Published in J Biol Chem on October 25, 1982
Highly conserved sequences in the 3' untranslated region of mRNAs coding for homologous proteins in distantly related species. Nucleic Acids Res (1985) 2.83
The molecular basis of alpha-thalassaemia in Thailand. EMBO J (1984) 1.30
Compensatory increase in alpha 1-globin gene expression in individuals heterozygous for the alpha-thalassemia-2 deletion. J Clin Invest (1985) 1.00
Hematologic and biosynthetic studies in homozygous hemoglobin Constant Spring. J Clin Invest (1984) 0.98
Locus assignment of alpha-globin structural mutations by hybrid-selected translation. J Clin Invest (1985) 0.93
Secondary structure model for mouse beta Maj globin mRNA derived from enzymatic digestion data, comparative sequence and computer analysis. Nucleic Acids Res (1986) 0.91
Different hematologic phenotypes are associated with the leftward (-alpha 4.2) and rightward (-alpha 3.7) alpha+-thalassemia deletions. J Clin Invest (1987) 0.91
Translational profiles of alpha 1-, alpha 2-, and beta-globin messenger ribonucleic acids in human reticulocytes. J Clin Invest (1986) 0.85
Thalassemic hemoglobinopathies. Am J Pathol (1983) 0.76
Polymorphism of DNA sequence adjacent to human beta-globin structural gene: relationship to sickle mutation. Proc Natl Acad Sci U S A (1978) 16.54
The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling. Cell (1985) 7.45
Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci U S A (1994) 6.72
Antenatal diagnosis of sickle-cell anaemia by D.N.A. analysis of amniotic-fluid cells. Lancet (1978) 6.19
beta 0 thalassemia, a nonsense mutation in man. Proc Natl Acad Sci U S A (1979) 4.58
An important function of Nrf2 in combating oxidative stress: detoxification of acetaminophen. Proc Natl Acad Sci U S A (2001) 4.49
NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc Natl Acad Sci U S A (1996) 4.41
Rapid duplication and loss of genes coding for the alpha chains of hemoglobin. Proc Natl Acad Sci U S A (1980) 4.33
Evolution of the hemoglobin S and C genes in world populations. Science (1980) 4.24
Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science (1994) 3.97
Detection of sickle cell anaemia and thalassaemias. Nature (1987) 3.94
Suppressor T cells. J Immunol (1972) 3.92
Identification of a nondeletion defect in alpha-thalassemia. N Engl J Med (1977) 3.86
Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A (1999) 3.79
Polymorphism of DNA sequence in the beta-globin gene region. Application to prenatal diagnosis of beta 0 thalassemia in Sardinia. N Engl J Med (1980) 3.72
Genetic lesion in homozygous alpha thalassaemia (hydrops fetalis). Nature (1974) 3.58
Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Proc Natl Acad Sci U S A (1993) 3.39
Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton. Proc Natl Acad Sci U S A (1986) 3.22
Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin. Nature (1981) 2.97
Human beta-globin gene expression in transgenic mice is enhanced by a distant DNase I hypersensitive site. Proc Natl Acad Sci U S A (1989) 2.92
A sensitive new prenatal test for sickle-cell anemia. N Engl J Med (1982) 2.91
Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J (1995) 2.87
Prenatal diagnosis of beta-thalassemia. Detection of a single nucleotide mutation in DNA. N Engl J Med (1983) 2.78
The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs. Proc Natl Acad Sci U S A (1977) 2.75
Detection of specific DNA sequences by fluorescence amplification: a color complementation assay. Proc Natl Acad Sci U S A (1989) 2.67
Construction of a functional human suppressor tRNA gene: an approach to gene therapy for beta-thalassaemia. Nature (1982) 2.65
Cloning and complete nucleotide sequence of human 5'-alpha-globin gene. Proc Natl Acad Sci U S A (1980) 2.62
Triplicated alpha-globin loci in humans. Proc Natl Acad Sci U S A (1980) 2.61
Globin chain synthesis in the alpha thalassemia syndromes. J Clin Invest (1969) 2.46
Deletion of the beta-globin structure gene in hereditary persistence of foetal haemoglobin. Nature (1975) 2.45
Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood. Nat Genet (1996) 2.45
Synergistic enhancement of globin gene expression by activator protein-1-like proteins. Proc Natl Acad Sci U S A (1990) 2.45
Cloning, sequencing, and chromosomal localization of human term placental alkaline phosphatase cDNA. Proc Natl Acad Sci U S A (1985) 2.44
Two different molecular organizations account for the single alpha-globin gene of the alpha-thalassemia-2 genotype. J Clin Invest (1980) 2.38
Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes. J Clin Invest (1979) 2.37
Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol (1995) 2.36
beta zero thalassemia in Sardinia is caused by a nonsense mutation. J Clin Invest (1981) 2.30
alpha-Globin gene organisation in blacks precludes the severe form of alpha-thalassaemia. Nature (1979) 2.25
Substrate specificity of the dsRNA unwinding/modifying activity. EMBO J (1991) 2.18
Versatile cosmid vectors for the isolation, expression, and rescue of gene sequences: studies with the human alpha-globin gene cluster. Proc Natl Acad Sci U S A (1983) 2.14
Prenatal diagnosis of alpha-thalassemia. Clinical application of molecular hybridization. N Engl J Med (1976) 2.10
In vivo protein-DNA interactions at the beta-globin gene locus. Proc Natl Acad Sci U S A (1991) 2.05
Erythroid cell-specific mRNA stability elements in the alpha 2-globin 3' nontranslated region. Mol Cell Biol (1995) 2.04
Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest (1999) 2.02
Four highly stable eukaryotic mRNAs assemble 3' untranslated region RNA-protein complexes sharing cis and trans components. Proc Natl Acad Sci U S A (1997) 1.97
Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J (1998) 1.97
Erythroid cell-specific determinants of alpha-globin mRNA stability. Mol Cell Biol (1994) 1.96
Deletion of alpha-globin genes in haemoglobin-H disease demonstrates multiple alpha-globin structural loci. Nature (1975) 1.95
The LIM/double zinc-finger motif functions as a protein dimerization domain. Proc Natl Acad Sci U S A (1994) 1.94
A rapid screening test for antenatal sex determination. Lancet (1984) 1.92
Isolation of cDNA encoding the human NF-E2 protein. Proc Natl Acad Sci U S A (1993) 1.91
Germ-line transmission and developmental regulation of a 150-kb yeast artificial chromosome containing the human beta-globin locus in transgenic mice. Proc Natl Acad Sci U S A (1993) 1.88
A distant gene deletion affects beta-globin gene function in an atypical gamma delta beta-thalassemia. J Clin Invest (1985) 1.85
Concurrent sickle-cell anemia and alpha-thalassemia: effect on severity of anemia. N Engl J Med (1982) 1.85
Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate. J Biol Chem (1984) 1.85
Dissection of the enhancer activity of beta-globin 5' DNase I-hypersensitive site 2 in transgenic mice. Proc Natl Acad Sci U S A (1992) 1.84
Construction of human chromosome 21-specific yeast artificial chromosomes. Proc Natl Acad Sci U S A (1989) 1.83
High-resolution chromosome sorting and DNA spot-blot analysis assign McArdle's syndrome to chromosome 11. Science (1984) 1.80
Prenatal diagnosis of beta-thalassaemia and sickle-cell anaemia. Experience with 24 cases. Lancet (1977) 1.77
Comparative chromosome mapping of a conserved homoeo box region in mouse and human. Nature (1985) 1.77
Authentic beta-globin mRNA sequences in homozygous betaO-thalassemia. Proc Natl Acad Sci U S A (1977) 1.75
The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J Biol Chem (1999) 1.69
Intracavernosal vascular endothelial growth factor (VEGF) injection and adeno-associated virus-mediated VEGF gene therapy prevent and reverse venogenic erectile dysfunction in rats. Int J Impot Res (2003) 1.68
Assignment of human beta-, gamma-, and delta-globin genes to the short arm of chromosome 11 by chromosome sorting and DNA restriction enzyme analysis. Proc Natl Acad Sci U S A (1979) 1.67
Assembly of the alpha-globin mRNA stability complex reflects binary interaction between the pyrimidine-rich 3' untranslated region determinant and poly(C) binding protein alphaCP. Mol Cell Biol (1999) 1.66
Prenatal diagnosis of hemoglobin disorders. Prog Hematol (1977) 1.61
Mild thalassemia: the result of interactions of alpha and beta thalassemia genes. J Clin Invest (1970) 1.59
Prenatal diagnosis of hemoglobin H disease. J Pediatr (1978) 1.55
The human growth hormone gene is regulated by a multicomponent locus control region. Mol Cell Biol (1995) 1.54
Optimized RNA targets of two closely related triple KH domain proteins, heterogeneous nuclear ribonucleoprotein K and alphaCP-2KL, suggest Distinct modes of RNA recognition. J Biol Chem (2001) 1.53
Adeno-associated viral vector-mediated vascular endothelial growth factor gene transfer induces neovascular formation in ischemic heart. Proc Natl Acad Sci U S A (2000) 1.50
Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1. J Biol Chem (1991) 1.50
Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells. Proc Natl Acad Sci U S A (1988) 1.49
The molecular defects of alpha-thalassemia in the Filipino. Hemoglobin (1977) 1.47
cDNA sequence for human erythrocyte ankyrin. Proc Natl Acad Sci U S A (1990) 1.46
Diagnosis of homozygous alpha-thalassemia in cultured amniotic-fluid fibroblasts. N Engl J Med (1978) 1.46
Initiation codon mutation as a cause of alpha thalassemia. J Biol Chem (1984) 1.45
Direct isolation of the functional human thymidine kinase gene with a cosmid shuttle vector. Proc Natl Acad Sci U S A (1984) 1.45
Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics. J Clin Invest (1981) 1.43
A native RNA secondary structure controls alternative splice-site selection and generates two human growth hormone isoforms. J Biol Chem (1992) 1.43
Targeted recruitment of histone acetyltransferase activity to a locus control region. J Biol Chem (2000) 1.40
Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa. Proc Natl Acad Sci U S A (1986) 1.37
Globin structural mutant alpha 125Leu leads to Pro is a novel cause of alpha-thalassaemia. Nature (1982) 1.37
Antenatal diagnosis of sickle cell anaemia by direct analysis of the sickle mutation. Lancet (1981) 1.36
The untranslated regions of beta-globin mRNA evolve at a functional rate in higher primates. Cell (1981) 1.35
Fetal blood-sampling in utero. Lancet (1974) 1.34
Demonstration of non-functional beta-globin mRNA in homozygous beta (0) thalassemia. Proc Natl Acad Sci U S A (1975) 1.33
Ligand-directed retroviral targeting of human breast cancer cells. Proc Natl Acad Sci U S A (1995) 1.32
Molecular basis of beta thalassemia in south China. Strategy for DNA analysis. Hum Genet (1988) 1.32
hMAF, a small human transcription factor that heterodimerizes specifically with Nrf1 and Nrf2. J Biol Chem (1997) 1.31
Platelet glycoprotein IIb. Chromosomal localization and tissue expression. J Clin Invest (1987) 1.31
The inactive beta globin gene on a gamma delta beta thalassemia chromosome has a normal structure and functions normally in vitro. Blood (1988) 1.29
Patterns of histone acetylation suggest dual pathways for gene activation by a bifunctional locus control region. EMBO J (2000) 1.28
Pit-1 binding sites at the somatotrope-specific DNase I hypersensitive sites I, II of the human growth hormone locus control region are essential for in vivo hGH-N gene activation. J Biol Chem (1999) 1.27
Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue. Nat Genet (1995) 1.27