Published in Cell on April 20, 2001
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO J (2002) 6.37
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Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell (2002) 2.80
Comparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packaging. Nucleic Acids Res (2004) 2.62
Structure of the RPA trimerization core and its role in the multistep DNA-binding mechanism of RPA. EMBO J (2002) 2.62
The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nat Struct Biol (2002) 2.24
Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A (2001) 2.23
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Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
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Structural basis for nicotinamide inhibition and base exchange in Sir2 enzymes. Mol Cell (2007) 1.77
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics (2003) 1.73
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Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine. Biochemistry (2006) 1.49
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Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylases. Proc Natl Acad Sci U S A (2004) 1.45
4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chem Res Toxicol (2011) 1.35
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS Chem Biol (2011) 1.33
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Search for potential vaccine candidate open reading frames in the Bacillus anthracis virulence plasmid pXO1: in silico and in vitro screening. Infect Immun (2002) 1.26
Mutations in Saccharomyces cerevisiae gene SIR2 can have differential effects on in vivo silencing phenotypes and in vitro histone deacetylation activity. Mol Biol Cell (2002) 1.24
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Redox regulation of sirtuin-1 by S-glutathiolation. Antioxid Redox Signal (2010) 1.13
Deciphering NAD-dependent deacetylases. Cell (2001) 1.11
Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae. Mol Biol Cell (2006) 1.10
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Substitution as a mechanism for genetic robustness: the duplicated deacetylases Hst1p and Sir2p in Saccharomyces cerevisiae. PLoS Genet (2007) 1.08
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Rejuvenating sirtuins: the rise of a new family of cancer drug targets. Curr Pharm Des (2013) 1.01
Human sirt-1: molecular modeling and structure-function relationships of an unordered protein. PLoS One (2008) 1.01
A unique class of conditional sir2 mutants displays distinct silencing defects in Saccharomyces cerevisiae. Genetics (2002) 1.01
Structural and functional analysis of human SIRT1. J Mol Biol (2013) 1.01
Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation. Biochemistry (2015) 1.00
Sum1p, the origin recognition complex, and the spreading of a promoter-specific repressor in Saccharomyces cerevisiae. Mol Cell Biol (2005) 0.99
Sirtuin regulation in aging and injury. Biochim Biophys Acta (2015) 0.98
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase. J Bacteriol (2009) 0.98
Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Mol Cell (2008) 0.98
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A silencer promotes the assembly of silenced chromatin independently of recruitment. Mol Cell Biol (2008) 0.96
Histone acetyltransferases and histone deacetylases in B- and T-cell development, physiology and malignancy. Genes Cancer (2015) 0.95
SIRT7 is a histone desuccinylase that functionally links to chromatin compaction and genome stability. Nat Commun (2016) 0.94
Swapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases. Mol Cell Biol (2007) 0.94
Comparative and pharmacophore model for deacetylase SIRT1. J Comput Aided Mol Des (2006) 0.93
Computational studies on the histone deacetylases and the design of selective histone deacetylase inhibitors. Curr Top Med Chem (2009) 0.93
SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion. Cell Metab (2017) 0.92
Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectives. Curr Pharm Des (2013) 0.91
SIRT1 undergoes alternative splicing in a novel auto-regulatory loop with p53. PLoS One (2010) 0.89
Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. Diabetes Metab J (2014) 0.89
Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol. Genes Dev (2015) 0.89
Structure and biochemical characterization of protein acetyltransferase from Sulfolobus solfataricus. J Biol Chem (2009) 0.88
Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding. Genes Dev (2013) 0.87
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Identification of an intrinsic determinant critical for maspin subcellular localization and function. PLoS One (2013) 0.86
A yeast sir2 mutant temperature sensitive for silencing. Genetics (2008) 0.86
Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. Am J Transl Res (2013) 0.85
Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain. PLoS One (2013) 0.85
A metal-binding site in the catalytic subunit of anaerobic ribonucleotide reductase. Proc Natl Acad Sci U S A (2003) 0.85
Characterization of metalloproteins by high-throughput X-ray absorption spectroscopy. Genome Res (2011) 0.84
Glutaredoxin regulates vascular development by reversible glutathionylation of sirtuin 1. Proc Natl Acad Sci U S A (2013) 0.84
Sirtuins in neurodegenerative diseases: a biological-chemical perspective. Neurodegener Dis (2011) 0.83
Sirtuin Deacetylation Mechanism and Catalytic Role of the Dynamic Cofactor Binding Loop. J Phys Chem Lett (2013) 0.82
Potential Modulation of Sirtuins by Oxidative Stress. Oxid Med Cell Longev (2015) 0.81
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Overexpression of cytoplasmic TcSIR2RP1 and mitochondrial TcSIR2RP3 impacts on Trypanosoma cruzi growth and cell invasion. PLoS Negl Trop Dis (2015) 0.81
Change in mRNA expression of sirtuin 1 and sirtuin 3 in cats fed on high fat diet. BMC Vet Res (2013) 0.79
Looking for putative functions of the Leishmania cytosolic SIR2 deacetylase. Parasitol Res (2006) 0.79
Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci (2014) 0.78
Design of a novel nucleoside analog as potent inhibitor of the NAD dependent deacetylase, SIRT2. Syst Synth Biol (2011) 0.77
Autophagy in Ischemic Livers: A Critical Role of Sirtuin 1/Mitofusin 2 Axis in Autophagy Induction. Toxicol Res (2016) 0.77
The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae. Genetics (2016) 0.77
Silent information regulator 2 proteins encoded by Cryptosporidium parasites. Parasitol Res (2010) 0.76
Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2). PLoS One (2015) 0.76
Phosphorylation Modulates Catalytic Activity of Mycobacterial Sirtuins. Front Microbiol (2016) 0.76
The Opportunity of Precision Medicine for Breast Cancer With Context-Sensitive Tumor Suppressor Maspin. J Cell Biochem (2017) 0.75
Molecular cloning, modeling and differential expression of a gene encoding a silent information regulator-like protein from Sporothrix schenckii. Int J Mol Med (2014) 0.75
Mutations that Allow SIR2 Orthologs to Function in a NAD(+)-Depleted Environment. Cell Rep (2017) 0.75
Physical nature of intermolecular interactions inside Sir2 homolog active site: molecular dynamics and ab initio study. J Mol Model (2016) 0.75
SIRT1 inhibits EV71 genome replication and RNA translation by interfering viral polymerase and 5'UTR RNA. J Cell Sci (2016) 0.75
Chemical and structural biology of protein lysine deacetylases. Proc Jpn Acad Ser B Phys Biol Sci (2017) 0.75
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