Published in Proc Natl Acad Sci U S A on August 01, 1978
The interaction of RNA polymerase and lac repressor with the lac control region. Nucleic Acids Res (1979) 6.17
DNA double-strand breaks caused by replication arrest. EMBO J (1997) 4.18
Map of distamycin, netropsin, and actinomycin binding sites on heterogeneous DNA: DNA cleavage-inhibition patterns with methidiumpropyl-EDTA.Fe(II). Proc Natl Acad Sci U S A (1982) 3.81
Methidiumpropyl-EDTA.Fe(II) and DNase I footprinting report different small molecule binding site sizes on DNA. Nucleic Acids Res (1983) 3.18
Patterns of lambda Int recognition in the regions of strand exchange. Cell (1983) 3.07
Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences. Proc Natl Acad Sci U S A (1981) 2.92
The lambda phage att site: functional limits and interaction with Int protein. Nature (1980) 2.91
Interaction of int protein with specific sites on lambda att DNA. Cell (1979) 2.61
Enzymatic properties of purified Escherichia coli uvrABC proteins. Proc Natl Acad Sci U S A (1983) 2.54
Interaction of the lambda site-specific recombination protein Xis with attachment site DNA. Proc Natl Acad Sci U S A (1985) 1.95
DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards. Nucleic Acids Res (1986) 1.72
3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends. Nucleic Acids Res (1997) 1.72
Metallo-intercalators and metallo-insertors. Chem Commun (Camb) (2007) 1.70
Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: evidence for a possible role in mutagenesis. Proc Natl Acad Sci U S A (1985) 1.66
Roles of chromophore and apo-protein in neocarzinostatin action. Proc Natl Acad Sci U S A (1980) 1.47
Bleomycin-induced DNA lesions at mutational hot spots: implications for the mechanism of double-strand cleavage. Proc Natl Acad Sci U S A (1990) 1.37
Contacts between Escherichia coli RNA polymerase and thymines in the lac UV5 promoter. Proc Natl Acad Sci U S A (1979) 1.31
Site-specific cleavage of RNA by Fe(II).bleomycin. Proc Natl Acad Sci U S A (1990) 1.13
Comparison of the sequence specificity of bleomycin cleavage in two slightly different DNA sequences. Nucleic Acids Res (1985) 1.12
Nucleotide-specific cleavage and minor-groove interaction of DNA with esperamicin antitumor antibiotics. Proc Natl Acad Sci U S A (1989) 1.12
Analogous cleavage of DNA by micrococcal nuclease and a 1-10-phenanthroline-cuprous complex. Nucleic Acids Res (1982) 1.09
Crystal structure of DNA-bound Co(III) bleomycin B2: Insights on intercalation and minor groove binding. Proc Natl Acad Sci U S A (2008) 1.08
Identification of thymidine-5'-aldehyde at DNA strand breaks induced by neocarzinostatin chromophore. Proc Natl Acad Sci U S A (1982) 1.05
Distribution and specificity of mutations induced by neocarzinostatin in the lacI gene of Escherichia coli. J Bacteriol (1983) 1.05
Mutagenesis by neocarzinostatin in Escherichia coli and Salmonella typhimurium: requirement for umuC+ or plasmid pKM101. J Bacteriol (1980) 1.05
Alteration and activation of sequence-specific cleavage of DNA by bleomycin in the presence of the antitumor drug cis-diamminedichloroplatinum(II). Proc Natl Acad Sci U S A (1983) 1.02
Structural studies of of "active complex" of bleomycin: assignment of ligands to the ferrous ion in a ferrous-bleomycin-carbon monoxide complex. Proc Natl Acad Sci U S A (1979) 1.01
Further characterizations of bleomycin-sensitive (blm) mutants of Saccharomyces cerevisiae with implications for a radiomimetic model. J Bacteriol (1991) 0.97
Bleomycin-induced DNA repair by Saccharomyces cerevisiae ATP-dependent polydeoxyribonucleotide ligase. J Bacteriol (1988) 0.96
Base substitution mutations induced in the cI gene of lambda phage by neocarzinostatin chromophore: correlation with depyrimidination hotspots at the sequence AGC. Nucleic Acids Res (1986) 0.94
Iron-induced DNA damage and synthesis in isolated rat liver nuclei. Biochem J (1982) 0.94
Sequence-selective binding of phleomycin to DNA. Biochem J (1987) 0.89
Tandem mass spectrometry-based detection of c4'-oxidized abasic sites at specific positions in DNA fragments. Chem Res Toxicol (2009) 0.89
Primary effect of chemotherapy on the transcription profile of AIDS-related Kaposi's sarcoma. BMC Cancer (2002) 0.89
Total syntheses of (-)-pyrimidoblamic acid and P-3A. J Am Chem Soc (2014) 0.85
Studying the effect of a charged surface on the interaction of bleomycin with DNA using an atomic force microscope. Eur Biophys J (2004) 0.85
Accurate and rapid modeling of iron-bleomycin-induced DNA damage using tethered duplex oligonucleotides and electrospray ionization ion trap mass spectrometric analysis. Nucleic Acids Res (2000) 0.84
Diethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin. Nucleic Acids Res (1988) 0.84
cdc9 ligase-defective mutants of Saccharomyces cerevisiae exhibit lowered resistance to lethal effects of bleomycin. J Bacteriol (1982) 0.83
DNA structure influences sequence specific cleavage by bleomycin. Nucleic Acids Res (1993) 0.83
Noncovalent intermolecular crosslinks are produced by bleomycin reaction with duplex DNA. Proc Natl Acad Sci U S A (1979) 0.82
Interaction of bleomycin with a bent DNA fragment. Biochem J (1992) 0.82
Sequence specific damage of DNA induced by reducing sugars. Nucleic Acids Res (1985) 0.81
Preferential localization of γH2AX foci in euchromatin of retina rod cells after DNA damage induction. Chromosome Res (2013) 0.80
Bleomycin mediated degradation of DNA-RNA hybrids does not involve C-1' chemistry. Nucleic Acids Res (1992) 0.80
Identification of oligonucleotide fragments produced in a strand scission reaction of the d(C-G-C-G-C-G) duplex by bleomycin. Nucleic Acids Res (1984) 0.79
Effects of hypoxanthine substitution on bleomycin-mediated DNA strand degradation in DNA-RNA hybrids. Nucleic Acids Res (1997) 0.78
Mechanistic analyses of site-specific degradation in DNA-RNA hybrids by prototypic DNA cleavers. Nucleic Acids Res (1997) 0.78
Zorbamycin has a different DNA sequence selectivity compared with bleomycin and analogues. Bioorg Med Chem (2016) 0.78
DNA of a circular minichromosome linearized by restriction enzymes or other reagents is resistant to further cleavage: an influence of chromatin topology on the accessibility of DNA. Nucleic Acids Res (2012) 0.77
Characterization of intracellular DNA strand breaks induced by neocarzinostatin in Escherichia coli cells. Nucleic Acids Res (1984) 0.77
Sequence-specific DNA damage induced by reduced mitomycin C and 7-N-(p-hydroxyphenyl)mitomycin C. Nucleic Acids Res (1984) 0.77
Induction of ATM/ATR pathway combined with Vγ2Vδ2 T cells enhances cytotoxicity of ovarian cancer cells. Biochim Biophys Acta (2014) 0.76
Catalytic site-specific cleavage of a DNA-target by an oligonucleotide carrying bleomycin A5. Nucleic Acids Res (1995) 0.76
Human telomeric DNA sequences are a major target for the antitumour drug bleomycin. J Biol Inorg Chem (2011) 0.76
The determination of the DNA sequence specificity of bleomycin-induced abasic sites. J Biol Inorg Chem (2016) 0.76
Evaluating the use of Apo-neocarzinostatin as a cell penetrating protein. Protein Eng Des Sel (2013) 0.75
Site specificity of bleomycin cleavage in purified and intracellular simian virus 40 DNA. Nucleic Acids Res (1987) 0.75
Novel DNA photocleaving agents with high DNA sequence specificity related to the antibiotic bleomycin A2. Nucleic Acids Res (1995) 0.75
Aerobic Exercise Attenuated Bleomycin-Induced Lung Fibrosis in Th2-Dominant Mice. PLoS One (2016) 0.75
The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence. J Biol Inorg Chem (2017) 0.75
Interaction of Zn(II)bleomycin-A2 and Zn(II)peplomycin with a DNA hairpin containing the 5'-GT-3' binding site in comparison with the 5'-GC-3' binding site studied by NMR spectroscopy. J Biol Inorg Chem (2017) 0.75
A new method for sequencing DNA. Proc Natl Acad Sci U S A (1977) 250.51
Construction of a colicin E1-R factor composite plasmid in vitro: means for amplification of deoxyribonucleic acid. J Bacteriol (1975) 13.95
The nucleotide sequence of the lac operator. Proc Natl Acad Sci U S A (1973) 11.28
The nucleotide sequence of the lactose messenger ribonucleic acid transcribed from the UV5 promoter mutant of Escherichia coli. Proc Natl Acad Sci U S A (1973) 5.88
Ordered transcription of RNA tumor virus genomes. J Mol Biol (1976) 4.78
New antibiotics, bleomycin A and B. J Antibiot (Tokyo) (1966) 3.58
The nature of mutants in the lac promoter region. J Mol Biol (1968) 2.62
Chemical analysis of DNA alterations. I. Base liberation and backbone breakage of DNA and oligodeoxyadenylic acid induced by hydrogen peroxide and hydroxylamine. Biochim Biophys Acta (1968) 1.66
Primary structure of neocarzinostatin, an antitumor protein. Science (1972) 1.55
A role for ferrous ion and oxygen in the degradation of DNA by bleomycin. Biochem Biophys Res Commun (1976) 1.52
Characterization of DNA strand breakage in vitro by the antitumor protein neocarzinostatin. Biochemistry (1977) 1.51
Fragmentation of deoxyribonucleic acid by bleomycin. Mol Pharmacol (1971) 1.48
The mechanism of the bleomycin-induced cleavage of DNA. Biochem Biophys Res Commun (1977) 1.44
Release of free bases from deoxyribonucleic acid after reaction with bleomycin. Mol Pharmacol (1972) 1.33
Bleomycin, a review. J Med (1976) 1.26
Neocarzinostatin-induced breakdown of deoxyribonucleic acid in HeLa-S3 cells. J Antibiot (Tokyo) (1975) 1.07
The mechanism of the neocarzinostatin-induced cleavage of DNA. Biochem Biophys Res Commun (1978) 1.05
The relationship between DNA strand-scission and DNA synthesis inhibition in HeLa cells treated with neocarzinostatin. Biochim Biophys Acta (1977) 1.04
Chemical analysis of DNA alterations. II. Alteration and liberation of bases of deoxynucleotides and deoxynucleosides induced by hydrogen peroxide and hydroxylamine. Biochim Biophys Acta (1968) 0.98
A facile method of purification of neocarzinostatin, an antitumor protein. J Natl Cancer Inst (1977) 0.92
Bleomycin-induced breakage of closed-circular DNA. Biochem Biophys Res Commun (1977) 0.91
Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1989) 12.54
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell (1985) 11.28
The trans-activator gene of the human T cell lymphotropic virus type III is required for replication. Cell (1986) 10.76
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature (1986) 10.62
Effect of mutations affecting the p6 gag protein on human immunodeficiency virus particle release. Proc Natl Acad Sci U S A (1991) 10.05
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science (1984) 9.14
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (1989) 9.08
Mutation of a mutL homolog in hereditary colon cancer. Science (1994) 9.04
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. Mol Cell (2001) 8.99
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science (1985) 8.53
Rous sarcoma virus genome is terminally redundant: the 5' sequence. Proc Natl Acad Sci U S A (1977) 7.09
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science (1985) 6.51
Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature (1994) 6.21
Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes. J Virol (1992) 5.85
Functional role of human immunodeficiency virus type 1 vpu. Proc Natl Acad Sci U S A (1989) 5.72
Determination of viral proteins present in the human immunodeficiency virus type 1 preintegration complex. J Virol (1991) 5.49
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virus. Proc Natl Acad Sci U S A (1988) 5.47
Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III. Nature (1986) 5.24
Determination of the leukaemogenicity of a murine retrovirus by sequences within the long terminal repeat. Nature (1984) 4.90
Ordered transcription of RNA tumor virus genomes. J Mol Biol (1976) 4.78
Integration of human immunodeficiency virus type 1 DNA in vitro. Proc Natl Acad Sci U S A (1990) 4.75
Activation of cell growth by binding of Friend spleen focus-forming virus gp55 glycoprotein to the erythropoietin receptor. Nature (1990) 4.59
Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J Virol (1986) 4.48
Identification of HIV-1 vpr product and function. J Acquir Immune Defic Syndr (1990) 4.35
Human immunodeficiency virus vpr product is a virion-associated regulatory protein. J Virol (1990) 4.35
Tissue-specific transcription preference as a determinant of cell tropism and leukaemogenic potential of murine retroviruses. Nature (1984) 4.30
Role of the matrix protein in the virion association of the human immunodeficiency virus type 1 envelope glycoprotein. J Virol (1994) 4.28
Mapping of functionally important residues of a cysteine-histidine box in the human immunodeficiency virus type 1 nucleocapsid protein. J Virol (1993) 4.22
Identification of a protein encoded by the vpu gene of HIV-1. Nature (1988) 4.05
MSI and MSII made on ribosome in idling step of protein synthesis. Nature (1972) 3.89
Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus. Nature (1987) 3.77
UV-induced mutation hotspots occur at DNA damage hotspots. Nature (1982) 3.63
Vpu protein of human immunodeficiency virus type 1 enhances the release of capsids produced by gag gene constructs of widely divergent retroviruses. Proc Natl Acad Sci U S A (1993) 3.63
Structural and functional characterization of human immunodeficiency virus tat protein. J Virol (1989) 3.57
Synthesis of guanosine tetra- and pentaphosphate requires the presence of a codon-specific, uncharged transfer ribonucleic acid in the acceptor site of ribosomes. Proc Natl Acad Sci U S A (1973) 3.52
Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Science (1984) 3.20
Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis. J Virol (1977) 2.99
Specific binding of tryptophan transfer RNA to avian myeloblastosis virus RNA-dependent DNA polymerase (reverse transcriptase). Proc Natl Acad Sci U S A (1975) 2.97
Cis-acting sequences responsive to the rev gene product of the human immunodeficiency virus. J Acquir Immune Defic Syndr (1988) 2.97
Distribution of UV light-induced damage in a defined sequence of human DNA: detection of alkaline-sensitive lesions at pyrimidine nucleoside-cytidine sequences. Proc Natl Acad Sci U S A (1981) 2.92
HIV/HTLV gene nomenclature. Nature (1988) 2.72
Cleavage of pyrimidine dimers in specific DNA sequences by a pyrimidine dimer DNA-glycosylase of M. luteus. Nature (1980) 2.72
Structure of the genome of Moloney murine leukemia virus: a terminally redundant sequence. Cell (1978) 2.68
Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1. Proc Natl Acad Sci U S A (1987) 2.66
Subcellular localization of the human immunodeficiency virus trans-acting art gene product. J Virol (1988) 2.64
Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector. Proc Natl Acad Sci U S A (1989) 2.64
Construction of recombinant murine retroviruses that express the human T-cell leukemia virus type II and human T-cell lymphotropic virus type III trans activator genes. J Virol (1986) 2.50
Sites and structure of gamma radiation-induced DNA strand breaks. J Biol Chem (1982) 2.47
gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini. J Biol Chem (1983) 2.41
A micromethod for detailed characterization of high molecular weight RNA. Methods Enzymol (1980) 2.36
Positional cloning of a novel Fanconi anemia gene, FANCD2. Mol Cell (2001) 2.33
Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region. Science (1984) 2.32
Tissue selectivity of murine leukemia virus infection is determined by long terminal repeat sequences. J Virol (1985) 2.29
Genetic analysis of the human immunodeficiency virus type 1 integrase protein. J Virol (1994) 2.26
Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat. Proc Natl Acad Sci U S A (1985) 2.25
Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures. Proc Natl Acad Sci U S A (1991) 2.25
Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I. Science (1985) 2.25
Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc Natl Acad Sci U S A (1987) 2.25
Friend spleen focus-forming virus glycoprotein gp55 interacts with the erythropoietin receptor in the endoplasmic reticulum and affects receptor metabolism. Proc Natl Acad Sci U S A (1990) 2.23
Role of human T-cell leukemia virus type 1 X region proteins in immortalization of primary human lymphocytes in culture. J Virol (1992) 2.21
Requirement of the Pr55gag precursor for incorporation of the Vpr product into human immunodeficiency virus type 1 viral particles. J Virol (1994) 2.20
Circularization of human immunodeficiency virus type 1 DNA in vitro. J Virol (1991) 2.14
Prevention of T cell anergy by signaling through the gamma c chain of the IL-2 receptor. Science (1994) 2.10
Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody. Proc Natl Acad Sci U S A (1993) 2.10
Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export. J Virol (1992) 2.05
Genomic changes associated with antigenic variation of visna virus durig persistent infection. Proc Natl Acad Sci U S A (1980) 2.04
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression. Science (1986) 2.03
Polymorphism of the 3' open reading frame of the virus associated with the acquired immune deficiency syndrome, human T-lymphotropic virus type III. Nucleic Acids Res (1985) 2.01
A tripartite HIV-1 tat-env-rev fusion protein. EMBO J (1990) 2.01
Use of exonuclease III to determine the site of stable lesions in defined sequences of DNA: the cyclobutane pyrimidine dimer and cis and trans dichlorodiammine platinum II examples. Nucleic Acids Res (1981) 1.97
Novel leukaemogenic retroviruses isolated from cell line derived from spontaneous AKR tumour. Nature (1981) 1.97
Construction and use of a replication-competent human immunodeficiency virus (HIV-1) that expresses the chloramphenicol acetyltransferase enzyme. Proc Natl Acad Sci U S A (1989) 1.96
Terminal redundancy and the origin of replication of Rous sarcoma virus RNA. Proc Natl Acad Sci U S A (1977) 1.94
Comparison of the cleavage of pyrimidine dimers by the bacteriophage T4 and Micrococcus luteus UV-specific endonucleases. J Biol Chem (1980) 1.92
Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication. J Virol (1989) 1.91
Biochemical evidence that "new" influenza virus strains in nature may arise by recombination (reassortment). Proc Natl Acad Sci U S A (1978) 1.86
Transepithelial transport of HIV-1 by intestinal M cells: a mechanism for transmission of AIDS. J Acquir Immune Defic Syndr (1991) 1.85
Expression of reverse transcriptase activity of human T-lymphotropic virus type III (HTLV-III/LAV) in Escherichia coli. J Virol (1986) 1.84
A new relaxed mutant of Escherichia coli with an altered 50S ribosomal subunit. Proc Natl Acad Sci U S A (1974) 1.83
Mouse beta-globin DNA-binding protein B1 is identical to a proto-oncogene, the transcription factor Spi-1/PU.1, and is restricted in expression to hematopoietic cells and the testis. Mol Cell Biol (1993) 1.80
Alkaline lability of fluorescent photoproducts produced in ultraviolet light-irradiated DNA. J Biol Chem (1982) 1.79
Allelic variation in the effects of the nef gene on replication of human immunodeficiency virus type 1. Proc Natl Acad Sci U S A (1991) 1.75
Enzyme action at 3' termini of ionizing radiation-induced DNA strand breaks. J Biol Chem (1983) 1.74
Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex. Mol Cell Biol (1999) 1.73
5'-terminus of Moloney murine leukemia virus 35s RNA is m7G5' ppp5' GmpCp. J Virol (1976) 1.70
Identification of cis-acting repressive sequences within the negative regulatory element of human immunodeficiency virus type 1. J Virol (1990) 1.70
Analysis of the genome of an endogenous, ecotropic retrovirus of the AKR strain of mice: micromethod for detailed characterization of high-molecular-weight RNA. J Virol (1980) 1.69
Animal model for the therapy of acquired immunodeficiency syndrome with reverse transcriptase inhibitors. Proc Natl Acad Sci U S A (1995) 1.69
Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells. Science (1985) 1.67
T4 DNA polymerase (3'-5') exonuclease, an enzyme for the detection and quantitation of stable DNA lesions: the ultraviolet light example. Nucleic Acids Res (1985) 1.66
Targeted disruption of the murine Fanconi anemia gene, Fancg/Xrcc9. Blood (2001) 1.64
Mechanism of action of a mammalian DNA repair endonuclease. Biochemistry (1986) 1.63
The C-C (6-4) UV photoproduct is mutagenic in Escherichia coli. Proc Natl Acad Sci U S A (1986) 1.61
Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function. Proc Natl Acad Sci U S A (1992) 1.58
Transcellular transactivation by the human immunodeficiency virus type 1 tat protein. J Virol (1991) 1.57
Structure and transcription of the mouse erythropoietin receptor gene. Mol Cell Biol (1990) 1.57
Human erythropoietin receptor: cloning, expression, and biologic characterization. Blood (1990) 1.55
Hepatitis B virus infection in cultured human lymphoblastoid cells. Science (1983) 1.54
Identification of membrane anchorage domains of the HIV-1 gp160 envelope glycoprotein precursor. J Acquir Immune Defic Syndr (1991) 1.53
Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol (1997) 1.52