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Transmembrane helices predicted at 95% accuracy. Protein Sci (1995) 5.05

G protein-coupled receptor rhodopsin. Annu Rev Biochem (2006) 4.95

Topology prediction for helical transmembrane proteins at 86% accuracy. Protein Sci (1996) 4.50

Hypothesis about the function of membrane-buried proline residues in transport proteins. Proc Natl Acad Sci U S A (1986) 2.90

Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum. Proc Natl Acad Sci U S A (1985) 2.64

Folding patterns of porin and bacteriorhodopsin. EMBO J (1985) 2.34

Thermal adaptation analyzed by comparison of protein sequences from mesophilic and extremely thermophilic Methanococcus species. Proc Natl Acad Sci U S A (1999) 2.14

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Sequence homology and structural similarity between cytochrome b of mitochondrial complex III and the chloroplast b6-f complex: position of the cytochrome b hemes in the membrane. Proc Natl Acad Sci U S A (1984) 2.01

Amino acid side-chain partition energies and distribution of residues in soluble proteins. Biophys J (1985) 1.92

Refinement and prediction of protein prenylation motifs. Genome Biol (2005) 1.84

Membrane protein insertion at the endoplasmic reticulum. Annu Rev Cell Dev Biol (2011) 1.74

Structure and functional organization of light-harvesting complexes and photochemical reaction centers in membranes of phototrophic bacteria. Microbiol Rev (1985) 1.69

The opsin family of proteins. Biochem J (1986) 1.67

Topology of the non-structural rotavirus receptor glycoprotein NS28 in the rough endoplasmic reticulum. EMBO J (1989) 1.60

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The significance of G protein-coupled receptor crystallography for drug discovery. Pharmacol Rev (2011) 1.39

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Glycolipid anchors are attached to Thy-1 glycoprotein rapidly after translation. Biochem J (1987) 1.23

The structure of bovine brain myelin proteolipid and its organization in myelin. Proc Natl Acad Sci U S A (1984) 1.21

Predicting the topology of transmembrane helical proteins using mean burial propensity and a hidden-Markov-model-based method. Protein Sci (2003) 1.17

Conserved DegP protease in gram-positive bacteria is essential for thermal and oxidative tolerance and full virulence in Streptococcus pyogenes. Infect Immun (2001) 1.15

Cloning and characterization of livH, the structural gene encoding a component of the leucine transport system in Escherichia coli. J Bacteriol (1986) 1.13

Transfer functions of the conjugative integrating element pSAM2 from Streptomyces ambofaciens: characterization of a kil-kor system associated with transfer. J Bacteriol (1993) 1.13

Asymmetry of the rhodopsin dimer in complex with transducin. FASEB J (2013) 1.08

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Localization of the immunity protein-reactive domain in unmodified and chemically modified COOH-terminal peptides of colicin E1. J Bacteriol (1985) 1.06

The calnexin homologue cnx1+ in Schizosaccharomyces pombe, is an essential gene which can be complemented by its soluble ER domain. EMBO J (1995) 1.05

Rewiring of PDZ domain-ligand interaction network contributed to eukaryotic evolution. PLoS Genet (2012) 1.02

Sensitive light scattering probe of enzymatic processes in retinal rod photoreceptor membranes. Proc Natl Acad Sci U S A (1984) 1.02

Molecular dynamics simulations of individual alpha-helices of bacteriorhodopsin in dimyristoylphosphatidylcholine. II. Interaction energy analysis. Biophys J (1998) 1.02

Reformation of crystalline purple membrane from purified bacteriorhodopsin fragments. EMBO J (1986) 1.00

Sequence variability in the retinal-attachment domain of mammalian rhodopsins. Biochem J (1984) 0.93

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The cleverSuite approach for protein characterization: predictions of structural properties, solubility, chaperone requirements and RNA-binding abilities. Bioinformatics (2014) 0.89

Temperature adaptation at homologous sites in proteins from nine thermophile-mesophile species pairs. Genome Biol Evol (2010) 0.85

A strategy to select suitable physicochemical attributes of amino acids for protein fold recognition. BMC Bioinformatics (2013) 0.83

PDZ domain-containing 1 (PDZK1) protein regulates phospholipase C-β3 (PLC-β3)-specific activation of somatostatin by forming a ternary complex with PLC-β3 and somatostatin receptors. J Biol Chem (2012) 0.81

Protein sequence and structure relationship ARMA spectral analysis: application to membrane proteins. Biophys J (1994) 0.80

Chemistry and biology of the initial steps in vision: the Friedenwald lecture. Invest Ophthalmol Vis Sci (2014) 0.79

Molecular characterization of HTLV-1 gp46 glycoprotein from health carriers and HAM/TSP infected individuals. Virol J (2013) 0.77

Hidden markov model for the prediction of transmembrane proteins using MATLAB. Bioinformation (2011) 0.77

Hydrophobicity profiles in G protein-coupled receptor transmembrane helical domains. J Receptor Ligand Channel Res (2010) 0.77

The Q300 gene: a novel transcription unit induced in simian virus 40-infected and -transformed mouse cells. J Virol (1991) 0.76

Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil. Mem Inst Oswaldo Cruz (2014) 0.75

Functional and Structural Consequence of Rare Exonic Single Nucleotide Polymorphisms: One Story, Two Tales. Genome Biol Evol (2015) 0.75

50 years of amino acid hydrophobicity scales: revisiting the capacity for peptide classification. Biol Res (2016) 0.75

Amyloidogenic motifs revealed by n-gram analysis. Sci Rep (2017) 0.75

SRS--an indexing and retrieval tool for flat file data libraries. Comput Appl Biosci (1993) 24.73

SRS: information retrieval system for molecular biology data banks. Methods Enzymol (1996) 24.30

Knowledge-based protein secondary structure assignment. Proteins (1995) 14.08

Analysis of insertions/deletions in protein structures. J Mol Biol (1992) 13.12

Weighting aligned protein or nucleic acid sequences to correct for unequal representation. J Mol Biol (1990) 11.50

Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature (1986) 11.35

Primary structural comparison of RNA-dependent polymerases from plant, animal and bacterial viruses. Nucleic Acids Res (1984) 8.36

The integrase family of site-specific recombinases: regional similarities and global diversity. EMBO J (1986) 8.12

An attempt to unify the structure of polymerases. Protein Eng (1990) 7.93

Motif recognition and alignment for many sequences by comparison of dot-matrices. J Mol Biol (1991) 7.40

Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell (1991) 5.10

A conformational preference parameter to predict helices in integral membrane proteins. Biochim Biophys Acta (1986) 4.91

The primary structure of transcription factor TFIIIA has 12 consecutive repeats. FEBS Lett (1985) 4.73

The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors. EMBO J (1986) 4.47

Overseer: a nucleotide sequence searching tool. Comput Appl Biosci (1992) 4.46

Cloning of the human cDNA for the U1 RNA-associated 70K protein. EMBO J (1986) 4.43

Prediction of transmembrane segments in proteins utilising multiple sequence alignments. J Mol Biol (1994) 4.07

An assessment of amino acid exchange matrices in aligning protein sequences: the twilight zone revisited. J Mol Biol (1995) 3.74

The structure of bovine rhodopsin. Biophys Struct Mech (1983) 3.33

Similarity in gene organization and homology between proteins of animal picornaviruses and a plant comovirus suggest common ancestry of these virus families. Nucleic Acids Res (1984) 2.99

Suggestions for "safe" residue substitutions in site-directed mutagenesis. J Mol Biol (1991) 2.80

Thermal stability and protein structure. Biochemistry (1979) 2.73

A data bank merging related protein structures and sequences. Protein Eng (1992) 2.73

Crystal structure of a retroviral protease proves relationship to aspartic protease family. Nature (1989) 2.72

Protein thermal stability, hydrogen bonds, and ion pairs. J Mol Biol (1997) 2.69

A fast and sensitive multiple sequence alignment algorithm. Comput Appl Biosci (1989) 2.66

Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science (1988) 2.66

A possible nucleotide-binding domain in the tertiary fold of phosphoribosyltransferases. J Biol Chem (1983) 2.60

Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences. Proteins (1988) 2.57

Anti-rhodopsin monoclonal antibodies of defined specificity: characterization and application. Vision Res (1991) 2.41

Human adenosine deaminase. cDNA and complete primary amino acid sequence. J Biol Chem (1984) 2.33

The release of growth arrest by microinjection of adenovirus E1A DNA. EMBO J (1985) 2.32

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med (1992) 2.27

Side-chain clusters in protein structures and their role in protein folding. J Mol Biol (1991) 2.24

Incorporation of non-local interactions in protein secondary structure prediction from the amino acid sequence. Protein Eng (1996) 2.24

Exploring structural homology of proteins. J Mol Biol (1976) 2.23

Protein folding. Annu Rev Biochem (1981) 2.21

Ribosome-mediated translational pause and protein domain organization. Protein Sci (1996) 2.20

Evidence for a repeating domain in type I restriction enzymes. EMBO J (1985) 2.20

Seventy-five percent accuracy in protein secondary structure prediction. Proteins (1997) 2.16

Arrangement of rhodopsin transmembrane alpha-helices. Nature (1997) 2.10

A model for the tertiary structure of the 28 residue DNA-binding motif ('zinc finger') common to many eukaryotic transcriptional regulatory proteins. Protein Eng (1988) 1.98

Intramolecular cavities in globular proteins. Protein Eng (1994) 1.97

Rotamers: to be or not to be? An analysis of amino acid side-chain conformations in globular proteins. J Mol Biol (1993) 1.92

Protein-protein crystal-packing contacts. Protein Sci (1997) 1.89

Molecular biology of the visual pigments. Vision Res (1986) 1.84

Automated protein sequence database classification. I. Integration of compositional similarity search, local similarity search, and multiple sequence alignment. Bioinformatics (1998) 1.84

A sensitive procedure to compare amino acid sequences. J Mol Biol (1987) 1.84

Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci U S A (1989) 1.83

Primary structural relationships may reflect similar DNA replication strategies. Virology (1986) 1.81

Sequence analysis and characterization of a maize gene encoding a high-sulfur zein protein of Mr 15,000. J Biol Chem (1986) 1.77

Engineering protein thermal stability. Sequence statistics point to residue substitutions in alpha-helices. J Mol Biol (1989) 1.74

A comparison of the heme binding pocket in globins and cytochrome b5. J Biol Chem (1975) 1.74

A structural model for maize zein proteins. J Biol Chem (1982) 1.73

Topology prediction of membrane proteins. Protein Sci (1996) 1.71

Transforming a set of biological flat file libraries to a fast access network. Comput Appl Biosci (1993) 1.69

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase. Nucleic Acids Res (1991) 1.68

Determination of reliable regions in protein sequence alignments. Protein Eng (1990) 1.66

Regulation of sorting and post-Golgi trafficking of rhodopsin by its C-terminal sequence QVS(A)PA. Proc Natl Acad Sci U S A (1998) 1.66

Sugar permeases of the bacterial phosphoenolpyruvate-dependent phosphotransferase system: sequence comparisons. FASEB J (1988) 1.64

NADP-dependent enzymes. I: Conserved stereochemistry of cofactor binding. Proteins (1997) 1.63

Light-induced binding of guanosinetriphosphatase to bovine photoreceptor membranes: effect of limited proteolysis of the membranes. Biochemistry (1981) 1.63

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Automated protein sequence database classification. II. Delineation Of domain boundaries from sequence similarities. Bioinformatics (1998) 1.61

The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation. J Biol Chem (1989) 1.60

Fingers and helices. Nature (1987) 1.59

Three-dimensional Fourier synthesis of calf liver cytochrome b 5 at 2-8 A resolution. J Mol Biol (1972) 1.58

OBSTRUCT: a program to obtain largest cliques from a protein sequence set according to structural resolution and sequence similarity. Comput Appl Biosci (1992) 1.57

Prediction of membrane protein topology utilizing multiple sequence alignments. J Protein Chem (1997) 1.56

Crystal structure of Escherichia coli L-asparaginase, an enzyme used in cancer therapy. Proc Natl Acad Sci U S A (1993) 1.56

The occurrence of serum autoantibodies against enolase in cancer-associated retinopathy. Clin Immunol Immunopathol (1996) 1.54

Rhodopsin carbohydrate. Structure of small oligosaccharides attached at two sites near the NH2 terminus. J Biol Chem (1979) 1.49

Structural similarity between legumin and vicilin storage proteins from legumes. EMBO J (1985) 1.49

The structure of cytochrome b 5 at 2.0 Angstrom resolution. Cold Spring Harb Symp Quant Biol (1972) 1.49

Amino acid distribution in protein secondary structures. Int J Pept Protein Res (1982) 1.49

Protein secondary structural types are differentially coded on messenger RNA. Protein Sci (1996) 1.47

A method to recognize distant repeats in protein sequences. Proteins (1993) 1.47

Projection structure of frog rhodopsin in two crystal forms. Proc Natl Acad Sci U S A (1995) 1.45

Identification of a trpG-related glutamine amide transfer domain in Escherichia coli GMP synthetase. J Biol Chem (1985) 1.44

Similarities in active center geometries of zinc-containing enzymes, proteases and dehydrogenases. J Mol Biol (1978) 1.40

Optimization of peptide synthesis on polyethylene rods. Pept Res (1994) 1.39

DOMO: a new database of aligned protein domains. Trends Biochem Sci (1998) 1.38

Automated protein sequence pattern handling and PROSITE searching. Comput Appl Biosci (1991) 1.37

Principles of helix-helix packing in proteins: the helical lattice superposition model. J Mol Biol (1996) 1.37

Protein thermal stability: hydrogen bonds or internal packing? Fold Des (1997) 1.36

Protein secondary structure. Studies on the limits of prediction accuracy. Int J Pept Protein Res (1982) 1.35

Cavities and packing at protein interfaces. Protein Sci (1994) 1.34

Comparison of atomic solvation parametric sets: applicability and limitations in protein folding and binding. Protein Sci (1995) 1.33

TMAP: a new email and WWW service for membrane-protein structural predictions. Trends Biochem Sci (1995) 1.32

Hydrophobic patches on protein subunit interfaces: characteristics and prediction. Proteins (1997) 1.31

Folding the main chain of small proteins with the genetic algorithm. J Mol Biol (1994) 1.28

An assessment of protein secondary structure prediction methods based on amino acid sequence. Biochim Biophys Acta (1976) 1.28

Sensitivity comparison of protein amino acid sequences. Methods Enzymol (1990) 1.28

Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry (1997) 1.27

Regulation of rhodopsin dephosphorylation by arrestin. J Biol Chem (1989) 1.27

Site of attachment of 11-cis-retinal in bovine rhodopsin. Biochemistry (1980) 1.26

Anatomy and evolution of proteins displaying the viral capsid jellyroll topology. J Mol Biol (1992) 1.25

Scrutineer: a computer program that flexibly seeks and describes motifs and profiles in protein sequence databases. Comput Appl Biosci (1990) 1.25