importance of asymmetric cell division for predictable and robust layer formation. J R Soc Interface (2014) 0.82

Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBO J (2016) 0.80

Identification of an epidermal cell-adhesion glycoprotein. Biochem J (1985) 0.79

Serum-induced keratinization processes in an immortalized human meibomian gland epithelial cell line. PLoS One (2015) 0.78

Changes in oncogene mRNA expression during human keratinocyte differentiation. Arch Dermatol Res (1994) 0.78

Vimentin is necessary for colony growth of human diploid keratinocytes. Histochem Cell Biol (2014) 0.78

Differentiation-related changes in glycoprotein synthesis by human keratinocytes. Biochem J (1986) 0.77

A two-colour flowcytometric study of cell kinetics and differentiation of human keratinocytes in culture. Arch Dermatol Res (1992) 0.76

Cell anchorage determines whether mammary tumor virus glycoproteins are processed for plasma membranes or secretion. J Cell Biol (1985) 0.76

Expression of Toll-like Receptor 2 in Cultured Human Keratinocytes: The Effect of Bacterial Antigens, Cytokines and Calcium Concentration. Ann Dermatol (2009) 0.75

Differential Expression of TGF-β Isoforms in Human Kerationocytes by Narrow Band UVB. Ann Dermatol (2008) 0.75

Extra-cellular calcium concentration regulates the expression of skin calcium binding protein (SCaBP) in mouse keratinocyte cultures. Arch Dermatol Res (1983) 0.75

Formation of keratinocyte multilayers on filters under airlifted or submerged culture conditions in medium containing calcium, ascorbic acid, and keratinocyte growth factor. Histochem Cell Biol (2016) 0.75

Articles by these authors

Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell (1975) 15.93

The initiation of cell division in a contact-inhibited mammalian cell line. J Cell Physiol (1965) 12.07

An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell (1975) 8.29

Three clonal types of keratinocyte with different capacities for multiplication. Proc Natl Acad Sci U S A (1987) 6.30

An established pre-adipose cell line and its differentiation in culture. Cell (1974) 5.97

Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell (1993) 5.86

Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell (1980) 5.83

Stem cell patterning and fate in human epidermis. Cell (1995) 5.22

Two types of ribosome in mouse-hamster hybrid cells. Nat New Biol (1971) 5.19

Epidermal growth factor and the multiplication of cultured human epidermal keratinocytes. Nature (1977) 4.90

Human-mouse hybrid cell lines containing partial complements of human chromosomes and functioning human genes. Proc Natl Acad Sci U S A (1967) 4.83

Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells. Cell (1976) 4.63

Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. Cell (1979) 4.38

Immunofluorescent staining of keratin fibers in cultured cells. Cell (1978) 4.25

Molecular cloning of mRNA from 3T3 adipocytes. Regulation of mRNA content for glycerophosphate dehydrogenase and other differentiation-dependent proteins during adipocyte development. J Biol Chem (1983) 4.14

Regulation of development and differentiation by the extracellular matrix. Development (1993) 4.13

Keratin filaments of cultured human epidermal cells. Formation of intermolecular disulfide bonds during terminal differentiation. J Biol Chem (1978) 3.82

Growth of cultured human epidermal cells into multiple epithelia suitable for grafting. Proc Natl Acad Sci U S A (1979) 3.79

Growth control in cultured cells: selection of sublines with increased sensitivity to contact inhibition and decreased tumor-producing ability. Proc Natl Acad Sci U S A (1968) 3.78

Permanent coverage of large burn wounds with autologous cultured human epithelium. N Engl J Med (1984) 3.70

Susceptibility of human diploid fibroblast strains to transformation by SV40 virus. Science (1966) 3.68

Regulation of terminal differentiation of cultured human keratinocytes by vitamin A. Cell (1981) 3.61

Cell growth and the initiation of transformation by SV40. Proc Natl Acad Sci U S A (1966) 3.50

Keratin cytoskeletons in epithelial cells of internal organs. Proc Natl Acad Sci U S A (1979) 3.45

Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet (2000) 3.42

Terminal differentiation of cultured human epidermal cells. Cell (1977) 3.39

The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis. Development (1999) 3.31

Differentiation of the epidermal keratinocyte in cell culture: formation of the cornified envelope. Cell (1976) 3.30

Cell migration is essential for sustained growth of keratinocyte colonies: the roles of transforming growth factor-alpha and epidermal growth factor. Cell (1987) 3.26

c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol (2001) 3.22

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes. J Invest Dermatol (1999) 3.15

High frequency of SV40 transformation of mouse cell line 3T3. Virology (1966) 3.04

The cornified envelope of terminally differentiated human epidermal keratinocytes consists of cross-linked protein. Cell (1977) 3.00

The expression of keratin genes in epidermis and cultured epidermal cells. Cell (1978) 2.87

Two distinct classes of keratin genes and their evolutionary significance. Cell (1981) 2.84

Fibronectin inhibits the terminal differentiation of human keratinocytes. Nature (1989) 2.77

Structure and evolution of the human involucrin gene. Cell (1986) 2.76

Cyclic AMP in relation to proliferation of the epidermal cell: a new view. Cell (1978) 2.64

Stimulation of human epidermal differentiation by delta-notch signalling at the boundaries of stem-cell clusters. Curr Biol (2000) 2.58

Stem cells: the generation and maintenance of cellular diversity. Development (1989) 2.54

Involucrin synthesis and tissue assembly by keratinocytes in natural and cultured human epithelia. J Cell Biol (1981) 2.44

c-Myc promotes differentiation of human epidermal stem cells. Genes Dev (1997) 2.37

Pyrimidine starvation induced by adenosine in fibroblasts and lymphoid cells: role of adenosine deaminase. Science (1973) 2.37

Cell size as a determinant of the clone-forming ability of human keratinocytes. Proc Natl Acad Sci U S A (1985) 2.34

Participation of one isozyme of cytosolic glycerophosphate dehydrogenase in the adipose conversion of 3T3 cells. J Biol Chem (1979) 2.33

Control of specific protein biosynthesis during the adipose conversion of 3T3 cells. J Biol Chem (1980) 2.33

Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J Cell Physiol (1979) 2.27

Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis. Cell (1995) 2.24

The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell (2000) 2.22

Changes in keratinocyte adhesion during terminal differentiation: reduction in fibronectin binding precedes alpha 5 beta 1 integrin loss from the cell surface. Cell (1990) 2.19

Multiple keratins of cultured human epidermal cells are translated from different mRNA molecules. Cell (1979) 2.18

Cultured epithelial cells of cornea, conjunctiva and skin: absence of marked intrinsic divergence of their differentiated states. Nature (1977) 2.17

Involucrin synthesis is correlated with cell size in human epidermal cultures. J Cell Biol (1981) 2.14

The nucleotide sequence of three genes participating in the adipose differentiation of 3T3 cells. J Biol Chem (1986) 2.07

Formation of a keratinizing epithelium in culture by a cloned cell line derived from a teratoma. Cell (1975) 2.06

Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro. Proc Natl Acad Sci U S A (1999) 2.06

Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. J Cell Biol (1994) 2.05

The keratinocyte as differentiated cell type. Harvey Lect (1980) 2.04

Calcium-induced reorganization of desmosomal components in cultured human keratinocytes. J Cell Biol (1984) 2.00

A study of the adipose conversion of suspended 3T3 cells by using glycerophosphate dehydrogenase as differentiation marker. Proc Natl Acad Sci U S A (1979) 1.94

Differentiated cell types and the regulation of collagen synthesis. Nature (1966) 1.94

Enzymatic cross-linking of involucrin and other proteins by keratinocyte particulates in vitro. Cell (1985) 1.94

Selective migration of terminally differentiating cells from the basal layer of cultured human epidermis. J Cell Biol (1984) 1.93

Reversible arrest of growth in G1 of an established fibroblast line (3T3). Exp Cell Res (1965) 1.92

Desmosomal glycoprotein DGI, a component of intercellular desmosome junctions, is related to the cadherin family of cell adhesion molecules. Proc Natl Acad Sci U S A (1991) 1.91

beta-catenin signalling modulates proliferative potential of human epidermal keratinocytes independently of intercellular adhesion. Development (1999) 1.89

Increasing activity of enzymes on pathway of triacylglycerol synthesis during adipose conversion of 3T3 cells. J Biol Chem (1977) 1.86

Synthesis of collagen by mammalian cell lines of fibroblastic and nonfibroblastic origin. Proc Natl Acad Sci U S A (1965) 1.86

Participation of membrane-associated proteins in the formation of the cross-linked envelope of the keratinocyte. Cell (1984) 1.85

An assay for cellular transformation by SV40. Virology (1964) 1.84

Properties and uses of human-mouse hybrid cell lines. Nature (1968) 1.82

Adipose conversion of 3T3 cells depends on a serum factor. Proc Natl Acad Sci U S A (1978) 1.82

Studies of lipoprotein lipase during the adipose conversion of 3T3 cells. Cell (1978) 1.77

Collagen synthesis in fibroblasts transformed by oncogenic viruses. Nature (1966) 1.76

Antigenic and cultural properties of cells doubly transformed by polyoma virus and SV40. Virology (1965) 1.74

Expression of a dominant negative cadherin mutant inhibits proliferation and stimulates terminal differentiation of human epidermal keratinocytes. J Cell Sci (1996) 1.74

Ribosomal RNA synthesis in human-mouse hybrid cells. J Mol Biol (1969) 1.71

Proliferative heterogeneity in the human prostate: evidence for epithelial stem cells. Lab Invest (2000) 1.66

Induction of a deoxycytidineless state in cultured mammalian cells by bromodeoxyuridine. Cell (1974) 1.65

Antinuclear autoantibodies and lupus nephritis in transgenic mice expressing interferon gamma in the epidermis. J Exp Med (1997) 1.63

Cultured epithelial autografts for giant congenital nevi. Plast Reconstr Surg (1989) 1.63

DNA amplification is rare in normal human cells. Proc Natl Acad Sci U S A (1990) 1.63

Stimulation of RNA synthesis and cell division in resting cells by a factor present in serum. Wistar Inst Symp Monogr (1967) 1.62

Diet, breakfast, and academic performance in children. Ann Nutr Metab (2002) 1.61

Human genetic diseases due to codon reiteration: relationship to an evolutionary mechanism. Cell (1993) 1.60

Changes in RNA in relation to growth of the fibroblast. III. Posttranscriptional regulation of mRNA formation in resting and growing cells. Cell (1975) 1.59

Regulation of RNA synthesis in fibroblasts during transition from resting to growing state. Proc Natl Acad Sci U S A (1973) 1.59

Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis. J Clin Invest (1992) 1.58

Involucrin and other markers of keratinocyte terminal differentiation. J Invest Dermatol (1983) 1.58

Somatic cell hybrid between the established human line D98 (presumptive HeLa) and 3T3. Science (1969) 1.58

Lethality of adenosine for cultured mammalian cells by interference with pyrimidine biosynthesis. J Cell Sci (1973) 1.55

Epithelial cell differentiation pathways in the human prostate: identification of intermediate phenotypes by keratin expression. J Histochem Cytochem (2001) 1.50

Relation of protein synthesis and transglutaminase activity to formation of the cross-linked envelope during terminal differentiation of the cultured human epidermal keratinocyte. J Cell Biol (1978) 1.50

Periplakin, a novel component of cornified envelopes and desmosomes that belongs to the plakin family and forms complexes with envoplakin. J Cell Biol (1997) 1.50

Cyclooxygenase-2 expression in the Barrett's metaplasia-dysplasia-adenocarcinoma sequence. Am J Gastroenterol (2001) 1.49

Interruption of the adipose conversion of 3T3 cells by biotin deficiency: differentiation without triglyceride accumulation. Cell (1978) 1.48

Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation. J Cell Biol (1995) 1.48

A new reduced human-mouse somatic cell hybrid containing the human gene for adenine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1971) 1.47

The activation of specific gene transcription in the adipose conversion of 3T3 cells. J Cell Physiol (1985) 1.45