Published in Anal Biochem on August 01, 1981
SLC1A5 mediates glutamine transport required for lung cancer cell growth and survival. Clin Cancer Res (2012) 1.46
Modulation of cellular proliferation alters glutamine transport and metabolism in human hepatoma cells. Ann Surg (1994) 1.34
Amino acid transport system A resembles system N in sequence but differs in mechanism. Proc Natl Acad Sci U S A (2000) 1.26
Accumulation of ciprofloxacin and minocycline by cultured human gingival fibroblasts. J Dent Res (2002) 1.02
Uremic levels of urea inhibit L-arginine transport in cultured endothelial cells. Am J Physiol Renal Physiol (2001) 1.00
Circulating endothelial nitric oxide synthase inhibitory factor in some patients with chronic renal disease. Kidney Int (2001) 0.96
Modulation of ecotropic murine retroviruses by N-linked glycosylation of the cell surface receptor/amino acid transporter. J Virol (1996) 0.96
SLC7A14 linked to autosomal recessive retinitis pigmentosa. Nat Commun (2014) 0.93
An in vitro model of ciprofloxacin and minocycline transport by oral epithelial cells. J Periodontol (2002) 0.91
18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas. J Nucl Med (2013) 0.89
Role of the L-amino acid transporter-1 (LAT-1) in mouse trophoblast cell invasion. Placenta (2010) 0.86
TNF-stimulated arginine transport by human vascular endothelium requires activation of protein kinase C. Ann Surg (1995) 0.85
Structure-activity relationship of carbacephalosporins and cephalosporins: antibacterial activity and interaction with the intestinal proton-dependent dipeptide transport carrier of Caco-2 cells. Antimicrob Agents Chemother (1997) 0.85
Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport. Am J Physiol Renal Physiol (2002) 0.84
Modulation of gingival fibroblast minocycline accumulation by biological mediators. J Dent Res (2005) 0.83
Amino acid transport into cultured McCoy cells infected with Chlamydia trachomatis. Infect Immun (2000) 0.82
Altered tryptophan and alanine transport in fibroblasts from boys with attention-deficit/hyperactivity disorder (ADHD): an in vitro study. Behav Brain Funct (2011) 0.81
Threonine synthesis from homoserine as a selectable marker in mammalian cells. Biochem J (1994) 0.81
Tryptophan transport in human fibroblast cells-a functional characterization. Int J Tryptophan Res (2011) 0.79
Differential sensitivity of RSVts (temperature-sensitive Rous-sarcoma virus)-infected rat kidney cells to nucleoside antibiotics at permissive and non-permissive temperatures. Biochem J (1985) 0.78
Radiosynthesis and biological evaluation of alpha-[F-18]fluoromethyl phenylalanine for brain tumor imaging. Nucl Med Biol (2013) 0.78
Synthesis and Biological Evaluation of (S)-Amino-2-methyl-4-[(76)Br]bromo-3-(E)-butenoic Acid (BrVAIB) for Brain Tumor Imaging. J Med Chem (2015) 0.77
Characterization of a Chinese hamster-human hybrid cell line with increased system L amino acid transport activity. Mol Cell Biol (1984) 0.77
Interleukin-1 beta-induced changes in the kinetic constants of L-proline uptake in human skin fibroblasts. Biochem J (1991) 0.76
Glutamine regulates amino acid transport and glutathione levels in a human neuroblastoma cell line. Pediatr Surg Int (2005) 0.75
Cytokine modulation of Na(+)-dependent glutamine transport across the brush border membrane of monolayers of human intestinal Caco-2 cells. Ann Surg (1992) 0.75
IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57
Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes (1999) 7.14
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50
Visual processing impairment and risk of motor vehicle crash among older adults. JAMA (1998) 4.49
Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32
The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J (1993) 3.80
Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57
Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41
Nucleosome mobilization catalysed by the yeast SWI/SNF complex. Nature (1999) 3.28
Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet (1999) 3.27
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18
Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01
IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A (1992) 2.75
The regulation of amino acid transport in animal cells. Biochim Biophys Acta (1978) 2.68
IRS-2 pathways integrate female reproduction and energy homeostasis. Nature (2000) 2.45
Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol (1993) 2.44
Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem (2000) 2.32
Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest (1992) 2.31
The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 2.17
Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci U S A (1984) 2.09
IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. Endocrinology (1993) 2.07
Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem (1995) 2.06
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05
Expression and function of IRS-1 in insulin signal transmission. J Biol Chem (1992) 1.98
Human IL6 enhances leptin action in mice. Diabetologia (2009) 1.98
The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol (1995) 1.97
Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem (2000) 1.95
The junction-resolving enzymes. Nat Rev Mol Cell Biol (2001) 1.89
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem (1996) 1.85
Insulin signal transduction and the IRS proteins. Annu Rev Pharmacol Toxicol (1996) 1.81
Cross-talk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci U S A (1996) 1.81
YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A (1992) 1.79
Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem (1988) 1.74
The IRS-signalling system during insulin and cytokine action. Bioessays (1997) 1.71
Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol Cell Biol (1996) 1.70
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem (2000) 1.67
The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta (1985) 1.64
Structure of Alba: an archaeal chromatin protein modulated by acetylation. EMBO J (2002) 1.61
Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci U S A (1993) 1.58
Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus. Nucleic Acids Res (2001) 1.58
The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes (1993) 1.57
4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem (1995) 1.56
Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. J Biol Chem (1984) 1.56
Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol (1988) 1.55
The IRS-1 signaling system. Trends Biochem Sci (1994) 1.53
Role of IRS-1-GRB-2 complexes in insulin signaling. Mol Cell Biol (1994) 1.53
Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J Biol Chem (1994) 1.52
Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J Biol Chem (1992) 1.50
Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin. J Biol Chem (1985) 1.45
Characterization of the insulin receptor kinase purified from human placental membranes. J Biol Chem (1983) 1.45
Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. J Biol Chem (2001) 1.45
Operative laparoscopy: removal of intra-abdominal IUD with biopsy tongs. Obstet Gynecol (1970) 1.39
Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem (1988) 1.39
Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem (1993) 1.38
The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem (1998) 1.35
The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol Endocrinol (1997) 1.34
PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem (1995) 1.34
Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. J Biol Chem (1985) 1.32
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem (1996) 1.31
Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem (1995) 1.31
The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. J Biol Chem (1995) 1.30
Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A (1993) 1.30
An archaeal XPF repair endonuclease dependent on a heterotrimeric PCNA. Mol Microbiol (2003) 1.29
Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem (1998) 1.29
Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus. Proc Natl Acad Sci U S A (2001) 1.28
IRS proteins and beta-cell function. Diabetes (2001) 1.26
Determining significant fold differences in gene expression analysis. Pac Symp Biocomput (2001) 1.25
Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.25
Characterization of an endogenous substrate of the insulin receptor in cultured cells. J Biol Chem (1987) 1.24
Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res (1998) 1.24
Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem (1995) 1.23
Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22
Characterization of apoptotic phenomena induced by treatment with L-asparaginase in NIH3T3 cells. Exp Cell Res (1995) 1.22
Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. J Biol Chem (1982) 1.22
The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett (1999) 1.20
Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin. Mol Cell Biol (1997) 1.20
M-plasty techniques. J Dermatol Surg (1976) 1.19
Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells. J Cell Biol (1987) 1.19
The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem (1996) 1.18
The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. J Biol Chem (1996) 1.18
Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol Chem (1987) 1.18
Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc Natl Acad Sci U S A (1996) 1.18
Adaptive regulation of amino acid transport in cultured human fibroblasts. Sites and mechanism of action. J Biol Chem (1981) 1.18
YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Mol Cell Biol (1996) 1.17
Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. J Biol Chem (1990) 1.15
Regulation of amino acid transport in chick embryo heart cells. I. Adaptive system of mediation for neutral amino acids. Biochim Biophys Acta (1972) 1.13
Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. J Biol Chem (1987) 1.13
The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. J Cell Biol (1992) 1.13
Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J Biol Chem (1993) 1.12
Adaptive increase of amino acid transport system A requires ERK1/2 activation. J Biol Chem (1999) 1.12
Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. J Biol Chem (1990) 1.11
The adaptive regulation of amino acid transport system A is associated to changes in ATA2 expression. FEBS Lett (2001) 1.11