PubRank

J Saklatvala

Author PubWeight™ 108.14‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 1994 4.50
2 Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage. Nature 1986 4.24
3 Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 2001 3.12
4 Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein. Biochem J 1984 2.47
5 Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Mol Cell Biol 2000 2.45
6 p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. J Biol Chem 1999 2.38
7 A cartilage catabolic factor from synovium. Biochem J 1979 2.11
8 The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol 2001 2.09
9 Prevalence of radiographic osteoarthritis--it all depends on your point of view. Rheumatology (Oxford) 2006 1.94
10 Pig interleukin 1. Purification of two immunologically different leukocyte proteins that cause cartilage resorption, lymphocyte activation, and fever. J Exp Med 1985 1.70
11 Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term? Rheumatology (Oxford) 2000 1.67
12 Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Lett 2000 1.66
13 Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels. J Immunol 1997 1.64
14 Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes. J Biol Chem 1992 1.57
15 Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Mol Cell Biol 2001 1.55
16 Purification to homogeneity of pig leucocyte catabolin, a protein that causes cartilage resorption in vitro. Biochem J 1983 1.54
17 A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Lett 1998 1.52
18 Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts. J Exp Med 1986 1.50
19 Characterization of catabolin, the major product of pig synovial tissue that induces resorption of cartilage proteoglycan in vitro. Biochem J 1981 1.46
20 Identification of catabolin, a protein fro synovium which induces degradation of cartilage in organ culture. Biochem Biophys Res Commun 1980 1.45
21 Identification of a common class of high affinity receptors for both types of porcine interleukin-1 on connective tissue cells. Nature 1987 1.45
22 Interleukin-1. Int J Biochem Cell Biol 1998 1.44
23 Patterns of radiological progression in early rheumatoid arthritis: results of an 8 year prospective study. J Rheumatol 1998 1.40
24 FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer. Osteoarthritis Cartilage 2007 1.40
25 How does interleukin 1 activate cells? Interleukin 1 signal transduction. Immunol Today 1990 1.37
26 IL-1 and TNF transmodulate epidermal growth factor receptors by a protein kinase C-independent mechanism. J Immunol 1989 1.33
27 Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation. Arthritis Rheum 1993 1.30
28 p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes. J Immunol 1998 1.26
29 T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation. J Biol Chem 1997 1.24
30 Identification of proteinases in rheumatoid synovium. Detection of leukocyte elastase cathepsin G and another serine proteinase. Biochim Biophys Acta 1980 1.21
31 Involvement of stress-activated protein kinase and p38 mitogen-activated protein kinase in mIgM-induced apoptosis of human B lymphocytes. Proc Natl Acad Sci U S A 1996 1.19
32 Radiographic patterns and response to corticosteroid hip injection. Ann Rheum Dis 1997 1.18
33 Down-modulation of epidermal growth factor receptor affinity in fibroblasts treated with interleukin 1 or tumor necrosis factor is associated with phosphorylation at a site other than threonine 654. J Biol Chem 1990 1.18
34 The chemotactic factor N-formylmethionyl-leucyl-phenylalanine activates microtubule-associated protein 2 (MAP) kinase and a MAP kinase kinase in polymorphonuclear leucocytes. Biochem J 1993 1.17
35 Interleukin-1 beta and interleukin-1 alpha stimulate the plasminogen activator activity and prostaglandin E2 levels of human synovial cells. Arthritis Rheum 1987 1.14
36 Pig interleukin 1 (catabolin) is a potent stimulator of bone resorption in vitro. Calcif Tissue Int 1985 1.13
37 Characterization of proteins from human synovium and mononuclear leucocytes that induce resorption of cartilage proteoglycan in vitro. Biochem J 1983 1.12
38 Lymphocytes induce resorption of cartilage by producing catabolin. Biochem J 1982 1.11
39 Interleukin 1 and tumour necrosis factor increase phosphorylation of fibroblast proteins. FEBS Lett 1988 1.09
40 Stress-activated protein kinase/Jun N-terminal kinase is required for interleukin (IL)-1-induced IL-6 and IL-8 gene expression in the human epidermal carcinoma cell line KB. J Biol Chem 1998 1.08
41 Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein. J Biol Chem 1993 1.08
42 Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7. FEBS Lett 1997 1.07
43 Interleukin 1 and tumour necrosis factor increase phosphorylation of the small heat shock protein. Effects in fibroblasts, Hep G2 and U937 cells. FEBS Lett 1989 1.06
44 Evidence of two mechanisms for the activation of the glucose transporter GLUT1 by anisomycin: p38(MAP kinase) activation and protein synthesis inhibition in mammalian cells. J Physiol 1997 1.05
45 Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor. J Biol Chem 1994 1.03
46 Murine interleukin-1 receptor: differences in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model. FEBS Lett 1987 1.01
47 Murine interleukin 1 receptor. Direct identification by ligand blotting and purification to homogeneity of an interleukin 1-binding glycoprotein. J Biol Chem 1988 0.99
48 Measurement and prediction of radiological progression in early rheumatoid arthritis. J Rheumatol 1994 0.99
49 Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases. Biochem J 1992 0.99
50 Interleukin 1 stimulates hexose transport in fibroblasts by increasing the expression of glucose transporters. J Biol Chem 1990 0.99
51 Interleukin 1 alpha activates two forms of p54 alpha mitogen-activated protein kinase in rabbit liver. J Exp Med 1994 0.96
52 Interleukin-1 activates a novel protein kinase that phosphorylates the epidermal-growth-factor receptor peptide T669. Biochem J 1994 0.92
53 The cartilage-resorbing protein catabolin is made by synovial fibroblasts and its production is increased by phorbol myristate acetate. Biochem J 1983 0.91
54 Interleukin-1 alpha modulates collagen gene expression in cultured synovial cells. Biochem J 1988 0.89
55 Interleukin 1-induced phosphorylation of MAD3, the major inhibitor of nuclear factor kappa B of HeLa cells. Interference in signalling by the proteinase inhibitors 3,4-dichloroisocoumarin and tosylphenylalanyl chloromethylketone. Biochem J 1995 0.89
56 Interleukin-1 inhibits the synthesis of collagen by fibroblasts. Biochem Int 1986 0.89
57 Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M. Rheumatology (Oxford) 2006 0.88
58 Phosphorylated HSP27 associates with the activation-dependent cytoskeleton in human platelets. Blood 1994 0.88
59 Lysosomal cysteine endopeptidases mediate interleukin 1-stimulated cartilage proteoglycan degradation. Biochem J 1992 0.87
60 Neutral protease from the polymorphonuclear leucocytes of human rheumatoid synovial fluid. Clin Sci Mol Med 1974 0.87
61 Interleukin-1 signal transduction. Increased GTP binding and hydrolysis in membranes of a murine thymoma line (EL4). J Biol Chem 1990 0.87
62 Multiple joint avascular necrosis: beware of tuberculosis and human immunodeficiency virus--a rare but important cause. Br J Rheumatol 1995 0.86
63 Synergistic activation of JNK/SAPK by interleukin-1 and platelet-derived growth factor is independent of Rac and Cdc42. Biochem J 1999 0.85
64 D-2-hydroxyglutaric aciduria in association with spondyloenchondromatosis. Skeletal Radiol 2000 0.85
65 Studies on the fate of receptor-bound 125I-interleukin 1 beta in porcine synovial fibroblasts. J Immunol 1987 0.84
66 Isolation and characterization of human plasma alpha 1-proteinase inhibitor and a conformational study of its interaction with proteinases. Biochem J 1976 0.83
67 Analysis of mitogen-activated protein kinase pathways used by interleukin 1 in tissues in vivo: activation of hepatic c-Jun N-terminal kinases 1 and 2, and mitogen-activated protein kinase kinases 4 and 7. Biochem J 2001 0.83
68 Interleukin 1: purification and biochemical aspects of its action on cartilage. J Rheumatol 1987 0.82
69 Interleukin 1 activates jun N-terminal kinases JNK1 and JNK2 but not extracellular regulated MAP kinase (ERK) in human glomerular mesangial cells. FEBS Lett 1996 0.82
70 The mechanical joint score: a new clinical index of joint damage in rheumatoid arthritis. Rheumatology (Oxford) 2002 0.82
71 Prediction of radiographic damage in hands and feet in rheumatoid arthritis by clinical evaluation. Clin Rheumatol 1994 0.81
72 High-density lipoproteins differentially modulate cytokine-induced expression of E-selectin and cyclooxygenase-2. Arterioscler Thromb Vasc Biol 1999 0.80
73 A common class of receptors for the two types of porcine interleukin-1 on articular chondrocytes. Lymphokine Res 1986 0.80
74 Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage? Biochem Soc Trans 2006 0.80
75 Reduction of post-traumatic osteoporosis after external fixation of tibial fractures. Injury 1995 0.80
76 Small joint synovitis in rheumatoid arthritis: should it be assessed separately? Br J Rheumatol 1995 0.80
77 The binding subunit of pertussis toxin inhibits IL-1 induction of IL-2 and prostaglandin production. J Immunol 1992 0.80
78 Serological characterization of acidic (pI 5.5) and neutral (pI 7.1) forms of 17kD and 35kD interleukin-1. Lymphokine Res 1986 0.78
79 Dual specificity of the interleukin 1- and tumor necrosis factor-activated beta casein kinase. J Biol Chem 1997 0.78
80 Porcine collagenase from synovial fibroblasts: cDNA sequence and modulation of expression of RNA in vitro by various cytokines. Matrix 1991 0.78
81 The proinflammatory and chondral activities of leukemia inhibitory factor in goat joints are partially a function of interleukin-1. J Interferon Cytokine Res 1999 0.77
82 Identification of a cytoplasmic protein kinase regulated by IL-1 that phosphorylates the small heat shock protein, hsp27. J Immunol 1991 0.77
83 Specific activation of beta-casein kinase by the inflammatory cytokines interleukin 1 and tumour necrosis factor. Biochem J 1994 0.77
84 Molecular cloning and sequence of porcine interleukin 6 cDNA and expression of mRNA in synovial fibroblasts in vitro. Cytokine 1991 0.77
85 Interleukin 1 increases the production of collagenase but does not influence the phagocytosis of collagen fibrils. Matrix 1990 0.76
86 Regulation of GLUT1 in response to cellular stress. Biochem Soc Trans 1997 0.76
87 The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators. Agents Actions Suppl 1993 0.76
88 Hydrolysis of the elastase substrate succinyltrialanine nitroanilide by a metal-dependent enzyme in rheumatoid synovial fluid. J Clin Invest 1977 0.75
89 Isolation and characterization of tryase, a serine proteinase from rat liver. Biochem J 1981 0.75
90 Specific detection of an interleukin 1- and tumour necrosis factor-activated beta-casein kinase in HeLa and KB cells. Cytokine 1997 0.75
91 Studies on the murine interleukin-1 receptor. Dev Biol Stand 1988 0.75