ZAP-70 binding specificity to T cell receptor tyrosine-based activation motifs: the tandem SH2 domains of ZAP-70 bind distinct tyrosine-based activation motifs with varying affinity.

PubWeight™: 1.40‹?› | Rank: Top 5%

🔗 View Article (PMC 2191847)

Published in J Exp Med on January 01, 1995

Authors

N Isakov1, R L Wange, W H Burgess, J D Watts, R Aebersold, L E Samelson

Author Affiliations

1: Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892.

Articles citing this

The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade. J Biol Chem (2007) 2.24

Positive and negative regulation of T-cell activation through kinases and phosphatases. Biochem J (2003) 1.84

Altered pattern of TCR/CD3-mediated protein-tyrosyl phosphorylation in T cells from patients with systemic lupus erythematosus. Deficient expression of the T cell receptor zeta chain. J Clin Invest (1998) 1.80

CD3 delta deficiency arrests development of the alpha beta but not the gamma delta T cell lineage. EMBO J (1997) 1.54

Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling. Proc Natl Acad Sci U S A (2004) 1.33

ZAP-70 association with T cell receptor zeta (TCRzeta): fluorescence imaging of dynamic changes upon cellular stimulation. J Cell Biol (1998) 1.29

Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc Natl Acad Sci U S A (1995) 1.26

Organization of proximal signal initiation at the TCR:CD3 complex. Immunol Rev (2009) 1.25

Combinational targeting offsets antigen escape and enhances effector functions of adoptively transferred T cells in glioblastoma. Mol Ther (2013) 1.25

T cell receptor engagement leads to phosphorylation of clathrin heavy chain during receptor internalization. J Exp Med (2004) 1.19

One of the CD3epsilon subunits within a T cell receptor complex lies in close proximity to the Cbeta FG loop. J Exp Med (1998) 1.16

Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc Natl Acad Sci U S A (1996) 1.13

Qualitative and quantitative contributions of the T cell receptor zeta chain to mature T cell apoptosis. J Exp Med (1996) 1.10

Imaging T-cell receptor activation reveals accumulation of tyrosine-phosphorylated CD3ζ in the endosomal compartment. Proc Natl Acad Sci U S A (2010) 1.10

ITAM-mediated signaling by the T-cell antigen receptor. Cold Spring Harb Perspect Biol (2010) 1.08

Requirement for tyrosine residues 315 and 319 within zeta chain-associated protein 70 for T cell development. J Exp Med (2001) 0.99

Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. J Exp Med (1997) 0.97

ZAP-70 protein tyrosine kinase is constitutively targeted to the T cell cortex independently of its SH2 domains. J Cell Biol (1997) 0.95

Function of CD3 epsilon-mediated signals in T cell development. J Exp Med (2000) 0.95

Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity. PLoS Comput Biol (2013) 0.94

Phosphorylation site dynamics of early T-cell receptor signaling. PLoS One (2014) 0.93

Contributions of the T cell receptor-associated CD3gamma-ITAM to thymocyte selection. J Exp Med (2002) 0.90

Signalling pathways induced by protease-activated receptors and integrins in T cells. Immunology (2002) 0.88

Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med (2002) 0.88

Induction and stability of the anergic phenotype in T cells. Semin Immunol (2013) 0.87

Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains. Mol Cell Biol (1996) 0.87

T cell receptor dwell times control the kinase activity of Zap70. Nat Immunol (2015) 0.84

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection. J Recept Signal Transduct Res (2010) 0.81

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response. Biophys J (2016) 0.80

T cell receptor (TCR) engagement in apoptosis-defective, but interleukin 2 (IL-2)-producing, T cells results in impaired ZAP70/CD3-zeta association. J Exp Med (1998) 0.79

Molecular mechanism of selective recruitment of Syk kinases by the membrane antigen-receptor complex. J Biol Chem (2011) 0.79

Critical role of Ser-520 phosphorylation for membrane recruitment and activation of the ZAP-70 tyrosine kinase in T cells. Mol Cell Biol (2003) 0.78

Selective phosphorylation of the Dlg1AB variant is critical for TCR-induced p38 activation and induction of proinflammatory cytokines in CD8+ T cells. J Immunol (2014) 0.77

The middle ear immune defense changes with age. Eur Arch Otorhinolaryngol (2015) 0.77

Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development. J Immunol (2017) 0.75

Articles cited by this

SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28

Signal transduction by lymphocyte antigen receptors. Cell (1994) 10.63

Antigen receptor tail clue. Nature (1989) 7.32

The cytoplasmic domain of the T cell receptor zeta chain is sufficient to couple to receptor-associated signal transduction pathways. Cell (1991) 6.13

Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases. Science (1994) 4.23

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules. Cell (1992) 3.11

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein. Proc Natl Acad Sci U S A (1991) 2.74

Sequence requirements for induction of cytolysis by the T cell antigen/Fc receptor zeta chain. Cell (1992) 2.69

Activation of T cells by a tyrosine kinase activation domain in the cytoplasmic tail of CD3 epsilon. Science (1992) 2.67

Interaction of Shc with the zeta chain of the T cell receptor upon T cell activation. Science (1993) 2.25

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J Biol Chem (1993) 2.19

Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med (1993) 2.17

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor. J Biol Chem (1992) 2.05

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem (1988) 2.04

Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A (1994) 1.49

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol (1994) 1.45

Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J (1994) 1.43

A tyrosine-phosphorylated 70-kDa protein binds a photoaffinity analogue of ATP and associates with both the zeta chain and CD3 components of the activated T cell antigen receptor. J Biol Chem (1992) 1.35

Association of phosphatidylinositol 3-kinase with a specific sequence of the T cell receptor zeta chain is dependent on T cell activation. J Biol Chem (1994) 1.27

Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation. J Biol Chem (1993) 1.25

Reconstitution of T cell receptor zeta-mediated calcium mobilization in nonlymphoid cells. Science (1993) 1.14

Delineation of a T-cell activation motif required for binding of protein tyrosine kinases containing tandem SH2 domains. Proc Natl Acad Sci U S A (1994) 1.07

Purification and initial characterization of the lymphocyte-specific protein-tyrosyl kinase p56lck from a baculovirus expression system. J Biol Chem (1992) 0.98

The role of tyrosine kinases and phosphotyrosine-containing recognition motifs in regulation of the T cell-antigen receptor-mediated signal transduction pathway. J Leukoc Biol (1994) 0.86

Articles by these authors

Quantitative analysis of complex protein mixtures using isotope-coded affinity tags. Nat Biotechnol (1999) 21.92

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science (2001) 17.11

Correlation between protein and mRNA abundance in yeast. Mol Cell Biol (1999) 16.95

Molecular characterization of mitochondrial apoptosis-inducing factor. Nature (1999) 14.41

Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24

A cellular gene encodes scrapie PrP 27-30 protein. Cell (1985) 8.86

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev (1999) 8.14

A systematic approach to the analysis of protein phosphorylation. Nat Biotechnol (2001) 6.66

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell (1998) 6.15

Quantitative profiling of differentiation-induced microsomal proteins using isotope-coded affinity tags and mass spectrometry. Nat Biotechnol (2001) 5.69

In vitro cell-mediated immune responses to the male specific(H-Y) antigen in mice. J Exp Med (1975) 5.53

Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A (1992) 5.50

Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (1989) 5.20

Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A (2000) 4.79

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing. Nature (2000) 4.68

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity (1998) 4.56

Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50

Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (1995) 4.23

Identification of the components of the murine T cell antigen receptor complex. Cell (1985) 4.20

T cell antigen receptor activation pathways: the tyrosine kinase connection. Cell (1991) 3.95

Essential role of LAT in T cell development. Immunity (1999) 3.94

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc Natl Acad Sci U S A (1997) 3.75

The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A (1992) 3.74

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction. Proc Natl Acad Sci U S A (1990) 3.69

Monoclonal antibodies against the antigen receptor on a cloned T-cell hybrid. Proc Natl Acad Sci U S A (1983) 3.66

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation. J Immunol (1990) 3.51

Smooth muscle cell phenotypic transition associated with calcification: upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res (2001) 3.50

Identification of RFC(Ctf18p, Ctf8p, Dcc1p): an alternative RFC complex required for sister chromatid cohesion in S. cerevisiae. Mol Cell (2001) 3.40

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists. Science (1995) 3.40

The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell (1982) 3.38

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity (1998) 3.36

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor. Cell (1986) 3.30

Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. Immunity (2001) 3.29

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J Biol Chem (1990) 3.25

Cloning and expression of two distinct high-affinity receptors cross-reacting with acidic and basic fibroblast growth factors. EMBO J (1990) 3.10

Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem (2000) 3.03

Molecular basis of T cell inactivation by CTLA-4. Science (1998) 3.00

A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci U S A (1991) 2.93

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82

Identification of six novel autophosphorylation sites on fibroblast growth factor receptor 1 and elucidation of their importance in receptor activation and signal transduction. Mol Cell Biol (1996) 2.80

A brain-specific activator of cyclin-dependent kinase 5. Nature (1994) 2.71

Building a multichain receptor: synthesis, degradation, and assembly of the T-cell antigen receptor. Proc Natl Acad Sci U S A (1987) 2.58

Molecular cloning of the zeta chain of the T cell antigen receptor. Science (1988) 2.58

T cell activation induces rapid tyrosine phosphorylation of a limited number of cellular substrates. J Biol Chem (1989) 2.50

LAT is essential for Fc(epsilon)RI-mediated mast cell activation. Immunity (2000) 2.48

Interaction of calcium and calmodulin in the presence of sodium dodecyl sulfate. Biochim Biophys Acta (1980) 2.43

Complex complexes: signaling at the TCR. Immunity (1996) 2.42

Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO J (2000) 2.40

Tyrosine phosphorylation and activation of homologous protein kinases during oocyte maturation and mitogenic activation of fibroblasts. Mol Cell Biol (1991) 2.36

Association of two novel proteins, TbMP52 and TbMP48, with the Trypanosoma brucei RNA editing complex. Mol Cell Biol (2001) 2.28

The glycophosphatidylinositol-anchored Thy-1 molecule interacts with the p60fyn protein tyrosine kinase in T cells. J Biol Chem (1992) 2.25

Purification of three cytotoxic lymphocyte granule serine proteases that induce apoptosis through distinct substrate and target cell interactions. J Exp Med (1992) 2.25

The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor. Science (1989) 2.23

High throughput protein characterization by automated reverse-phase chromatography/electrospray tandem mass spectrometry. Protein Sci (1998) 2.23

Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide. Biochemistry (1991) 2.20

Protein identification by solid phase microextraction-capillary zone electrophoresis-microelectrospray-tandem mass spectrometry. Nat Biotechnol (1996) 2.19

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells. J Biol Chem (1993) 2.19

Mass spectrometric approaches for the identification of gel-separated proteins. Electrophoresis (1995) 2.13

Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem (1999) 2.12

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. Mol Cell Biol (2000) 2.06

The T cell antigen receptor zeta chain is tyrosine phosphorylated upon activation. J Biol Chem (1988) 2.04

Cloning of the cDNA encoding an RNA regulatory protein--the human iron-responsive element-binding protein. Proc Natl Acad Sci U S A (1990) 2.03

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. Mol Cell Biol (1998) 2.01

A natural killer cell granule protein that induces DNA fragmentation and apoptosis. J Exp Med (1992) 2.01

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int Immunol (1999) 2.00

Characterization of lipocortin I and an immunologically unrelated 33-kDa protein as epidermal growth factor receptor/kinase substrates and phospholipase A2 inhibitors. J Biol Chem (1987) 1.98

Four related proteins of the Trypanosoma brucei RNA editing complex. Mol Cell Biol (2001) 1.97

Cloning and characterization of a novel insulin-regulated membrane aminopeptidase from Glut4 vesicles. J Biol Chem (1995) 1.95

Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase beta (HPTP beta) using synthetic phosphopeptides. Biochem J (1994) 1.94

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase. Biochemistry (1986) 1.94

Independent evolution of the prochlorophyte and green plant chlorophyll a/b light-harvesting proteins. Proc Natl Acad Sci U S A (1996) 1.93

Characterization of an anti-peptide antibody that recognizes the murine analogue of the human T cell antigen receptor-T3 delta-chain. J Immunol (1986) 1.91

Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4. Science (1990) 1.89

Identification of flow-dependent endothelial nitric-oxide synthase phosphorylation sites by mass spectrometry and regulation of phosphorylation and nitric oxide production by the phosphatidylinositol 3-kinase inhibitor LY294002. J Biol Chem (1999) 1.87

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain. Mol Cell Biol (1992) 1.87

A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. Nat Genet (1998) 1.84

Automated chemical synthesis of a protein growth factor for hemopoietic cells, interleukin-3. Science (1986) 1.84

The protein information and property explorer: an easy-to-use, rich-client web application for the management and functional analysis of proteomic data. Bioinformatics (2008) 1.81

Tyrosine phosphorylation in T cells is regulated by phosphatase activity: studies with phenylarsine oxide. Proc Natl Acad Sci U S A (1990) 1.80

Disulfide linkage of the zeta and eta chains of the T cell receptor. Possible identification of two structural classes of receptors. J Biol Chem (1988) 1.79

Identification by electrospray ionization mass spectrometry of the sites of tyrosine phosphorylation induced in activated Jurkat T cells on the protein tyrosine kinase ZAP-70. J Biol Chem (1994) 1.77

IA mutant functional antigen-presenting cell lines. J Immunol (1983) 1.76

Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. Protein Expr Purif (1998) 1.75

The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the T cell antigen receptor. J Biol Chem (1994) 1.72

p90(RSK) is a serum-stimulated Na+/H+ exchanger isoform-1 kinase. Regulatory phosphorylation of serine 703 of Na+/H+ exchanger isoform-1. J Biol Chem (1999) 1.72

Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain. Cell (1989) 1.69

Purification and identification of secreted oxidative stress-induced factors from vascular smooth muscle cells. J Biol Chem (2000) 1.68

Isolation and characterization of platelet glycoprotein IV (CD36). J Biol Chem (1989) 1.68

Glu-537, not Glu-461, is the nucleophile in the active site of (lac Z) beta-galactosidase from Escherichia coli. J Biol Chem (1992) 1.68

T cell antigen-receptor signal transduction. Curr Opin Immunol (1999) 1.68

Localization of a major receptor-binding domain for epidermal growth factor by affinity labeling. Mol Cell Biol (1988) 1.67