Published in Nature on December 11, 1980
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Programmed gene rearrangements altering gene expression. Science (1987) 4.12
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Glycosyl-sn-1,2-dimyristylphosphatidylinositol is covalently linked to Trypanosoma brucei variant surface glycoprotein. J Biol Chem (1985) 3.64
Molecular cloning of a human DNA repair gene. Nature (1984) 3.50
A presumed DNA helicase encoded by ERCC-3 is involved in the human repair disorders xeroderma pigmentosum and Cockayne's syndrome. Cell (1990) 3.48
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Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr Biol (2000) 3.34
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Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. Cell (1986) 3.17
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Eukaryotic protein modification and membrane attachment via phosphatidylinositol. Cell (1987) 3.08
Gel electrophoresis of RNA under denaturing conditions. Biochim Biophys Acta (1973) 3.05
Action of DNA repair endonuclease ERCC1/XPF in living cells. Science (1999) 3.00
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence. Curr Biol (1997) 2.99
Gene replacement in Toxoplasma gondii with chloramphenicol acetyltransferase as selectable marker. Science (1993) 2.98
Inactivation of transcription by UV irradiation of T. brucei provides evidence for a multicistronic transcription unit including a VSG gene. Cell (1987) 2.93
Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei. Nature (1990) 2.91
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci U S A (1997) 2.91
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MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine. Cell (1996) 2.87
RNA splicing is required to make the messenger RNA for a variant surface antigen in trypanosomes. Nucleic Acids Res (1982) 2.87
Unusual abundance of atypical strains associated with human ocular toxoplasmosis. J Infect Dis (2001) 2.86
Apparent discontinuous transcription of Trypanosoma brucei variant surface antigen genes. Nature (1984) 2.85
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Genomic environment of the expression-linked extra copies of genes for surface antigens of Trypanosoma brucei resembles the end of a chromosome. Nature (1982) 2.75
Alpha-amanitin-insensitive transcription of variant surface glycoprotein genes provides further evidence for discontinuous transcription in trypanosomes. Nucleic Acids Res (1984) 2.74
Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription? Cell (1983) 2.67
Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines. Cancer Res (1997) 2.67
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N-terminal amino acid sequences of variant-specific surface antigens from Trypanosoma brucei. Nature (1976) 2.64
The anatomy and transcription of a telomeric expression site for variant-specific surface antigens in T. brucei. Cell (1987) 2.63
Polycistronic transcripts in trypanosomes and their accumulation during heat shock: evidence for a precursor role in mRNA synthesis. Mol Cell Biol (1988) 2.63
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Overexpression and amplification of five genes in a multidrug-resistant Chinese hamster ovary cell line. Mol Cell Biol (1986) 2.59
Transcripts coding for variant surface glycoproteins of Trypanosoma brucei have a short, identical exon at their 5' end. Gene (1982) 2.58
Discontinuous synthesis of mRNA in trypanosomes. EMBO J (1984) 2.57
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Protective monoclonal antibodies recognising stage-specific merozoite antigens of a rodent malaria parasite. Nature (1980) 2.55
Biosynthesis of Trypanosoma brucei variant surface glycoproteins. N-glycosylation and addition of a phosphatidylinositol membrane anchor. J Biol Chem (1986) 2.54
Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. Proc Natl Acad Sci U S A (1991) 2.53
An insert in the single gene for the large ribosomal RNA in yeast mitochondrial DNA. Nature (1978) 2.53
Expression of a bacterial gene in a trypanosomatid protozoan. Science (1989) 2.52
Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport. Proc Natl Acad Sci U S A (1994) 2.52
Novel expression-linked copies of the genes for variant surface antigens in trypanosomes. Nature (1980) 2.51
Hypermodified bases in DNA. FASEB J (1995) 2.49
RAD26, the functional S. cerevisiae homolog of the Cockayne syndrome B gene ERCC6. EMBO J (1994) 2.46
Evidence for a repair enzyme complex involving ERCC1 and complementing activities of ERCC4, ERCC11 and xeroderma pigmentosum group F. EMBO J (1993) 2.45
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Molecular cloning and cellular localization of a BiP homologue in Trypanosoma brucei. Divergent ER retention signals in a lower eukaryote. J Cell Sci (1993) 2.44
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The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei. EMBO J (1990) 2.41
Comparison of the genes coding for the common 5' terminal sequence of messenger RNAs in three trypanosome species. Nucleic Acids Res (1984) 2.40
Overproduction of the poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in mammalian cells. EMBO J (1993) 2.38
Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition. Cell (1997) 2.38