Published in Biochem Biophys Res Commun on August 22, 1977
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Interaction of bleomycin with DNA. Proc Natl Acad Sci U S A (1978) 2.17
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Comparison of the sequence specificity of bleomycin cleavage in two slightly different DNA sequences. Nucleic Acids Res (1985) 1.12
Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex. Proc Natl Acad Sci U S A (1979) 1.01
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Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin. Nucleic Acids Res (1984) 0.79
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The mechanism of the degradation of DNA by streptonigrin. Can J Biochem (1976) 1.27
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Strand scission of DNA by bound adriamycin and daunorubicin in the presence of reducing agents. Biochem Biophys Res Commun (1977) 1.22
High-field NMR and restrained molecular modeling studies on a DNA heteroduplex containing a modified apurinic abasic site in the form of covalently linked 9-aminoellipticine. Biochemistry (1994) 1.20
alpha-DNA-V. Parallel annealing, handedness and conformation of the duplex of the unnatural alpha-hexadeoxyribonucleotide alpha-[d(CpApTpGpCpG)] with its beta-complement beta-[d(GpTpApCpGpC)] deduced from high field 1H-NMR. Nucleic Acids Res (1987) 1.16
Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay. Can J Biochem (1976) 1.13
Podophyllotoxins: current status and recent developments. Curr Med Chem (1998) 1.10
Effects of analogs of the DNA minor groove binder Hoechst 33258 on topoisomerase II and I mediated activities. Biochim Biophys Acta (1992) 1.09
Characteristics of the binding of the anticancer agents mitoxantrone and ametantrone and related structures to deoxyribonucleic acids. Biochemistry (1985) 1.08
Deoxyribonucleic acid cleavage specificity of a series of acridine- and acodazole-iron porphyrins as functional bleomycin models. Biochemistry (1986) 1.06
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The mechanism of the neocarzinostatin-induced cleavage of DNA. Biochem Biophys Res Commun (1978) 1.05
Photosensitization by antitumor agents--1. Production of singlet oxygen during irradiation of anthrapyrazoles with visible light. Photochem Photobiol (1986) 1.04
Recent developments in sequence selective minor groove DNA effectors. Curr Med Chem (2001) 1.03
Design, synthesis and investigation of mechanisms of action of novel protein kinase C inhibitors: perylenequinonoid pigments. Biochem Pharmacol (1994) 1.03
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alpha-DNA-III. Characterization by high field 1H-NMR, anti-parallel self-recognition and conformation of the unnatural hexadeoxyribonucleotides alpha-[d(CpApTpGpCpG)] and alpha-[d(CpGpCpApTpG)]. Alpha-oligodeoxynucleotides as potential cellular probes for gene control. Nucleic Acids Res (1987) 1.02
Characteristics of the interaction of anthrapyrazole anticancer agents with deoxyribonucleic acids: structural requirements for DNA binding, intercalation, and photosensitization. Mol Pharmacol (1988) 1.01
The mechanism of action of quinone antibiotics. Mol Cell Biochem (1983) 1.00
Chemotherapy of gonorrhea: a review of current status. Can Med Assoc J (1972) 0.99
Molecular mechanisms of binding and single-strand scission of deoxyribonucleic acid by the antitumor antibiotics saframycins A and C. Biochemistry (1982) 0.99
Molecular recognition between oligopeptides and nucleic acids. Monocationic imidazole lexitropsins that display enhanced GC sequence dependent DNA binding. Biochemistry (1987) 0.98
Pyrroloquinoline and pyridoacridine alkaloids from marine sources. Curr Med Chem (1999) 0.97
Novel DNA groove binding alkylators: design, synthesis, and biological evaluation. J Med Chem (1988) 0.95
Design, synthesis and antitumor cytotoxicity of novel bis-benzimidazoles. Anticancer Drug Des (2000) 0.92
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Structural and dynamic aspects of binding of a prototype lexitropsin to the decadeoxyribonucleotide d(CGCAATTGCG)2 deduced from high-resolution 1H NMR Studies. Biochemistry (1988) 0.91
Redox activities of antitumor anthracyclines determined by microsomal oxygen consumption and assays for superoxide anion and hydroxyl radical generation. Biochem Pharmacol (1986) 0.91
Preclinical assessment of hypocrellin B and hypocrellin B derivatives as sensitizers for photodynamic therapy of cancer: progress update. Photochem Photobiol (1997) 0.90
Further studies on the generation of reactive oxygen species from activated anthracyclines and the relationship to cytotoxic action and cardiotoxic effects. Biochem Pharmacol (1982) 0.89
Enzymatic oxidative activation and transformation of the antitumor agent mitoxantrone. Free Radic Biol Med (1988) 0.88
Mode of action of saframycin antitumor antibiotics: sequence selectivities in the covalent binding of saframycins A and S to deoxyribonucleic acid. Chem Res Toxicol (1991) 0.88
Sequence specific molecular recognition by a monocationic lexitropsin of the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies. Nucleic Acids Res (1988) 0.88
DNA sequence selectivities in the covalent bonding of antibiotic saframycins Mx1, Mx3, A, and S deduced from MPE.Fe(II) footprinting and exonuclease III stop assays. Biochemistry (1992) 0.87
Molecular recognition between ligands and nucleic acids: novel pyridine- and benzoxazole-containing agents related to Hoechst 33258 that exhibit altered DNA sequence specificity deduced from footprinting analysis and spectroscopic studies. Chem Res Toxicol (1991) 0.86
Interactions of the antitumor agents mitoxantrone and bisantrene with deoxyribonucleic acids studied by electron microscopy. Mol Pharmacol (1984) 0.86
Structure of a dicationic monoimidazole lexitropsin bound to DNA. Biochemistry (1995) 0.86
Studies on the ability of minor groove binders to induce supercoiling in DNA. FEBS Lett (1993) 0.86
Studies related to antitumor antibiotics. Part XIV. Reactions of mitomycin B with DNA. Can J Biochem (1978) 0.85
Interaction of the peroxidase-derived metabolite of mitoxantrone with nucleic acids. Evidence for covalent binding of 14C-labeled drug. Biochem Pharmacol (1989) 0.85
Structure and conformation of the duplex consensus acceptor exon:intron junction d[(CpTpApCpApGpGpT). (ApCpCpTpGpTpApG)] deduced from high-field 1H-NMR of non-exchangeable and imino protons. J Biomol Struct Dyn (1986) 0.85
Synthesis, complete 1H assignments and conformations of the self-complementary hexadeoxyribonucleotide [d(CpGpApTpCpG)]2 and its fragments by high field NMR. Nucleic Acids Res (1984) 0.85
Stopped-flow kinetic analysis of the interaction of anthraquinone anticancer drugs with calf thymus DNA, poly[d(G-C)].poly[d(G-C)], and poly[d(A-T)].poly[d(A-T)]. Biochemistry (1986) 0.84
Horseradish peroxidase-catalyzed oxidation of mitoxantrone: spectrophotometric and electron paramagnetic resonance studies. J Free Radic Biol Med (1986) 0.84
Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI--N-methylpyrrole hybrids. Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency. Anticancer Drug Des (1996) 0.83
Ethidium binding assay for reactive oxygen species generated from reductively activated adriamycin (doxorubicin). Methods Enzymol (1984) 0.83
Sequence specific molecular recognition and binding by a GC recognizing Hoechst 33258 analogue to the decadeoxyribonucleotide d-[CATGGCCATG]2: structural and dynamic aspects deduced from high field 1H-NMR studies. J Biomol Struct Dyn (1990) 0.83
Highly potent synthetic polyamides, bisdistamycins, and lexitropsins as inhibitors of human immunodeficiency virus type 1 integrase. Mol Pharmacol (1998) 0.83
Photosensitization by anticancer agents. 11. Mechanisms of photosensitization of human leukemic cells by diaminoanthraquinones: singlet oxygen and radical reactions. J Photochem Photobiol B (1992) 0.83
Linked lexitropsins and the in vitro inhibition of HIV-1 reverse transcriptase RNA-directed DNA polymerization: a novel induced-fit of 3,5 m-pyridyl bisdistamycin to enzyme-associated template-primer. Biochemistry (1996) 0.82
Minor-groove binders are inhibitors of the catalytic activity of DNA gyrases. FEBS Lett (1993) 0.82
Nitrosourea-induced DNA single-strand breaks. Biochem Pharmacol (1979) 0.82
Mode of DNA binding of bis-benzimidazoles and related structures studied by electric linear dichroism. J Biomol Struct Dyn (1994) 0.82
FTIR study of specific binding interactions between DNA minor groove binding ligands and polynucleotides. J Biomol Struct Dyn (1992) 0.82
Hydroxyl radical production by free and DNA-bound aminoquinone antibiotics and its role in DNA degradation. Electron spin resonance detection of hydroxyl radicals by spin trapping. Can J Biochem (1978) 0.82
Effects of alkylation by dimethyl sulfate, nitrogen mustard, and mitomycin C on DNA structure as studied by the ethidium binding assay. Can J Biochem (1976) 0.82
Uptake kinetics and intracellular localization of hypocrellin photosensitizers for photodynamic therapy: a confocal microscopy study. Photochem Photobiol (1995) 0.82
Structure and conformation of saframycin R determined by high field 1H and 13C NMR and its interactions with DNA in solution. J Antibiot (Tokyo) (1983) 0.82
Molecular recognition between oligopeptides and nucleic acids: DNA sequence specificity and binding properties of thiazole-lexitropsins incorporating the concepts of base site acceptance and avoidance. Anticancer Drug Des (1990) 0.81
Netropsin and bis-netropsin analogs as inhibitors of the catalytic activity of mammalian DNA topoisomerase II and topoisomerase cleavable complexes. Biochim Biophys Acta (1991) 0.81
Synthesis and sequence-specific DNA binding of a topoisomerase inhibitory analog of Hoechst 33258 designed for altered base and sequence recognition. Chem Res Toxicol (1992) 0.81
Molecular recognition between ligands and nucleic acids: DNA binding characteristics of analogues of Hoechst 33258 designed to exhibit altered base and sequence recognition. Chem Res Toxicol (1992) 0.81
Photosensitization with anticancer agents. 16. The photo-oxidation of hypocrellin A. A mechanism study using 18O labelling. J Photochem Photobiol B (1993) 0.81
Membranous nephropathy with anti-tubular basement membrane antibody may be X-linked. Pediatr Nephrol (2000) 0.80
DNA binding studies and influence on the activity of DNA topoisomerases of bis-netropsins: different effects of analogs containing cis and trans ethylene linkers. J Biomol Struct Dyn (1997) 0.80
A 1H-NMR study of the DNA binding characteristics of thioformyldistamycin, an amide isosteric lexitropsin. Biochemistry (1992) 0.80
Studies related to antitumor antibiotics. Part IX. Reactions of carzinophillin with DNA assayed by ethidium fluorescence. Can J Biochem (1977) 0.80
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Methadone. Can Med Assoc J (1973) 0.80
Design and synthesis of novel thiazole-containing cross-linked polyamides related to the antiviral antibiotic distamycin. J Org Chem (2000) 0.80
Interactions of the glycopeptide antitumor antibiotics bleomycin and tallysomycin with deoxyribonucleic acid in vitro. Biochem Pharmacol (1980) 0.80
Structure-activity relationship of novel oligopeptide antiviral and antitumor agents related to netropsin and distamycin. J Med Chem (1986) 0.80
Photosensitization with anticancer agents. 15. Perylenequinonoid pigments as potential photodynamic therapeutic agents: formation of semiquinone radicals and reactive oxygen species on illumination. J Photochem Photobiol B (1993) 0.80
Bisindolylmaleimides linked to DNA minor groove binding lexitropsins: synthesis, inhibitory activity against topoisomerase I, and biological evaluation. J Med Chem (1996) 0.79
Phototherapeutic potential of alternative photosensitizers to porphyrins. Pharmacol Ther (1994) 0.79
Optimization of cross-linked lexitropsins. J Biomol Struct Dyn (1996) 0.79
DNA sequence specificity of antitumor agents. Oncogenes as possible targets for cancer therapy. Acta Oncol (1988) 0.79
Structure and dynamics of ligand-template interactions of topoisomerase inhibitory analogs of Hoechst 33258: high field 1H-NMR and restrained molecular mechanics studies. J Biomol Struct Dyn (1992) 0.79
Hypocrellins and their use in photosensitization. Photochem Photobiol (1990) 0.79
Structure and conformation of the duplex consensus 5'-splice site d[(CpApGpGpTpApApGpT).(ApCpTpTpApCpCpTpG)] deduced from high field 1H-NMR of the non-exchangeable and imino protons. J Biomol Struct Dyn (1987) 0.79
Studies related to antitumor antibiotics. Part VIII. Cleavage of DNA by streptonigrin analogues and the relationship to antineoplastic activity. Can J Biochem (1976) 0.79
Molecular recognition between oligopeptides and nucleic acids. DNA sequence specificity and binding properties of an acridine-linked netropsin hybrid ligand. J Mol Recognit (1990) 0.79
Shape-selective recognition of a model Okazaki fragment by geometrically-constrained bis-distamycins. J Biomol Struct Dyn (1999) 0.79
Molecular mechanism of binding of pyrrolo(1,4)benzodiazepine antitumour agents to deoxyribonucleic acid--anthramycin and tomaymycin. Biochem Pharmacol (1979) 0.78
Photosensitization of human leukemic cells by anthracenedione antitumor agents. Cancer Res (1990) 0.78
Trimethoprim-sulfonamide therapy: a brief literature review. Am J Pharm Sci Support Public Health (1972) 0.78
Photosensitization with anticancer agents. 18. Perylenequinonoid pigments as potential photodynamic therapeutic agents: preparation and photodynamic properties of amino-substituted hypocrellin derivatives. Anticancer Drug Des (1993) 0.78
Design, synthesis, and intracellular localization of a fluorescently labeled DNA binding polyamide related to the antibiotic distamycin. Bioorg Med Chem Lett (2001) 0.78
Hypocrellins as photosensitizers for photodynamic therapy: a screening evaluation and pharmacokinetic study. Cancer Chemother Pharmacol (1996) 0.78
Biodistribution of Photofrin II and 5-aminolevulinic acid-induced protoporphyrin IX in normal rat bladder and bladder tumor models: implications for photodynamic therapy. Photochem Photobiol (1998) 0.78