Published in RNA on October 01, 1995
The intronerator: exploring introns and alternative splicing in Caenorhabditis elegans. Nucleic Acids Res (2000) 14.77
Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis. Microbiol Mol Biol Rev (1999) 11.32
AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes. Mol Cell Biol (1999) 4.87
Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol Cell Biol (1999) 3.36
Identification of a new class of exonic splicing enhancers by in vivo selection. Mol Cell Biol (1997) 3.36
G triplets located throughout a class of small vertebrate introns enforce intron borders and regulate splice site selection. Mol Cell Biol (1997) 3.20
A coactivator of pre-mRNA splicing. Genes Dev (1998) 3.04
Exonic splicing enhancer motif recognized by human SC35 under splicing conditions. Mol Cell Biol (2000) 3.01
The polypyrimidine tract binding protein binds upstream of neural cell-specific c-src exon N1 to repress the splicing of the intron downstream. Mol Cell Biol (1997) 2.93
The RNA-binding protein TIA-1 is a novel mammalian splicing regulator acting through intron sequences adjacent to a 5' splice site. Mol Cell Biol (2000) 2.75
Multiple distinct splicing enhancers in the protein-coding sequences of a constitutively spliced pre-mRNA. Mol Cell Biol (1999) 2.72
A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol (1997) 2.66
The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation. EMBO J (1997) 2.43
Modulation of exon skipping by high-affinity hnRNP A1-binding sites and by intron elements that repress splice site utilization. EMBO J (1999) 2.34
Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly. Mol Cell Biol (1996) 2.29
Architectural limits on split genes. Proc Natl Acad Sci U S A (1996) 2.29
Role of an inhibitory pyrimidine element and polypyrimidine tract binding protein in repression of a regulated alpha-tropomyosin exon. RNA (1998) 2.18
Intron self-complementarity enforces exon inclusion in a yeast pre-mRNA. Proc Natl Acad Sci U S A (1997) 2.08
Functional analysis of the polypyrimidine tract in pre-mRNA splicing. Nucleic Acids Res (1997) 2.05
Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon. Mol Cell Biol (1999) 2.05
An intron element modulating 5' splice site selection in the hnRNP A1 pre-mRNA interacts with hnRNP A1. Mol Cell Biol (1997) 2.00
The RNA binding protein YB-1 binds A/C-rich exon enhancers and stimulates splicing of the CD44 alternative exon v4. EMBO J (2001) 1.92
Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nat Struct Mol Biol (2008) 1.91
Interaction of the U1 snRNP with nonconserved intronic sequences affects 5' splice site selection. Genes Dev (1999) 1.91
A model system for activation-induced alternative splicing of CD45 pre-mRNA in T cells implicates protein kinase C and Ras. Mol Cell Biol (2000) 1.90
Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol (1996) 1.90
The SR splicing factors ASF/SF2 and SC35 have antagonistic effects on intronic enhancer-dependent splicing of the beta-tropomyosin alternative exon 6A. EMBO J (1997) 1.84
Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proc Natl Acad Sci U S A (1997) 1.82
Muscle-specific splicing enhancers regulate inclusion of the cardiac troponin T alternative exon in embryonic skeletal muscle. Mol Cell Biol (1996) 1.81
Context-dependent regulatory mechanism of the splicing factor hnRNP L. Mol Cell (2010) 1.74
An intronic sequence element mediates both activation and repression of rat fibroblast growth factor receptor 2 pre-mRNA splicing. Mol Cell Biol (1998) 1.64
A yeast cap binding protein complex (yCBC) acts at an early step in pre-mRNA splicing. Nucleic Acids Res (1996) 1.57
Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Mol Cell Biol (2000) 1.53
Identification of a bidirectional splicing enhancer: differential involvement of SR proteins in 5' or 3' splice site activation. Mol Cell Biol (1999) 1.52
Regularities of context-dependent codon bias in eukaryotic genes. Nucleic Acids Res (2002) 1.50
Participation of the C-terminal domain of RNA polymerase II in exon definition during pre-mRNA splicing. Mol Cell Biol (2000) 1.48
Stop codons affect 5' splice site selection by surveillance of splicing. Proc Natl Acad Sci U S A (2002) 1.47
Luc7p, a novel yeast U1 snRNP protein with a role in 5' splice site recognition. Genes Dev (1999) 1.46
Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Genes Dev (1998) 1.35
Evidence for splice site pairing via intron definition in Schizosaccharomyces pombe. Mol Cell Biol (2000) 1.34
A 5' splice site-proximal enhancer binds SF1 and activates exon bridging of a microexon. Mol Cell Biol (2000) 1.28
RNA structure is a critical determinant of poly(A) site recognition by cleavage and polyadenylation specificity factor. Mol Cell Biol (1996) 1.23
Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta. J Biol Chem (2003) 1.22
Muscle-specific splicing of a heterologous exon mediated by a single muscle-specific splicing enhancer from the cardiac troponin T gene. Mol Cell Biol (1998) 1.22
hnRNP A1: the Swiss army knife of gene expression. Int J Mol Sci (2013) 1.19
SRp30c is a repressor of 3' splice site utilization. Mol Cell Biol (2002) 1.16
RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Mol Cell Biol (1998) 1.15
Trans-acting factors required for inclusion of regulated exons in the Ultrabithorax mRNAs of Drosophila melanogaster. Genetics (1999) 1.14
A role for SRp54 during intron bridging of small introns with pyrimidine tracts upstream of the branch point. Mol Cell Biol (1998) 1.13
Biased Brownian ratcheting leads to pre-mRNA remodeling and capture prior to first-step splicing. Nat Struct Mol Biol (2013) 1.11
SR proteins are sufficient for exon bridging across an intron. Proc Natl Acad Sci U S A (1998) 1.10
p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation. RNA (2006) 1.09
Structural, functional, and protein binding analyses of bovine papillomavirus type 1 exonic splicing enhancers. J Virol (1997) 1.09
Polypyrimidine track-binding protein binding downstream of caspase-2 alternative exon 9 represses its inclusion. J Biol Chem (2000) 1.09
Enhancer-dependent 5'-splice site control of fruitless pre-mRNA splicing. J Biol Chem (2003) 1.08
A short sequence within two purine-rich enhancers determines 5' splice site specificity. Mol Cell Biol (1998) 1.08
Analysis of the role of Caenorhabditis elegans GC-AG introns in regulated splicing. Nucleic Acids Res (2002) 1.06
Requirements for mini-exon inclusion in potato invertase mRNAs provides evidence for exon-scanning interactions in plants. RNA (2000) 1.06
Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP. RNA (1998) 1.05
Alternative splicing of the latency-related transcript of bovine herpesvirus 1 yields RNAs containing unique open reading frames. J Virol (1998) 1.03
Identification of a male-specific RNA binding protein that regulates sex-specific splicing of Bmdsx by increasing RNA binding activity of BmPSI. Mol Cell Biol (2010) 1.01
Enhancer elements activate the weak 3' splice site of alpha-tropomyosin exon 2. RNA (1998) 1.00
Alternative splicing and retinal degeneration. Clin Genet (2013) 0.98
CA- and purine-rich elements form a novel bipartite exon enhancer which governs inclusion of the minute virus of mice NS2-specific exon in both singly and doubly spliced mRNAs. Mol Cell Biol (1999) 0.98
Competing upstream 5' splice sites enhance the rate of proximal splicing. Mol Cell Biol (2010) 0.97
Disruption of exon definition produces a dominant-negative growth hormone isoform that causes somatotroph death and IGHD II. Hum Genet (2003) 0.96
Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. Nucleic Acids Res (2002) 0.95
U1 small nuclear RNA-promoted exon selection requires a minimal distance between the position of U1 binding and the 3' splice site across the exon. Mol Cell Biol (1997) 0.94
SR proteins are required for nematode trans-splicing in vitro. RNA (1999) 0.92
Expression of the pseudorabies virus latency-associated transcript gene during productive infection of cultured cells. J Virol (1999) 0.92
Activation of a cryptic 5' splice site by U1 snRNA. RNA (2001) 0.90
Control of hnRNP A1 alternative splicing: an intron element represses use of the common 3' splice site. Mol Cell Biol (2000) 0.90
Inverse splicing of a discontinuous pre-mRNA intron generates a circular exon in a HeLa cell nuclear extract. Nucleic Acids Res (1996) 0.89
An exonic splicing silencer in the testes-specific DNA ligase III beta exon. Nucleic Acids Res (2000) 0.88
A simple answer for a splicing conundrum. Proc Natl Acad Sci U S A (2005) 0.86
Interactions between two fission yeast serine/arginine-rich proteins and their modulation by phosphorylation. Biochem J (2002) 0.86
Species-specific regulation of alternative splicing in the C-terminal region of the p53 tumor suppressor gene. Nucleic Acids Res (2000) 0.85
Mutational analysis of a plant branchpoint and polypyrimidine tract required for constitutive splicing of a mini-exon. RNA (2002) 0.84
A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity. J Virol (1997) 0.84
The Sex-lethal early splicing pattern uses a default mechanism dependent on the alternative 5' splice sites. Mol Cell Biol (1997) 0.82
Transposable element insertions respecify alternative exon splicing in three Drosophila myosin heavy chain mutants. Genetics (1998) 0.80
SURVEY AND SUMMARY: exon-intron organization of genes in the slime mold Physarum polycephalum. Nucleic Acids Res (2000) 0.77
Selection on synonymous codons in mammalian rhodopsins: a possible role in optimizing translational processes. BMC Evol Biol (2014) 0.77
Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori. Int J Mol Sci (2014) 0.77
Hyperstable U1snRNA complementary to the K-ras transcripts induces cell death in pancreatic cancer cells. Br J Cancer (2002) 0.77
Alternative splicing of mini-exons in the Arabidopsis leaf rust receptor-like kinase LRK10 genes affects subcellular localisation. Plant Cell Rep (2014) 0.76
Splicing of designer exons informs a biophysical model for exon definition. RNA (2014) 0.76
Illuminating the Transcriptome through the Genome. Genes (Basel) (2014) 0.76