Published in Therapie on April 21, 1981
A new population-enrichment strategy to improve efficiency of placebo-controlled clinical trials of antidepressant drugs. Clin Pharmacol Ther (2010) 2.74
Plasma concentration of amitriptyline and clinical response. Lancet (1972) 2.44
PHARM--an interactive graphic program for individual and population pharmacokinetic parameter estimation. Comput Biol Med (1984) 2.09
Routine nortriptyline levels in treatment of depression. Br Med J (1977) 1.82
IGPHARM: interactive graphic package for pharmacokinetic analysis. Comput Biomed Res (1978) 1.71
New injection recommendations for patients with diabetes. Diabetes Metab (2010) 1.67
Pharmacokinetics of N-demethyldiazepam in patients suffering from insomnia and treated with nortriptyline. Br J Clin Pharmacol (1975) 1.63
A two-step iterative algorithm for estimation in nonlinear mixed-effect models with an evaluation in population pharmacokinetics. J Biopharm Stat (1995) 1.54
[Arterial hypertension and diabetes. Members of the Board of Directors and Scientific Directors of ALFEDIAM]. Diabetes Metab (1996) 1.50
Lead poisoning from Asian traditional remedies in the West Midlands--report of a series of five cases. Hum Exp Toxicol (1995) 1.42
Joint modeling of efficacy, dropout, and tolerability in flexible-dose trials: a case study in depression. Clin Pharmacol Ther (2012) 1.41
A specific gas-chromatographic method for the measurement of "steady-state" plasma levels of amitriptyline and nortriptyline in patients. Clin Chim Acta (1971) 1.39
Simplified method for monitoring tricyclic antidepressant therapy using gas--liquid chromatography with nitrogen detection. J Chromatogr (1978) 1.30
Gas chromatographic method for the determination of nomifensine in human plasma. J Chromatogr (1976) 1.29
[Comparative study of gastro-intestinal blood loss after antrafenine, aspirin and placebo in healthy volunteers (author's transl)]. Therapie (1981) 1.28
Pharmacokinetics and effects of propranolol in terminal uraemic patients and in patients undergoing regular dialysis treatment. Clin Pharmacokinet (1976) 1.25
Relationship between clinical features of tricyclic antidepressant poisoning and plasma concentrations in children. Arch Dis Child (1978) 1.21
Experimental drug intoxication: treatment with charcoal haemoperfusion. Arch Toxicol (1975) 1.20
Influence of age on mianserin pharmacokinetics. Psychopharmacology (Berl) (1982) 1.13
Studies on the mechanism of the vasodilator effects of prazosin in dogs and rabbits. Eur J Pharmacol (1978) 1.13
Emergency analysis of paraquat in biological fluids. Hum Toxicol (1987) 1.10
The significance of drug interactions in the evaluation of psychotropic drugs. Br J Clin Pharmacol (1976) 1.10
Trace elements and inflammation. Ann Clin Biochem (2000) 1.05
Subcutaneous insulin: pharmacokinetic variability and glycemic variability. Diabetes Metab (2005) 1.02
Steady-state plasma concentrations during single and multiple dosage schedules of amitriptyline. Psychol Med (1974) 0.98
Estimating antemortem drug concentrations from postmortem blood samples: the influence of postmortem redistribution. J Clin Pathol (2000) 0.97
Adaptive-optimal design in PET occupancy studies. Clin Pharmacol Ther (2010) 0.96
Effect of activated charcoal on absorption of nortriptyline. Lancet (1977) 0.96
Unusual case of tetrahydrocannabinol intoxication confirmed by radioimmunoassay. Br Med J (1977) 0.95
EEG profile of intravenous zolpidem in healthy volunteers. Psychopharmacology (Berl) (1994) 0.95
Steady-state pharmacokinetics of ciprofloxacin in plasma from patients with nosocomial pneumonia: penetration of the bronchial mucosa. Antimicrob Agents Chemother (1991) 0.93
Pharmacokinetics and absolute bioavailability of colchicine after i.v. and oral administration in healthy human volunteers and elderly subjects. Eur J Clin Pharmacol (1994) 0.93
[Diagnosis and classification of diabetes mellitus: the new criteria]. Diabetes Metab (1999) 0.92
Time-course analysis of the cardiovascular effects of clonidine resulting from the activation of cardiac pre- and vascular postsynaptic alpha-adrenoceptors in the pithed rat [proceedings]. Br J Pharmacol (1978) 0.92
Comparison of haemoperfusion and haemodialysis in the therapy of barbiturate intoxication in dogs. Arch Toxikol (1973) 0.91
Systemic and regional hemodynamic characterization of alpha-1 and alpha-2 adrenoceptor agonists in pithed rats. J Pharmacol Exp Ther (1987) 0.89
Pharmacokinetics and pharmacodynamics of vecuronium (ORG NC 45) in patients with cirrhosis. Anesthesiology (1985) 0.89
Absolute bioavailability and electroencephalographic effects of conventional and extended-release formulations of venlafaxine in healthy subjects. J Clin Pharmacol (1998) 0.88
Sulpiride pharmacokinetics in humans after intramuscular administration at three dose levels. J Pharm Sci (1984) 0.87
In vivo measurements of cadmium and lead in occupationally-exposed workers and an urban population. Biol Trace Elem Res (1991) 0.87
The poppy seed defense: a novel solution. Drug Test Anal (2013) 0.87
Preserved insulin sensitivity and {beta}-cell activity, but decreased glucose effectiveness in normal-weight women with the polycystic ovary syndrome. J Clin Endocrinol Metab (2005) 0.87
A comparison between propranolol, practolol and betaxolol (SL75212) on the circulatory and metabolic responses to insulin-induced hypoglycaemia. Eur J Clin Pharmacol (1981) 0.87
Long-term monitoring of tricyclic antidepressant plasma concentrations. Br J Psychiatry (1980) 0.87
Elemental mercury-induced skin granuloma: a case report and review of the literature. J Toxicol Clin Toxicol (1996) 0.87
High-performance liquid chromatographic determination of alfuzosin in biological fluids with fluorimetric detection and large-volume injection. J Chromatogr (1986) 0.86
Induction of DNA strand breaks in peripheral lymphocytes by soluble chromium compounds. Hum Exp Toxicol (1992) 0.86
Binding of lead to a metallothionein-like protein in human erythrocytes. J Inorg Biochem (1993) 0.86
Analysis of tricyclic antidepressant drugs by gas chromatography using nitrogen-selective detection with packed and capillary columns. J Chromatogr (1980) 0.86
Fertility in patients with multiple sclerosis: current knowledge and future perspectives. Neurol Sci (2006) 0.86
Bayesian estimate of vinorelbine pharmacokinetic parameters in elderly patients with advanced metastatic cancer. Clin Cancer Res (2000) 0.85
Endotracheal and aerosol administrations of ceftazidime in patients with nosocomial pneumonia: pharmacokinetics and absolute bioavailability. Antimicrob Agents Chemother (1992) 0.85
Pharmacokinetics of propranolol in normal healthy volunteers. J Pharmacokinet Biopharm (1977) 0.85
A radioimmunoassay for amitriptyline and nortriptyline [proceedings]. Br J Pharmacol (1978) 0.85
Effect of a conjugated oestrogen (Premarin) cream on ageing facial skin. A comparative study with a placebo cream. Maturitas (1994) 0.84
Beta-adrenoceptor blocking effects and pharmacokinetics of betaxolol (SL 75212) in man. Br J Clin Pharmacol (1980) 0.84
[Anatomic incidence of meniscochondrocalcinosis of the knee]. Rev Rhum Mal Osteoartic (1982) 0.84
High-performance liquid chromatographic determination of zolpidem, a new sleep inducer, in biological fluids with fluorimetric detection. J Chromatogr (1986) 0.84
Prediction of steady-state plasma concentrations and individual dosage regimens of tricyclic antidepressants from a single test dose. Ther Drug Monit (1982) 0.84
Functional and biochemical evidence for the lack of cardiac presynaptic alpha-2 adrenoceptor stimulant properties of cirazoline (LD 3098), a potent alpha-1 adrenoceptor agonist in dogs and rats. J Pharmacol Exp Ther (1982) 0.84
Blood lead, ethnic origin, and lead exposure. Arch Dis Child (1988) 0.84
Befloxatone, a new reversible and selective monoamine oxidase-A inhibitor. I. Biochemical profile. J Pharmacol Exp Ther (1996) 0.84
Disintegration of mercury disc cells in simulated gastric juice: implications for management of disc cell ingestion. Arch Emerg Med (1990) 0.84
Circadian rhythm of 5-fluorouracil population pharmacokinetics in patients with metastatic colorectal cancer. Cancer Chemother Pharmacol (1999) 0.84
[Articular chondrocalcinosis after 80 years of age]. Rev Rhum Mal Osteoartic (1978) 0.83
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocking agents betaxolol (SL 75212) in healthy volunteers. Br J Clin Pharmacol (1980) 0.83
Pharmacokinetics of theophylline: a dose-range study. Br J Clin Pharmacol (1982) 0.83
The blood pressure lowering effects of intravenous versus intracerebroventricular prazosin in anaesthetised cats. Eur J Pharmacol (1978) 0.82
A Kinetic Model for Simultaneous Fit of Clozapine and Norclozapine Concentrations in Chronic Schizophrenic Patients during Long-Term Treatment. Clin Drug Investig (1998) 0.82
EEG profile of litoxetine after single and repeated administration in healthy volunteers. Br J Clin Pharmacol (1994) 0.82
Pharmacokinetic and pharmacodynamic interaction between toloxatone, a new reversible monoamine oxidase-A inhibitor, and oral tyramine in healthy subjects. Clin Pharmacol Ther (1992) 0.82
Cardiovascular effects of single oral doses of the new beta-adrenoceptor blocker SL 75212 in healthy volunteers [proceedings]. Br J Clin Pharmacol (1979) 0.82
Plasma protein binding of maprotiline in geriatric patients--influence of alpha1-acid glycoprotein [proceedings]. Br J Clin Pharmacol (1978) 0.81
Determination of mizolastine, a new antihistaminic drug, in human plasma by liquid-liquid extraction, solid-phase extraction and column-switching techniques in combination with high-performance liquid chromatography. J Chromatogr (1993) 0.81
Comparison of single-dose pharmacokinetics of imipramine and maprotiline in the elderly. Psychopharmacology (Berl) (1980) 0.81
Comparison of mianserin with desipramine, maprotiline and phentolamine on cardiac presynaptic and vascular postsynaptic alpha-adrenoceptors and noradrenaline reuptake in pithed normotensive rats. Br J Pharmacol (1980) 0.81
Heart rate lowering effects of N,N-di-n-propyl-dopamine in rats: evidence for stimulation of central dopamine receptors leading to inhibition of sympathetic tone and enhancement of parasympathetic outflow. J Pharmacol Exp Ther (1981) 0.81
Model-based approach and signal detection theory to evaluate the performance of recruitment centers in clinical trials with antidepressant drugs. Clin Pharmacol Ther (2008) 0.81
Population pharmacokinetics of mycophenolic acid in kidney transplant pediatric and adolescent patients. Ther Drug Monit (2005) 0.81
Specific gas chromatographic determination of amitriptyline in human urine following therapeutic doses. J Chromatogr (1970) 0.81
Meal-dependent absorption of enteric-coated sodium valproate. Epilepsia (1980) 0.81
Slow-release caffeine: a new response to the effects of a limited sleep deprivation. Sleep (2000) 0.81
Plasma-protein binding of tricyclic antidepressants. Postgrad Med J (1980) 0.80
Pharmacokinetics and metabolism of diltiazem in man. Acta Cardiol (1980) 0.80
Blood pressure lowering effects of N,N-di-n-propyl-dopamine in rats: evidence for stimulation of peripheral dopamine receptors leading to inhibition of sympathetic vascular tone. J Pharmacol Exp Ther (1981) 0.80
The effect of glutaraldehyde adulteration of urine specimens on syva EMIT II drugs-of-abuse assays. J Anal Toxicol (1996) 0.80
Pharmacokinetics and time-course of D(2) receptor occupancy induced by atypical antipsychotics in stabilized schizophrenic patients. J Psychopharmacol (2008) 0.80
Determination of nifuroxazide in biological fluids by automated high-performance liquid chromatography with large-volume injection. J Chromatogr (1981) 0.80
Placental transfer of pethidine and norpethidine and their pharmacokinetics in the newborn. Eur J Clin Pharmacol (1980) 0.80
Simple and specific high performance liquid chromatographic method for the routine monitoring of clonazepam in plasma. Ther Drug Monit (1980) 0.80
Benzodiazepines and tricyclic antidepressant plasma levels. Br Med J (1973) 0.80
Plasma concentrations and cardiotoxic effects of desipramine and protriptyline in the rat. Br J Pharmacol (1977) 0.80
Population pharmacokinetics of amikacin in critically ill patients. Antimicrob Agents Chemother (1996) 0.80
Plasma and brain pharmacokinetics of mianserin after single and multiple dosing in mice. Prog Neuropsychopharmacol Biol Psychiatry (1987) 0.79
Pharmacokinetics of the new beta-adrenoceptor blocking agent betaxolol (SL 75212) in man after repeated oral administration. Arzneimittelforschung (1980) 0.79
Turnover of free and conjugated (sulphonyloxy) dihydroxyphenylacetic acid and homovanillic acid in rat striatum. J Neurochem (1979) 0.79
Cardiac effects of tricyclic antidepressant medication. A preliminary study of nortriptyline. Br Heart J (1978) 0.79
Blood concentrations and pharmacodynamic effects of SL 75212, a new beta-adrenoceptor antagonist, after oral and intravenous administration [proceedings]. Br J Clin Pharmacol (1979) 0.79