Published in Nature on March 12, 1981
Monoclonal antibody to transferrin receptor blocks transferrin binding and inhibits human tumor cell growth in vitro. Proc Natl Acad Sci U S A (1982) 2.42
Advances in anticancer immunotoxin therapy. Oncologist (2015) 1.22
Monoclonal antibodies to rat sarcomata. I. Immunization procedures and source of lymphoid cells for hybridoma production. Immunology (1982) 1.17
Immunotoxins: the role of the toxin. Toxins (Basel) (2013) 1.13
Synergy of ricin A chain-containing immunotoxins and ricin B chain-containing immunotoxins in in vitro killing of neoplastic human B cells. Proc Natl Acad Sci U S A (1983) 1.11
Enhancement of toxicity of antitransferrin receptor antibody-Pseudomonas exotoxin conjugates by adenovirus. Proc Natl Acad Sci U S A (1983) 1.09
Chemotherapy by intravenous administration of conjugates of daunomycin with monoclonal and conventional anti-rat alpha-fetoprotein antibodies. Proc Natl Acad Sci U S A (1982) 1.03
Selective cytotoxicity against human tumour cells by a vindesine-monoclonal antibody conjugate. Br J Cancer (1983) 1.02
Therapy of murine leukemia with monoclonal antibody against a normal differentiation antigen. J Exp Med (1983) 1.01
Antitumor effects of an immunotoxin made with Pseudomonas exotoxin in a nude mouse model of human ovarian cancer. Proc Natl Acad Sci U S A (1986) 1.01
Effect of a conjugate of daunomycin and antibodies to rat alpha-fetoprotein on the growth of alpha-fetoprotein-producing tumor cells. Proc Natl Acad Sci U S A (1982) 1.01
In vivo therapy of a murine B cell tumor (BCL1) using antibody-ricin A chain immunotoxins. J Exp Med (1982) 0.96
Macrophage-targeted therapy: CD64-based immunotoxins for treatment of chronic inflammatory diseases. Toxins (Basel) (2012) 0.91
Selective cytotoxic activity of immunotoxins composed of a monoclonal anti-Thy 1.1 antibody and the ribosome-inactivating proteins bryodin and momordin. Br J Cancer (1988) 0.87
Immunotoxin Therapies for the Treatment of Epidermal Growth Factor Receptor-Dependent Cancers. Toxins (Basel) (2016) 0.78
Alkylating agents and immunotoxins exert synergistic cytotoxic activity against ovarian cancer cells. Mechanism of action. J Clin Invest (1993) 0.77
Alpha particles more promising than toxins? Eur J Nucl Med Mol Imaging (2010) 0.77
LDL-mediated targeting of liposomes to leukemic lymphocytes in vitro. EMBO J (1985) 0.77
Immunotoxin Therapy for Lung Cancer. Chin Med J (Engl) (2017) 0.75
Designing the Sniper: Improving Targeted Human Cytolytic Fusion Proteins for Anti-Cancer Therapy via Molecular Simulation. Biomedicines (2017) 0.75
Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr D Biol Crystallogr (1998) 169.28
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev (2002) 8.50
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4) J Exp Med (1999) 7.62
Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell (1993) 6.99
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 5.51
The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem (1997) 4.55
Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem (1995) 4.53
Genetic regulation of resistance to intracellular pathogens. Nature (1982) 4.45
Susceptibility to mouse cytomegalovirus is associated with deletion of an activating natural killer cell receptor of the C-type lectin superfamily. Nat Genet (2001) 3.96
Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol (1981) 3.95
The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene. J Exp Med (1995) 3.86
Isolation and expression of a complementary DNA that confers multidrug resistance. Nature (1986) 3.84
Specific chemical and structural damage to proteins produced by synchrotron radiation. Proc Natl Acad Sci U S A (2000) 3.53
Ltap, a mammalian homolog of Drosophila Strabismus/Van Gogh, is altered in the mouse neural tube mutant Loop-tail. Nat Genet (2001) 3.47
Splotch (Sp2H), a mutation affecting development of the mouse neural tube, shows a deletion within the paired homeodomain of Pax-3. Cell (1991) 3.21
SR 144528, the first potent and selective antagonist of the CB2 cannabinoid receptor. J Pharmacol Exp Ther (1998) 3.20
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc Natl Acad Sci U S A (1986) 3.19
Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J Clin Endocrinol Metab (2000) 2.88
Phosphatidylcholine translocase: a physiological role for the mdr2 gene. Cell (1994) 2.86
Haplotype mapping and sequence analysis of the mouse Nramp gene predict susceptibility to infection with intracellular parasites. Genomics (1994) 2.80
Divalent-metal transport by NRAMP proteins at the interface of host-pathogen interactions. Trends Microbiol (2001) 2.53
The three mouse multidrug resistance (mdr) genes are expressed in a tissue-specific manner in normal mouse tissues. Mol Cell Biol (1989) 2.35
Natural resistance to infection with intracellular pathogens: the Nramp1 protein is recruited to the membrane of the phagosome. J Exp Med (1997) 2.34
Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane. J Exp Med (2000) 2.28
Crystal structure of the outer membrane protease OmpT from Escherichia coli suggests a novel catalytic site. EMBO J (2001) 2.24
Immunopathology of BCG infection in genetically resistant and susceptible mouse strains. J Immunol (1982) 2.23
Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A (1986) 2.19
Discrete mutations introduced in the predicted nucleotide-binding sites of the mdr1 gene abolish its ability to confer multidrug resistance. Mol Cell Biol (1989) 2.18
Reliability and feasibility of pregnancy home-use tests: laboratory validation and diagnostic evaluation by 638 volunteers. Clin Chem (1993) 2.17
Differences in response among inbred mouse strains to infection with small doses of Mycobacterium bovis BCG. Infect Immun (1981) 2.16
Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood (1999) 2.13
Phenotypic expression of genetically-controlled natural resistance to Mycobacterium bovis (BCG). J Immunol (1984) 2.13
Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities. Mol Cell Biol (1990) 2.07
The Bcg/Ity/Lsh locus: genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1 Gly169 allele. Infect Immun (1996) 2.02
Identification of the Escherichia coli K-12 Nramp orthologue (MntH) as a selective divalent metal ion transporter. Mol Microbiol (2000) 1.94
Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1. Biochem J (1995) 1.93
Standardization of mRNA titration using a polymerase chain reaction method involving co-amplification with a multispecific internal control. J Biol Chem (1992) 1.92
Acquisition of Mn(II) in addition to Fe(II) is required for full virulence of Salmonella enterica serovar Typhimurium. Infect Immun (2002) 1.89
Host genetics of mycobacterial diseases in mice and men: forward genetic studies of BCG-osis and tuberculosis. Annu Rev Genomics Hum Genet (2007) 1.88
A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites. Infect Immun (1983) 1.86
Human natural resistance-associated macrophage protein: cDNA cloning, chromosomal mapping, genomic organization, and tissue-specific expression. J Exp Med (1994) 1.82
Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes (2001) 1.81
Identification and characterization of a second mouse Nramp gene. Genomics (1995) 1.81
Cellular mechanisms of genetically controlled host resistance to Mycobacterium bovis (BCG). J Immunol (1983) 1.81
Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains. J Immunol (1996) 1.78
Nramp defines a family of membrane proteins. Proc Natl Acad Sci U S A (1995) 1.78
Differences in mRNA expression of the proteins secreted by the adipocytes in human subcutaneous and visceral adipose tissues. Biochim Biophys Acta (2000) 1.76
Functional complementation of yeast ste6 by a mammalian multidrug resistance mdr gene. Science (1992) 1.74
Host resistance to intracellular infection: mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification. J Exp Med (1998) 1.73
TNF-alpha and IL-10 modulate the induction of apoptosis by virulent Mycobacterium tuberculosis in murine macrophages. J Immunol (1999) 1.69
Absence of p53 gene mutations in primary neuroblastomas. Cancer Res (1993) 1.69
The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes. Diabetologia (2004) 1.65
Regulation of resistance to leprosy by chromosome 1 locus in the mouse. Immunogenetics (1984) 1.63
Depot-specific differences in adipose tissue gene expression in lean and obese subjects. Diabetes (1998) 1.63
Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur J Biochem (1996) 1.60
Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure. EMBO J (1999) 1.58
Reciprocal effect of Waardenburg syndrome mutations on DNA binding by the Pax-3 paired domain and homeodomain. Hum Mol Genet (1997) 1.56
Cannabinoid-receptor expression in human leukocytes. Eur J Biochem (1993) 1.53
Macrophage NRAMP1 and its role in resistance to microbial infections. Inflamm Res (1998) 1.53
A mechanism for P-glycoprotein action in multidrug resistance: are we there yet? Trends Pharmacol Sci (1994) 1.53
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med (1999) 1.53
Infection genomics: Nramp1 as a major determinant of natural resistance to intracellular infections. Annu Rev Med (1998) 1.52
Subcellular localization of peripheral benzodiazepine receptors on human leukocytes. Lab Invest (1994) 1.50
Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Genomics (2000) 1.49
Plasma acylation stimulating protein concentration and subcutaneous adipose tissue C3 mRNA expression in nondiabetic and type 2 diabetic men. Arterioscler Thromb Vasc Biol (2001) 1.48
Association between high concentrations of Mr 52,000 cathepsin D and poor prognosis in primary human breast cancer. Cancer Res (1989) 1.48
[Cutaneous-splanchnic neurofibromatosis]. Ann Dermatol Venereol (1998) 1.47
Large scale purification of detergent-soluble P-glycoprotein from Pichia pastoris cells and characterization of nucleotide binding properties of wild-type, Walker A, and Walker B mutant proteins. J Biol Chem (1999) 1.46
Nramp 2 (DCT1/DMT1) expressed at the plasma membrane transports iron and other divalent cations into a calcein-accessible cytoplasmic pool. J Biol Chem (2000) 1.45
A mutation within intron 3 of the Pax-3 gene produces aberrantly spliced mRNA transcripts in the splotch (Sp) mouse mutant. Proc Natl Acad Sci U S A (1993) 1.44
TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine. J Biol Chem (1991) 1.44
Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood (2001) 1.43
Functional expression of Nramp1 in vitro in the murine macrophage line RAW264.7. Infect Immun (1999) 1.42
Recombinant congenic strains derived from A/J and C57BL/6J: a tool for genetic dissection of complex traits. Genomics (2001) 1.42
Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family. J Biol Chem (1997) 1.41
Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions. Plant Mol Biol (1997) 1.39
Genetic control of susceptibility to infection with Mycobacterium tuberculosis in mice. Genes Immun (2000) 1.38
Monitoring cellular responses to Listeria monocytogenes with oligonucleotide arrays. J Biol Chem (2000) 1.37
Resistance to intracellular infections: comparative genomic analysis of Nramp. Trends Genet (1996) 1.36
Peroxisome proliferator-activated receptor gamma is induced during differentiation of colon epithelium cells. J Endocrinol (1999) 1.35
Identification of polymorphisms and sequence variants in the human homologue of the mouse natural resistance-associated macrophage protein gene. Am J Hum Genet (1995) 1.35
Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem (1984) 1.34
Increased uncoupling protein-2 and -3 mRNA expression during fasting in obese and lean humans. J Clin Invest (1997) 1.33
Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry (1995) 1.33
Tissue, cellular and sub-cellular localization of the Vangl2 protein during embryonic development: effect of the Lp mutation. Gene Expr Patterns (2006) 1.33
Circulating cardiac troponin I in severe congestive heart failure. Circulation (1997) 1.32
Expression of key genes of fatty acid oxidation, including adiponectin receptors, in skeletal muscle of Type 2 diabetic patients. Diabetologia (2004) 1.32
Characterization of the multidrug resistance protein expressed in cell clones stably transfected with the mouse mdr1 cDNA. Cancer Res (1989) 1.30
Solvent behaviour in flash-cooled protein crystals at cryogenic temperatures. Acta Crystallogr D Biol Crystallogr (2001) 1.29
Susceptibility to malaria as a complex trait: big pressure from a tiny creature. Hum Mol Genet (2002) 1.29
Cloning and mRNA tissue distribution of human PPARgamma coactivator-1. Int J Obes Relat Metab Disord (1999) 1.28
Complex genetic control of susceptibility to malaria in mice. Genes Immun (2002) 1.28
Toward understanding the genetic basis of neural tube defects. Clin Genet (2007) 1.28
Physical mapping, amplification, and overexpression of the mouse mdr gene family in multidrug-resistant cells. Mol Cell Biol (1990) 1.27
An alternative splicing event in the Pax-3 paired domain identifies the linker region as a key determinant of paired domain DNA-binding activity. Mol Cell Biol (1996) 1.26
Release kinetics of serum cardiac troponin I in ischemic myocardial injury. Clin Biochem (1996) 1.26
15-deoxy-Delta 12,14-prostaglandin J2 induces apoptosis of human hepatic myofibroblasts. A pathway involving oxidative stress independently of peroxisome-proliferator-activated receptors. J Biol Chem (2001) 1.25