Published in Science on February 19, 1982
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Complete structure of the alpha B-crystallin gene: conservation of the exon-intron distribution in the two nonlinked alpha-crystallin genes. Proc Natl Acad Sci U S A (1985) 1.43
The lens protein alpha A-crystallin of the blind mole rat, Spalax ehrenbergi: evolutionary change and functional constraints. Proc Natl Acad Sci U S A (1987) 1.31
A novel mouse chromosome 17 hybrid sterility locus: implications for the origin of t haplotypes. Genetics (1991) 1.06
Gene for OTC: characterisation and linkage to Duchenne muscular dystrophy. Nucleic Acids Res (1985) 0.99
The locus encoding alpha A-crystallin is closely linked to H-2K on mouse chromosome 17. Genetics (1985) 0.93
Extensive intragenic sequence homology in two distinct rat lens gamma-crystallin cDNAs suggests duplications of a primordial gene. Proc Natl Acad Sci U S A (1982) 0.92
Polymorphism and linkage of the alpha A-crystallin gene in t-haplotypes of the mouse. Genetics (1987) 0.88
A contiguous Not I restriction map of band q22.3 of human chromosome 21. Proc Natl Acad Sci U S A (1992) 0.85
Crystallin gene expression and lentoid body formation in quail embryo neuroretina cultures transformed by the oncogenic retrovirus Mill Hill 2 or Rous sarcoma virus. Mol Cell Biol (1986) 0.82
Characterization and metabolic regulation of a liver-specific 5.4-kilobase mRNA whose synthesis is transcriptionally induced by carbohydrates and repressed by glucagon and cyclic AMP. Biochem J (1985) 0.76
Xenopus fibrinogen: characterization of the mRNAs for the three subunits. Mol Cell Biol (1984) 0.75
Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science (1985) 6.56
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science (1987) 6.36
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms. EMBO J (1987) 4.33
Lens crystallins: the evolution and expression of proteins for a highly specialized tissue. Annu Rev Biochem (1988) 4.01
Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development. Nature (1989) 3.75
Lens differentiation in vertebrates. A review of cellular and molecular features. Differentiation (1981) 3.65
Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics (1995) 3.60
Oncogenesis of the lens in transgenic mice. Science (1987) 3.40
Alternative RNA splicing of the murine alpha A-crystallin gene: protein-coding information within an intron. Cell (1983) 3.32
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell (1991) 3.21
Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: prognostic significance of erbB-2 protein overexpression in primary breast cancer. J Clin Oncol (1990) 3.12
The cellular basis of corneal transparency: evidence for 'corneal crystallins'. J Cell Sci (1999) 2.55
Identification of a second human nm23 gene, nm23-H2. Cancer Res (1991) 2.31
Demonstration of epidermal growth factor-induced receptor dimerization in living cells using a chemical covalent cross-linking agent. J Biol Chem (1988) 2.30
Recruitment of enzymes as lens structural proteins. Science (1987) 2.25
Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci U S A (1985) 2.22
Expression of the murine alpha B-crystallin gene is not restricted to the lens. Mol Cell Biol (1989) 2.12
Lens development and crystallin gene expression: many roles for Pax-6. Bioessays (1996) 1.87
Ablation of transplanted HTLV-I Tax-transformed tumors in mice by antisense inhibition of NF-kappa B. Science (1992) 1.85
Aldose reductase and p-crystallin belong to the same protein superfamily as aldehyde reductase. FEBS Lett (1987) 1.69
Mother-infant skin-to-skin contact after delivery results in early recognition of own mother's milk odour. Acta Paediatr (2004) 1.68
Reducing the native tropism of adenovirus vectors requires removal of both CAR and integrin interactions. J Virol (2001) 1.66
Three-dimensional structure, catalytic properties, and evolution of a sigma class glutathione transferase from squid, a progenitor of the lens S-crystallins of cephalopods. Biochemistry (1995) 1.66
Lens-specific expression of the chloramphenicol acetyltransferase gene promoted by 5' flanking sequences of the murine alpha A-crystallin gene in explanted chicken lens epithelia. Proc Natl Acad Sci U S A (1985) 1.65
Origin and disposal of 1,5-anhydroglucitol, a major polyol in the human body. Am J Physiol (1992) 1.63
Serum levels of interleukin 6 in patients with lung cancer. Br J Cancer (1995) 1.60
Pregnancy in a patient with 47,XX,i(Xq) karyotype. J Med Genet (1982) 1.51
Laboratory and clinical outcomes of pharmacogenetic vs. clinical protocols for warfarin initiation in orthopedic patients. J Thromb Haemost (2008) 1.51
Immunoconjugates of geldanamycin and anti-HER2 monoclonal antibodies: antiproliferative activity on human breast carcinoma cell lines. J Natl Cancer Inst (2000) 1.46
Therapy of an animal model of human gastric cancer using a combination of anti-erbB-2 monoclonal antibodies. Cancer Res (1992) 1.45
Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am J Pathol (1991) 1.45
LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes. Biochem Biophys Res Commun (2001) 1.44
Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12-21.32. Genomics (1989) 1.43
Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression. J Cell Sci (2000) 1.43
Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene. Mol Cell Biol (1988) 1.42
The normal erbB-2 product is an atypical receptor-like tyrosine kinase with constitutive activity in the absence of ligand. New Biol (1990) 1.42
Manipulation of human minichromosomes to carry greater than megabase-sized chromosome inserts. Nat Biotechnol (2000) 1.38
Gene and protein structure of a beta-crystallin polypeptide in murine lens: relationship of exons and structural motifs. Nature (1983) 1.37
Regulation of the mouse alpha A-crystallin gene: isolation of a cDNA encoding a protein that binds to a cis sequence motif shared with the major histocompatibility complex class I gene and other genes. Mol Cell Biol (1990) 1.36
A polymorphism in the VKORC1 regulator calumenin predicts higher warfarin dose requirements in African Americans. Clin Pharmacol Ther (2010) 1.35
Cellular immune responses of patients with uveitis to retinal antigens and their fragments. Am J Ophthalmol (1990) 1.35
Lens crystallins of invertebrates--diversity and recruitment from detoxification enzymes and novel proteins. Eur J Biochem (1996) 1.35
Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing. Gene (2000) 1.32
Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues. Adv Enzymol Relat Areas Mol Biol (1994) 1.32
Expression of multiple classes of the nuclear factor-1 family in the developing human brain: differential expression of two classes of NF-1 genes. J Neurovirol (1996) 1.32
Squid Pax-6 and eye development. Proc Natl Acad Sci U S A (1997) 1.31
Transcriptional regulation of the mouse alpha A-crystallin gene: activation dependent on a cyclic AMP-responsive element (DE1/CRE) and a Pax-6-binding site. Mol Cell Biol (1995) 1.31
Evidence for positive and negative regulation in the promoter of the chicken delta 1-crystallin gene. Dev Biol (1988) 1.30
Dual roles for Pax-6: a transcriptional repressor of lens fiber cell-specific beta-crystallin genes. Mol Cell Biol (1998) 1.30
Pregnancy and the Turner syndrome. Obstet Gynecol (1978) 1.29
Tau-crystallin/alpha-enolase: one gene encodes both an enzyme and a lens structural protein. J Cell Biol (1988) 1.29
Modulation of myocilin/TIGR expression in human trabecular meshwork. Invest Ophthalmol Vis Sci (1999) 1.29
Human HER2 (neu) promoter: evidence for multiple mechanisms for transcriptional initiation. Mol Cell Biol (1987) 1.28
Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific gene expression. J Biol Chem (2000) 1.28
Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress. J Biol Chem (2001) 1.26
Oxidative stress increases production of beta-amyloid precursor protein and beta-amyloid (Abeta) in mammalian lenses, and Abeta has toxic effects on lens epithelial cells. J Biol Chem (1996) 1.25
Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts. Biochem Biophys Res Commun (2000) 1.25
Protein synthesis and ultrastructure during the formation of embryonic chick lens fibers in vivo and in vitro. Dev Biol (1972) 1.25
Confirmation of assignment of the human alpha 1-crystallin gene (CRYA1) to chromosome 21 with regional localization to q22.3. Hum Genet (1987) 1.25
Lens-specific promoter activity of a mouse gamma-crystallin gene. Mol Cell Biol (1985) 1.24
Overexpression of hypoxia-inducible-factor 1alpha(HIF-1alpha) in oesophageal squamous cell carcinoma correlates with lymph node metastasis and pathologic stage. Br J Cancer (2003) 1.24
Delta crystallins and their nucleic acids. Mol Cell Biochem (1984) 1.24
A pseudo-exon in the functional human alpha A-crystallin gene. Nature (1989) 1.23
Lens crystallins and their gene families. Cell (1984) 1.23
Cytokine-mediated activation of a neuronal retinal resident cell provokes antigen presentation. J Immunol (1990) 1.23
Double trans-chromosomic mice: maintenance of two individual human chromosome fragments containing Ig heavy and kappa loci and expression of fully human antibodies. Proc Natl Acad Sci U S A (2000) 1.22
Ability of VKORC1 and CYP2C9 to predict therapeutic warfarin dose during the initial weeks of therapy. J Thromb Haemost (2009) 1.22
Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats. Invest Ophthalmol Vis Sci (2001) 1.20
Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma. Br J Cancer (2002) 1.19
High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res (1993) 1.19
Human alpha B-crystallin gene and preferential promoter function in lens. Genomics (1990) 1.19
Human tumor cell lines with EGF receptor gene amplification in the absence of aberrant sized mRNAs. Nucleic Acids Res (1985) 1.18
Chicken homeobox gene Prox 1 related to Drosophila prospero is expressed in the developing lens and retina. Dev Dyn (1996) 1.18
Chondroitin-6-sulphaturia, defective cellular immunity, and nephrotic syndrome. Lancet (1971) 1.17
Aldehyde dehydrogenase-derived omega-crystallins of squid and octopus. Specialization for lens expression. J Biol Chem (1993) 1.16
Tumor seeding after endoscopic ultrasound-guided fine-needle aspiration of cancer in the body of the pancreas. Endoscopy (2012) 1.16
The complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region. J Biol Chem (1985) 1.15
A complex array of positive and negative elements regulates the chicken alpha A-crystallin gene: involvement of Pax-6, USF, CREB and/or CREM, and AP-1 proteins. Mol Cell Biol (1994) 1.15
Dynamic changes in cytokine levels in serum and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis. J Clin Apher (2001) 1.15
Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proc Natl Acad Sci U S A (1992) 1.14
Improved binding and antitumor activity of a recombinant anti-erbB2 immunotoxin by disulfide stabilization of the Fv fragment. J Biol Chem (1994) 1.14
Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res (2001) 1.14
Differentiation of lens fibers in explanted embryonic chick lens epithelia. Dev Biol (1973) 1.14
The New York Maternal Mortality Study: a conflict of professionalization. Bull Hist Med (1991) 1.14
Chicken lens crystallin DNA sequences show at least two delta-crystallin genes. Nature (1980) 1.13
Quantitation of delta-crystallin messenger RNA during lens induction in chick embryos. Proc Natl Acad Sci U S A (1976) 1.12
Lens epithelium-derived growth factor: increased resistance to thermal and oxidative stresses. Invest Ophthalmol Vis Sci (1999) 1.11
Pax-6 and lens-specific transcription of the chicken delta 1-crystallin gene. Proc Natl Acad Sci U S A (1995) 1.11
Differential display detects altered gene expression between cataractous and normal human lenses. Invest Ophthalmol Vis Sci (1998) 1.11
Transketolase is a major protein in the mouse cornea. J Biol Chem (1996) 1.10
In situ hybridisation with digoxigenin-labelled DNA probes for detection of viral genomes. J Clin Pathol (1990) 1.10
Activation of LEDGF gene by thermal-and oxidative-stresses. Biochem Biophys Res Commun (2000) 1.09
Structural and functional evidence for differential promoter activity of the two linked delta-crystallin genes in the chicken. EMBO J (1985) 1.09
GENAS: a database system for nucleic acid sequence analysis. Nucleic Acids Res (1984) 1.09
Estimation of plasma glucose fluctuation with a combination test of hemoglobin A1c and 1,5-anhydroglucitol. Metabolism (1992) 1.08