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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Brefeldin A, a drug that blocks secretion, prevents the assembly of non-clathrin-coated buds on Golgi cisternae. Cell 1991 4.17
2 Bidirectional transport by distinct populations of COPI-coated vesicles. Cell 1997 3.24
3 COPI- and COPII-coated vesicles bud directly from the endoplasmic reticulum in yeast. Cell 1995 2.87
4 Direct identification of prohormone conversion site in insulin-secreting cells. Cell 1985 2.64
5 Heterogeneous distribution of filipin--cholesterol complexes across the cisternae of the Golgi apparatus. Proc Natl Acad Sci U S A 1981 2.45
6 Proteolytic maturation of insulin is a post-Golgi event which occurs in acidifying clathrin-coated secretory vesicles. Cell 1987 2.33
7 Budding from Golgi membranes requires the coatomer complex of non-clathrin coat proteins. Nature 1993 2.21
8 Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching. Exp Cell Res 1978 2.15
9 Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles. J Cell Biol 1986 2.06
10 The trans-most cisternae of the Golgi complex: a compartment for sorting of secretory and plasma membrane proteins. Cell 1987 2.00
11 A clathrin-coated, Golgi-related compartment of the insulin secreting cell accumulates proinsulin in the presence of monensin. Cell 1984 1.99
12 Quantitation of endocrine cell content in the pancreas of nondiabetic and diabetic humans. Diabetes 1982 1.94
13 Quantitative immunocytochemical localization of pancreatic secretory proteins in subcellular compartments of the rat acinar cell. J Histochem Cytochem 1980 1.80
14 Megavesicles implicated in the rapid transport of intracisternal aggregates across the Golgi stack. Cell 2000 1.70
15 Endocrine pancreas: three-dimensional reconstruction shows two types of islets of langerhans. Science 1979 1.67
16 Absence of filipin-sterol complexes from large coated pits on the surface of culture cells. Proc Natl Acad Sci U S A 1979 1.67
17 Membrane particle changes attending the acrosome reaction in guinea pig spermatozoa. J Cell Biol 1977 1.58
18 Clathrin-immunoreactive sites in the Golgi apparatus are concentrated at the trans pole in polypeptide hormone-secreting cells. Proc Natl Acad Sci U S A 1985 1.54
19 In vivo assembly of tight junctions in fetal rat liver. J Cell Biol 1975 1.53
20 Vesicles on strings: morphological evidence for processive transport within the Golgi stack. Proc Natl Acad Sci U S A 1998 1.44
21 Freeze-fracture of membrane fusions during exocytosis in pancreatic B-cells. J Cell Biol 1977 1.41
22 Anterograde flow of cargo across the golgi stack potentially mediated via bidirectional "percolating" COPI vesicles. Proc Natl Acad Sci U S A 2000 1.41
23 A freeze-etch study of the tight junctions of the rat kidney tubules. Lab Invest 1974 1.31
24 Patterns of calcium localization in pancreatic endocrine cells. J Cell Sci 1976 1.30
25 Membrane-associated particles: increase at sites of pinocytosis demonstrated by freeze-etching. Science 1973 1.29
26 A morphological basis for intercellular communication between alpha- and beta-cells in the endocrine pancreas. J Clin Invest 1975 1.23
27 "BFA bodies": a subcompartment of the endoplasmic reticulum. Proc Natl Acad Sci U S A 1993 1.22
28 Circulating somatostatin acts on the islets of Langerhans by way of a somatostatin-poor compartment. Science 1982 1.22
29 Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell. J Cell Biol 1984 1.21
30 Increase of gap junctions between pancreatic B-cells during stimulation of insulin secretion. J Cell Biol 1979 1.21
31 Exclusion of golgi residents from transport vesicles budding from Golgi cisternae in intact cells. J Cell Biol 2000 1.21
32 The fine structure of the retina of the honey bee drone. An electron microscopical study. Z Zellforsch Mikrosk Anat 1970 1.14
33 Opposite polarity of filipin-induced deformations in the membrane of condensing vacuoles and zymogen granules. Science 1980 1.13
34 Pancreatic-polypeptide-rich regions in human pancreas. Lancet 1978 1.11
35 Identification of a lobe in the adult human pancreas rich in pancreatic polypeptide. Diabetologia 1979 1.10
36 Membrane ultrastructure in urinary tubules. Int Rev Cytol 1981 1.09
37 Intercellular junctions in podocytes of the nephrotic glomerulus as seen with freeze-fracture. Lab Invest 1975 1.08
38 Potassium depletion and hypertonic medium reduce "non-coated" and clathrin-coated pit formation, as well as endocytosis through these two gates. J Cell Physiol 1989 1.07
39 Coatomer-rich endoplasmic reticulum. Proc Natl Acad Sci U S A 1994 1.03
40 Specific plasma membrane differentiations in the cells of the kidney collecting tubule. J Ultrastruct Res 1975 1.03
41 Transport of horseradish peroxidase from the cell surface to the Golgi in insulin-secreting cells: preferential labelling of cisternae located in an intermediate position in the stack. EMBO J 1986 0.99
42 Nonconverted, amino acid analog-modified proinsulin stays in a Golgi-derived clathrin-coated membrane compartment. J Cell Biol 1984 0.98
43 Gap junction development is correlated with insulin content in the pancreatic B cell. Science 1980 0.97
44 pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle. J Cell Biol 1994 0.97
45 A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas. Diabetes 1983 0.96
46 In vivo induction of tight junction proliferation in rat liver. J Cell Biol 1976 0.96
47 Less-understood aspects of the morphology of insulin secretion and binding. Recent Prog Horm Res 1978 0.94
48 Symposium III: Hormones and hormone receptors. A morphological approach to surface receptors in islet and liver cells. Isr J Med Sci 1975 0.94
49 Gap junctions in mesangial and lacis cells. J Cell Biol 1974 0.93
50 A peculiar substructure in the postsynaptic membrane of Torpedo electroplax. Proc Natl Acad Sci U S A 1974 0.92
51 Morphological changes of the adipose cell plasma membrane during lipolysis. J Cell Biol 1977 0.91
52 Microheterogeneity of protein and sterol content in kidney podocyte membrane. Nature 1981 0.90
53 Evidence for extracellular space in the rhabdome of the honeybee drone eye. J Cell Biol 1969 0.89
54 (Pro)insulin associates with Golgi membranes of pancreatic B cells. Proc Natl Acad Sci U S A 1984 0.89
55 Islet cell membrane alteration by diabetogenic drugs. Lab Invest 1976 0.89
56 Distribution of filipin-cholesterol complexes at sites of exocytosis - a freeze-fracture study of degranulating mast cells. Cell Biol Int Rep 1980 0.88
57 Nonrandom distribution of gap junctions between pancreatic beta-cells. Am J Physiol 1980 0.87
58 Distribution of intramembrane particles and filipin-sterol complexes in plasma membranes of kidney. I. Corpuscle of Malpighi. Lab Invest 1982 0.87
59 Insulin immunoreactive sites demonstrated in the Golgi apparatus of pancreatic B cells. Proc Natl Acad Sci U S A 1981 0.87
60 Metabolic coupling between cultured pancreatic b-cells. Exp Cell Res 1981 0.87
61 Protein synthesis in the visual cells of the honeybee drone as studied with electron microscope radioautography. J Cell Biol 1972 0.86
62 Cell contacts in human islets of Langerhans. J Clin Endocrinol Metab 1975 0.86
63 Horseradish peroxidase uptake and crinophagy in insulin-secreting cells. Exp Cell Res 1986 0.85
64 Morphological evidence for calcium stores in photoreceptors of the honeybee drone retina. J Ultrastruct Res 1978 0.85
65 The effects of anoxia on the morphology and composite metabolism of the intact aortic intima-media preparation. J Clin Invest 1977 0.85
66 The pancreatic polypeptide-rich lobe of the human pancreas: definitive identification of its derivation from the ventral pancreatic primordium. Diabetologia 1982 0.84
67 Orthogonal arrays of particles in the gastric parietal cell of the rat: differences between superficial and basal cells in the gland and after pentagastrin or metiamide treatment. Anat Rec 1986 0.84
68 Postsynaptic membrane domains in the molecular layer of the cerebellum: a correlation between presynaptic inputs and postsynaptic plasma membrane organization. Brain Res 1984 0.84
69 Morphological characterization of membrane systems in A- and B-cells of the Chinese hamster. Diabetologia 1974 0.83
70 Pancreatic fat. N Engl J Med 1979 0.83
71 Orthogonal arrays of particles in plasma membranes of the gastric parietal cell. Anat Rec 1978 0.83
72 Fenestrae in the rough endoplasmic reticulum of the exocrine pancreatic cells. J Cell Biol 1972 0.83
73 Interleaflet clear space is reduced in the membrane of COP I and COP II-coated buds/vesicles. Proc Natl Acad Sci U S A 1996 0.83
74 The insulin factory. Sci Am 1988 0.83
75 Junctions in developing human and rat kidney: a freeze-fracture study. J Ultrastruct Res 1976 0.82
76 Morphological changes in tight junctions of Necturus maculosus proximal tubules undergoing saline diuresis. J Cell Biol 1976 0.82
77 A study of Fabry's disease. II. Light and electron microscopy. Dermatologica 1969 0.81
78 Ultrastructure of the nerves associated with the epistellar body of the octopod Eledone moschata and the parolfactory vesicles of the squid Todarodes sagittatus. Brain Res 1972 0.81
79 A pressure device for intracellular injection. Experientia 1974 0.81
80 Perturbation of the adipose cell plasma membrane in obese (ob/ob) mice. Lab Invest 1977 0.80
81 'Obligatory' association between A and D cells demonstrated by bipolar islets of neonatal pancreas. Diabetologia 1981 0.80
82 Pore-like structures in biological membranes. J Cell Sci 1977 0.80
83 [Membrane binding of insulin antigenic sites in the Golgi apparatus of pancreatic B cells]. C R Seances Acad Sci III 1983 0.80
84 Topology of morphologically detectable protein and cholesterol in membranes of polypeptide-secreting cells. Philos Trans R Soc Lond B Biol Sci 1981 0.80
85 Freeze-fracture differences between plasma membranes of descending and ascending branches of the rat Henle's thin loop. Lab Invest 1975 0.80
86 [Localization by intracellular coloration of various types of response to the light in the eye of drones]. J Physiol (Paris) 1970 0.79
87 A specialized membrane junction between nerve endings and B-cells in islets of Langerhans. Eur J Clin Invest 1973 0.79
88 Effects of insulin, glucagon, and epinephrine on the plasma membrane of the white adipose cell: a freeze-fracture study. J Lipid Res 1976 0.79
89 Immunocytochemical localization of the vitamin D-dependent calcium binding protein in chick duodenum. J Cell Biol 1982 0.79
90 [Functional and morphologic study of the retinal cell of the drone during adaptation to light and darkness]. Helv Physiol Pharmacol Acta 1967 0.79
91 Anatomic and hormonal markers for the ventral primordium in the human pancreas? N Engl J Med 1979 0.78
92 Freeze-fracture of membrane fusions in phagocytosing polymorphonuclear leukocytes. Lab Invest 1978 0.78
93 [Ultrastructural changes in the organization of plasma membranes in adipocytes of obese mice (ob/ob)]. C R Acad Sci Hebd Seances Acad Sci D 1976 0.78
94 Glicentin precedes glucagon in the developing human pancreas. Endocrinology 1982 0.78
95 Distribution of cytochemically detectable cholesterol in the electric organ of Torpedo marmorata. Proc Natl Acad Sci U S A 1982 0.78
96 Climbing fiber destruction affects dendrite and spine membrane organization in Purkinje cells. Brain Res 1982 0.78
97 Studies of the effects of an elevated glucose concentration on the ultrastructure and composite metabolism of the intact rabbit aortic intima-media preparation. Diabetes 1979 0.77
98 Instability of pancreatic endocrine cell populations throughout life. Lancet 1979 0.77
99 Preparation of a plasma membrane fraction from the brown adipose tissue. Experientia 1971 0.77
100 Inhomogeneity of surface labelling of B-cells at prospective sites of exocytosis. Diabetologia 1979 0.77
101 Gap junctions and B-cell function. Horm Metab Res Suppl 1980 0.77
102 Differential filipin labeling of the luminal membranes lining the pancreatic acinus. J Histochem Cytochem 1983 0.77
103 Freeze-fracture of developing neuronal plasma membrane in postnatal cerebellum. Brain Res 1981 0.76
104 Immunocytochemical characterization of secretory granule maturation in pancreatic A-cells. Endocrinology 1984 0.76
105 Evidence for granulolysis in the retinula cells of a stomatopod crustacean, Squilla mantis. J Cell Biol 1971 0.75
106 Clarification of the osmiophilic granules of the rat pinealocytes by p-chlorophenylalanin. Experientia 1968 0.75
107 Exocytosis-endocytosis as seen with morphological probes of membrane organization. Methods Cell Biol 1981 0.75
108 [Asymmetrical distribution of clathrin in the Golgi apparatus of polypeptide-secreting cells]. C R Acad Sci III 1984 0.75
109 Isolation by polyacrylamide gel electrophoresis of a light-sensitive vitamin A-protein complex from the retina of the honeybee drone. Vision Res 1976 0.75
110 Tight junctions in fetal rat liver explants grown in vitro. J Ultrastruct Res 1978 0.75
111 Morphology and DNA synthesis of cells recovering from thymineless death in E. coli K12. Experientia 1974 0.75
112 Feasibility of freeze-fracturing single isolated renal tubules. Kidney Int 1977 0.75
113 [Evidence for existence of pores in intramembranous particles revealed by freeze fracturing]. C R Acad Sci Hebd Seances Acad Sci D 1976 0.75
114 Simultaneous assessment of prohormone transport and processing in four separate islet cell types: a combined autoradiographic and biochemical study. Pancreas 1988 0.75
115 [Experimental studies on the ultrastructure of rat epiphysis]. Verh Anat Ges 1969 0.75
116 [Functional morphology of endocrine cells in the gastrointestinal tract]. Verh Anat Ges 1970 0.75
117 Effects of climbing fiber destruction on large dendrite spines of Purkinje cells. Exp Brain Res 1982 0.75
118 [Physiological properties of eye pigment cells in drones (Apis mellifera)]. J Physiol (Paris) 1972 0.75
119 Lateral distribution of intramembrane particles in Purkinje and granule cells of the rat cerebellar cortex. Neurosci Lett 1984 0.75
120 [State of advancement of reform in medical studies at the University of Geneva]. Rev Med Suisse Romande 1994 0.75