Insulin signal transduction and the IRS proteins.

PubWeight™: 1.81‹?› | Rank: Top 3%

🔗 View Article (PMID 8725404)

Published in Annu Rev Pharmacol Toxicol on January 01, 1996

Authors

M G Myers1, M F White

Author Affiliations

1: Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Articles citing this

Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylinositol 3-kinase, and Akt. Mol Cell Biol (1997) 4.70

Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells. Mol Cell Biol (1999) 3.50

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41

Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol (2012) 2.18

Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest (1999) 2.00

Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk. J Clin Invest (1997) 1.88

Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. J Physiol (2002) 1.61

Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A (1997) 1.56

Brain insulin receptor causes activity-dependent current suppression in the olfactory bulb through multiple phosphorylation of Kv1.3. J Neurophysiol (2000) 1.33

Growing knowledge of the mTOR signaling network. Semin Cell Dev Biol (2014) 1.33

Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. J Cell Biol (2001) 1.26

Targeting insulin and insulin-like growth factor pathways in epithelial ovarian cancer. J Oncol (2010) 1.06

MAPK phosphatase-3 promotes hepatic gluconeogenesis through dephosphorylation of forkhead box O1 in mice. J Clin Invest (2010) 1.05

Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol (2006) 1.04

Mitogen-activated protein kinase phosphatase 3 (MKP-3)-deficient mice are resistant to diet-induced obesity. Diabetes (2014) 1.02

Metabolic actions of insulin-like growth factor-I in normal physiology and diabetes. Endocrinol Metab Clin North Am (2012) 1.02

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling. Biochem J (1999) 1.02

Insulin-mediated down-regulation of apolipoprotein A5 gene expression through the phosphatidylinositol 3-kinase pathway: role of upstream stimulatory factor. Mol Cell Biol (2005) 1.02

Logical analysis of timing-dependent receptor signalling specificity: application to the insulin receptor metabolic and mitogenic signalling pathways. Biochem J (1997) 1.01

Targeting the Peroxisome Proliferator-Activated Receptor-γ to Counter the Inflammatory Milieu in Obesity. Diabetes Metab J (2013) 0.99

A hepatocyte growth factor receptor (Met)-insulin receptor hybrid governs hepatic glucose metabolism. Nat Med (2011) 0.97

Isoform-specific insulin receptor signaling involves different plasma membrane domains. J Cell Biol (2003) 0.96

Nuclear IRS-1 and cancer. J Cell Physiol (2012) 0.94

Expression of nuclear insulin receptor substrate 1 in breast cancer. J Clin Pathol (2006) 0.93

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase. Mol Cell Biol (2000) 0.90

Role of tyrosine phosphorylation in leptin activation of ATP-sensitive K+ channels in the rat insulinoma cell line CRI-G1. J Physiol (1998) 0.89

Insulin utilizes the PI 3-kinase pathway to inhibit SP-A gene expression in lung epithelial cells. Respir Res (2002) 0.89

Overexpression of insulin receptor substrate-1 emerges early in hepatocarcinogenesis and elicits preneoplastic hepatic glycogenosis. Am J Pathol (1998) 0.89

Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein. J Biol Chem (2012) 0.89

Mapping MKP-3/FOXO1 interaction and evaluating the effect on gluconeogenesis. PLoS One (2012) 0.87

Insulin signaling. West J Med (1997) 0.86

PDGF-induced vascular smooth muscle cell proliferation is associated with dysregulation of insulin receptor substrates. Am J Physiol Cell Physiol (2011) 0.85

Cellular compartmentalization in insulin action: altered signaling by a lipid-modified IRS-1. Mol Cell Biol (2000) 0.84

Differential expression and signaling activation of insulin receptor isoforms A and B: A link between breast cancer and diabetes. Growth Factors (2011) 0.84

C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Mol Cell Biol (2013) 0.83

Arrest of endosome acidification by bafilomycin A1 mimics insulin action on GLUT4 translocation in 3T3-L1 adipocytes. Biochem J (1999) 0.82

Insulin occludes leptin activation of ATP-sensitive K+ channels in rat CRI-G1 insulin secreting cells. J Physiol (1998) 0.82

Diabetes-associated dry eye syndrome in a new humanized transgenic model of type 1 diabetes. Mol Vis (2013) 0.81

Genetic engineering in mice: impact on insulin signalling and action. Biochem J (1998) 0.80

Timing-dependence of insulin-receptor mitogenic versus metabolic signalling: a plausible model based on coincidence of hormone and effector binding. Biochem J (1999) 0.80

IRS1 gene polymorphisms Gly972Arg and Ala513Pro are not associated with insulin resistance and type 2 diabetes risk in non-obese Turkish population. Meta Gene (2014) 0.80

FOXO1 is regulated by insulin and IGF1 in pituitary gonadotropes. Mol Cell Endocrinol (2015) 0.77

Phosphorylation of P20 is associated with the actions of insulin in rat skeletal and smooth muscle. Biochem J (1999) 0.76

Nitric oxide agents impair insulin-mediated signal transduction in rat skeletal muscle. BMC Biochem (2006) 0.75

Interaction between Marine-Derived n-3 Long Chain Polyunsaturated Fatty Acids and Uric Acid on Glucose Metabolism and Risk of Type 2 Diabetes Mellitus: A Case-Control Study. Mar Drugs (2015) 0.75

The biological activity of structurally defined inositol glycans. Future Med Chem (2009) 0.75

Correlation of alpha-fetoprotein expression in normal hepatocytes during development with tyrosine phosphorylation and insulin receptor expression. Mol Biol Cell (1998) 0.75

Decreased expression of alpha-2-HS glycoprotein in the sera of rats treated with Eurycoma longifolia extract. Front Pharmacol (2015) 0.75

Dietary Reversal Ameliorates Short- and Long-Term Memory Deficits Induced by High-fat Diet Early in Life. PLoS One (2016) 0.75

Articles by these authors

(truncated to the top 100)

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (1996) 8.57

Disruption of IRS-2 causes type 2 diabetes in mice. Nature (1998) 7.94

The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem (2000) 7.41

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes (1999) 7.14

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature (1991) 6.50

Visual processing impairment and risk of motor vehicle crash among older adults. JAMA (1998) 4.49

Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A (1990) 4.32

The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J (1993) 3.80

Insulin rapidly stimulates tyrosine phosphorylation of a Mr-185,000 protein in intact cells. Nature (1985) 3.57

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest (2001) 3.41

Nucleosome mobilization catalysed by the yeast SWI/SNF complex. Nature (1999) 3.28

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling. Nat Genet (1999) 3.27

Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23

Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest (1999) 3.18

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2. J Clin Invest (2000) 3.01

IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proc Natl Acad Sci U S A (1992) 2.75

IRS-2 pathways integrate female reproduction and energy homeostasis. Nature (2000) 2.45

Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol (1993) 2.44

Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem (2000) 2.32

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest (1992) 2.31

The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 2.17

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells. Proc Natl Acad Sci U S A (1984) 2.09

IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase. Endocrinology (1993) 2.07

Regulation of phosphatidylinositol 3'-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem (1995) 2.06

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia (2012) 2.05

Expression and function of IRS-1 in insulin signal transmission. J Biol Chem (1992) 1.98

Human IL6 enhances leptin action in mice. Diabetologia (2009) 1.98

The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol (1995) 1.97

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem (2000) 1.95

The junction-resolving enzymes. Nat Rev Mol Cell Biol (2001) 1.89

Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem (1996) 1.85

Cross-talk between the insulin and angiotensin signaling systems. Proc Natl Acad Sci U S A (1996) 1.81

YMXM motifs of IRS-1 define substrate specificity of the insulin receptor kinase. Proc Natl Acad Sci U S A (1992) 1.79

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity. J Biol Chem (1988) 1.74

The IRS-signalling system during insulin and cytokine action. Bioessays (1997) 1.71

Stimulation of protein synthesis, eukaryotic translation initiation factor 4E phosphorylation, and PHAS-I phosphorylation by insulin requires insulin receptor substrate 1 and phosphatidylinositol 3-kinase. Mol Cell Biol (1996) 1.70

Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes. J Biol Chem (2000) 1.67

The transport of cationic amino acids across the plasma membrane of mammalian cells. Biochim Biophys Acta (1985) 1.64

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells. J Biol Chem (1998) 1.64

Structure of Alba: an archaeal chromatin protein modulated by acetylation. EMBO J (2002) 1.61

Nck associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci U S A (1993) 1.58

Identification and properties of the crenarchaeal single-stranded DNA binding protein from Sulfolobus solfataricus. Nucleic Acids Res (2001) 1.58

The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes (1993) 1.57

Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. J Biol Chem (1984) 1.56

4PS/insulin receptor substrate (IRS)-2 is the alternative substrate of the insulin receptor in IRS-1-deficient mice. J Biol Chem (1995) 1.56

Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol (1988) 1.55

The IRS-1 signaling system. Trends Biochem Sci (1994) 1.53

Role of IRS-1-GRB-2 complexes in insulin signaling. Mol Cell Biol (1994) 1.53

Insulin receptor substrate-1 mediates phosphatidylinositol 3'-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J Biol Chem (1994) 1.52

Insulin stimulation of phosphatidylinositol 3-kinase activity maps to insulin receptor regions required for endogenous substrate phosphorylation. J Biol Chem (1992) 1.50

The cluster-tray method for rapid measurement of solute fluxes in adherent cultured cells. Anal Biochem (1981) 1.47

Predominance of tyrosine phosphorylation of insulin receptors during the initial response of intact cells to insulin. J Biol Chem (1985) 1.45

Characterization of the insulin receptor kinase purified from human placental membranes. J Biol Chem (1983) 1.45

Regulation of insulin/insulin-like growth factor-1 signaling by proteasome-mediated degradation of insulin receptor substrate-2. J Biol Chem (2001) 1.45

Operative laparoscopy: removal of intra-abdominal IUD with biopsy tongs. Obstet Gynecol (1970) 1.39

Tryptic activation of the insulin receptor. Proteolytic truncation of the alpha-subunit releases the beta-subunit from inhibitory control. J Biol Chem (1988) 1.39

Association of IRS-1 with the insulin receptor and the phosphatidylinositol 3'-kinase. Formation of binary and ternary signaling complexes in intact cells. J Biol Chem (1993) 1.38

The COOH-terminal tyrosine phosphorylation sites on IRS-1 bind SHP-2 and negatively regulate insulin signaling. J Biol Chem (1998) 1.35

The IRS-2 gene on murine chromosome 8 encodes a unique signaling adapter for insulin and cytokine action. Mol Endocrinol (1997) 1.34

PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J Biol Chem (1995) 1.34

Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro. J Biol Chem (1985) 1.32

Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786. J Biol Chem (1996) 1.31

Interferon-alpha engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3'-kinase. J Biol Chem (1995) 1.31

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells. Proc Natl Acad Sci U S A (1993) 1.30

The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. J Biol Chem (1995) 1.30

Insulin receptor substrate-1 is the predominant signaling molecule activated by insulin-like growth factor-I, insulin, and interleukin-4 in estrogen receptor-positive human breast cancer cells. J Biol Chem (1998) 1.29

An archaeal XPF repair endonuclease dependent on a heterotrimeric PCNA. Mol Microbiol (2003) 1.29

Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus. Proc Natl Acad Sci U S A (2001) 1.28

IRS proteins and beta-cell function. Diabetes (2001) 1.26

Determining significant fold differences in gene expression analysis. Pac Symp Biocomput (2001) 1.25

Calmodulin activates phosphatidylinositol 3-kinase. J Biol Chem (1997) 1.25

Characterization of an endogenous substrate of the insulin receptor in cultured cells. J Biol Chem (1987) 1.24

Enhanced expression of the insulin receptor substrate-2 docking protein in human pancreatic cancer. Cancer Res (1998) 1.24

Growth hormone, interferon-gamma, and leukemia inhibitory factor promoted tyrosyl phosphorylation of insulin receptor substrate-1. J Biol Chem (1995) 1.23

Insulin rapidly stimulates phosphorylation of a 46-kDa membrane protein on tyrosine residues as well as phosphorylation of several soluble proteins in intact fat cells. Proc Natl Acad Sci U S A (1987) 1.22

Cationic amino acid transport into cultured animal cells. I. Influx into cultured human fibroblasts. J Biol Chem (1982) 1.22

The two analogous phosphoglycerate mutases of Escherichia coli. FEBS Lett (1999) 1.20

Requirement of protein kinase C zeta for stimulation of protein synthesis by insulin. Mol Cell Biol (1997) 1.20

M-plasty techniques. J Dermatol Surg (1976) 1.19

Direct visualization of the phosphorylated epidermal growth factor receptor during its internalization in A-431 cells. J Cell Biol (1987) 1.19

The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem (1996) 1.18

Regulation of insulin receptor internalization in vascular endothelial cells by insulin and phorbol ester. J Biol Chem (1987) 1.18

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites. Proc Natl Acad Sci U S A (1996) 1.18

The pleckstrin homology domain is the principal link between the insulin receptor and IRS-1. J Biol Chem (1996) 1.18

YMXM motifs and signaling by an insulin receptor substrate 1 molecule without tyrosine phosphorylation sites. Mol Cell Biol (1996) 1.17

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit. J Biol Chem (1990) 1.15

The insulin receptor juxtamembrane region contains two independent tyrosine/beta-turn internalization signals. J Cell Biol (1992) 1.13

Insulin-like growth factor I rapidly stimulates tyrosine phosphorylation of a Mr 185,000 protein in intact cells. J Biol Chem (1987) 1.13

Insulin stimulates serine and tyrosine phosphorylation in the juxtamembrane region of the insulin receptor. J Biol Chem (1993) 1.12

Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats. J Biol Chem (1990) 1.11

Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes. Proc Natl Acad Sci U S A (1993) 1.11

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies. J Biol Chem (1992) 1.11

Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity. Biochemistry (1984) 1.11

An archaeal Holliday junction resolving enzyme from Sulfolobus solfataricus exhibits unique properties. J Mol Biol (2000) 1.11

High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase. J Biol Chem (2000) 1.10

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth. Proc Natl Acad Sci U S A (1990) 1.10

Molecular insights into insulin action and secretion. Eur J Clin Invest (2002) 1.10

Endothelin-1 modulates insulin signaling through phosphatidylinositol 3-kinase pathway in vascular smooth muscle cells. Diabetes (1999) 1.10

Interleukins 2, 4, 7, and 15 stimulate tyrosine phosphorylation of insulin receptor substrates 1 and 2 in T cells. Potential role of JAK kinases. J Biol Chem (1995) 1.09

The insulin receptor and its substrate: molecular determinants of early events in insulin action. Recent Prog Horm Res (1993) 1.09