Published in Bioinorg Chem on August 01, 1978
Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrob Agents Chemother (1994) 3.57
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA. Proc Natl Acad Sci U S A (1985) 3.18
Mechanisms of quinolone resistance in Escherichia coli: characterization of nfxB and cfxB, two mutant resistance loci decreasing norfloxacin accumulation. Antimicrob Agents Chemother (1989) 2.99
Penetration of lipophilic agents with multiple protonation sites into bacterial cells: tetracyclines and fluoroquinolones as examples. Antimicrob Agents Chemother (1993) 2.52
Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers. Antimicrob Agents Chemother (1989) 1.98
Construction and use of halobacterial shuttle vectors and further studies on Haloferax DNA gyrase. J Bacteriol (1991) 1.63
Inhibition of enoxacin absorption by antacids or ranitidine. Antimicrob Agents Chemother (1989) 1.59
Quinolone mode of action. Drugs (1995) 1.44
Mutations affecting substrate specificity of the Bacillus subtilis multidrug transporter Bmr. J Bacteriol (1997) 1.33
Pharmacokinetics of gatifloxacin and interaction with an antacid containing aluminum and magnesium. Antimicrob Agents Chemother (1999) 1.24
Iron supplements: a common cause of drug interactions. Br J Clin Pharmacol (1991) 1.18
Effect of magnesium complexation by fluoroquinolones on their antibacterial properties. Antimicrob Agents Chemother (1994) 1.15
Milk and yoghurt do not impair the absorption of ofloxacin. Br J Clin Pharmacol (1992) 1.00
Effect of antacid on absorption of the quinolone lomefloxacin. Antimicrob Agents Chemother (1992) 0.96
Fluoroquinolones: interaction profile during enteral absorption. Drugs (1993) 0.91
Effects of magnesium-aluminum hydroxide antacid on absorption of rufloxacin. Antimicrob Agents Chemother (1993) 0.84
Synthesis, characterization, and biological activity studies of copper(II) mixed compound with histamine and nalidixic acid. Bioinorg Chem Appl (2009) 0.75
The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci U S A (1991) 15.52
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell (1985) 6.23
Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes. Cell (1982) 6.11
DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc Natl Acad Sci U S A (1984) 5.75
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol (1995) 5.71
Studies on the mechanism of action of nalidixic acid. Antimicrob Agents Chemother (1973) 5.64
Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition. Proc Natl Acad Sci U S A (1981) 5.60
Elimination of false positives that arise in using the two-hybrid system. Biotechniques (1993) 5.06
The two-hybrid system: an assay for protein-protein interactions. Trends Genet (1994) 5.06
Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J (1989) 4.08
Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94
Perinuclear localization of chromatin facilitates transcriptional silencing. Nature (1998) 3.68
Crystal structure of a SIR2 homolog-NAD complex. Cell (2001) 3.57
Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature (1987) 3.56
Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature (1996) 3.26
Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell (1988) 3.22
Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell (1993) 2.91
The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev (2000) 2.77
Cloning, characterization, and sequence of the yeast DNA topoisomerase I gene. Proc Natl Acad Sci U S A (1985) 2.75
Human homologues of yeast helicase. Nature (1996) 2.71
Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochem Biophys Res Commun (2000) 2.65
Two new S-phase-specific genes from Saccharomyces cerevisiae. Yeast (1997) 2.64
Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem (1995) 2.62
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs. Oncogene (2007) 2.29
A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting. EMBO J (2000) 2.17
Yeast ASF1 protein is required for cell cycle regulation of histone gene transcription. Genetics (2001) 2.08
Identification of Saccharomyces cerevisiae mutants deficient in DNA topoisomerase I activity. J Biol Chem (1984) 2.07
Recent excitement in the DNA replication problem. Nature (1977) 2.05
The SIR1 gene of Saccharomyces cerevisiae and its role as an extragenic suppressor of several mating-defective mutants. Mol Cell Biol (1991) 1.99
PNG1, a yeast gene encoding a highly conserved peptide:N-glycanase. J Cell Biol (2000) 1.98
Structure of the histone acetyltransferase Hat1: a paradigm for the GCN5-related N-acetyltransferase superfamily. Cell (1998) 1.96
Evidence that DNA topoisomerase I is necessary for the cytotoxic effects of camptothecin. Mol Pharmacol (1988) 1.95
Bacteriophage T7 lysozyme is an N-acetylmuramyl-L-alanine amidase. J Biol Chem (1973) 1.92
Topoisomerases and yeast rRNA transcription: negative supercoiling stimulates initiation and topoisomerase activity is required for elongation. Genes Dev (1992) 1.84
Signal-mediated import of bacteriophage T7 RNA polymerase into the Saccharomyces cerevisiae nucleus and specific transcription of target genes. Mol Cell Biol (1990) 1.84
Targeting of the yeast Ty5 retrotransposon to silent chromatin is mediated by interactions between integrase and Sir4p. Mol Cell Biol (2001) 1.81
Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily. J Mol Biol (1999) 1.70
Identification and characterization of yeast mutants and the gene for a cruciform cutting endonuclease. EMBO J (1992) 1.69
A novel form of transcriptional silencing by Sum1-1 requires Hst1 and the origin recognition complex. Mol Cell Biol (2001) 1.64
The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size. J Clin Invest (1979) 1.57
The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev (2001) 1.52
Identification of two RNA-binding proteins associated with human telomerase RNA. Mol Biol Cell (2000) 1.50
Gene expression. Chromatin contract to silence. Nature (1990) 1.50
Reduced expression of the isoleucine and valine enzymes in integration host factor mutants of Escherichia coli. J Mol Biol (1984) 1.45
Identification and characterization of the genes for two topoisomerase I-interacting proteins from Saccharomyces cerevisiae. Yeast (1999) 1.32
Mapping of the active site tyrosine of eukaryotic DNA topoisomerase I. J Biol Chem (1989) 1.20
Two separate conserved domains of eukaryotic DNA topoisomerase I bind to each other and reconstitute enzymatic activity. Chromosoma (1998) 1.16
Calcium can disrupt the SNARE protein complex on sea urchin egg secretory vesicles without irreversibly blocking fusion. J Biol Chem (1998) 1.14
Effect of nalidixic acid on the growth of deoxyribonucleic acid bacteriophages. J Virol (1972) 1.14
Origin of the residual transforming activity of denatured Bacillus subtilis DNA. J Mol Biol (1968) 1.09
The role of DNA replication in the repression of the yeast mating-type silent loci. Cold Spring Harb Symp Quant Biol (1984) 1.08
Conditional-lethal deoxyribonucleic acid ligase mutant of Escherichia coli. J Bacteriol (1979) 1.08
Mutations in GCR3, a gene involved in the expression of glycolytic genes in Saccharomyces cerevisiae, suppress the temperature-sensitive growth of hpr1 mutants. Genetics (1996) 1.08
The Escherichia coli supX locus is topA, the structural gene for DNA topoisomerase I. Proc Natl Acad Sci U S A (1985) 1.02
The Saccharomyces cerevisiae MUM2 gene interacts with the DNA replication machinery and is required for meiotic levels of double strand breaks. Genetics (2001) 1.02
Evidence that both growing DNA chains at a replication fork are synthesized discontinuously. Biochemistry (1976) 1.00
Nucleosome structural changes during derepression of silent mating-type loci in yeast. J Biol Chem (1993) 1.00
ENP1, an essential gene encoding a nuclear protein that is highly conserved from yeast to humans. Gene (1997) 0.95
Thymine-labelled deoxyoligonucleotide involved in DNA chain growth in Bacillus subtilis. Nature (1974) 0.93
Structure of the yeast histone acetyltransferase Hat1: insights into substrate specificity and implications for the Gcn5-related N-acetyltransferase superfamily. Cold Spring Harb Symp Quant Biol (1998) 0.93
A screen for yeast mutants with defects in the dolichol-mediated pathway for N-glycosylation. Proc Natl Acad Sci U S A (1994) 0.87
DNA topoisomerase activity is required as a swivel for DNA replication and for ribosomal RNA transcription. NCI Monogr (1987) 0.85
Escherichia coli DNA topoisomerase I mutants have compensatory mutations at or near DNA gyrase genes. Cold Spring Harb Symp Quant Biol (1983) 0.85
Involvement of host DNA gyrase in growth of bacteriophage T5. J Virol (1986) 0.85
Nalidixic acid-sensitive and resistant modes of DNA replication in Escherichia coli. Biochem Biophys Res Commun (1974) 0.83
Molecular cloning and genetic mapping of the DNA topoisomerase II gene of Saccharomyces cerevisiae. Gene (1986) 0.78
Effects of undernutrition and refeeding on enzyme activities and rates of glucose catabolism in rat epididymal adipose tissue. J Nutr (1980) 0.77
Beta-endorphin, ACTH, and catecholamine responses in chronic autonomic failure. Ann Neurol (1987) 0.77
Cloning and characterization of the gene for the somatic form of DNA topoisomerase I from Xenopus laevis. Nucleic Acids Res (1996) 0.75