The voltage sensor of the mitochondrial permeability transition pore is tuned by the oxidation-reduction state of vicinal thiols. Increase of the gating potential by oxidants and its reversal by reducing agents.

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Published in J Biol Chem on June 17, 1994

Authors

V Petronilli1, P Costantini, L Scorrano, R Colonna, S Passamonti, P Bernardi

Author Affiliations

1: Department of Biomedical Sciences, University of Padova Medical School, Italy.

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