Published in Proc Natl Acad Sci U S A on October 25, 1994
The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. EMBO J (1997) 6.36
Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. J Cell Biol (1996) 2.63
A conserved LIM protein that affects muscular adherens junction integrity and mechanosensory function in Caenorhabditis elegans. J Cell Biol (1999) 2.17
Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. J Clin Invest (1999) 2.02
SCL assembles a multifactorial complex that determines glycophorin A expression. Mol Cell Biol (2004) 1.89
Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex. Mol Cell Biol (1997) 1.83
P-Lim, a LIM homeodomain factor, is expressed during pituitary organ and cell commitment and synergizes with Pit-1. Proc Natl Acad Sci U S A (1995) 1.77
The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A (1997) 1.76
Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Mol Cell Biol (1998) 1.75
Growth factor-induced tyrosine phosphorylation of Hrs, a novel 115-kilodalton protein with a structurally conserved putative zinc finger domain. Mol Cell Biol (1995) 1.73
Muscle LIM protein promotes myogenesis by enhancing the activity of MyoD. Mol Cell Biol (1997) 1.66
Interactions between distinct types of DNA binding proteins enhance binding to ocs element promoter sequences. Plant Cell (1995) 1.65
A CCHC metal-binding domain in Nanos is essential for translational regulation. EMBO J (1997) 1.49
Overexpression Beadex mutations and loss-of-function heldup-a mutations in Drosophila affect the 3' regulatory and coding components, respectively, of the Dlmo gene. Genetics (1998) 1.41
Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin. Mol Biol Cell (1998) 1.39
Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling. Plant Cell (2006) 1.38
Two muscle-specific LIM proteins in Drosophila. J Cell Biol (1996) 1.33
GATA transcription factors associate with a novel class of nuclear bodies in erythroblasts and megakaryocytes. EMBO J (1996) 1.32
Dimerization of Ste5, a mitogen-activated protein kinase cascade scaffold protein, is required for signal transduction. Proc Natl Acad Sci U S A (1996) 1.32
CRP1, a LIM domain protein implicated in muscle differentiation, interacts with alpha-actinin. J Cell Biol (1997) 1.29
Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. J Cell Biol (1997) 1.25
Molecular dissection of a LIM domain. Mol Biol Cell (1997) 1.24
PDZ motifs in PTP-BL and RIL bind to internal protein segments in the LIM domain protein RIL. Mol Biol Cell (1998) 1.24
Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. Mol Med (1998) 1.23
The Drosophila LIM-only gene, dLMO, is mutated in Beadex alleles and might represent an evolutionarily conserved function in appendage development. Proc Natl Acad Sci U S A (1998) 1.18
Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity. Mol Cell Biol (1997) 1.17
LMX1B mutations cause hereditary FSGS without extrarenal involvement. J Am Soc Nephrol (2013) 1.16
REST/NRSF-interacting LIM domain protein, a putative nuclear translocation receptor. Mol Cell Biol (2003) 1.16
Nucleocytoplasmic functions of the PDZ-LIM protein family: new insights into organ development. Bioessays (2010) 1.10
The LIM domain-containing Dbm1 GTPase-activating protein is required for normal cellular morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol (1996) 0.97
Mutations in an Atypical TIR-NB-LRR-LIM Resistance Protein Confer Autoimmunity. Front Plant Sci (2011) 0.96
Novel LMX1B mutation in familial nail-patella syndrome with variable expression of open angle glaucoma. Mol Vis (2007) 0.95
Pxl1p, a paxillin-like protein in Saccharomyces cerevisiae, may coordinate Cdc42p and Rho1p functions during polarized growth. Mol Biol Cell (2004) 0.94
RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2. Nucleic Acids Res (2004) 0.90
Fine mapping of the alpha-actinin binding site within cysteine-rich protein. Biochem J (2000) 0.90
Myofibril assembly visualized by imaging N-RAP, alpha-actinin, and actin in living cardiomyocytes. Exp Cell Res (2009) 0.87
Leupaxin is similar to paxillin in focal adhesion targeting and tyrosine phosphorylation but has distinct roles in cell adhesion and spreading. Cell Adh Migr (2011) 0.87
Transforming growth factor beta up-regulates cysteine-rich protein 2 in vascular smooth muscle cells via activating transcription factor 2. J Biol Chem (2008) 0.87
Identification and characterization of thymus LIM protein: targeted disruption reduces thymus cellularity. Mol Cell Biol (2001) 0.84
A network of transcription factors operates during early tooth morphogenesis. Mol Cell Biol (2013) 0.84
Characterisation of four LIM protein-encoding genes involved in infection-related development and pathogenicity by the rice blast fungus Magnaporthe oryzae. PLoS One (2014) 0.81
Investigating lasp-2 in cell adhesion: new binding partners and roles in motility. Mol Biol Cell (2013) 0.80
Cloning of two LIMCH1 isoforms: characterization of their distribution in rat brain and their agmatinase activity. Histochem Cell Biol (2015) 0.77
Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J Cell Biol (2016) 0.76
Identification of CLP36 as a tumor antigen that induces an antibody response in pancreatic cancer. Cancer Res Treat (2005) 0.76
TRIP6 regulates p27 KIP1 to promote tumorigenesis. Mol Cell Biol (2013) 0.76
Lhx6 and Lhx8: cell fate regulators and beyond. FASEB J (2015) 0.76
Prickle3 synergizes with Wtip to regulate basal body organization and cilia growth. Sci Rep (2016) 0.76
Genome of Cnaphalocrocis medinalis Granulovirus, the First Crambidae-Infecting Betabaculovirus Isolated from Rice Leaffolder to Sequenced. PLoS One (2016) 0.75
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells. Mol Cell Biol (1982) 116.75
Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (1988) 52.71
A novel genetic system to detect protein-protein interactions. Nature (1989) 43.83
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science (1988) 27.01
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54
The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. Proc Natl Acad Sci U S A (1991) 15.52
The protein Id: a negative regulator of helix-loop-helix DNA binding proteins. Cell (1990) 15.36
Leucine repeats and an adjacent DNA binding domain mediate the formation of functional cFos-cJun heterodimers. Science (1989) 6.51
PAS is a dimerization domain common to Drosophila period and several transcription factors. Nature (1993) 4.96
Insulin gene enhancer binding protein Isl-1 is a member of a novel class of proteins containing both a homeo- and a Cys-His domain. Nature (1990) 4.35
Interaction cloning: identification of a helix-loop-helix zipper protein that interacts with c-Fos. Science (1992) 4.17
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-11. Nature (1990) 4.17
mec-3, a homeobox-containing gene that specifies differentiation of the touch receptor neurons in C. elegans. Cell (1988) 4.12
NF-kappa B and related proteins: Rel/dorsal homologies meet ankyrin-like repeats. Trends Biochem Sci (1992) 3.81
Structure of the carboxy-terminal LIM domain from the cysteine rich protein CRP. Nat Struct Biol (1994) 3.51
Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton. J Cell Biol (1992) 3.20
Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex. Genes Dev (1992) 2.86
apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev (1992) 2.33
Metal binding 'finger' structures in the glucocorticoid receptor defined by site-directed mutagenesis. EMBO J (1988) 2.26
The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol (1989) 2.24
Cooperative interactions between the Caenorhabditis elegans homeoproteins UNC-86 and MEC-3. Science (1993) 2.07
The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif. Oncogene (1990) 1.68
The LIM family transcription factor Isl-1 requires cAMP response element binding protein to promote somatostatin expression in pancreatic islet cells. Proc Natl Acad Sci U S A (1992) 1.64
Karyoplasmic interaction selection strategy: a general strategy to detect protein-protein interactions in mammalian cells. Proc Natl Acad Sci U S A (1992) 1.60
LIM domains. Nature (1990) 1.38
The LIM motif defines a specific zinc-binding protein domain. Proc Natl Acad Sci U S A (1993) 1.37
Human cysteine-rich protein. A member of the LIM/double-finger family displaying coordinate serum induction with c-myc. J Biol Chem (1992) 1.26
Characterization of a human cDNA encoding a widely expressed and highly conserved cysteine-rich protein with an unusual zinc-finger motif. Nucleic Acids Res (1990) 1.22
Conversion of the E1A Cys4 zinc finger to a nonfunctional His2,Cys2 zinc finger by a single point mutation. Proc Natl Acad Sci U S A (1991) 1.13
Common metal ion coordination in LIM domain proteins. Biochemistry (1994) 1.04
The sequence of the human genome. Science (2001) 101.55
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell (1997) 24.57
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell (1996) 16.73
Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science (1997) 16.09
Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell (1998) 13.87
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science (2000) 13.62
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell (1997) 12.83
Orchestrated transcription of key pathways in Arabidopsis by the circadian clock. Science (2000) 12.35
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell (2000) 11.90
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev (1998) 11.86
Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med (2000) 11.35
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia. Nature (2000) 9.80
Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol (1999) 8.21
SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Cell (1993) 6.95
An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem (1999) 6.88
HOLE: a program for the analysis of the pore dimensions of ion channel structural models. J Mol Graph (1996) 6.48
Endonuclease G is an apoptotic DNase when released from mitochondria. Nature (2001) 6.20
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell (1997) 5.95
Identification of a point mutation in the voltage-gated sodium channel gene of Kenyan Anopheles gambiae associated with resistance to DDT and pyrethroids. Insect Mol Biol (2000) 5.81
Speech recognition in noise as a function of the number of spectral channels: comparison of acoustic hearing and cochlear implants. J Acoust Soc Am (2001) 5.75
The Ebola virus VP35 protein functions as a type I IFN antagonist. Proc Natl Acad Sci U S A (2000) 5.46
Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Proc Natl Acad Sci U S A (2000) 5.38
DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide. J Bacteriol (2001) 5.35
Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci (2001) 4.99
Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 4.71
SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci U S A (1993) 4.61
POWER_SAGE: comparing statistical tests for SAGE experiments. Bioinformatics (2000) 4.56
Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett (1997) 4.48
SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res (1999) 4.23
Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol (1996) 4.11
Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem (1998) 4.02
Treatment of supraventricular tachycardia due to atrioventricular nodal reentry, by radiofrequency catheter ablation of slow-pathway conduction. N Engl J Med (1992) 3.95
Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci (2000) 3.95
Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors. Proc Natl Acad Sci U S A (1998) 3.94
Suppressor T cells. J Immunol (1972) 3.92
Multiple transcription-factor genes are early targets of phytochrome A signaling. Proc Natl Acad Sci U S A (2001) 3.91
Language comprehension in language-learning impaired children improved with acoustically modified speech. Science (1996) 3.84
The peptide antibiotic LL-37/hCAP-18 is expressed in epithelia of the human lung where it has broad antimicrobial activity at the airway surface. Proc Natl Acad Sci U S A (1998) 3.83
Self-terminating diffraction gates femtosecond X-ray nanocrystallography measurements. Nat Photonics (2012) 3.68
Structural basis of IAP recognition by Smac/DIABLO. Nature (2001) 3.66
Temporal and rate representations of time-varying signals in the auditory cortex of awake primates. Nat Neurosci (2001) 3.62
Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature (2000) 3.54
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. J Clin Invest (1998) 3.51
Dark is a Drosophila homologue of Apaf-1/CED-4 and functions in an evolutionarily conserved death pathway. Nat Cell Biol (1999) 3.45
Association of Rab25 and Rab11a with the apical recycling system of polarized Madin-Darby canine kidney cells. Mol Biol Cell (1999) 3.45
Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. Cell (2000) 3.39
Myocyte death in the failing human heart is gender dependent. Circ Res (1999) 3.38
The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem (1996) 3.38
Bestrophin, the product of the Best vitelliform macular dystrophy gene (VMD2), localizes to the basolateral plasma membrane of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2000) 3.32
Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology (1995) 3.26
Assignment of the membrane attachment, DNA binding, and transcriptional activation domains of sterol regulatory element-binding protein-1 (SREBP-1). J Biol Chem (1994) 3.09
Nuclear protein that binds sterol regulatory element of low density lipoprotein receptor promoter. I. Identification of the protein and delineation of its target nucleotide sequence. J Biol Chem (1993) 3.04
Homology and concerted evolution at the alpha 1 and alpha 2 loci of human alpha-globin. Nature (1981) 2.97
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J Clin Invest (1997) 2.93
Mobile microbiome: oral bacteria in extra-oral infections and inflammation. J Dent Res (2013) 2.89
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell (1998) 2.89
Identification of two KH domain proteins in the alpha-globin mRNP stability complex. EMBO J (1995) 2.87
The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest (1999) 2.77
Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature (2001) 2.76
Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol (2000) 2.74
Radiofrequency catheter ablation of idiopathic left ventricular tachycardia guided by a Purkinje potential. Circulation (1993) 2.71
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science (2000) 2.70
Increased sensitivity to dextran sodium sulfate colitis in IRE1beta-deficient mice. J Clin Invest (2001) 2.67
Cloning and complete nucleotide sequence of human 5'-alpha-globin gene. Proc Natl Acad Sci U S A (1980) 2.62
Development and validation of an ECG algorithm for identifying accessory pathway ablation site in Wolff-Parkinson-White syndrome. J Cardiovasc Electrophysiol (1998) 2.59
Glucagon-like peptide-1 increases cAMP but fails to augment contraction in adult rat cardiac myocytes. Circ Res (2001) 2.56
Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemia. Circ Res (2001) 2.55
Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment. Cell Death Dis (2013) 2.52
Effects of noise and spectral resolution on vowel and consonant recognition: acoustic and electric hearing. J Acoust Soc Am (1998) 2.46
Inflammation and stroke: putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia. Brain Pathol (2000) 2.46
Comparison of in vivo tissue temperature profile and lesion geometry for radiofrequency ablation with a saline-irrigated electrode versus temperature control in a canine thigh muscle preparation. Circulation (1995) 2.45
Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A (1997) 2.44
Structure of cloned DNA complementary to rat prolactin messenger RNA. J Biol Chem (1980) 2.44
Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1. J Biol Chem (2000) 2.42
Long-term outcomes in nondiabetic chronic kidney disease. Kidney Int (2008) 2.41
The acidosis of chronic renal failure activates muscle proteolysis in rats by augmenting transcription of genes encoding proteins of the ATP-dependent ubiquitin-proteasome pathway. J Clin Invest (1996) 2.39
Acute effects of total suspended particles and sulfur dioxides on preterm delivery: a community-based cohort study. Arch Environ Health (1996) 2.39
Consonant recordings for speech testing. J Acoust Soc Am (1999) 2.38
The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A (1998) 2.38
A randomized, double-blind, crossover clinical trial of diclofenac plus misoprostol versus acetaminophen in patients with osteoarthritis of the hip or knee. Arthritis Rheum (2001) 2.37
Detection and characterization of a 3' untranslated region ribonucleoprotein complex associated with human alpha-globin mRNA stability. Mol Cell Biol (1995) 2.36
IDH1 or IDH2 mutations predict longer survival and response to temozolomide in low-grade gliomas. Neurology (2010) 2.36
Identification of a novel class of insect glutathione S-transferases involved in resistance to DDT in the malaria vector Anopheles gambiae. Biochem J (2001) 2.35
Torque generation in the flagellar motor of Escherichia coli: evidence of a direct role for FliG but not for FliM or FliN. J Bacteriol (1996) 2.32
Effects of cigarette smoking on lung function in adolescent boys and girls. N Engl J Med (1996) 2.31
beta zero thalassemia in Sardinia is caused by a nonsense mutation. J Clin Invest (1981) 2.30
Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7. Neuron (2001) 2.29
Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation. Mech Dev (1998) 2.28
Determinants of atherosclerosis susceptibility in the C3H and C57BL/6 mouse model: evidence for involvement of endothelial cells but not blood cells or cholesterol metabolism. Circ Res (2000) 2.28
The smallest known non-avian theropod dinosaur. Nature (2000) 2.26
The influence of age on apoptotic and other mechanisms of cell death after cerebral hypoxia-ischemia. Cell Death Differ (2005) 2.22
Endogenous cellulases in animals: isolation of beta-1, 4-endoglucanase genes from two species of plant-parasitic cyst nematodes. Proc Natl Acad Sci U S A (1998) 2.21
Human prolactin. cDNA structural analysis and evolutionary comparisons. J Biol Chem (1981) 2.19
Substrate specificity of the dsRNA unwinding/modifying activity. EMBO J (1991) 2.18
Taste genes associated with dental caries. J Dent Res (2010) 2.17
Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling. Immunity (2000) 2.16