Published in Sangyo Igaku on May 01, 1980
The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics (1969) 21.57
Whole genome sequencing of meticillin-resistant Staphylococcus aureus. Lancet (2001) 18.55
Slightly deleterious mutant substitutions in evolution. Nature (1973) 13.79
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08
The whole structure of the 13-subunit oxidized cytochrome c oxidase at 2.8 A. Science (1996) 9.32
GENIA corpus--semantically annotated corpus for bio-textmining. Bioinformatics (2003) 8.89
Linkage disequilibrium at steady state determined by random genetic drift and recurrent mutation. Genetics (1969) 7.33
Role of very slightly deleterious mutations in molecular evolution and polymorphism. Theor Popul Biol (1976) 6.91
Protein polymorphism as a phase of molecular evolution. Nature (1971) 6.68
Differences in susceptibility to quinolones of outer membrane mutants of Salmonella typhimurium and Escherichia coli. Antimicrob Agents Chemother (1986) 6.03
Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12. Antimicrob Agents Chemother (1986) 6.00
Structures of metal sites of oxidized bovine heart cytochrome c oxidase at 2.8 A. Science (1995) 5.43
On some principles governing molecular evolution. Proc Natl Acad Sci U S A (1974) 4.97
The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation. J Biol Chem (2001) 4.51
The age of a neutral mutant persisting in a finite population. Genetics (1973) 4.44
Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell (1998) 3.80
Purification and properties of DNA gyrase from a fluoroquinolone-resistant strain of Escherichia coli. Antimicrob Agents Chemother (1986) 3.69
Distribution of allelic frequencies in a finite population under stepwise production of neutral alleles. Proc Natl Acad Sci U S A (1975) 3.64
On the evolution of multigene families. Theor Popul Biol (1983) 3.61
Population biology of antigen presentation by MHC class I molecules. Science (1996) 3.58
Linkage disequilibrium between two segregating nucleotide sites under the steady flux of mutations in a finite population. Genetics (1971) 3.51
In vitro and in vivo antibacterial activity of AM-833, a new quinolone derivative. Antimicrob Agents Chemother (1986) 3.38
Stepwise mutation model and distribution of allelic frequencies in a finite population. Proc Natl Acad Sci U S A (1978) 3.29
Stem-loop binding protein, the protein that binds the 3' end of histone mRNA, is cell cycle regulated by both translational and posttranslational mechanisms. Mol Cell Biol (2000) 2.90
Peptidoglycan synthetic activities in membranes of Escherichia coli caused by overproduction of penicillin-binding protein 2 and rodA protein. J Biol Chem (1986) 2.84
Mutation and evolution at the molecular level. Genetics (1973) 2.79
Allelic and nonallelic homology of a supergene family. Proc Natl Acad Sci U S A (1982) 2.72
Rad52 forms ring structures and co-operates with RPA in single-strand DNA annealing. Genes Cells (1998) 2.66
Purification and characterization of the human interleukin-18 receptor. J Biol Chem (1997) 2.58
Simulating evolution by gene duplication. Genetics (1987) 2.52
Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J Cancer Res Clin Oncol (1992) 2.40
In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone. Antimicrob Agents Chemother (1992) 2.32
Physical aspects of a real-time tumor-tracking system for gated radiotherapy. Int J Radiat Oncol Biol Phys (2000) 2.24
Polyallelic mutational equilibria. Genetics (1975) 2.13
Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin. J Med Chem (1999) 2.10
The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1. Mol Cell Biol (2000) 2.09
The balance between different peptidoglycan precursors determines whether Escherichia coli cells will elongate or divide. J Bacteriol (1990) 2.07
Observation of the one-dimensional diffusion of nanometer-sized dislocation loops. Science (2007) 2.07
Isolation of Dictyostelium discoideum cytokinesis mutants by restriction enzyme-mediated integration of the blasticidin S resistance marker. Biochem Biophys Res Commun (1994) 2.05
Population genetics of multigene families that are dispersed into two or more chromosomes. Proc Natl Acad Sci U S A (1983) 2.05
Ingested arsenic and internal cancer: a historical cohort study followed for 33 years. Am J Epidemiol (1995) 1.99
Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis. Proc Natl Acad Sci U S A (1999) 1.98
Nucleotide sequence of the pbpA gene and characteristics of the deduced amino acid sequence of penicillin-binding protein 2 of Escherichia coli K12. Eur J Biochem (1986) 1.98
Simple model for treating evolution of multigene families. Nature (1976) 1.98
The effect of selected linked locus on heterozygosity of neutral alleles (the hitch-hiking effect). Genet Res (1975) 1.95
Abdominal ultrasonography for the diagnosis of strangulation in small bowel obstruction. Br J Surg (1994) 1.95
Neurons but not glial cells show reciprocal imprinting of sense and antisense transcripts of Ube3a. Hum Mol Genet (2003) 1.92
Eukaryotes-prokaryotes divergence estimated by 5S ribosomal RNA sequences. Nat New Biol (1973) 1.88
Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons. Am J Hum Genet (2003) 1.82
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med (1998) 1.81
Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis. Proc Natl Acad Sci U S A (1990) 1.79
Still's disease associated with necrotizing lymphadenitis (Kikuchi's disease): report of 3 cases. J Rheumatol (1988) 1.78
Systemic toxicity and resuscitation in bupivacaine-, levobupivacaine-, or ropivacaine-infused rats. Anesth Analg (2001) 1.76
Complete nucleotide sequence of the chloroplast genome from the green alga Chlorella vulgaris: the existence of genes possibly involved in chloroplast division. Proc Natl Acad Sci U S A (1997) 1.75
Primary structure of the alpha-subunit of Torpedo californica (Na+ + K+)ATPase deduced from cDNA sequence. Nature (1985) 1.71
Identical reactivity of monoclonal antibodies HNK-1 and NC-1: conservation in vertebrates on cells derived from the neural primordium and on some leukocytes. Cell Differ (1984) 1.70
Four-dimensional treatment planning and fluoroscopic real-time tumor tracking radiotherapy for moving tumor. Int J Radiat Oncol Biol Phys (2000) 1.68
Interleukin-6 is a useful marker for early prediction of the severity of acute pancreatitis. Pancreas (1997) 1.68
Behavior of neutral mutants influenced by asociated overdominant loci in finite populations. Genetics (1971) 1.68
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons. Blood (1998) 1.68
Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover. J Clin Invest (2000) 1.67
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis. Cancer Res (1999) 1.65
D-lactate dehydrogenase is a member of the D-isomer-specific 2-hydroxyacid dehydrogenase family. Cloning, sequencing, and expression in Escherichia coli of the D-lactate dehydrogenase gene of Lactobacillus plantarum. J Biol Chem (1991) 1.63
Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography. J Pharm Biomed Anal (1999) 1.62
Development of posterior fossa dural sinuses, emissary veins, and jugular bulb: morphological and radiologic study. AJNR Am J Neuroradiol (1994) 1.61
Isolation and the gene cloning of an alkaline shock protein in methicillin resistant Staphylococcus aureus. Biochem Biophys Res Commun (1995) 1.60
Results of extensive surgery for pancreatic carcinoma. Cancer (1996) 1.60
Site-directed mutants, at position 166, of RTEM-1 beta-lactamase that form a stable acyl-enzyme intermediate with penicillin. J Biol Chem (1991) 1.59
Development of associative overdominance through linkage disequilibrium in finite populations. Genet Res (1970) 1.59
Nucleotide sequence and characteristics of the gene for L-lactate dehydrogenase of Thermus caldophilus GK24 and the deduced amino-acid sequence of the enzyme. Eur J Biochem (1986) 1.58
Intralesional steroid injection to prevent stricture after endoscopic submucosal dissection for esophageal cancer: a controlled prospective study. Endoscopy (2012) 1.58
Genetic variation in small multigene families. Genet Res (1981) 1.57
Pancreatitis and anomalous union of the pancreaticobiliary ductal system in childhood. J Pediatr Surg (1993) 1.57
Nucleotide sequence of the rodA gene, responsible for the rod shape of Escherichia coli: rodA and the pbpA gene, encoding penicillin-binding protein 2, constitute the rodA operon. J Bacteriol (1989) 1.57
An outbreak of hepatitis A caused by consumption of raw oysters. J Hyg (Lond) (1983) 1.57
An evaluation of radical resection for pancreatic cancer based on the mode of recurrence as determined by autopsy and diagnostic imaging. Cancer (1993) 1.56
Population size and rate of evolution. J Mol Evol (1972) 1.55
Percutaneous radio-frequency ablation therapy using a clustered electrode for malignant liver tumors. J Clin Gastroenterol (2001) 1.53
Genes encoding two lipoproteins in the leuS-dacA region of the Escherichia coli chromosome. J Bacteriol (1987) 1.53
Probability of gene fixation in an expanding finite population. Proc Natl Acad Sci U S A (1974) 1.52
TOM1, an Arabidopsis gene required for efficient multiplication of a tobamovirus, encodes a putative transmembrane protein. Proc Natl Acad Sci U S A (2000) 1.52
Multiseptate gallbladder: diagnostic value of MR cholangiography and ultrasonography. Abdom Imaging (2004) 1.50
Inactivation of aerobic and hypoxic cells from three different cell lines by accelerated (3)He-, (12)C- and (20)Ne-ion beams. Radiat Res (2000) 1.49
Characterization of fibrous retrocorneal membrane by confocal microscopy. Cornea (1998) 1.47
An ecological study on the association of public dental health activities and sociodemographic characteristics with caries prevalence in Japanese 3-year-old children. Caries Res (2006) 1.46
Induction of thyroid tumors in (C57BL/6N x C3H/N)F1 mice by oral administration of 9-3',4',5',6'-tetrachloro-o-carboxy phenyl-6-hydroxy-2,4,5,7-tetraiodo-3-isoxanthone sodium (Food Red 105, rose bengal B). J Natl Cancer Inst (1986) 1.45
Depressed natural killer cell activity due to decreased natural killer cell population in a vitamin E-deficient patient with Shwachman syndrome: reversible natural killer cell abnormality by alpha-tocopherol supplementation. Eur J Pediatr (1997) 1.44
Unique precursor structure of an extracellular protease, aqualysin I, with NH2- and COOH-terminal pro-sequences and its processing in Escherichia coli. J Biol Chem (1990) 1.44
Modification of a nasal speculum for transsphenoidal surgery. Technical note. J Neurosurg (2000) 1.44
Immunoreactive E-cadherin, alpha-catenin, beta-catenin, and gamma-catenin proteins in hepatocellular carcinoma: relationships with tumor grade, clinicopathologic parameters, and patients' survival. Hum Pathol (2000) 1.42
A new neurosurgical ventriculoscope--technical note. Neurol Med Chir (Tokyo) (1990) 1.41
The role of guanosine 5'-triphosphate in the initiation of peptide synthesis. 3. Binding of formylmethionyl-tRNA to ribosomes. Proc Natl Acad Sci U S A (1967) 1.40
Survival probabilities f new inversions in large populations. Biometrics (1968) 1.39
The effect of 1,24(R)(OH)2D3 cream and ointment on epidermal proliferation and differentiation in mice. Dermatology (1996) 1.39
Separation anxiety leads to nonpsychotic hallucinations. J Am Acad Child Adolesc Psychiatry (2000) 1.39
Surgical strategy for carcinoma of the pancreas head area based on clinicopathologic analysis of nodal involvement and plexus invasion. Surgery (1995) 1.38
Acetylpolyamine amidohydrolase from Mycoplana ramosa: gene cloning and characterization of the metal-substituted enzyme. J Bacteriol (1996) 1.38
Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem Biophys Res Commun (1997) 1.37