Published in Nouv Presse Med on April 10, 1982
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell (1993) 6.99
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 5.51
Genetic regulation of resistance to intracellular pathogens. Nature (1982) 4.45
Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet (2001) 3.96
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol (1981) 3.95
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med (1995) 3.86
Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (1986) 3.84
Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A (2000) 3.53
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet (2001) 3.47
Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell (1991) 3.21
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell (1994) 2.86
Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites. Genomics (1994) 2.80
Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol (2001) 2.53
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med (1997) 2.34
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J Exp Med (2000) 2.28
Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site. EMBO J (2001) 2.24
Immunopathology of BCG infection in genetically resistant and susceptible mouse strains. J Immunol (1982) 2.23
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance. Mol Cell Biol (1989) 2.18
Differences in response among inbred mouse strains to infection with small doses of Mycobacterium bovis BCG. Infect Immun (1981) 2.16
Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood (1999) 2.13
Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG). J Immunol (1984) 2.13
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol (1990) 2.07
The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. Infect Immun (1996) 2.02
Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol Microbiol (2000) 1.94
Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of Salmonella enterica serovar Typhimurium. Infect Immun (2002) 1.89
Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis. Annu Rev Genomics Hum Genet (2007) 1.88
A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. Infect Immun (1983) 1.86
Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med (1994) 1.82
Identification and characterization of a second mouse Nramp gene. Genomics (1995) 1.81
Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG). J Immunol (1983) 1.81
Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J Immunol (1996) 1.78
Nramp defines a family of membrane proteins. Proc Natl Acad Sci U S A (1995) 1.78
Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science (1992) 1.74
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med (1998) 1.73
TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages. J Immunol (1999) 1.69
Absence of p53 gene mutations in primary neuroblastomas. Cancer Res (1993) 1.69
Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics (1984) 1.63
Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure. EMBO J (1999) 1.58
Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain. Hum Mol Genet (1997) 1.56
Macrophage NRAMP1 and its role in resistance to microbial infections. Inflamm Res (1998) 1.53
A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends Pharmacol Sci (1994) 1.53
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med (1999) 1.53
Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Annu Rev Med (1998) 1.52
Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics (2000) 1.49
[Cutaneous-splanchnic neurofibromatosis]. Ann Dermatol Venereol (1998) 1.47
Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins. J Biol Chem (1999) 1.46
Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem (2000) 1.45
A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Natl Acad Sci U S A (1993) 1.44
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem (1991) 1.44
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood (2001) 1.43
Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7. Infect Immun (1999) 1.42
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics (2001) 1.42
Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J Biol Chem (1997) 1.41
Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions. Plant Mol Biol (1997) 1.39
Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun (2000) 1.38
Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet (1996) 1.36
Immunotoxins: hybrid molecules of monoclonal antibodies and a toxin subunit specifically kill tumour cells. Nature (1981) 1.35
Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet (1995) 1.35
Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem (1984) 1.34
Immune response of the guinea pig to bovine parathyroid hormone antigen: influence of the booster dose on antisera titer and sensitivity. J Immunoassay (1981) 1.33
Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry (1995) 1.33
Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr Patterns (2006) 1.33
Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA. Cancer Res (1989) 1.30
Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. Acta Crystallogr D Biol Crystallogr (2001) 1.29
Susceptibility to malaria as a complex trait: big pressure from a tiny creature. Hum Mol Genet (2002) 1.29
Complex genetic control of susceptibility to malaria in mice. Genes Immun (2002) 1.28
Toward understanding the genetic basis of neural tube defects. Clin Genet (2007) 1.28
Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol (1990) 1.27
An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity. Mol Cell Biol (1996) 1.26
The Nramp1 protein and its role in resistance to infection and macrophage function. Proc Assoc Am Physicians (1999) 1.25
Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores. J Biol Chem (1984) 1.24
Mapping of genetic modulators of natural resistance to infection with Salmonella typhimurium in wild-derived mice. Genomics (1998) 1.24
Contribution of VANGL2 mutations to isolated neural tube defects. Clin Genet (2010) 1.23
Linkage analysis of the Bcg gene on mouse chromosome 1. Identification of a tightly linked marker. J Immunol (1989) 1.23
Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8. Nat Genet (1997) 1.22
Antigenic specificities of bursal and thymic lymphocytes in the chicken. Immunology (1970) 1.22
Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood (2001) 1.21
Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice. Proc Natl Acad Sci U S A (2001) 1.21
C-terminal domain of transcription cofactor PC4 reveals dimeric ssDNA binding site. Nat Struct Biol (1997) 1.21
An outbreak of toxoplasmosis in pregnant women in northern Québec. J Infect Dis (1990) 1.20
Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo. J Leukoc Biol (1997) 1.20
Crystal structure of the A3 domain of human von Willebrand factor: implications for collagen binding. Structure (1997) 1.20
Consequence of Nramp1 deletion to Mycobacterium tuberculosis infection in mice. Infect Immun (1999) 1.19
Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus. J Leukoc Biol (1995) 1.19
The splotch-delayed (Spd) mouse mutant carries a point mutation within the paired box of the Pax-3 gene. Genomics (1993) 1.18
Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites. Biochemistry (1998) 1.18
Genomic structure, promoter sequence, and induction of expression of the mouse Nramp1 gene in macrophages. Genomics (1995) 1.18
Retroviral transfer of a murine cDNA for multidrug resistance confers pleiotropic drug resistance to cells without prior drug selection. Proc Natl Acad Sci U S A (1988) 1.16
Host resistance to infection: genetic control of lipopolysaccharide responsiveness by TOLL-like receptor genes. Trends Genet (1999) 1.16
High-resolution linkage map in the vicinity of the host resistance locus Bcg. Genomics (1993) 1.15
Natural resistance to infection with Legionella pneumophila: chromosomal localization of the Lgn1 susceptibility gene. Mamm Genome (1995) 1.15
Interaction of PC4 with melted DNA inhibits transcription. EMBO J (1998) 1.15
Transmembrane organization of mouse P-glycoprotein determined by epitope insertion and immunofluorescence. J Biol Chem (1996) 1.14