Published in N Engl J Med on November 11, 1982
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Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci U S A (1985) 7.98
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma. Proc Natl Acad Sci U S A (1986) 5.54
Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-Ig fusion gene in lymphoma. EMBO J (1988) 3.77
Mechanism of the t(14;18) chromosomal translocation: structural analysis of both derivative 14 and 18 reciprocal partners. Proc Natl Acad Sci U S A (1987) 3.18
The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t(14;18) translocation. Mol Cell Biol (1989) 2.84
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The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein. Mol Cell Biol (1989) 2.24
Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas. J Exp Med (1986) 2.21
Expression of bcl-2 in fetal tissues suggests a role in morphogenesis. Am J Pathol (1993) 2.16
Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci U S A (1993) 2.05
A 14;18 and an 8;14 chromosome translocation in a cell line derived from an acute B-cell leukemia. Proc Natl Acad Sci U S A (1984) 1.79
DNA rearrangements in human follicular lymphoma can involve the 5' or the 3' region of the bcl-2 gene. Proc Natl Acad Sci U S A (1987) 1.74
Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc Natl Acad Sci U S A (1992) 1.63
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Overexpression of the human BCL-2 gene product results in growth enhancement of Epstein-Barr virus-immortalized B cells. Proc Natl Acad Sci U S A (1989) 1.50
Conversion of a stem cell leukemia from a T-lymphoid to a myeloid phenotype induced by the adenosine deaminase inhibitor 2'-deoxycoformycin. Proc Natl Acad Sci U S A (1984) 1.46
A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma. EMBO J (1992) 1.46
Clonal expansion in follicular lymphoma occurs subsequent to antigenic selection. J Exp Med (1992) 1.37
Genetic pathway to recurrent chromosome translocations in murine lymphoma involves V(D)J recombinase. J Clin Invest (1999) 1.35
Follicular lymphomas of the gastrointestinal tract. Pathologic features in 31 cases and bcl-2 oncogenic protein expression. Am J Pathol (1992) 1.30
Evolution of B-cell malignancy: pre-B-cell leukemia resulting from MYC activation in a B-cell neoplasm with a rearranged BCL2 gene. Proc Natl Acad Sci U S A (1988) 1.30
Primary intraocular lymphoma: a review of the clinical, histopathological and molecular biological features. Graefes Arch Clin Exp Ophthalmol (2004) 1.29
Single cell origin of bigenotypic and biphenotypic B cell proliferations in human follicular lymphomas. J Exp Med (1988) 1.25
Frequent biclonality and Ig gene alterations among B cell lymphomas that show multiple histologic forms. J Exp Med (1985) 1.19
The chromosome 14 breakpoint in neoplastic B cells with the t(11;14) translocation involves the immunoglobulin heavy chain locus. Proc Natl Acad Sci U S A (1984) 1.17
IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma. Blood (2008) 1.12
Trisomy 3 is not a common feature in malignant lymphomas of mucosa-associated lymphoid tissue type. Am J Pathol (1998) 1.11
The dual PI3K/mTOR inhibitor, NVP-BEZ235, is efficacious against follicular lymphoma. Leukemia (2010) 1.10
Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals. Int J Cancer (2009) 1.10
Lymphocytic lymphoma/B-chronic lymphocytic leukaemia--an immunohistopathological study of peripheral B lymphocyte neoplasia. Br J Cancer (1984) 1.07
bcl-2 overexpression inhibits cell death and promotes the morphogenesis, but not tumorigenesis of human mammary epithelial cells. J Cell Biol (1995) 1.06
The biology of tumor growth in the non-Hodgkin's lymphomas. A dual parameter flow cytometry study of 220 cases. J Clin Invest (1984) 1.03
Sequential bcl-2 and c-myc oncogene rearrangements associated with the clinical transformation of non-Hodgkin's lymphoma. J Clin Invest (1989) 1.01
Quantification of bcl-2/JH fusion sequences and a control gene by multiplex real-time PCR coupled with automated amplicon sizing by capillary electrophoresis. J Mol Diagn (2002) 0.95
The cellular and molecular carcinogenic effects of radon exposure: a review. Int J Mol Sci (2013) 0.95
Detection of BCL2 rearrangements in follicular lymphoma. Am J Pathol (2002) 0.95
Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization. Proc Natl Acad Sci U S A (1984) 0.94
Microarray analysis of B-cell lymphoma cell lines with the t(14;18). J Mol Diagn (2002) 0.88
Low frequency association of the t(2;5)(p23;q35) chromosomal translocation with CD30+ lymphomas from American and Asian patients. A reverse transcriptase-polymerase chain reaction study. Am J Pathol (1995) 0.83
The detection of specific gene rearrangements in non-Hodgkin's lymphoma using the polymerase chain reaction. Br J Cancer (1992) 0.83
Detection of bcl-2/JH rearrangement in follicular and diffuse lymphoma: concordant results of peripheral blood and bone marrow analysis at diagnosis. Br J Cancer (1993) 0.83
Primary testicular and intraocular lymphomas: two case reports and a review of the literature. Surv Ophthalmol (2006) 0.83
The immunoglobulin heavy chain gene 3' enhancers induce Bcl2 deregulation and lymphomagenesis in murine B cells. Leukemia (2011) 0.82
Detection of numerical chromosomal abnormalities in neoplastic hematopoietic cells by in situ hybridization with a chromosome-specific probe. Am J Pathol (1990) 0.82
Molecular monitoring of low grade non-Hodgkin's lymphoma by gene amplification. Br J Cancer (1991) 0.79
Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesis. Blood (2008) 0.79
The bcl-2 gene translocation is undetectable in Hodgkin's disease by Southern blot hybridization and polymerase chain reaction. Am J Pathol (1992) 0.78
Chronic Lymphocytic Leukemia with t(14;18)(q32;q21) As a Sole Cytogenetic Abnormality. Clin Med Insights Pathol (2014) 0.78
Development and validation of a quantitative polymerase chain reaction assay to evaluate minimal residual disease for T-cell acute lymphoblastic leukemia and follicular lymphoma. Am J Pathol (1999) 0.76
Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens. J Mol Diagn (2011) 0.76
Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation. Mol Cell Biol (1992) 0.76
The molecular biology of chromosome alterations in myelogenous leukemia. West J Med (1985) 0.75
Non-Hodgkin lymphoma with t(14;18): clonal evolution patterns and cytogenetic-pathologic-clinical correlations. J Cancer Res Clin Oncol (2007) 0.75
Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol (1982) 43.81
Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials (2000) 10.99
Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma. N Engl J Med (1993) 6.77
An improved rosetting assay for detection of human T lymphocytes. J Immunol Methods (1974) 6.54
Prognostic effect of weight loss prior to chemotherapy in cancer patients. Eastern Cooperative Oncology Group. Am J Med (1980) 6.12
High resolution of human chromosomes. Science (1976) 5.56
The chromosomal basis of human neoplasia. Science (1983) 4.26
The origin of man: a chromosomal pictorial legacy. Science (1982) 4.02
Constitutive fragile sites and cancer. Science (1984) 3.30
Retinoblastoma and subband deletion of chromosome 13. Am J Dis Child (1978) 3.11
Regional assignment of genes for human esterase D and retinoblastoma to chromosome band 13q14. Science (1980) 2.72
Acute megakaryocytic leukemia: the Eastern Cooperative Oncology Group experience. Blood (2000) 2.65
bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma. N Engl J Med (1989) 2.18
Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored working group. Am J Hematol (1988) 2.06
Multiple recurrent genomic defects in follicular lymphoma. A possible model for cancer. N Engl J Med (1987) 1.94
New chromosome techniques in the study of human neoplasia. Hum Pathol (1981) 1.82
The characterization of high-resolution G-banded chromosomes of man. Chromosoma (1978) 1.79
Mid-prophase human chromosomes. The attainment of 2000 bands. Hum Genet (1981) 1.79
A high resolution in situ hybridization technique for the direct visualization of labeled G-banded early metaphase and prophase chromosomes. Cytogenet Cell Genet (1978) 1.75
A simple G-banding technique. Lancet (1973) 1.72
Heterochromatin, satellite DNA, and cell function. Structural DNA of eucaryotes may support and protect genes and aid in speciation. Science (1971) 1.67
High-resolution chromosome analysis in clinical medicine. Prog Clin Pathol (1978) 1.64
Clinical and biological significance of RAS mutations in multiple myeloma. Leukemia (2008) 1.56
Activating mutations of N- and K-ras in multiple myeloma show different clinical associations: analysis of the Eastern Cooperative Oncology Group Phase III Trial. Blood (1996) 1.54
MOPP/ABV hybrid chemotherapy for advanced Hodgkin's disease significantly improves failure-free and overall survival: the 8-year results of the intergroup trial. J Clin Oncol (1998) 1.51
New chromosomal syndromes. Am J Dis Child (1975) 1.39
Prognostic factors for hyperdiploid-myeloma: effects of chromosome 13 deletions and IgH translocations. Leukemia (2006) 1.39
Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3. Nucleic Acids Res (1992) 1.38
Cancer cachexia. Cancer (1979) 1.36
Satellite DNA in constitutive heterochromatin of the guinea pig. Science (1970) 1.32
All patients with acute nonlymphocytic leukemia may have a chromosomal defect. N Engl J Med (1981) 1.29
Physician knowledge and attitudes about cancer pain management: a survey from the Minnesota cancer pain project. J Pain Symptom Manage (1995) 1.28
Characterization of banding patterns of metaphase-prophase G-banded chromosomes and their use in gene mapping. Cytogenet Cell Genet (1978) 1.26
Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes. Chromosoma (1977) 1.24
Cryoglobulinemia in infectious mononucleosis: quantitation and characterization of the cryoproeins. J Lab Clin Med (1968) 1.23
Trisomy 9 mosaicism. Clin Genet (1977) 1.22
Partial trisomy 8 (8q24) and the trisomy-8 syndrome. Humangenetik (1974) 1.22
Influence of treatment and response status on infection risk in multiple myeloma. Am J Med (1981) 1.21
Frequent association of IgMlambda with crystalline inclusions in chronic lymphatic leukemic lymphocytes. N Engl J Med (1973) 1.20
Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndromes. Blood (1986) 1.20
Congenital asymmetry associated with trisomy 18 mosaicism. Am J Dis Child (1965) 1.18
Antinuclear antibodies in infectious mononucleosis. Lancet (1968) 1.17
Opportunistic infections in neoplastic diseases. Geriatrics (1970) 1.17
Localization of mouse satellite DNA in constitutive heterochromatin. Exp Cell Res (1970) 1.15
Trisomy for the distal segment of chromosome 13: a new syndrome. Am J Dis Child (1974) 1.14
The striking resemblance of high-resolution G-banded chromosomes of man and chimpanzee. Science (1980) 1.14
Partial trisomy 11 in a child resulting from a complex maternal rearrangement of chromosomes 11, 12 and 13. Humangenetik (1974) 1.14
Varying intensity of postremission therapy in acute myeloid leukemia. Blood (1992) 1.13
Abnormalities of bone marrow mesenchymal cells in multiple myeloma patients. Cancer (2001) 1.13
Detection and quantitation of malignant cells in the peripheral blood of multiple myeloma patients. Blood (1992) 1.12
Immunochemical studies on blood groups. XXXIII. The effects. of alkaline borohydride and of alkali on blood group A, B, and H substances. Biochemistry (1965) 1.12
The t(4;14)(p16.3;q32) is strongly associated with chromosome 13 abnormalities in both multiple myeloma and monoclonal gammopathy of undetermined significance. Blood (2001) 1.12
Adjuvant active specific immunotherapy for stage II and III colon cancer with an autologous tumor cell vaccine: Eastern Cooperative Oncology Group Study E5283. J Clin Oncol (2000) 1.11
Familial occurrence of the aniridia-Wilms tumor syndrome with deletion 11p13-14.1. J Pediatr (1980) 1.10
Studies on human antibodies. IV. Purification and properties of anti-A and anti-B obtained by absorption and elution from insoluble blood group substances. J Exp Med (1966) 1.09
Human monocyte and macrophage modulation of lymphocyte proliferation. Cell Immunol (1979) 1.07
Recurrent chromosomal defects are found in most patients with non-Hodgkin's-lymphoma. Cancer Genet Cytogenet (1984) 1.06
Cell-cell interaction in erythropoiesis. Role of human monocytes. J Clin Invest (1978) 1.06
Alterations at the rel locus in human lymphoma. Oncogene (1991) 1.05
From efficacy to safety: a Polycythemia Vera Study group report on hydroxyurea in patients with polycythemia vera. Semin Hematol (1997) 1.05
Endogenous pyrogen production by human blood monocytes stimulated by staphylococcal cell wall components. Infect Immun (1981) 1.04
Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy. Leukemia (2001) 1.04
Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1992) 1.04
Interferon alfa combined with cytotoxic chemotherapy for patients with non-Hodgkin's lymphoma. N Engl J Med (1992) 1.03
Complement-dependent opsonization of incompatible erythrocytes by human secretory IgA. J Immunol (1972) 1.02
Staining of satellite DNA in metaphase chromosomes. Nature (1971) 1.02
Is flow cytometric DNA content hypodiploidy prognostic in multiple myeloma? Leuk Lymphoma (1999) 1.02
Chromosomal rearrangements, genes, and fragile sites in cancer: clinical and biologic implications. Important Adv Oncol (1986) 1.02
Trisomy for the proximal segment of the long arm of chromosome 13: a new entity? Am J Dis Child (1974) 1.02
The G-banded prophase chromosomes of man. Humangenetik (1975) 1.01
Enhanced T cell suppression is directed toward sensitive circulating B cells in multiple myeloma. J Lab Clin Med (1982) 1.01
Urinary light chain excretion in leukaemia and lymphoma. Clin Exp Immunol (1969) 1.00
Hemoglobin Andrew-Minneapolis alpha 2 A beta 2 144 Lys leads to Asn: a new high-oxygen-affinity mutant human hemoglobin. Blood (1974) 1.00
Value of alkaline phosphatase, 5'-nucleotidase, gamma-glutamyltransferase, and glutamate dehydrogenase activity measurements (single and combined) in serum in diagnosis of metastasis to the liver. Clin Chem (1977) 0.99
Genes coding for histone proteins in man are located on the distal end of the long arm of chromosome 7. Science (1979) 0.99
Red-cell-membrane polypeptide aggregates in glucose-6-phosphate dehydrogenase mutants with chronic hemolytic disease. A clue to the mechanism of hemolysis. N Engl J Med (1979) 0.98
Neoplastic cardiac tamponade. Semin Oncol (1978) 0.98
Improving cancer pain management in communities: main results from a randomized controlled trial. J Pain Symptom Manage (1997) 0.97
A new syndrome resulting from partial trisomy for the distal third of the long arm of chromosome 10. J Pediatr (1974) 0.97
Membrane polypeptide aggregates in glucose 6-phosphate dehydrogenase-deficient and in vitro aged red blood cells. J Lab Clin Med (1978) 0.97
Chronic myelodysplastic syndrome: short survival with or without evolution to acute leukaemia. Br J Haematol (1983) 0.97
Species and tissue specificity of very lysine-rich and serine-rich histones. Exp Cell Res (1969) 0.95
HLA-DQB1 allele typing by a new PCR-RFLP method: correlation with a PCR-SSO method. Tissue Antigens (1992) 0.95
Maternal and paternal lineages of the Samaritan isolate: mutation rates and time to most recent common male ancestor. Ann Hum Genet (2003) 0.95
Trisomy for the distal half of the short arm of chromosome 9. A variant of the trisomy 9p syndrome. Am J Dis Child (1976) 0.95
Molecular quantification of residual disease in chronic myelogenous leukemia after bone marrow transplantation. Blood (1992) 0.95
Heterogeneity among human lymphocyte effector cells mediating spontaneous lymphocyte-mediated cytotoxicity. Int J Cancer (1978) 0.95
Autonomic dysreflexia in a paraplegic man with catecholamine-secreting neuroblastoma. Arch Phys Med Rehabil (1986) 0.94
Concurrent radiation therapy and chemotherapy for locally unresectable squamous cell head and neck cancer: an Eastern Cooperative Oncology Group pilot study. J Clin Oncol (1993) 0.94
G-banding patterns of high-resolution human chromosomes 6--22, X, and Y. Hum Genet (1979) 0.94
T-cell subpopulations in multiple myeloma: correlation with clinical disease status. Br J Haematol (1981) 0.94
In vitro suppression of erythropoiesis by bone marrow adherent cells from some patients with fungal infection. Br J Haematol (1982) 0.94