Human homologues of yeast helicase.

DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev (2008) 5.07

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics (2001) 4.73

rqh1+, a fission yeast gene related to the Bloom's and Werner's syndrome genes, is required for reversible S phase arrest. EMBO J (1997) 4.31

RecQ helicases: suppressors of tumorigenesis and premature aging. Biochem J (2003) 3.71

Alternate pathways involving Sgs1/Top3, Mus81/ Mms4, and Srs2 prevent formation of toxic recombination intermediates from single-stranded gaps created by DNA replication. Proc Natl Acad Sci U S A (2002) 3.70

The yeast Sgs1p helicase acts upstream of Rad53p in the DNA replication checkpoint and colocalizes with Rad53p in S-phase-specific foci. Genes Dev (2000) 3.40

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1. EMBO J (2003) 3.15

Bloom's and Werner's syndrome genes suppress hyperrecombination in yeast sgs1 mutant: implication for genomic instability in human diseases. Proc Natl Acad Sci U S A (1998) 3.14

RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination. Genes Dev (1998) 2.92

Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae. Nature (2010) 2.79

Role of Schizosaccharomyces pombe RecQ homolog, recombination, and checkpoint genes in UV damage tolerance. Mol Cell Biol (1997) 2.76

Cloning-free PCR-based allele replacement methods. Genome Res (1997) 2.56

Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae. Genetics (2000) 2.55

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene. Genes Dev (1998) 2.12

Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J (2006) 1.99

Mapping the DNA topoisomerase III binding domain of the Sgs1 DNA helicase. J Biol Chem (2000) 1.96

Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance. EMBO J (2004) 1.94

Characterization of Werner syndrome protein DNA helicase activity: directionality, substrate dependence and stimulation by replication protein A. Nucleic Acids Res (1998) 1.80

Mutations in recombinational repair and in checkpoint control genes suppress the lethal combination of srs2Delta with other DNA repair genes in Saccharomyces cerevisiae. Genetics (2001) 1.78

Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities. Mol Cell Biol (2004) 1.78

Possible association of BLM in decreasing DNA double strand breaks during DNA replication. EMBO J (2000) 1.78

Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis. Proc Natl Acad Sci U S A (1998) 1.76

The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells. Mol Biol Cell (1999) 1.73

Mrc1 and Srs2 are major actors in the regulation of spontaneous crossover. EMBO J (2006) 1.65

Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta. Nucleic Acids Res (2000) 1.63

Nuclear structure in normal and Bloom syndrome cells. Proc Natl Acad Sci U S A (2000) 1.60

The short life span of Saccharomyces cerevisiae sgs1 and srs2 mutants is a composite of normal aging processes and mitotic arrest due to defective recombination. Genetics (2001) 1.59

Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene. Mol Cell Biol (1998) 1.53

Evolution of the RECQ family of helicases: A drosophila homolog, Dmblm, is similar to the human bloom syndrome gene. Genetics (1999) 1.48

Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc Natl Acad Sci U S A (2001) 1.47

Sgs1 regulates gene conversion tract lengths and crossovers independently of its helicase activity. Mol Cell Biol (2006) 1.45

Functional interaction between the Werner Syndrome protein and DNA polymerase delta. Proc Natl Acad Sci U S A (2000) 1.42

Role of SGS1 and SLX4 in maintaining rDNA structure in Saccharomyces cerevisiae. Curr Genet (2002) 1.42

Domain mapping of Escherichia coli RecQ defines the roles of conserved N- and C-terminal regions in the RecQ family. Nucleic Acids Res (2003) 1.41

Hmo1, an HMG-box protein, belongs to the yeast ribosomal DNA transcription system. EMBO J (2002) 1.40

Characterization of the enzymatic activity of hChlR1, a novel human DNA helicase. Nucleic Acids Res (2000) 1.38

Examination of the roles of Sgs1 and Srs2 helicases in the enforcement of recombination fidelity in Saccharomyces cerevisiae. Genetics (2004) 1.32

Distinct roles for the Saccharomyces cerevisiae mismatch repair proteins in heteroduplex rejection, mismatch repair and nonhomologous tail removal. Genetics (2004) 1.30

Sgs1 function in the repair of DNA replication intermediates is separable from its role in homologous recombinational repair. EMBO J (2009) 1.29

SGS1 is a multicopy suppressor of srs2: functional overlap between DNA helicases. Nucleic Acids Res (2002) 1.24

RecQ helicases: multiple structures for multiple functions? HFSP J (2009) 1.20

Bloom's syndrome protein, BLM, colocalizes with replication protein A in meiotic prophase nuclei of mammalian spermatocytes. Proc Natl Acad Sci U S A (1999) 1.16

The absence of Top3 reveals an interaction between the Sgs1 and Pif1 DNA helicases in Saccharomyces cerevisiae. Genetics (2006) 1.15

Rudimentary G-quadruplex-based telomere capping in Saccharomyces cerevisiae. Nat Struct Mol Biol (2011) 1.14

Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes. Mol Cell (2012) 1.11

Association of yeast DNA topoisomerase III and Sgs1 DNA helicase: studies of fusion proteins. Proc Natl Acad Sci U S A (2001) 1.11

Evidence that the S.cerevisiae Sgs1 protein facilitates recombinational repair of telomeres during senescence. Nucleic Acids Res (2006) 1.10

A yeast gene, MGS1, encoding a DNA-dependent AAA(+) ATPase is required to maintain genome stability. Proc Natl Acad Sci U S A (2001) 1.06

Sit down, relax and unwind: structural insights into RecQ helicase mechanisms. Nucleic Acids Res (2006) 1.05

Homologous recombination-dependent rescue of deficiency in the structural maintenance of chromosomes (Smc) 5/6 complex. J Biol Chem (2010) 1.05

Sgs1 helicase activity is required for mitotic but apparently not for meiotic functions. Mol Cell Biol (2000) 1.02

Rtt107/Esc4 binds silent chromatin and DNA repair proteins using different BRCT motifs. BMC Mol Biol (2006) 0.99

Saccharomyces cerevisiae Mer3 is a DNA helicase involved in meiotic crossing over. Mol Cell Biol (2002) 0.97

Interaction between the N-terminus of human topoisomerase I and SV40 large T antigen. Nucleic Acids Res (1998) 0.94

An essential DNA strand-exchange activity is conserved in the divergent N-termini of BLM orthologs. EMBO J (2010) 0.94

The MER3 helicase involved in meiotic crossing over is stimulated by single-stranded DNA-binding proteins and unwinds DNA in the 3' to 5' direction. J Biol Chem (2001) 0.93

The genetic consequences of ablating helicase activity and the Top3 interaction domain of Sgs1. DNA Repair (Amst) (2008) 0.91

Resection activity of the Sgs1 helicase alters the affinity of DNA ends for homologous recombination proteins in Saccharomyces cerevisiae. Genetics (2013) 0.85

Srs2 and RecQ homologs cooperate in mei-3-mediated homologous recombination repair of Neurospora crassa. Nucleic Acids Res (2005) 0.82

Somatic hypermutation of immunoglobulin genes is independent of the Bloom's syndrome DNA helicase. Clin Exp Immunol (1998) 0.81

Minisatellite variants generated in yeast meiosis involve DNA removal during gene conversion. Genetics (2000) 0.80

Differential developmental expression of the rep B and rep D xeroderma pigmentosum related DNA helicase genes from Dictyostelium discoideum. Nucleic Acids Res (1997) 0.80

The roles of the Saccharomyces cerevisiae RecQ helicase SGS1 in meiotic genome surveillance. PLoS One (2010) 0.78

DNA resection proteins Sgs1 and Exo1 are required for G1 checkpoint activation in budding yeast. DNA Repair (Amst) (2013) 0.77

The contribution of the S-phase checkpoint genes MEC1 and SGS1 to genome stability maintenance in Candida albicans. Fungal Genet Biol (2011) 0.77

A Rad53 independent function of Rad9 becomes crucial for genome maintenance in the absence of the Recq helicase Sgs1. PLoS One (2013) 0.77

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Characterization of a "silencer" in yeast: a DNA sequence with properties opposite to those of a transcriptional enhancer. Cell (1985) 6.23

Assessment of the sensitivity and specificity of oligonucleotide (50mer) microarrays. Nucleic Acids Res (2000) 6.20

Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes. Cell (1982) 6.11

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication. Proc Natl Acad Sci U S A (1984) 5.75

Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol (1995) 5.71

Studies on the mechanism of action of nalidixic acid. Antimicrob Agents Chemother (1973) 5.64

Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition. Proc Natl Acad Sci U S A (1981) 5.60

Serum cholesterol concentration and coronary heart disease in population with low cholesterol concentrations. BMJ (1991) 5.45

Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeast. Cell (1988) 5.09

Elimination of false positives that arise in using the two-hybrid system. Biotechniques (1993) 5.06

The two-hybrid system: an assay for protein-protein interactions. Trends Genet (1994) 5.06

Requirement for three novel protein complexes in the absence of the Sgs1 DNA helicase in Saccharomyces cerevisiae. Genetics (2001) 4.73

Simulation of Sahel drought in the 20th and 21st centuries. Proc Natl Acad Sci U S A (2005) 4.70

Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3. Science (2000) 4.57

Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. EMBO J (1989) 4.08

PEBP2/PEA2 represents a family of transcription factors homologous to the products of the Drosophila runt gene and the human AML1 gene. Proc Natl Acad Sci U S A (1993) 4.05

Functional overlap between Sgs1-Top3 and the Mms4-Mus81 endonuclease. Genes Dev (2001) 3.99

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94

Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res (1998) 3.80

Perinuclear localization of chromatin facilitates transcriptional silencing. Nature (1998) 3.68

Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res (1996) 3.60

Crystal structure of a SIR2 homolog-NAD complex. Cell (2001) 3.57

Need for DNA topoisomerase activity as a swivel for DNA replication for transcription of ribosomal RNA. Nature (1987) 3.56

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Role of interactions between the origin recognition complex and SIR1 in transcriptional silencing. Nature (1996) 3.26

Transcription-dependent DNA supercoiling in yeast DNA topoisomerase mutants. Cell (1988) 3.22

Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes Dev (1990) 3.15

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Targeting of SIR1 protein establishes transcriptional silencing at HM loci and telomeres in yeast. Cell (1993) 2.91

Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat Med (2000) 2.79

Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci (2001) 2.79

The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex. Genes Dev (2000) 2.77

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Two new S-phase-specific genes from Saccharomyces cerevisiae. Yeast (1997) 2.64

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Requirement of the MADS-box transcription factor MEF2C for vascular development. Development (1998) 2.63

Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem (1995) 2.62

The histone acetylase PCAF is a nuclear receptor coactivator. Genes Dev (1998) 2.58

Bipartite structure of the SGS1 DNA helicase in Saccharomyces cerevisiae. Genetics (2000) 2.55

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